Acute overexpression of wt p53 facilitates anticancer drug-induced death of cancer and normal cells.

abstract：:Combining the specificity of tumor-targeting bacteria with the sensitivity of biomarker detection would create a screening method able to detect small tumors and metastases. To create this system, we genetically modified an attenuated strain of Salmonella enterica to release a recombinant fluorescent biomarker (or flu...

journal_title：International journal of cancer

authors： Panteli JT,Van Dessel N,Forbes NS

更新日期：2020-01-01 00:00:00

abstract：:Resistance to cisplatin-based chemotherapy is a major cause of treatment failure in human ovarian cancer. Wild-type TP53 status is often, but not always, associated with cisplatin sensitivity, suggesting that additional factors may be involved. Overexpression/activation of the phosphatidylinositol-3-kinase/Akt pathway...

journal_title：International journal of cancer

authors： Fraser M,Bai T,Tsang BK

更新日期：2008-02-01 00:00:00

abstract：:Human B- or T-cell lymphoma lines and primary murine lymphomas were treated with DNA oligonucleotides homologous to the telomere (TTAGGG repeat; "T-oligo"), either alone or in combination with standard, widely-used anticancer chemotherapeutic agents. T-oligo induces cell cycle arrest and apoptosis in cultured human or...

journal_title：International journal of cancer

authors： Longe HO,Romesser PB,Rankin AM,Faller DV,Eller MS,Gilchrest BA,Denis GV

更新日期：2009-01-15 00:00:00

abstract：:Insulin-like growth factor-1 receptor (IGF-1R) and human epidermal growth factor receptor-2 (HER2) receptor expression has been found to be a key regulator of tumorigenesis. The purpose of our study was to establish the prognostic significance of IGF-1R in esophageal cancer and to determine the effect of IGF-1R and HE...

journal_title：International journal of cancer

authors： Kalinina T,Bockhorn M,Kaifi JT,Thieltges S,Güngör C,Effenberger KE,Strelow A,Reichelt U,Sauter G,Pantel K,Izbicki JR,Yekebas EF

更新日期：2010-10-15 00:00:00

abstract：:Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. Stanniocalcin 2 (STC2) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically investigated using real-time quantitative reverse transcription-polymerase chain r...

journal_title：International journal of cancer

authors： Ieta K,Tanaka F,Yokobori T,Kita Y,Haraguchi N,Mimori K,Kato H,Asao T,Inoue H,Kuwano H,Mori M

更新日期：2009-08-15 00:00:00

abstract：:We undertook a study to determine the role and regulation of expression of urokinase-type plasminogen activator in squamous-cell carcinoma of the oral cavity. The contribution of urokinase to the invasive process was clearly demonstrated in experiments in which in vitro invasion by a cultured squamous-cell carcinoma c...

journal_title：International journal of cancer

authors： Clayman G,Wang SW,Nicolson GL,el-Naggar A,Mazar A,Henkin J,Blasi F,Goepfert H,Boyd DD

更新日期：1993-04-22 00:00:00

abstract：:In our study, we aimed to investigate the expression of N-cadherin and E-cadherin and their dependency on epithelial-mesenchymal transition regulators SNAI1, SIP1 and TWIST in human colon cancer. Expression of E-cadherin and N-cadherin was examined by immunohistochemistry in 80 colon carcinomas by using paraffin embed...

journal_title：International journal of cancer

authors： Rosivatz E,Becker I,Bamba M,Schott C,Diebold J,Mayr D,Höfler H,Becker KF

更新日期：2004-09-20 00:00:00

abstract：:Individuals differ in their ability to repair DNA damage induced by carcinogens. Studies have shown that polymorphisms in DNA repair genes contribute to individual variation in DNA repair capacity and cancer risk. In a hospital-based case-control study, we tested the hypothesis that a C to T variant (Thr241Met) of DNA...

journal_title：International journal of cancer

authors： Shen H,Sturgis EM,Dahlstrom KR,Zheng Y,Spitz MR,Wei Q

更新日期：2002-06-20 00:00:00

abstract：:The monoclonal antibody trastuzumab has brought survival benefit to patients with advanced gastric cancer (AGC) that have human epidermal growth factor receptor 2 (HER2) over expression or amplification. This study was designed to compare the clinical outcomes of HER2-negative and HER2-positive AGC patients with or wi...

journal_title：International journal of cancer

authors： Qiu MZ,Li Q,Wang ZQ,Liu TS,Liu Q,Wei XL,Jin Y,Wang DS,Ren C,Bai L,Zhang DS,Wang FH,Li YH,Xu RH

更新日期：2014-05-15 00:00:00

abstract：:In this registry-based cohort study, we estimated the risk of human papillomavirus (HPV)-related anogenital premalignancies and cancer in renal transplant recipients (RTRs) compared to a nontransplanted comparison cohort. We identified all first-time RTRs in Denmark during 1990-2015 in a nationwide nephrology register...

journal_title：International journal of cancer

authors： Reinholdt K,Thomsen LT,Dehlendorff C,Larsen HK,Sørensen SS,Haedersdal M,Kjaer SK

