Abstract:
:We have analyzed the BRAF locus on chromosome 7q34 with microsatellites for allelic changes and exons 11 and 15 of the BRAF with sequencing for mutations in 50 kidney cancers including 20 papillary, 15 conventional and 15 chromophobe renal cell carcinomas (RCC). Allelic changes at the BRAF locus were seen in 16 of the 20 papillary, 3 of the 15 conventional RCCs and 2 of the 15 chromophobe RCCs. Sequencing failed to disclose mutations in exons 11 and 15 of the BRAF gene in any of the tumors. Our data indicate that BRAF mutation does not play a role in the development of renal cell tumors.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Nagy A,Balint I,Kovacs Gdoi
10.1002/ijc.11305keywords:
subject
Has Abstractpub_date
2003-10-10 00:00:00pages
980-1issue
6eissn
0020-7136issn
1097-0215journal_volume
106pub_type
杂志文章abstract::Sperm protein 17 (Sp17) is an antigenic protein highly expressed in spermatozoa. Sp17 expression was demonstrated recently in multiple myeloma, suggesting that it may be a novel cancer-testis antigen. Expression of Sp17 mRNA and protein was examined in human ovarian tumors. Sp17 mRNA was evaluated by reverse transcrip...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11617
更新日期:2004-03-01 00:00:00
abstract::We have previously reported that the negative signaling regulator Similar Expression to FGF (hSef) is downregulated in prostate cancer and its loss is associated with clinical metastasis. Here, we explored the mechanistic basis of this finding. We first confirmed our clinical observation by testing hSef manipulation i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30604
更新日期:2017-04-15 00:00:00
abstract::The aim of this study was to compare the seasonal variation in performance of a faecal immunochemical test for haemoglobin (FIT) and a guaiac test (gFOBT) for colorectal cancer screening. From June 2009 to May 2011, 18,290 screening participants (50-74 years old) performed OC-SENSOR quantitative FIT (1 sample) and Hem...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29187
更新日期:2015-04-15 00:00:00
abstract::It was suggested that the brain microenvironment plays a role in glioma progression. Here we investigate the mechanism by which astrocytes which are abundant in glioma tumors, promote cancer cell invasion. In this study, we evaluated the effects of astrocytes on glioma biology both in vitro and in vivo and determined ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29380
更新日期:2015-09-01 00:00:00
abstract::Non-small-cell lung cancers (NSCLC) are often infiltrated by T lymphocytes. It is postulated that the presence of tumor-infiltrating lymphocytes (TIL) reflects a local host immune response against autologous tumors. To identify the nature of NSCLC TIL, we have characterized the molecular structure of the TCRbeta chain...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0215(19990412)81:2<205::aid-ijc
更新日期:1999-04-12 00:00:00
abstract::Sera from 450 individuals between the age of 1 and 80 years, representing the general population of the Czech Republic, were tested for the presence of antibodies to human-papillomavirus(HPV)-derived antigens. The following antigens were used: (i) HPV1 virions; (ii) HPV16, -18 and -33-virus-like particles (VLP); (iii)...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980831)77:5<689::aid-ijc
更新日期:1998-08-31 00:00:00
abstract::Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...
journal_title:International journal of cancer
pub_type: 杂志文章
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更新日期:2010-08-01 00:00:00
abstract::Data on the incidence of childhood cancer in Queensland during the 10-year period 1979-88 are presented. During this period, 786 cases were registered. The average annual crude and age-standardized (to the world population) incidence rates for both sexes were 12.63 and 13.30 per 100,000 respectively. The incidence of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450603
更新日期:1990-06-15 00:00:00
abstract::Identification of loss of heterozygosity on specific genetic loci is crucial for understanding the pathogenesis of prostate cancer at the molecular level. This is especially important because the deleted regions may contain putative tumor suppressor genes. Chromosome 3p loss appears to be frequently associated with va...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970328)71:1<20::aid-ijc5
更新日期:1997-03-28 00:00:00
abstract::Posttransplant lymphoproliferative disorder (PTLD) is a common and life-threatening complication of immunosuppression used to prevent rejection of solid organ and bone marrow transplants. There is no standardized treatment algorithm, but numerous management strategies are available. We describe a patient who developed...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000420)90:2<104::aid-ijc
更新日期:2000-04-20 00:00:00
abstract::Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33362
更新日期:2021-02-15 00:00:00
abstract::We analyzed the number of circulating tumor cells (CTCs) and Epstein-Barr virus DNA (EBV DNA) for diagnosis, monitoring and prognosis of patients with metastatic nasopharyngeal carcinoma (mNPC). The levels of CTCs and EBV DNA were measured at baseline and after first-line chemotherapy in 148 mNPC patients prospectivel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32380
更新日期:2019-11-15 00:00:00
abstract::The following studies were undertaken to determine the levels of serum carotene and vitamin A (retinol) in Egyptian patients with intestinal, urinary, hepatosplenic schistosomiasis, and bladder cancer. These studies have shown that both serum carotene and serum retinol levels are significantly reduced in patients with...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300203
更新日期:1982-08-15 00:00:00
abstract::Several lines of evidence suggest that long-term treatment with non-steroidal anti-inflammatory drugs may reduce the risk of colon cancer and the size and number of colonic polyps in patients with familial adenomatous polyposis. Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971210)73:6<880::aid-ijc
