Abstract:
:The following studies were undertaken to determine the levels of serum carotene and vitamin A (retinol) in Egyptian patients with intestinal, urinary, hepatosplenic schistosomiasis, and bladder cancer. These studies have shown that both serum carotene and serum retinol levels are significantly reduced in patients with bladder cancer when compared to controls. These data, when viewed in light of previous animal studies noted, raise the question as to whether vitamin A administration can be beneficial in the prevention and/or treatment of human bladder cancer, particularly that associated with schistosomiasis.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Mahmoud LA,Robinson WAdoi
10.1002/ijc.2910300203subject
Has Abstractpub_date
1982-08-15 00:00:00pages
143-5issue
2eissn
0020-7136issn
1097-0215journal_volume
30pub_type
杂志文章abstract::2-methoxyestradiol (2ME(2)) is an endogenous metabolite of estradiol with estrogen-receptor-independent antitumor and antiangiogenic activity. We examined the effects of 2ME(2) on the cellular proliferation of 8 human melanoma cell lines. We show that 2ME(2) inhibited cell proliferation by inducing apoptosis and an ar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20473
更新日期:2004-12-10 00:00:00
abstract::Administration of highly purified interferon to DBA/2 mice inhibited the growth of interferon-sensitive or interferon-resistant Friend erythroleukemia cells implanted subcutaneously. Injection of interferon at the site of tumor inoculation was more effective than injection of interferon intraperitoneally. Histologic e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310518
更新日期:1983-05-15 00:00:00
abstract::Numerous studies have suggested that excess body weight is associated with increased cancer risk. To examine this putative association, we performed a systematic review and quantitative meta-analysis of cohort studies reporting body mass index (BMI) and the risk of 23 cancer types. PubMed, Embase, and Web of Science w...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.31553
更新日期:2018-10-01 00:00:00
abstract::The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010520)95:3<168::aid-ijc1029>3
更新日期:2001-05-20 00:00:00
abstract::Several tumour-derived factors have recently been identified which induce tissue factor (TF) expression in endothelial cells in vitro. However, there is only limited evidence that endothelial cells lining tumour blood vessels express elevated procoagulant activity (PCA) in vivo. We have investigated the effects of hum...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960611)66:6<784::AID-IJC
更新日期:1996-06-11 00:00:00
abstract::A glutamine analogue, L-glutamic acid gamma-monohydroxamate (GAH) demonstrated complete cytotoxicity against L1210 cells in culture and marked anti-tumoral activity in vivo against L1210 leukemia and B16 melanoma. In vitro, GAH caused concentration-dependent inhibition of L1210 cell growth, with complete cell death be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450428
更新日期:1990-04-15 00:00:00
abstract::We evaluated cell survival, DNA double strand breaks (dsbs), and DNA synthesis following camptothecin (CPT) alone or concurrent CPT and X-radiation treatments in exponential-phase cultures of a radioresistant human melanoma cell line. Cell survival was measured by a clonogenic assay. DNA dsbs were measured by pulsed-f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1031
更新日期:2001-10-20 00:00:00
abstract::Regression of EB-virus-induced transformation occurs exclusively in cultures of leukocytes from seropositive donors. Studies have shown that the strength of regression could be assayed in terms of the proportion of T cells which must be added to the autologous EB virus-infected T-cell-depleted population in order to e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230505
更新日期:1979-05-15 00:00:00
abstract::Flavone acetic acid (FAA) is a potentially useful anti-tumour agent which has been reported to induce changes in tumour vasculature, in particular loss of bloodflow. This led us to examine whether endothelium could be a cellular target of FAA action, with resultant modulation of cell-surface coagulant properties leadi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490219
更新日期:1991-09-09 00:00:00
abstract::Extensive hypermethylation and consecutive transcriptional silencing of tumorsuppressor genes have been documented in multiple tumor entities including breast cancer. In a microarray based genome-wide methylation analysis of five sporadic breast carcinomas we identified a hypermethylated CpG island within the first in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22705
更新日期:2007-08-01 00:00:00
abstract::A hamster lymphoid cell line, HCT-2, transformed by human T-cell leukemia virus type I (HTLV-I) was serially transplanted for 9 passages in newborn hamsters. A total of 34 newborn hamsters inoculated intraperitoneally (i.p.) with 0.2-2 X 10(7) HCT-2 cells developed fatal lymphomas with dissemination to various organs ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410617
更新日期:1988-06-15 00:00:00
abstract::Drug-induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen-stimulated lymphocytes from patients with a rare recessive disease (ICF: immunodeficiency, centromeric region instability, facial anomalies) are associated with karyotypic instability. This chromosomal recombination...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980911)77:6<833::aid-ijc
更新日期:1998-09-11 00:00:00
abstract::DNA sequences coding for simian virus 40 (SV40) large T antigen have been detected at different frequencies in human non-Hodgkin's lymphomas (NHL) by PCR techniques as well as immunohistochemistry. A highly sensitive quantitative real-time PCR specific for a sequence of SV40 large T antigen was established to test whe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21346
