Long-term C-cell-mediated immunity to Epstein-Barr virus in man. II. Components necessary for regression in virus-infected leukocyte cultures.

abstract：:Bcl-2 protein inhibits apoptosis, reduces the requirement for growth factors, and thereby extends the survival of cells. Recent findings of Bcl-2 in several solid tumors suggest that it might contribute to the genesis of some types of cancer. Over-expression of Bcl-2 might play a role in carcinogenesis and malignant p...

journal_title：International journal of cancer

authors： Sakuragi N,Ohkouchi T,Hareyama H,Ikeda K,Watari H,Fujimoto T,Kuwabara M,Yamamoto R,Sagawa T,Fujino T,Fujimoto S

更新日期：1998-04-17 00:00:00

abstract：:MAGE genes encoding tumor-rejection antigens recognized by cytotoxic T lymphocytes are expressed at the mRNA level in various malignant tumors. We have investigated the expression of genes MAGE-1, -2, -3/-6 and -4a/-4b at the mRNA level in malignant and non-malignant ovarian tumors as well as in normal ovaries by reve...

journal_title：International journal of cancer

authors： Yamada A,Kataoka A,Shichijo S,Kamura T,Imai Y,Nishida T,Itoh K

更新日期：1995-12-20 00:00:00

abstract：:With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor be...

journal_title：International journal of cancer

authors： Huang W,Sundquist K,Sundquist J,Ji J

更新日期：2020-11-13 00:00:00

abstract：:Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...

journal_title：International journal of cancer

authors： Ziegler HW,Kay NE,Zarling JM

更新日期：1981-03-15 00:00:00

abstract：:Non-specific cross-reacting antigens (NCA-95 = CD66b and NCA-50/90 = CD66c) are members of the CEA (carcinoembryonic antigen = CD66e) family. Analysis of mRNA levels of CD66c in colon tumors suggests that this antigen is strongly up-regulated compared to its normal counterpart and could, therefore, be of clinical inte...

journal_title：International journal of cancer

authors： Grunert F,Daniel S,Nagel G,von Kleist S,Jantscheff P

更新日期：1995-11-03 00:00:00

abstract：:Human B- or T-cell lymphoma lines and primary murine lymphomas were treated with DNA oligonucleotides homologous to the telomere (TTAGGG repeat; "T-oligo"), either alone or in combination with standard, widely-used anticancer chemotherapeutic agents. T-oligo induces cell cycle arrest and apoptosis in cultured human or...

journal_title：International journal of cancer

authors： Longe HO,Romesser PB,Rankin AM,Faller DV,Eller MS,Gilchrest BA,Denis GV

更新日期：2009-01-15 00:00:00

abstract：:The impact of the ABC transporters breast cancer resistance protein/mitoxantrone resistance associated transporter (BCRP/MXR), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance gene-1/P-glycoprotein (MDR1/PGP) on the multidrug resistance (MDR) phenotype in chemoresistance and thermoresistance w...

journal_title：International journal of cancer

authors： Stein U,Lage H,Jordan A,Walther W,Bates SE,Litman T,Hohenberger P,Dietel M

更新日期：2002-02-20 00:00:00

abstract：:High BMI is a well-known risk factor for postmenopausal breast cancer. There have been some reports of excess risk in association with weight gain and WHR, but little is known about the influence of body fatness per se. Using data from the Malmö Diet and Cancer Study, a prospective cohort study, 12,159 postmenopausal ...

journal_title：International journal of cancer

authors： Lahmann PH,Lissner L,Gullberg B,Olsson H,Berglund G

更新日期：2003-01-10 00:00:00

abstract：:Although cervical cancer (CC) is a leading cause of cancer-related deaths in developing countries, incidence rates vary considerably, ranging from 3 to 61 per 10(5) females. Identifying determinants of high vs. low rates may suggest population-level prevention strategies. CC rates for 175 countries were obtained from ...

journal_title：International journal of cancer

authors： Drain PK,Holmes KK,Hughes JP,Koutsky LA

更新日期：2002-07-10 00:00:00

abstract：:Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinog...

journal_title：International journal of cancer

authors： Evans CH,DiPaolo JA

更新日期：1981-01-15 00:00:00

abstract：:We evaluated RS5444, a thiazolidinedione high affinity PPARgamma agonist, for the ability to inhibit colon carcinogenesis in azoxymethane (AOM)-treated mice. In our initial experiment, mice were treated with RS5444 during AOM treatment, and the drug was withdrawn 12 weeks after the last injection of AOM. RS5444 signif...

