Abstract:
:Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that form rosettes with sheep red blood cells (SRBC) or (2) lysed the CLL cells with a monoclonal anti-B cell antibody and complement. NK activity in either lymphocyte preparation from nine of 10 patients with advanced disease was not detectable and, when calculated in terms of lytic units per ml of blood, as at least seven times lower than in controls; only one of these patients exhibited activity within the control range. Two patients with early disease had measurable, but low, NK-cell activity. Prolongation of the NK cell assay from 6 to 18h gave rise to significant killing in the CLL patients lacking NK cell activity in the 6-h assay; however, the activity still was six times lower than in controls. Treatment of leukemia cell-depleted lymphocytes from CLL patients with human fibroblast interferon or the interfeon inducer poly 1:C enhanced NK-cell activity in the two early stage patients but this treatment was ineffective in three later stage patients. The percentage of cells with characteristics of NK cells, i.e. those with receptors for SRBC and Fc-portion of IgG, was four times higher in CLL patients and the percentage of lymphocytes binding to NK-sensitive target cells was equal to that in controls despite the fact that, in the majority of patients, lysis of the target cells by the lymphocytes does not ensue. The NK deficiency may be responsible for the increased incidence of secondary malignancies in CLL patients.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ziegler HW,Kay NE,Zarling JMdoi
10.1002/ijc.2910270310subject
Has Abstractpub_date
1981-03-15 00:00:00pages
321-7issue
3eissn
0020-7136issn
1097-0215journal_volume
27pub_type
杂志文章abstract::To obtain a comprehensive overview of chromosomal alterations that may underlie human papillomavirus (HPV)-mediated immortalization, 4 foreskin keratinocyte cell lines generated by transfection with either HPV 16 (cell lines FK16A and FK16B) or HPV 18 (FK18A and FK18B) were subjected to chromosomal analysis using comp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980504)76:3<412::aid-ijc
更新日期:1998-05-04 00:00:00
abstract::The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010520)95:3<168::aid-ijc1029>3
更新日期:2001-05-20 00:00:00
abstract::The mRNA levels of the ras-related human rhoA, rhoB and rhoC genes were studied in human breast-cancer cell lines (HBCal), and in normal and immortalized mammary epithelial cells (HMEC) by Northern blot analysis and in situ hybridization. In contrast to the ubiquitous rhoA and rhoC gene expression, dramatic variations...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910590320
更新日期:1994-11-01 00:00:00
abstract::Pseudomyxoma peritonei (PMP) is a rare disorder with unique pathological and genetic changes. Although several studies have reported the clinical features and mutational changes of PMP that originates from the appendix, few studies on PMP originating from the ovary have been reported due to its extreme rarity. In orde...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33460
更新日期:2021-01-05 00:00:00
abstract::The current paradigm stipulates that inhibition of histone deacetylase (HDAC) 6 is essential for the combinatorial effect of proteasome and HDAC inhibitors for the treatment of cancers. Our study aims to investigate the effect of combining different class I HDAC inhibitors (without HDAC6 action) with a proteasome inhi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28924
更新日期:2014-12-15 00:00:00
abstract::3-Nitrobenzanthrone (3-NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3-NBA is likely to occur primarily via the respiratory tract. In our study female Sprague Dawley rats were...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21095
更新日期:2005-10-10 00:00:00
abstract::Apoptin is a chicken anemia virus-derived, p53-independent, bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis in tumor cells. To explore the use of the Apoptin gene in cancer gene therapy, we constructed a recombinant fowlpox virus expressing the Apoptin protein (vFV-Apoptin) and co...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22215
更新日期:2006-12-15 00:00:00
abstract::Hereditary non-polyposis colorectal cancer, HNPCC, is an autosomal dominant condition predisposing to cancers of primarily the colorectum and the endometrium. The aim of our study was to identify persons at a high risk of hereditary colorectal cancer and to estimate their risk of colon and other HNPCC-associated tumou...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(200002)9999:9999<::aid-ijc1093>3
更新日期:2001-02-15 00:00:00
abstract::Activation-induced cytidine deaminase (AID) plays a role as a genome mutator in activated B cells, and inappropriate expression of AID has been implicated in the immunopathological phenotype of human B-cell malignancies. Notably, we found that the transgenic mice overexpressing AID developed lung adenocarcinoma and he...