更新日期：2020-05-01 00:00:00

abstract：:In Bloom's syndrome (BS) the regulation of uracil-DNA glycosylase, an enzyme involved in the repair of DNA containing 5-FU, is altered. 5-FU induces higher levels of DNA fragmentation in BS cells than in non-BS cells. The increase in DNA fragmentation is connected to the cytotoxic mechanism where 5-FU is incorporated ...

journal_title：International journal of cancer

authors： Lönn U,Lönn S,Nylen U,Winblad G

更新日期：1990-03-15 00:00:00

abstract：:Differentiated thyroid carcinoma (TC) is threefold more common in women than in men and, therefore, a role of female hormones in the etiology of differentiated TC has been suggested. We assessed these hypotheses in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 345,157 women (mea...

journal_title：International journal of cancer

authors： Zamora-Ros R,Rinaldi S,Biessy C,Tjønneland A,Halkjaer J,Fournier A,Boutron-Ruault MC,Mesrine S,Tikk K,Fortner RT,Boeing H,Förster J,Trichopoulou A,Trichopoulos D,Papatesta EM,Masala G,Tagliabue G,Panico S,Tumino R,P

更新日期：2015-03-01 00:00:00

abstract：:Rabbits were immunized with extracts of primary or grafted intestinal adeno-carcinomas induced by carcinogenic drugs in inbred rats. After absorption with normal tissue extracts, the antisera were able to recognize three tumor-associated antigens. Two of them were glycoproteins, present in cancer cells but also, in tr...

journal_title：International journal of cancer

authors： Martin F,Martin MS,Bordes M,Knobel S

更新日期：1975-01-15 00:00:00

abstract：:Mammalian LIM kinase 1 (LIMK1) phosphorylates and inactivates the actin-binding and -depolymerizing factor cofilin and induces actin cytoskeletal changes. LIMK1 is reported to play an important role in cell motility, but the mechanism of induction of cell motility and the role of LIMK1 in tumor growth, angiogenesis an...

journal_title：International journal of cancer

authors： Bagheri-Yarmand R,Mazumdar A,Sahin AA,Kumar R

更新日期：2006-06-01 00:00:00

abstract：:Aberrant promoter methylation of normally unmethylated CpG-islands offers a promising tool for the development of molecular biomarkers. We investigated bronchial aspirates of patients admitted for suspected lung cancer with regard to the prevalence of aberrant methylation of potential marker genes. Applying quantitati...

journal_title：International journal of cancer

authors： Grote HJ,Schmiemann V,Geddert H,Rohr UP,Kappes R,Gabbert HE,Böcking A

更新日期：2005-09-20 00:00:00

abstract：:Several pathways have been implicated in the pathogenesis of endometrial carcinoma. Based on recent reports, BRAF mutations provide an alternative route for activation of the RAS signalling pathway. The CDKN2A (p16) tumour suppressor gene is also altered in several tumour types. We therefore wanted to assess the patte...

journal_title：International journal of cancer

authors： Salvesen HB,Kumar R,Stefansson I,Angelini S,MacDonald N,Smeds J,Jacobs IJ,Hemminki K,Das S,Akslen LA

更新日期：2005-07-20 00:00:00

abstract：:There is a growing evidence of the protective role of the Mediterranean diet (MD) on cancer. However, no prospective study has yet investigated its influence on lymphoma. We evaluated the association between adherence to the MD and risk of lymphoma and its subtypes in the European Prospective Investigation into Cancer...

journal_title：International journal of cancer

authors： Solans M,Benavente Y,Saez M,Agudo A,Naudin S,Hosnijeh FS,Noh H,Freisling H,Ferrari P,Besson C,Mahamat-Saleh Y,Boutron-Ruault MC,Kühn T,Kaaks R,Boeing H,Lasheras C,Rodríguez-Barranco M,Amiano P,Huerta JM,Barricarte A

更新日期：2019-07-01 00:00:00

abstract：:History of diabetes may be associated with decreased prostate cancer (PCa) risk. Published studies have not always accounted for time since diabetes diagnosis or confounding and effect modification by lifestyle factors. The authors investigated the relationship between diabetes and PCa risk in men in the Health Profes...

journal_title：International journal of cancer

authors： Kasper JS,Liu Y,Giovannucci E

更新日期：2009-03-15 00:00:00

abstract：:The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of ...

journal_title：International journal of cancer

authors： Kang S,Kim JW,Kang GH,Lee S,Park NH,Song YS,Park SY,Kang SB,Lee HP

更新日期：2006-05-01 00:00:00

abstract：:Hybridoma CE7 produces a murine antibody (gamma 1/kappa) which binds to a 190-kDa cell-surface glycoprotein of human neuroblastoma. Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma. We have isolated the gene segments coding for the variable region...

journal_title：International journal of cancer

authors： Amstutz H,Rytz C,Novak-Hofer I,Spycher M,Schubiger PA,Blaser K,Morgenthaler JJ

更新日期：1993-01-02 00:00:00

abstract：:The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the series has gone digital with the launch of a website as well as a series of books, known widely as ...

journal_title：International journal of cancer

authors： Washington MK,Goldberg RM,Chang GJ,Limburg P,Lam AK,Salto-Tellez M,Arends MJ,Nagtegaal ID,Klimstra DS,Rugge M,Schirmacher P,Lazar AJ,Odze RD,Carneiro F,Fukayama M,Cree IA,WHO Classification of Tumours Editorial Board.

