Therapeutic anti-tumor response induced with epitope-pulsed fibroblasts genetically engineered for B7.1 expression and IFN-gamma secretion.

abstract：:In order to understand the expression and modulation of adhesion molecules (AMs) on the surface of different gastric cancers, we studied 4 gastric-cancer cell lines including SC-M1, KATO-III, AGS and AZ-521. The expression of E-cadherin, integrins (beta1, beta2 and beta3), ICAMs (1 and 2), and CD11 (a, b and c) on the...

journal_title：International journal of cancer

authors： Hsieh MC,Wu CW,Wu LH,Lui WY,P'eng FK,Yu CL

更新日期：1996-09-04 00:00:00

abstract：:Hodgkin and Reed-Sternberg (H and RS) cells are generally considered to be the neoplastic cells of Hodgkin's disease (HD); however, such cells are found only in a minority of HD lesions. Very few data have so far been published on the cytogenetic abnormalities in HD. An analysis of unknown genetic aberrations has only...

journal_title：International journal of cancer

authors： Ohshima K,Ishiguro M,Ohgami A,Sugihara M,Haraoka S,Suzumiya J,Kikuchi M

更新日期：1999-07-19 00:00:00

abstract：:The relationship between renal-cell cancer (RCC) and occupation was investigated in an international multicenter population-based case-control study. Study centers in Australia, Denmark, Germany, Sweden and the United States interviewed 1732 incident RCC cases and 2309 controls. Significant associations were found wit...

journal_title：International journal of cancer

authors： Mandel JS,McLaughlin JK,Schlehofer B,Mellemgaard A,Helmert U,Lindblad P,McCredie M,Adami HO

更新日期：1995-05-29 00:00:00

abstract：:Experimental evidence suggests that vitamin D might play a role in the development of breast cancer. Although the results of case-control studies indicate that circulating 25-hydroxyvitamin D [25(OH)D] is inversely associated with the risk of breast cancer, the results of prospective studies are inconsistent. A case-c...

journal_title：International journal of cancer

authors： Kühn T,Kaaks R,Becker S,Eomois PP,Clavel-Chapelon F,Kvaskoff M,Dossus L,Tjønneland A,Olsen A,Overvad K,Chang-Claude J,Lukanova A,Buijsse B,Boeing H,Trichopoulou A,Lagiou P,Bamia C,Masala G,Krogh V,Sacerdote C,Tumi

更新日期：2013-10-01 00:00:00

abstract：:Single-cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin. The in vitro chemosensitivity of the cells...

journal_title：International journal of cancer

authors： Tveit KM,Fodstad O,Olsnes S,Pihl A

更新日期：1980-12-15 00:00:00

abstract：:To assess the effect of different hospital types or surgical volume on the survival of ovarian cancer patients, a nationwide and population-based analysis was carried out in Finland. The study included all 3,851 ovarian cancer patients operated from 1983-94. The patients were classified according to the hospital of th...

journal_title：International journal of cancer

authors： Kumpulainen S,Grénman S,Kyyrönen P,Pukkala E,Sankila R

更新日期：2002-12-10 00:00:00

abstract：:The relationship between chemosensitivity and p53 is currently considered from two mutually exclusive points of view: (1) wt p53 increases chemosensitivity due to apoptosis and (2) wt p53 decreases chemosensitivity due to growth arrest and DNA repair. We used p53-expressing adenovirus (Ad-p53) to directly evaluate eff...

journal_title：International journal of cancer

authors： Blagosklonny MV,El-Deiry WS

更新日期：1998-03-16 00:00:00

abstract：:In vitro, tumor-selective Hsp70 plasma membrane localization correlates with increased sensitivity to lysis mediated by a subpopulation of human natural killer (NK) cells that adhere to plastic following cytokine stimulation. In the present study, we analyzed the capacity of adoptively transferred human NK cells in SC...

journal_title：International journal of cancer

authors： Multhoff G,Pfister K,Botzler C,Jordan A,Scholz R,Schmetzer H,Burgstahler R,Hiddemann W

更新日期：2000-12-01 00:00:00

abstract：:Thiazolidinedione derivatives with potent antiarthritic activity, such as CGP 52608, have been suggested to exert their biological effects through the activation of the orphan nuclear receptor RORalpha. Since response elements for this receptor are present in the promoter region of cell cycle-related genes (i.e., p21(...

journal_title：International journal of cancer

authors： Moretti RM,Montagnani Marelli M,Motta M,Limonta P

更新日期：2001-06-01 00:00:00

abstract：:The age-adjusted incidence rates of cutaneous melanoma in Queensland in 1987 have been analysed for 16 anatomic sites, taking into account their surface areas. In men, the incidence of invasive melanoma on the ears, a chronically sun-exposed site, was extraordinarily high with annual rates of over 200 per 10(5) units ...

journal_title：International journal of cancer

authors： Green A,MacLennan R,Youl P,Martin N

更新日期：1993-01-21 00:00:00

abstract：:Loss of heterozygosity (LOH) on chromosome 13 and the age of patients at operation were studied in 46 cases of retinoblastoma (RB) tumors, of which 25 were hereditary and 21 were non-hereditary. The frequency of LOH was 70% for all informative tumors, but significantly higher in non-hereditary tumors (90%) than in her...