journal_title:International journal of cancer
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doi:10.1002/ijc.22292
更新日期:2007-02-01 00:00:00
abstract::Imatinib mesylate has become an effective agent for the treatment of chronic myeloid leukemia (CML). However, the development of drug resistance has led to examination of combination therapies. In this study, we investigated the effects of combining imatinib with immunotherapy against a murine bcr-abl(+) leukemia, 12B...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20115
更新日期:2004-06-10 00:00:00
abstract::Initial studies have investigated the association between inflammation and colorectal cancer (CRC) using C-reactive protein (CRP) as a proinflammatory biomarker and have noted inconsistent results among women. We here report the findings from a large prospective study with repeat measurements of CRP, as well as serum ...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.27942
更新日期:2013-06-01 00:00:00
abstract::Specific estrogen, progesterone and androgen receptors were determined in 19 well-characterized squamous-cell carcinoma (SCC) cell lines. Ten of the lines were derived from patients with SCC of the larynx and nine were from patients with SCC originating in other areas of the head and neck. Estrogen receptors (ER) were...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910330105
更新日期:1984-01-15 00:00:00
abstract::We have previously developed 3 monoclonal anti-idiotypic antibodies (Ab2) of LOU rat origin directed against the binding site of the murine monoclonal IgM LAM8, which recognizes the small-cell lung carcinoma (SCLC)-associated sialoglycoprotein antigen sGP 90-135. The aim of this study was to compare the efficiencies o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500118
更新日期:1992-01-02 00:00:00
abstract::Lethal phenotypes of human prostate cancer are characterized by progression to androgen-independence and metastasis. For want of a clinically relevant animal model, mechanisms behind this progression remain unclear. Our study used an in vivo model of androgen-sensitive LNCaP human prostate cancer cell xenografts in ma...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20206
更新日期:2004-07-20 00:00:00
abstract::Non-specific cross-reacting antigens (NCA-95 = CD66b and NCA-50/90 = CD66c) are members of the CEA (carcinoembryonic antigen = CD66e) family. Analysis of mRNA levels of CD66c in colon tumors suggests that this antigen is strongly up-regulated compared to its normal counterpart and could, therefore, be of clinical inte...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630308
更新日期:1995-11-03 00:00:00
abstract::Female residents of six counties in Washington and Utah in whom a diagnosis of ovarian cancer was made during 1975-79 were interviewed concerning prior use of oral contraceptives. Interviews with a random sample of women drawn from these same counties were obtained for comparison. A smaller proportion of women with ep...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280602
更新日期:1981-12-01 00:00:00
abstract::Diabetes is a risk factor for many cancers; chronic hyperglycemia is hypothesized to be, in part, explanatory. We evaluated the association between glycated hemoglobin, a time-integrated glycemia measure, and cancer incidence and mortality in nondiabetic and diabetic men and women. We conducted a prospective study of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27394
更新日期:2012-10-01 00:00:00
abstract::cis-Diamminedichloroplatinum(II) (CDDP) induced G2-phase arrest in PC-9 human cancer cells. To elucidate how CDDP acts on cell-cycle regulation, we analyzed the effect of CDDP on cell-cycle regulators such as p34cdc2 protein kinase. p34cdc2 protein kinase activity was maximum in G2 phase and decreased after G2/M trans...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550417
更新日期:1993-10-21 00:00:00
abstract::We conducted a case-control study of adenocarcinoma of the lung and exposure to environmental tobacco smoke (ETS) in 7 countries. We interviewed 70 cases of adenocarcinoma of the lung and 178 population or hospital controls. All subjects had smoked fewer than 400 cigarettes in their lifetimes. Ever exposure to ETS fro...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/(sici)1097-0215(19991126)83:5<635::aid-ijc
更新日期:1999-11-26 00:00:00
abstract::Meningioma, the most frequent tumor in the central nervous system, has few recognized risk factors. We explored the role of allergies in a population-based case-control consortium study of meningioma in five geographic areas. We also studied serum levels of a marker of atopic allergy (IgE) in a subset of study partici...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25858
更新日期:2011-10-15 00:00:00
abstract::CD43 is a leukocyte-associated sialoglycoprotein which is also expressed in human colon adenoma and carcinoma. To obtain monoclonal antibodies (MAbs) that would react with CD43 in a glycosylation-independent way, antibodies were raised against a peptide corresponding to a portion of the CD43 cytoplasmic domain. Hybrid...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990702)82:1<52::aid-ijc1
更新日期:1999-07-02 00:00:00
abstract::Infection by oncogenic human papillomavirus (HPV) is a necessary but not sufficient cause of cervical carcinoma. Several host genetic and viral factors have been reported to increase the risk of carcinoma development given an HPV infection. In our study, we have analysed the contribution of HPV 16 E6 sequence subtype ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21212
更新日期:2005-11-20 00:00:00
abstract::Serum samples from feral populations of African green monkeys (Cercopithecus aethiops) were screened for antibodies to the simian T-lymphotropic virus, type I (STLV-I). Blood samples had been collected from 336 monkeys in 4 regions of central and southern Kenya in 1978 and 1979, from 114 monkeys in central Ethiopia in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380412
更新日期:1986-10-15 00:00:00
abstract::Liquid-based cytology (LBC) has replaced conventional cytology (CC) for cervical cancer screening in some countries. However, it remains unclear whether LBC is superior to CC. A randomized controlled trial was conducted between August 2007 and March 2009 in Germany to compare LBC, alone and in combination with compute...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/ijc.27955
更新日期:2013-06-15 00:00:00
abstract::A long-term tissue culture cell line has been derived from a human prostate adenocarcinoma metastatic to the brain. The cell line, DU 145, has been passaged 90 times in vitro over a period of 2 years. The cells are epithelial, grow in isolated islands on plastic Petri dishes, and form colonies in soft agar suspension ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210305
更新日期:1978-03-15 00:00:00
abstract::Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As aspirin exhibits a well-supported chemopreventive effect on comm...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
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更新日期:2021-03-15 00:00:00
abstract::Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960703)67:1<24::AID-IJC6
更新日期:1996-07-03 00:00:00
abstract::3H-HSV-2 DNA has been hybridized in situ to frozen sectioned tissue from human cervical biopsies. RNA complementary to the virus-specific probe was detected in cells undergoing pre-malignant changes, but not in the cells of the fully developed squamous-cell cancer. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250102
更新日期:1980-01-15 00:00:00
abstract::Prospective cohort studies about cutaneous melanoma (CM) risk are still few. Host factor- and UVR exposure data were collected prospectively by questionnaire in this population-based cohort study including 40,000 Swedish born women, aged 25-64 years at enrolment (1990). Risk for CM (Cox regression and Stepwise Cox reg...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26408
更新日期:2012-08-01 00:00:00
abstract::Progress against cancer through prevention and treatment is often measured by survival statistics only instead of analyzing trends in incidence, survival and mortality simultaneously because of interactive influences. This study combines these parameters of major cancers to provide an overview of the progress achieved...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26315
更新日期:2012-06-15 00:00:00