journal_title：International journal of cancer

authors： Su W,Necela BM,Fujiwara K,Kurakata S,Murray NR,Fields AP,Thompson EA

更新日期：2008-09-01 00:00:00

abstract：:Human colon cancer cells produce and secrete a variety of polypeptide growth factors. The functional role of these growth factors, however, is poorly understood. Though the secretion of epidermal growth factor (EGF)-like activity and EGF-related molecules by human colon cancer cells in culture has been reported, it is...

journal_title：International journal of cancer

authors： Huang S,Trujillo JM,Chakrabarty S

更新日期：1992-12-02 00:00:00

abstract：:Ferric nitrilotriacetate (Fe-NTA) causes renal proximal tubular necrosis, a consequence of iron ion-mediated free-radical-associated damage, that finally leads to a high incidence of renal adenocarcinoma in male rats and mice. We have investigated the levels of typical hydroxyl radical-induced DNA base modifications i...

journal_title：International journal of cancer

authors： Toyokuni S,Mori T,Dizdaroglu M

更新日期：1994-04-01 00:00:00

abstract：:Previous literature, although not consistent, suggests that moderate alcohol consumption might be associated with decreased risk of renal cell carcinoma (RCC) in women. Thus, we examined the association between alcohol intake and the incidence of RCC by analyzing data from the Swedish Mammography Cohort, a population-...

journal_title：International journal of cancer

authors： Rashidkhani B,Akesson A,Lindblad P,Wolk A

更新日期：2005-12-10 00:00:00

abstract：:Smoking is a major contributor to all-cause mortality in Europe and accounts for one-fifth of the cancer-related deaths. Monitoring the tobacco epidemic via an analysis of lung cancer trends is essential in helping countries arrest the effects of tobacco epidemic in the region. The study aims to provide a comprehensiv...

journal_title：International journal of cancer

authors： Bray FI,Weiderpass E

更新日期：2010-03-15 00:00:00

abstract：:We have addressed the role of bacterial co-infection in viral oncogenesis using as model Epstein-Barr virus (EBV), a human herpesvirus that causes lymphoid malignancies and epithelial cancers. Infection of EBV carrying epithelial cells with the common oral pathogenic Gram-negative bacterium Aggregatibacter actinomycet...

journal_title：International journal of cancer

authors： Frisan T,Nagy N,Chioureas D,Terol M,Grasso F,Masucci MG

更新日期：2019-01-01 00:00:00

abstract：:Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated wi...

journal_title：International journal of cancer

authors： Pantavos A,Ruiter R,Feskens EF,de Keyser CE,Hofman A,Stricker BH,Franco OH,Kiefte-de Jong JC

更新日期：2015-05-01 00:00:00

abstract：:Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN). Additionally, regulatory T (Treg) cells are increasingly understoo...

journal_title：International journal of cancer

authors： Scott ME,Ma Y,Kuzmich L,Moscicki AB

更新日期：2009-03-15 00:00:00

abstract：:Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To explore whether phenotypic differences among PPGLs reflect a MAX-mediated mechanism and opposing influence...

journal_title：International journal of cancer

authors： Qin N,de Cubas AA,Garcia-Martin R,Richter S,Peitzsch M,Menschikowski M,Lenders JW,Timmers HJ,Mannelli M,Opocher G,Economopoulou M,Siegert G,Chavakis T,Pacak K,Robledo M,Eisenhofer G

更新日期：2014-11-01 00:00:00

abstract：:Annamycin (Ann) is a non-cross-resistant lipophilic anthracycline antiobiotic optimally suited for liposome delivery. We studied how vesicle size and presence of phospholipids with a high phase transition temperature and monosialoganglioside (GM I) in the liposome bilayers affect the pharmacokinetics, tumor selectivit...

journal_title：International journal of cancer

authors： Zou Y,Ling YH,Reddy S,Priebe W,Perez-Soler R

更新日期：1995-05-29 00:00:00

abstract：:We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990...

journal_title：International journal of cancer

authors： Martró E,Esteve A,Schulz TF,Sheldon J,Gambús G,Muñoz R,Whitby D,Casabona J,Euro-Shaks study group.