journal_title：International journal of cancer

authors： Kato MV,Ishizaki K,Ejima Y,Kaneko A,Tanooka H,Sasaki MS

更新日期：1993-07-30 00:00:00

abstract：:The early arrest patterns of a methylcholanthrene-induced fibrosarcoma were determined after injection of 125IUdR-labelled cells into the systemic circulation of mice bearing transplanted lymphosarcomas, and of normal animals. Similar experiments were performed using radiolabelled lymphosarcoma cells and normal or fib...

journal_title：International journal of cancer

authors： Weiss L,Glaves D

更新日期：1976-12-15 00:00:00

abstract：:There are approximately 100 genes which when mutated are known to predispose to one or more forms of cancer. Currently, genetic testing is offered for many of these, either as single genes or as multi-gene panels. Features of hereditary cancer include a positive family history of cancer, early age of onset and the app...

journal_title：International journal of cancer

authors： Cybulski C,Nazarali S,Narod SA

更新日期：2014-10-15 00:00:00

abstract：:Mouse-transformed keratinocytes cultured in the presence of transforming growth factor beta1 (TGF-beta1) acquire an array of morphologic and functional properties that give rise to a migratory phenotype that expresses mesenchymal molecular markers. This cellular conversion involves activation of the Ras-ERK pathway, e...

journal_title：International journal of cancer

authors： Santibáñez JF,Olivares D,Guerrero J,Martínez J

更新日期：2003-12-10 00:00:00

abstract：:The paired-like homeodomain transcription factor 2 (PITX2), a downstream effector of wnt/β-catenin signaling, is well known to play critical role during normal embryonic development. However, the possible involvement of PITX2 in human tumorigenesis remains unclear. In this study, we extend its function in human esopha...

journal_title：International journal of cancer

authors： Zhang JX,Tong ZT,Yang L,Wang F,Chai HP,Zhang F,Xie MR,Zhang AL,Wu LM,Hong H,Yin L,Wang H,Wang HY,Zhao Y

更新日期：2013-06-01 00:00:00

abstract：:Fluoropyrimidines induce cytotoxicity, in part, by inhibiting the proliferation-coordinated enzyme thymidylate synthase (TS), which is essential for DNA synthesis. Tumor TS levels are clinically predictive of post-surgical tumor recurrence and of response to fluoropyrimidine chemotherapy. Fluoropyrimidine drug toxicit...

journal_title：International journal of cancer

authors： Lincoln DW 2nd,Hrushesky WJ,Wood PA

更新日期：2000-11-01 00:00:00

abstract：:There is increasing use of multiple molecular markers to predict prognosis in human cancer. Our aim was to examine the prognostic significance of cyclin D1 and retinoblastoma (pRb) expression in association with human papillomavirus (HPV) status in oropharyngeal squamous cell carcinoma. Clinical records and specimens ...

journal_title：International journal of cancer

authors： Hong AM,Dobbins TA,Lee CS,Jones D,Fei J,Clark JR,Armstrong BK,Harnett GB,Milross CG,Tran N,Peculis LD,Ng C,Milne AG,Loo C,Hughes LJ,Forstner DF,O'Brien CJ,Rose BR

更新日期：2011-04-01 00:00:00

abstract：:Using differential screening of a breast cancer cDNA library, we isolated a cDNA encoding the psoriasin (S100A7) protein, previously identified in psoriatic epidermis. In the present study, we demonstrate that the psoriasin gene is expressed in breast cancer cell lines and in cancer cells of some breast carcinomas but...

journal_title：International journal of cancer

authors： Moog-Lutz C,Bouillet P,Régnier CH,Tomasetto C,Mattei MG,Chenard MP,Anglard P,Rio MC,Basset P

更新日期：1995-10-09 00:00:00

abstract：:Parathyroid hormone-related protein (PTHrP) is a causative factor of humoral hypercalcemia in malignancy. However, it is difficult to explain the mechanism of anorexia/cachexia with PTHrP secretion in detail. Previously, we demonstrated that the expressions of orexigenic peptides increased and anorexigenic peptides de...

journal_title：International journal of cancer

authors： Suzuki H,Hashimoto H,Kawasaki M,Watanabe M,Otsubo H,Ishikura T,Fujihara H,Ohnishi H,Onuma E,Yamada-Okabe H,Takuwa Y,Ogata E,Nakamura T,Ueta Y

更新日期：2011-05-01 00:00:00

abstract：:The clinical pathological findings of eight cases of ovarian endodermal sinus tumour (yolk sac tumour) are presented. Histological exmination in all eight cases showed a typical endodermal sinus tumour pattern, and in six of the patients other tumour elements such as dysgerminoma, choriocarcinoma, malignant teratoma, ...

journal_title：International journal of cancer

authors： Sell A,Sogaard H,Norgaard-Pedersen B

更新日期：1976-11-15 00:00:00

abstract：:The morphology of rat liver cells containing alpha-feto-protein (AFP) during early stages of carcinogenesis induced by 3'methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene was investigated. Indirect immunofluorescence was used to detect AFP. AFP was not found in the cells of hyperplastic nodules but was presen...

