Abstract:
:To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy specimens. A significant association was found between cag A-positive status and distal gastric carcinoma for both the intestinal and diffuse types of tumor for both males and females. On the other hand, no association was observed between cag A-positive status and proximal gastric carcinoma.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Queiroz DM,Mendes EN,Rocha GA,Oliveira AM,Oliveira CA,Magalhães PP,Moura SB,Cabral MM,Nogueira AMdoi
10.1002/(sici)1097-0215(19981005)78:2<135::aid-ijcsubject
Has Abstractpub_date
1998-10-05 00:00:00pages
135-9issue
2eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19981005)78:2<135::AID-IJCjournal_volume
78pub_type
杂志文章abstract::Gliomas are aggressive tumors of the central nervous system originating from proliferating neural cells. Regulators of neural stem or progenitor cells biology may thus influence aspects of brain tumorigenesis, such as the maintenance of tumor-propagating potential. We investigated the role of Pax6, a neurogenic transc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27606
更新日期:2012-10-01 00:00:00
abstract::Elevated plasma lipoprotein(a) has been associated with an increased risk of cardiovascular disease. We report a significant elevation of total plasma apolipoprotein(a) levels in cancer patients compared with hospitalized control patients and normal healthy blood donors. Of the cancer patients studied, 48% had levels ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430212
更新日期:1989-02-15 00:00:00
abstract::A series of 111 human bladder tumors were screened using oligonucleotide mutant specific probes, restriction enzyme analysis and single-stranded confirmation polymorphism (SSCP) for the presence of H-ras activation events. Thirty-three tumors were found to harbor H-ras mutations where a glycine to valine (G-->T) chang...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550516
更新日期:1993-11-11 00:00:00
abstract::MAGE genes are frequently expressed in several types of human malignancy and code for antigens recognized by cytotoxic T lymphocytes. We have previously described a monoclonal antibody (MAb), named 6C1, that recognizes the MAGE-1 protein and cross-reacts with a 72-kDa protein present in lysates of melanoma cells such ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990909)82:6<901::aid-ijc
更新日期:1999-09-09 00:00:00
abstract::Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In this study, two sorafenib-resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms lead...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31022
更新日期:2017-12-15 00:00:00
abstract::Prostate-specific antigen (PSA) is a serine protease secreted by prostatic epithelial cells and is widely used as a marker for prostate cancer. The tissue specificity of PSA makes it a potential target for active specific immunotherapy, especially in prostate cancer patients who have undergone prostatectomy and in who...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910630215
更新日期:1995-10-09 00:00:00
abstract::The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane d...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.28954
更新日期:2015-01-01 00:00:00
abstract::Exposure of Chinese hamster cells to polyamines at an elevated temperature (42 degrees C) results in synergistic cell killing. The effectiveness of polyamines in potentiating thermal killing decreases in the following order: spermine greater than spermidine greater than cadaverine greater than putrescine. The magnitud...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910220515
更新日期:1978-11-15 00:00:00
abstract::The evolution of precancerous cervical lesions is poorly understood. A widely held model of cervical intraepithelial neoplasia grade 3 (CIN3) development is sequential progression from normal through CIN1 and CIN2 to CIN3. Another hypothesis, the "molecular switch" model, postulates that CIN3 can evolve directly from ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31549
更新日期:2018-10-01 00:00:00
abstract::To compare the presentation and prognosis of non-Hodgkin lymphoma (NHL) in people with AIDS (PWA) and in the general Italian population, a record linkage study was carried out. The fraction of NHLs attributable to HIV/AIDS was also estimated. Information from the National AIDS Registry (RAIDS) was linked with records ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010801)93:3<430::aid-ijc1344>3
更新日期:2001-08-01 00:00:00
abstract::Nasopharyngeal carcinoma is an Epstein-Barr Virus (EBV) associated malignancy which is highly prevalent in Southeast Asia. EBV-related antibodies have been widely used as screening markers for early nasopharyngeal carcinoma (NPC) detection. However, due to its low positive predictive rate, it is essential to develop n...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31642
更新日期:2018-12-15 00:00:00
abstract::Non-steroidal anti-inflammatory drugs (NSAIDs), including aspirin, seem to have chemopreventive properties against several types of cancer, particularly colon cancer. Persons with rheumatoid arthritis, an autoimmune disease for which NSAIDs are used commonly, have been reported to be at lower risk of colon cancer but ...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ijc.11311
更新日期:2003-09-20 00:00:00
abstract::B-cell chronic lymphocytic leukaemia (B-CLL) cells fail to undergo apoptosis. The mechanism underlying this resistance to cell death is still largely unknown. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) effectively kills tumour cells but not normal cells, and thus represents an attractive tool for...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22495
更新日期:2007-03-15 00:00:00
abstract::Ionizing radiation remains a major therapeutic tool against human cancers, especially epithelial tumors, which account for the majority of human malignancies. Although Fas and Fas-L are essential determinants of apoptosis, few data support their role in the cytotoxic effect of ionizing radiation. Epstein-Barr-virus (E...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000415)86:2<229::aid-ijc
更新日期:2000-04-15 00:00:00