更新日期：2007-03-01 00:00:00

abstract：:Generation of cytotoxic T lymphocytes (CTL) in vitro and tumor-rejection responses by sensitization of semi-syngeneic mice with tumor-antigen-reconstituted liposomes were investigated. Liposomes were prepared from a crude butanol extract (CBE) of BALBRVD leukemia cells and egg phosphatidylcholine (PC): 1,2-dimyristoyl...

journal_title：International journal of cancer

authors： Shibata R,Noguchi T,Sato T,Akiyoshi K,Sunamoto J,Shiku H,Nakayama E

更新日期：1991-05-30 00:00:00

abstract：:BALB/cfC3H female mice which develop mammary tumor virus (MTV)-induced mammary tumors possess not only serun antibodies directed against virus-associated antigens which are expressed on mammary tumor cells but also antibodies directed against antigenic specificities which are unique to each tumor. The possible range o...

journal_title：International journal of cancer

authors： Blair PB,Lane ML

更新日期：1978-04-15 00:00:00

abstract：:A group of 83 Spanish BC/OC families were analysed for BRCA1 germ-line mutations. Analysis of the entire coding sequence was carried out by SSCP and PTT. We identified 5 frameshift mutations: 185delAG (2 times), 189insTGTC, 1241delAC, and 5537delA and 3 missense mutations in BRCA1: 330A > G, 1240C > T, and 5263G > A. ...

journal_title：International journal of cancer

authors： Díez O,Cortés J,Domènech M,Brunet J,Del Río E,Pericay C,Sanz J,Alonso C,Baiget M

更新日期：1999-11-12 00:00:00

abstract：:Tumour necrosis factor alpha (TNF) mRNA is detected in the macrophage infiltrate surrounding the tumour, but the cellular/molecular interactions leading to TNF gene expression in macrophages are unknown. The in vitro system in which human blood monocytes are stimulated with human cancer cells for TNF release was used ...

journal_title：International journal of cancer

authors： Zembala M,Siedlar M,Ruggiero I,Wieckiewicz J,Mytar B,Mattei M,Colizzi V

更新日期：1994-01-15 00:00:00

abstract：:Recurrent deletions of chromosome fragments observed in neoplasms are thought to participate in tumor development through the inactivation of tumor-suppressor genes. In gliomas, the most frequent deletions involve chromosome arms 9p, 10q, 17p, 19q and 22q. We have analysed deletions of chromosome 22 in gliomas by stud...

journal_title：International journal of cancer

authors： Hoang-Xuan K,Merel P,Vega F,Hugot JP,Cornu P,Delattre JY,Poisson M,Thomas G,Delattre O

更新日期：1995-02-08 00:00:00

abstract：:The alpha 5 beta 1 integrin (CD49e/CD29), a heterodimeric membrane protein, is the "classical" fibronectin receptor on many cell types. During B-cell ontogeny, expression of the alpha 5-subunit is developmentally regulated. The alpha 5 beta 1 is decisive for migration on fibronectin substrate and very likely cooperate...

journal_title：International journal of cancer

authors： Blase L,Daniel PT,Koretz K,Schwartz-Albiez R,Möller P

更新日期：1995-03-16 00:00:00

abstract：:Human epidermoid carcinoma A431 cells attach more rapidly to collagen type-I and -IV substrates than to surfaces coated with laminin or fibronectin. The diminished intercellular interaction and rounding up manifested when these cells are exposed to epidermal growth factor (EGF) in tissue culture plastic or collagen fi...

journal_title：International journal of cancer

authors： Rieber M,Gil F,Rieber MS,Urbina C

更新日期：1986-03-15 00:00:00

abstract：:In the setting of breast cancer screening, 5-9% of needle core biopsies are diagnosed as lesions of uncertain malignant potential (B3). The management of these lesions is potentially problematic as the data on their outcome remains limited. In our study, we aim to assess the outcome of screen-detected lesions diagnose...

journal_title：International journal of cancer

authors： Rakha EA,Lee AH,Jenkins JA,Murphy AE,Hamilton LJ,Ellis IO

更新日期：2011-09-15 00:00:00

abstract：:The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...

journal_title：International journal of cancer

authors： Hemminki K,Jiang Y,Dong C

更新日期：2001-07-15 00:00:00