journal_title：International journal of cancer

authors： Tchipysheva TA,Guelstein VI,Bannikov GA

更新日期：1977-09-15 00:00:00

abstract：:Two distinct cell lines (OPM-1 and OPM-2) were established from the peripheral blood of a 56-year-old female myeloma patient at the stage of terminal leukemic evolution associated with loss of cytoplasmic immunoglobulin heavy chain (G lambda----lambda). The lines grew in suspension with a doubling time of 36-42 hr and...

journal_title：International journal of cancer

authors： Katagiri S,Yonezawa T,Kuyama J,Kanayama Y,Nishida K,Abe T,Tamaki T,Ohnishi M,Tarui S

更新日期：1985-08-15 00:00:00

abstract：:Our previous studies demonstrate that introduction of a approximately 70 cM region (now estimated at 63.75 Mb by the Human Genome Project) of human chromosome 12 into the highly metastatic Dunning rat prostate cancer cell line AT6.1 results in >30-fold (>/=90%) reduction in the number of overt metastases in spontaneou...

journal_title：International journal of cancer

authors： Jaeger EB,Chekmareva MA,Tennant TR,Luu HH,Hickson JA,Chen SL,Samant RS,Sokoloff MH,Rinker-Schaeffer CW

更新日期：2004-01-01 00:00:00

abstract：:Noninvasive biomarkers for early pancreatic ductal adenocarcinoma (PDAC) diagnosis and disease risk stratification are greatly needed. We conducted a nested case-control study within the Prospective Investigation into Cancer and Nutrition (EPIC) cohort to evaluate prediagnostic microRNAs (miRs) as biomarkers of subseq...

journal_title：International journal of cancer

authors： Duell EJ,Lujan-Barroso L,Sala N,Deitz McElyea S,Overvad K,Tjonneland A,Olsen A,Weiderpass E,Busund LT,Moi L,Muller D,Vineis P,Aune D,Matullo G,Naccarati A,Panico S,Tagliabue G,Tumino R,Palli D,Kaaks R,Katzke VA,

更新日期：2017-09-01 00:00:00

abstract：:To understand specific interactions between stromal cells and epithelial cells in benign prostatic hyperplasia (BPH) and prostatic adenocarcinoma, we developed stromal-cell cultures from normal human prostate (PNX) and BPH (BH101), composed of fibroblasts and myofibroblasts. Their role in epithelial-cell growth was st...

journal_title：International journal of cancer

authors： Degeorges A,Tatoud R,Fauvel-Lafeve F,Podgorniak MP,Millot G,de Cremoux P,Calvo F

更新日期：1996-10-09 00:00:00

abstract：:Socioeconomic status (SES) is a determinant of outcome in various types of cancer. The aim of this study is to analyze the impact of the SES in Hodgkin's lymphoma (HL). From 2001 to 2005, 194 consecutive patients were prospectively followed in 5 institutions. Patients answered a questionnaire with a set of items used ...

journal_title：International journal of cancer

authors： Soares A,Biasoli I,Scheliga A,Luiz RR,Costa MA,Land M,Romano S,Morais JC,Spector N

更新日期：2007-02-15 00:00:00

abstract：:Fatty acid ester surfactants, e.g., Cremophor EL and Solutol HS 15, that modulate multi-drug resistance (MDR) have been described; however, the drug potential of these preparations is unclear because of the molecular heterogeneity of these and other commercial surfactants. In previous experiments, an active but still ...

journal_title：International journal of cancer

authors： Buckingham LE,Balasubramanian M,Safa AR,Shah H,Komarov P,Emanuele RM,Coon JS

更新日期：1996-01-03 00:00:00

abstract：:The Epstein-Barr virus nuclear antigen I (EBNA I) is the only latent EBV antigen consistently expressed in malignant tissues of the nasopharynx. A 20-amino-acid synthetic peptide, p107 contains a major epitope of EBNA I. We tested sera from 210 patients with nasopharyngeal carcinoma (NPC) and from 128 normal individua...

journal_title：International journal of cancer

authors： Foong YT,Cheng HM,Sam CK,Dillner J,Hinderer W,Prasad U

更新日期：1990-06-15 00:00:00

abstract：:Overuse of antibiotic drugs alters the composition of gut microbiota and has detrimental effects on the host. In our study, we investigated association of gut flora and antibiotics in the prognosis of patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospec...

journal_title：International journal of cancer

authors： Iida N,Mizukoshi E,Yamashita T,Terashima T,Arai K,Seishima J,Kaneko S

更新日期：2019-11-15 00:00:00

abstract：:Despite the steadily increasing number of patients suffering from squamous-cell carcinomas of the oropharyngeal region, little is known about the molecular steps involved in the induction of these neoplasms. We investigated oropharyngeal cancers from 38 patients for mutations in the p53 tumour-suppressor gene. The maj...

journal_title：International journal of cancer

authors： Zariwala M,Schmid S,Pfaltz M,Ohgaki H,Kleihues P,Schäfer R

更新日期：1994-03-15 00:00:00