Cis-diamminedichloroplatinum(II) inhibits p34cdc2 protein kinase in human lung-cancer cells.

abstract：:Evidence suggests that the majority of lung cancer patients have tumour-derived genetic alterations in circulating plasma DNA, and that this may be developed as a diagnostic tool. To this end, we have studied 60 individuals attending bronchoscopy clinic, with symptoms suspicious of lung cancer, for genetic alterations...

journal_title：International journal of cancer

authors： Allan JM,Hardie LJ,Briggs JA,Davidson LA,Watson JP,Pearson SB,Muers MF,Wild CP

更新日期：2001-02-01 00:00:00

abstract：:Complement-dependent cytotoxicity against melanoma cells was demonstrated with a microassay in sera from melanoma patients. The response was tumor-specific and histologic type-specific since 16 out of 52 (30%) melanoma patient sera taken before surgery reacted against melanoma cells, whereas 3 out of 43 (7%) control s...

journal_title：International journal of cancer

authors： Canevari S,Fossati G,Della Porta G,Balzarini GP

更新日期：1975-11-15 00:00:00

abstract：:BALB/c and C3H- mice were given a single injection of methylcholanthrene (MCA) and were tested at various times thereafter for immunologic reactivity and resistance to syngeneic tumor challenge. MCA treatment did not affect the rejection of H-2-incompatible tumor allografts, the rejection of H-2-compatible skin allogr...

journal_title：International journal of cancer

authors： Lill PH,Jessup JM,Kripke ML

更新日期：1978-04-15 00:00:00

abstract：:MAGE-1 and MAGE-3 or -6 are genes encoding melanoma-rejection antigens recognized by cytotoxic T lymphocytes in an HLA-A1 restriction manner. MAGE-1 and MAGE-3 or -6 were expressed in 5/14 (36%) and 6/14 (43%) neuroblastoma (NB) cell lines, and in 20/41 (49%) and 24/41 (59%) clinical NB-related tumors, respectively. A...

journal_title：International journal of cancer

authors： Ishida H,Matsumura T,Salgaller ML,Ohmizono Y,Kadono Y,Sawada T

更新日期：1996-10-21 00:00:00

abstract：:Inactivation of the tumor-suppressor gene p16 (MTS1/ CDKN2/INK4a) has been described in various human malignancies. Although p16 deletion has been found in various ovarian tumor cell lines, p16 inactivation by homozygous deletion or mutation has been reported only sporadically in primary ovarian carcinomas. In a compr...

journal_title：International journal of cancer

authors： Milde-Langosch K,Ocon E,Becker G,Löning T

更新日期：1998-02-20 00:00:00

abstract：:The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-...

journal_title：International journal of cancer

authors： Attner P,Näsman A,Du J,Hammarstedt L,Ramqvist T,Lindholm J,Munck-Wikland E,Dalianis T,Marklund L

更新日期：2012-09-01 00:00:00

abstract：:Lymphatic leukemia developed in C57BL/6 mice following inoculation of normal thymocytes that and been co-cultured on leukemic thymus epithelial reticulum monolayer cells. Using thymocytes genetically marked in Ly membrane antigens, we showed that the thymomas which developed were produced by the co-cultured thymocytes...

journal_title：International journal of cancer

authors： Haas M

更新日期：1978-01-15 00:00:00

abstract：:Mouse fibroblasts (H-2(b)) were genetically engineered to express a co-stimulatory B7.1 and an IFN-gamma (Fb/IFN-gamma/B7.1). The Fb/IFN-gamma/B7.1 cells were then pulsed with an ovalbumin epitope (amino acids 257-264, SIINFEKL, H-2K(b)-restricted) as a model antigen (Fb/IFN-gamma/B7.1/OVA) and tested for the inductio...

journal_title：International journal of cancer

authors： Kim TS,Chung SW,Kim SH,Kang SN,Kang BY

更新日期：2000-08-01 00:00:00

abstract：:The aim of our study was to analyze the alterations of some candidate tumor suppressor genes (TSGs) viz. LIMD1, LTF, CDC25A, SCOTIN, RASSF1A and CACNA2D2 located in the chromosomal region 3p21.31 associated with the development of early dysplastic lesions of head and neck. In analysis of 72 dysplastic lesions and 116 ...

journal_title：International journal of cancer

authors： Ghosh S,Ghosh A,Maiti GP,Alam N,Roy A,Roy B,Roychoudhury S,Panda CK

更新日期：2008-12-01 00:00:00

abstract：:A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcohol-formalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC). In the competitive...

journal_title：International journal of cancer

authors： de Cremoux P,Martin EC,Vincent-Salomon A,Dieras V,Barbaroux C,Liva S,Pouillart P,Sastre-Garau X,Magdelenat H