更新日期：2021-03-01 00:00:00

abstract：:Cell lines established from T-cell leukemias have recently been reported to exhibit a chromosome translocation t(8;14) involving proto-oncogene c-myc and the gene of the T-cell receptor alpha-chain(TcR-alpha). In this work, we have studied a case of T-cell leukemia presenting a t(8;14)(q24;q11) translocation that was ...

journal_title：International journal of cancer

authors： Mathieu-Mahul D,Sigaux F,Zhu C,Bernheim A,Mauchauffe M,Daniel MT,Berger R,Larsen CJ

更新日期：1986-12-15 00:00:00

abstract：:During the 7th annual follow-up of our cohort of homosexual men in 1989, we tested the hypotheses that infection with human immunodeficiency virus (HIV) may enhance the expression of human papilloma virus (HPV) and that the development of anal epithelial abnormality is related to a biologic interaction between these t...

journal_title：International journal of cancer

authors： Caussy D,Goedert JJ,Palefsky J,Gonzales J,Rabkin CS,DiGioia RA,Sanchez WC,Grossman RJ,Colclough G,Wiktor SZ

更新日期：1990-08-15 00:00:00

abstract：:Cytotoxic antibodies against glioblastoma-associated antigen(s) have been sought for in glioma patient sera. Complement-dependent cytotoxicity (CDC) I and antibody-dependent cell-mediated cytotoxicity (ADCC) assays were used to test sera from 80 patients using 51 Cr labelled target cells derived from eight different g...

journal_title：International journal of cancer

authors： Martin-Achard A,Diserens AC,de Tribolet N,Carrel S

更新日期：1980-02-15 00:00:00

abstract：:There are clear indications that inheritance plays an essential role in certain cases of human endometrial cancer, and there are at least 2 forms of early-onset heritable endometrial adenocarcinomas (EACs). Females of the BDII inbred rat strain are known to be genetically predisposed to endometrial carcinoma, and we h...

journal_title：International journal of cancer

authors： Roshani L,Wedekind D,Szpirer J,Taib Z,Szpirer C,Beckmann B,Rivière M,Hedrich HJ,Klinga-Levan K

更新日期：2001-12-15 00:00:00

abstract：:Numbers of B, T and total lymphocytes, monocytes, heterophils, eosinophils and basophils have been examined in the peripheral blood of chickens between 2 and 42 days after infection with Marek's disease virus. During the stage of the acute restrictively productive virus infection of lymphoid tissues at 2-9 days after ...

journal_title：International journal of cancer

authors： Payne LN,Rennie M

更新日期：1976-10-15 00:00:00

abstract：:IL-2 gene was introduced through retroviral vectors into the highly malignant and poorly immunogenic 3LL-D122 clone. Both high and low D122-IL-2 secretors showed elimination of tumorigenicity in syngeneic immune-competent mice; however, in nude mice only the high IL-2 secretor showed reduced tumorigenicity as compared...

journal_title：International journal of cancer

authors： Porgador A,Gansbacher B,Bannerji R,Tzehoval E,Gilboa E,Feldman M,Eisenbach L

更新日期：1993-02-01 00:00:00

abstract：:Human papillomavirus (HPV) genomes usually persist as episomal molecules in HPV associated preneoplastic lesions whereas they are frequently integrated into the host cell genome in HPV-related cancers cells. This suggests that malignant conversion of HPV-infected epithelia is linked to recombination of cellular and vi...

journal_title：International journal of cancer

authors： Luft F,Klaes R,Nees M,Dürst M,Heilmann V,Melsheimer P,von Knebel Doeberitz M

更新日期：2001-04-01 00:00:00

abstract：:CDKN2A (p16) disruption is reported as a frequent event in head and neck squamous cell carcinomas that confers poor prognosis. We investigated the frequency of different potential mechanisms of CDKN2A inactivation in oral tongue squamous cell carcinomas (OTSCC) and their impact on patient outcome. From a cohort of 153...

journal_title：International journal of cancer

authors： Lim AM,Do H,Young RJ,Wong SQ,Angel C,Collins M,Takano EA,Corry J,Wiesenfeld D,Kleid S,Sigston E,Lyons B,Fox SB,Rischin D,Dobrovic A,Solomon B

更新日期：2014-08-15 00:00:00

abstract：:To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy spec...

journal_title：International journal of cancer

authors： Queiroz DM,Mendes EN,Rocha GA,Oliveira AM,Oliveira CA,Magalhães PP,Moura SB,Cabral MM,Nogueira AM

更新日期：1998-10-05 00:00:00