abstract::Allelic losses on the chromosome arms 1p and 19q have been associated with favorable response to chemotherapy and good prognosis in anaplastic oligodendroglioma patients, but the molecular mechanisms responsible for this relationship are as yet unknown. The DNA repair enzyme O(6)-methylguanine DNA methyltransferase (M...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20575
更新日期:2005-01-20 00:00:00
abstract::Although multiple myeloma (MM) is predominantly a disease of the elderly, few studies have focused on the identification of prognostic factors in this group of patients. Four hundred twenty five MM patients >65 years were uniformly treated with chemotherapy (MP or VCMP/VBAD). Multivariate analysis identified 4 factors...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20491
更新日期:2004-12-10 00:00:00
abstract::The combination of cis-diamminedichloroplatinum(II) (CDDP) and 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11), a topoisomerase-I inhibitor, has been shown to be synergistic in vitro and clinically active against several human cancers refractory to chemotherapy. To elucidate the mechanism of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620114
更新日期:1995-07-04 00:00:00
abstract::Selenium is a promising chemopreventive agent for prostate cancer, possibly via an induction of apoptosis. Earlier studies have shown that selenite induces DNA single strand breaks (SSBs), reactive oxygen species (ROS), p53 Ser-15 phosphorylation and caspase-dependent and -independent apoptosis, whereas a methylseleno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22480
更新日期:2007-05-01 00:00:00
abstract::Expression levels of hTERT mRNA were investigated by RT-PCR in tissue specimens of patients with (Group A) and without (Group B) clinically overt bronchial carcinoma, respectively. Bronchial carcinoma (n = 9) and distant normal (n = 9) specimens were analyzed in Group A. The chance of carcinoma seemed to increase with...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11732
更新日期:2004-04-10 00:00:00
abstract::Complement-dependent cytotoxicity against melanoma cells was demonstrated with a microassay in sera from melanoma patients. The response was tumor-specific and histologic type-specific since 16 out of 52 (30%) melanoma patient sera taken before surgery reacted against melanoma cells, whereas 3 out of 43 (7%) control s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910160504
更新日期:1975-11-15 00:00:00
abstract::Exfoliated nasopharyngeal (NP) cells from 62 normal Cantonese Chinese having IgA/VCA antibodies for more than a year and from 39 similar persons without IgA/VCA antibodies, were tested for the presence of EBV/DNA sequences by spot followed by blot hybridization tests, using the cloned internal repeat of B95-8 viral DN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320504
更新日期:1983-11-15 00:00:00
abstract::The purpose of this study was to assess the relationship between progression-free survival (PFS) in patients treated with DFMO + PCV (procarbazine, CCNU, vincristine) chemotherapy for malignant gliomas with tumor cell ornithine decarboxylase (ODC) activity. Formalin-fixed slides were obtained for study patients with a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22914
更新日期:2007-11-15 00:00:00
abstract::The natural history of human T-lymphotropic virus type I (HTLV-I) has been shown to differ markedly by geographic area. The differences include contrasting patterns of risk of adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may be due in part to differences in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24012
更新日期:2009-02-01 00:00:00
abstract::A panel of 7 diagnostic cytopathologists, i.e., physicians trained to diagnose the malignant potential of human cells in Papanicolaou-stained smears, was asked to evaluate two sets of microscope slides of stained coverslip preparations of 28 cell culture lines, 15 of which were neoplastic. Slide Set I consisted of 13 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380310
更新日期:1986-09-15 00:00:00
abstract::Immunosuppressed patients who develop non-Hodgkin's lymphoma (NHL) have abnormal antibody responses against the Epstein-Barr virus (EBV) prior to the diagnosis of malignancy. To see if this is also true of "spontaneous" cases in the general population, we undertook a collaborative serologic case-control study. From 4 ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490313
更新日期:1991-09-30 00:00:00
abstract::Tumor cell migration involved in metastases is a tightly regulated, nonrandom process. Chemokines have been identified as critical molecules guiding cell migration. We performed a prospective study to analyze a possible association between the expression of chemokine receptors CXCR3 and CXCR4 by primary melanoma and c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21269
更新日期:2005-12-10 00:00:00
abstract::Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversial. To clarify thi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990719)82:2<187::aid-ijc
更新日期:1999-07-19 00:00:00
abstract::In vitro infection of EBV-negative lymphoma cell lines with immortalizing strains of Epstein-Barr virus induces the cell-surface expression of B-cell markers, such as the EBV receptor/CR2 (CD21) and the CD23 antigen. The non-immortalizing EBV variant, P3HRI, which carries a deletion encompassing the EBV nuclear antige...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460418
更新日期:1990-10-15 00:00:00
abstract::Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a carcinoma acquire an enhanced migratory phenotype in a process called epithelial-to-mesenchymal transition (EMT). This cellular pla...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30039
更新日期:2016-07-15 00:00:00
abstract::Single-cell suspensions prepared from five human melanomas, grown serially as xenografts in athymic nude mice, were exposed in vitro to increasing concentrations of DTIC (Dacarbazine), CCNU (Lomustine), procarbazine, vinblastine, and the cancerostatic lectins abrin and ricin. The in vitro chemosensitivity of the cells...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260604
更新日期:1980-12-15 00:00:00