更新日期：1999-10-08 00:00:00

abstract：:We showed earlier that interferon-gamma is a powerful inducer of differentiation of human neuroblastoma (NB) cells. Although 2',5' oligo-adenylate synthetase (2,5 OAS) may play a role in mediating the anti-proliferative and/or differentiative effects of interferons (IFNs), direct evidence is lacking. We have investiga...

journal_title：International journal of cancer

authors： Corrias MV,Gribaudo G,Guarnaccia F,Ponzoni M

更新日期：1995-07-17 00:00:00

abstract：:Experimental and epidemiological evidence supports a role for sex steroid hormones in the pathogenesis of ovarian cancer. We investigated the association between ovarian cancer risk and pre-diagnostic blood concentrations of testosterone, androstenedione, DHEAS, estrone and SHBG. A case-control study nested within 3 c...

journal_title：International journal of cancer

authors： Lukanova A,Lundin E,Akhmedkhanov A,Micheli A,Rinaldi S,Zeleniuch-Jacquotte A,Lenner P,Muti P,Biessy C,Krogh V,Berrino F,Hallmans G,Riboli E,Kaaks R,Toniolo P

更新日期：2003-05-01 00:00:00

abstract：:Conversion of solid sarcomas and carcinomas into ascites tumors depends on the in vivo selection of phenotypically altered tumor cell variants that can grow in the dissociated form. Once selected, they retain this property even after prolonged s.c. growth as solid tumors. From an s.c.-passaged subline of an ascites-co...

journal_title：International journal of cancer

authors： Minarovits J,Steinitz M,Boldog F,Imreh S,Wirschubsky Z,Ingvarsson S,Hedenskog M,Minarovits-Kormuta S,Klein G

更新日期：1990-03-15 00:00:00

abstract：:Kidney cancer often diagnosed at late stages when treatment options are severely limited. Thus, greater understanding of tumor metabolism leading ultimately to novel approaches to diagnosis is needed. Our laboratory has been utilizing metabolomics to evaluate compounds appearing in kidney cancer patients' biofluids at...

journal_title：International journal of cancer

authors： Ganti S,Taylor SL,Kim K,Hoppel CL,Guo L,Yang J,Evans C,Weiss RH

更新日期：2012-06-15 00:00:00

abstract：:In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and ...

journal_title：International journal of cancer

authors： Allday MJ,Kundu D,Finerty S,Griffin BE

更新日期：1990-06-15 00:00:00

abstract：:The role of retinoic acid receptor (RAR) expression in sensitivity to N-(4-hydroxyphenyl)retinamide (4HPR or fenretinide) as well as on the tumorigenicity of human ovarian carcinoma cells was examined. Two human ovarian cancer cell lines, A2780 and IGROV-1, with a 10-fold difference in sensitivity to 4HPR were chosen ...

journal_title：International journal of cancer

authors： Pergolizzi R,Appierto V,Crosti M,Cavadini E,Cleris L,Guffanti A,Formelli F

更新日期：1999-05-31 00:00:00

abstract：:We investigated the ability of endogenous and recombinant interleukin-2 (IL-2)-stimulated NK cells from normal donors and ovarian cancer patients to mediate lysis of ovarian tumors, and found that peripheral blood (PB) mononuclear cells of normal donors or cancer patients did not display tumoricidal activity against o...

journal_title：International journal of cancer

authors： Lotzová E,Savary CA,Freedman RS,Edwards CL,Wharton JT

更新日期：1988-08-15 00:00:00

abstract：:Cultured tumor cell lines, tumor xenografts grown in athymic nude mice, and a murine experimental metastasis model were used to assess the in vitro and in vivo anti-tumor activity of the potent IMP dehydrogenase (IMPDH) inhibitor, mycophenolic acid (MPA), and its morpholinoethyl ester pro-drug, mycophenolate mofetil (...

journal_title：International journal of cancer

authors： Tressler RJ,Garvin LJ,Slate DL

更新日期：1994-05-15 00:00:00

abstract：:A previously published case-control study of agricultural risk factors involved male cases of non-Hodgkin's lymphoma registered under code 202 of the International Classification of Diseases (ICD). This study has been expanded with the inclusion of cases registered under ICD code 200, and additional controls. The expa...

journal_title：International journal of cancer

authors： Pearce NE,Sheppard RA,Smith AH,Teague CA

更新日期：1987-02-15 00:00:00

abstract：:Anal squamous cell carcinomas are predominantly associated with high-risk human papillomaviruses (HPVs), particularly HPV 16, similar to cervical, vaginal and vulvar cancers. Although the presence of "low-risk" HPVs, in particular genotypes 6 and 11, have occasionally been reported in various HPV-related anogenital ca...