更新日期:2006-01-15 00:00:00
abstract::Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28199
更新日期:2013-10-15 00:00:00
abstract::A novel non-phorbol-ester-like tumor promoter, okadaic acid (OA) has been shown to be an inhibitor of protein phosphatase I and IIA and, thus, to cause an "apparent activation" of protein kinase C (PKC). We previously showed that cis-diamminedichloroplatinum(II) (CDDP)-resistant cells, PC-9/CDDP, were cross-resistant ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500319
更新日期:1992-02-01 00:00:00
abstract::The tumor-suppressor genes p14(ARF), p16(INK4a) and Tp53 are commonly inactivated in many tumors. We investigated their role in the pathogenesis of 9 bile tract cancer cell lines and 21 primary sporadic extrahepatic bile duct carcinomas. p53 and p16 protein expression was examined by Western blot analysis and immunohi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1639
更新日期:2002-02-01 00:00:00
abstract::Peripheral blood leukocytes from patients with confirmed pulmonary neoplasia were tested for cytotoxicity against cultured cells derived from lung tumours of various histological types, foetal and normal adult lung tissue and tumours arising in organs other than the lung. Leukocytes from 73 percent of patients were cy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150216
更新日期:1975-02-15 00:00:00
abstract::Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26229
更新日期:2012-05-01 00:00:00
abstract::The MDR1 gene product P-glycoprotein (Pgp) plays a key role in multidrug resistance of cancer cells. Pgp is an ATP-driven efflux pump that extrudes a variety of dissimilar hydrophobic cytotoxic compounds. P-glycoprotein overexpression results in multidrug resistance (MDR) of tumor cell lines in vitro as well as in can...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1552
更新日期:2001-12-15 00:00:00
abstract::Numerous studies support a role for Sox2 to keep stem cells and progenitor cells in an immature and proliferative state. Coexpression of Sox2 and GFAP has been found in regions of the adult brain where neural stem cells are present and in human glioma cells. In our study, we have investigated the roles of Sox2 and its...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25647
更新日期:2011-07-01 00:00:00
abstract::Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capaci...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150619
更新日期:1975-06-15 00:00:00
abstract::Mammalian LIM kinase 1 (LIMK1) phosphorylates and inactivates the actin-binding and -depolymerizing factor cofilin and induces actin cytoskeletal changes. LIMK1 is reported to play an important role in cell motility, but the mechanism of induction of cell motility and the role of LIMK1 in tumor growth, angiogenesis an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21650
更新日期:2006-06-01 00:00:00
abstract::The in vitro sponge-gel-supported three-dimensional histoculture chemosensitivity assay (Hoffman assay) allows the in vivo-like culture of human tumors. In this study, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H tetrazolium bromide (MTT) end point was applied to the Hoffman assay in an attempt to increase in vitr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510325
更新日期:1992-05-28 00:00:00
abstract::CD44 is a transmembrane glycoprotein that binds hyaluronan, extracellular matrix proteins and growth factors. Multiple isoforms of CD44 are generated by alternative splicing of 10 separate exons (V1-V10). Expression of the variable exons has been correlated with tumour progression and metastasis in a range of cell typ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960516)66:4<457::AID-IJC
更新日期:1996-05-16 00:00:00
abstract::Stimulated by a report on elevated IgA levels in nasopharyngeal carcinoma (NPC), we tested a total of 372 sera from patients with NPC, other carcinomas of head and neck or elsewhere, Burkitt's lymphoma (BL), infectious mononucleosis (IM) or healthy controls. The sera were titrated in indirect immunofluorescence tests ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170102
更新日期:1976-01-15 00:00:00
abstract::Tobacco smoking and alcohol drinking histories were obtained from 194 patients with hepatocellular carcinoma (HCC) and 456 hospital controls, and the results were analysed in conjunction with the results of serological determinations of hepatitis B surface antigen (HBsAg), antibody to HBsAg (anti-HBs) and antibody to ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390109
更新日期:1987-01-15 00:00:00
abstract::Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients we...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30911
更新日期:2017-11-15 00:00:00
abstract::An immunopotentiating factor associated with spleen cells of C57BL/6J mice bearing the 3LL tumor is described. Supernatants of cultured spleen cells from tumor-bearing mice (TBM) augmented the generation of both 19S and 7S antibody-producing cells, when injected with sheep erythrocytes into syngeneic C57BL/6J mice. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910220416
更新日期:1978-10-15 00:00:00
abstract::The growth of 7/9 Burkitt's lymphoma (BL) cell lines and 5/6 human melanoma cell lines was inhibited by certain human fibroblast-like cell lines, especially human myofibroblast cell lines. In contrast to BL lines, 3/5 lymphoblastoid cell lines were less susceptible and 3/4 human leukaemic lines were resistant. The eff...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350410
更新日期:1985-04-15 00:00:00
abstract::Human papillomavirus (HPV) vaccination of a birth cohort of girls in the 9-13 age range is recommended as a priority, but decreases in HPV vaccine cost may make catch-up of a few additional cohorts more attractive not only in high-income countries. We assessed the reduction in HPV16 and 18 infections that could be ach...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28197
更新日期:2013-10-15 00:00:00