更新日期:1997-12-10 00:00:00
abstract::The physiological stress response to surgery promotes wound healing and functional recovery and includes the activation of neural, inflammatory and proangiogenic signaling pathways. Paradoxically, the same pathways also promote metastatic spread and growth of residual cancer. Human and animal studies show that cancer ...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.32820
更新日期:2020-06-15 00:00:00
abstract::The relationship between renal-cell cancer (RCC) and occupation was investigated in an international multicenter population-based case-control study. Study centers in Australia, Denmark, Germany, Sweden and the United States interviewed 1732 incident RCC cases and 2309 controls. Significant associations were found wit...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910610503
更新日期:1995-05-29 00:00:00
abstract::Eleven population-based cancer registries tabulated second cancers among 133,411 patients diagnosed with testicular cancer, ovarian cancer or Hodgkin's disease between 1945 and 1984. Overall, 3,157 second cancers were observed, as compared with 2,420 expected at least one year after the first cancer. Survivors of test...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390506
更新日期:1987-05-15 00:00:00
abstract::Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23149
更新日期:2008-03-01 00:00:00
abstract::HER2 represents an important signaling pathway in breast and other cancers. Herceptin has demonstrated clinical activity, but resistance is common. Thus, new therapeutic approaches to the HER2 pathway are needed. Grb2 is an adaptor protein involved in Ras-dependent signaling induced by HER2 receptors. A specific Grb2-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22674
更新日期:2007-07-15 00:00:00
abstract::Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated as the cellular ori...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29835
更新日期:2016-02-15 00:00:00
abstract::DNA synthesis in heterokaryons of mouse peritoneal macrophages and various proliferating cultured cells was analyzed. Macrophages did not inhibit replication in the nuclei of non-immortalized and spontaneously immortalized cells (rat fibroblasts and macrophages, mouse pre-macrophages, NIH3T3 cells). On the contrary, t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440611
更新日期:1989-12-15 00:00:00
abstract::The high burden of cervical cancer and inadequate/suboptimal cytology screening in developing countries led to the evaluation of visual screening tests, like visual inspection with acetic acid (VIA) and Lugol's iodine (VILI). We describe the performance of VIA, VILI and cytology, carried out in a multinational project...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27633
更新日期:2012-09-15 00:00:00
abstract::A series of 42 patients with malignant melanoma treated with BCG adjuvant immunotherapy were studied for sequential changes in cellular immune reactivity to non-specific mitogens. Lymphocyte preparations were made monthly and stored in a viable condition in liquid nitrogen. After 6 months of treatment, all lymphocyte ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910190104
更新日期:1977-01-01 00:00:00
abstract::Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was ...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.20648
更新日期:2005-02-20 00:00:00
abstract::Tissue factor (TF)-mediated protease-activated receptor (PAR)-2 signaling is associated with a promigratory, invasive and proangiogenic phenotype in experimental models of breast cancer and has been mechanistically coupled to phosphorylation of the TF cytoplasmic domain (pTF). However, the clinical relevance of these ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24921
更新日期:2010-05-15 00:00:00
abstract::Previous studies have suggested that thyroid function is associated with breast cancer risk, which could have an important clinical impact, as one in eight women will develop a thyroid disorder during her lifetime. However, the underlying pathomechanism behind the association is still unknown. We used the Malmö Diet a...
journal_title:International journal of cancer
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doi:10.1002/ijc.31156
更新日期:2018-04-01 00:00:00
abstract::In a previous study, we showed that targeted delivery of bovine liver catalase to hepatocytes by direct galactosylation augmented the inhibitory effect of the enzyme on experimental hepatic metastasis of colon carcinoma cells (unpublished data). Here, we examined the ability of catalase to inhibit tumor metastasis to ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10387
更新日期:2002-05-20 00:00:00
abstract::In this study, the anticancer effect of prednisolone was investigated using rats with normal endogen adrenaline levels (intact), reduced adrenaline levels (metyrosine-induced) and adrenaline deficiency (adrenalectomized) via gastric adenocarcinoma model. Gastric adenocarcinoma was induced with N-methyl-N'-nitro-N-nitr...
journal_title:International journal of cancer
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abstract::Benzo(a)pyrene and benz(a) anthrancene which, in contrast to the K-region epoxides benzo(a)pyrene 4,5-oxide and benz(a)anthracene 5,6-oxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparations, were activated by liver microsomes from C3H mice, which had not received any ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180408
更新日期:1976-10-15 00:00:00
abstract::A population-based case-control study of risk factors for renal-cell carcinoma was conducted in Denmark from 1989 to 1992. A total of 368 histologically verified cases and 396 controls were included. Information on weight, height, physical activity and reproductive factors were collected in a structured interview, alo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560113
更新日期:1994-01-02 00:00:00