journal_title：International journal of cancer

authors： Cornall AM,Roberts JM,Garland SM,Hillman RJ,Grulich AE,Tabrizi SN

更新日期：2013-11-01 00:00:00

abstract：:It has been debated whether the reported increased risk of Hodgkin's lymphoma (HL) after tonsillectomy could be due to some underlying factor rather than the surgery itself. We studied whether not only tonsillectomy but also tonsillitis was associated with HL. This nationwide cohort study included all Danish residents...

journal_title：International journal of cancer

authors： Vestergaard H,Westergaard T,Wohlfahrt J,Hjalgrim H,Melbye M

更新日期：2010-08-01 00:00:00

abstract：:We have examined, in proliferating neoplastic cells, the effect on DNA of EGTA (a chelator of Ca2+) and W7 (an inhibitor of calmodulin). The treatment results in release of single-stranded DNA fragments (2-10 kb) from pre-labelled HMW DNA. When DNA from synchronized neoplastic cells in S phase is examined, almost all ...

journal_title：International journal of cancer

authors： Lönn U,Lönn S

更新日期：1986-06-15 00:00:00

abstract：:Prostate stem cell antigen (PSCA) and prostate-specific antigen (PSA) are overexpressed in most prostate cancers. PSCA- and PSA-derived, HLA-A2 binding peptides are specific targets for T-cell responses in vitro. A phase I/II trial was performed to demonstrate feasibility, safety and induction of antigen-specific immu...

journal_title：International journal of cancer

authors： Thomas-Kaskel AK,Zeiser R,Jochim R,Robbel C,Schultze-Seemann W,Waller CF,Veelken H

更新日期：2006-11-15 00:00:00

abstract：:A novel intra-operative chemotherapy nude mouse model for human hepatocellular carcinoma (HCC) has been developed. Intra-peritoneal (i.p.) administration of 5-fluorouracil (5-FU) was begun 2 hr before hepatic resection of HCC and then continued post-operatively for 4 consecutive days. This regime, termed intra-hepatec...

journal_title：International journal of cancer

authors： Rashidi B,An Z,Sun FX,Li X,Tang ZY,Moossa AR,Hoffman RM

更新日期：2001-01-15 00:00:00

abstract：:Stimulated by a report on elevated IgA levels in nasopharyngeal carcinoma (NPC), we tested a total of 372 sera from patients with NPC, other carcinomas of head and neck or elsewhere, Burkitt's lymphoma (BL), infectious mononucleosis (IM) or healthy controls. The sera were titrated in indirect immunofluorescence tests ...

journal_title：International journal of cancer

authors： Henle G,Henle W

更新日期：1976-01-15 00:00:00

abstract：:As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and resi...

journal_title：International journal of cancer

authors： Filippini G,Farinotti M,Lovicu G,Maisonneuve P,Boyle P

更新日期：1994-06-15 00:00:00

abstract：:Immunogenicity of a long 20-mer NY-ESO-1f peptide vaccine was evaluated in a lung cancer patient TK-f01, immunized with the peptide with Picibanil OK-432 and Montanide ISA-51. We showed that internalization of the peptide was necessary to present CD8 T-cell epitopes on APC, contrasting with the direct presentation of ...

journal_title：International journal of cancer

authors： Eikawa S,Kakimi K,Isobe M,Kuzushima K,Luescher I,Ohue Y,Ikeuchi K,Uenaka A,Nishikawa H,Udono H,Oka M,Nakayama E

更新日期：2013-01-15 00:00:00

abstract：:Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC versus SDC among screened women...

journal_title：International journal of cancer

authors： Strand F,Humphreys K,Eriksson M,Li J,Andersson TM,Törnberg S,Azavedo E,Shepherd J,Hall P,Czene K

更新日期：2017-01-01 00:00:00

abstract：:Cytokines and growth factors are powerful modulators of the immune response. Their aberrant expression either by the tumor cells or by the tumor infiltrating lymphocytes confers a selective advantage to the tumor to grow and suppress the cytotoxic activity of the infiltrating lymphocytes. Therefore, analysis of these ...

journal_title：International journal of cancer

authors： Marrogi AJ,Munshi A,Merogi AJ,Ohadike Y,El-Habashi A,Marrogi OL,Freeman SM

更新日期：1997-10-21 00:00:00

abstract：:Intestinal mucositis is a common side effect of chemotherapy leading to diarrhea, abdominal pain and increased risk of infections. The intestinal microbiota has been recognized as a key regulator of mucosal immune responses. Therefore, we hypothesized that intestinal microbial changes would be associated with enterocy...

journal_title：International journal of cancer

authors： De Pietri S,Ingham AC,Frandsen TL,Rathe M,Krych L,Castro-Mejía JL,Nielsen DS,Nersting J,Wehner PS,Schmiegelow K,Hasle H,Pamp SJ,Müller K

更新日期：2020-10-01 00:00:00