From junk to master regulators of invasion: lncRNA functions in migration, EMT and metastasis.


:Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a carcinoma acquire an enhanced migratory phenotype in a process called epithelial-to-mesenchymal transition (EMT). This cellular plasticity seems to drive the initiation of metastasis. Identifying important molecules and understanding their molecular mechanisms is a key to cancer prognosis and the development of therapeutics for late stage malignancies. Recent advances in sequencing technology uncovered that the mammalian genome is pervasively transcribed into many nonprotein-coding RNAs including the class of long noncoding RNA, a.k.a. lncRNA. Several lncRNAs are differentially expressed in carcinomas and they are emerging as potent regulators of tumor progression and metastasis. Here, we review the diverse molecular mechanisms, cellular roles and regulatory patterns that are becoming apparent for the noncoding transcriptome. Chromatin modification, epigenetic regulation, alternative splicing and translational control by MALAT1, HOTAIR and TRE lncRNAs represent important examples of lncRNA-mediated control of cell migration and invasion, EMT and metastasis. Beyond these better characterized examples, numerous additional transcripts have been associated with cancer metastasis, but their functional roles await their discovery.


Int J Cancer


Dhamija S,Diederichs S




Has Abstract


2016-07-15 00:00:00












  • The relationship between blood IL-12p40 level and melanoma progression.

    abstract::Cytokines such as Interleukin (IL)-12p70 ("IL-12") and IL-23 can influence tumor progression. We tested the hypothesis that blood levels of IL-12p40, the common subunit of both cytokines, are associated with melanoma progression. Blood from 2,048 white melanoma patients were collected at a single institution between M...

    journal_title:International journal of cancer

    pub_type: 杂志文章


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  • Inhibition of breast tumor growth and angiogenesis by a medicinal herb: Ocimum gratissimum.

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    pub_type: 杂志文章


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    journal_title:International journal of cancer

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    pub_type: 杂志文章


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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


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    journal_title:International journal of cancer

    pub_type: 杂志文章


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  • Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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  • GD2-directed CAR-T cells in combination with HGF-targeted neutralizing antibody (AMG102) prevent primary tumor growth and metastasis in Ewing sarcoma.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Charan M,Dravid P,Cam M,Audino A,Gross AC,Arnold MA,Roberts RD,Cripe TP,Pertsemlidis A,Houghton PJ,Cam H

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  • Metastatic tumor cells adhere preferentially to the extracellular matrix underlying vascular endothelial cells.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    journal_title:International journal of cancer

    pub_type: 杂志文章


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  • Unexpected paracrine action of prostate cancer cells harboring a new class of androgen receptor mutation--a new paradigm for cooperation among prostate tumor cells.

    abstract::The emergence of mutations in the androgen receptor (AR) gene is a recurrent event during progression of prostate cancer (PCa) on androgen ablation therapy. In this study, we show that nonsense mutations that lead to carboxyl-terminal end truncated ARs are found at high frequency in metastatic PCas. Transcriptional ac...

    journal_title:International journal of cancer

    pub_type: 杂志文章


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