Melanoma in Western Australia 1975-76 to 1980-81: trends in demographic and pathological characteristics.

abstract：:In experimental tumor immunotherapy, incomplete Freund's adjuvant (IFA) has been considered as the "gold standard" for T-cell vaccination in mice and humans in spite of its considerable adverse effects. Recently, we succeeded in eliciting strong CTL responses in mice after vaccination with biodegradable poly(D,L-lacti...

journal_title：International journal of cancer

authors： Mueller M,Schlosser E,Gander B,Groettrup M

更新日期：2011-07-15 00:00:00

abstract：:In mammals, transforming growth factor-beta (TGF-beta) is found in 3 highly homologous isoforms that exert their effects via heteromeric complexes of type-I and type-II receptors (TbetaR-I and TbetaR-II). TGF-beta regulates the growth and metabolism of various cell types, including keratinocytes. We have investigated ...

journal_title：International journal of cancer

authors： Furue M,Kato M,Nakamura K,Nashiro K,Kikuchi K,Okochi H,Miyazono K,Tamaki K

更新日期：1997-05-16 00:00:00

abstract：:Mutations of the p53 tumor-suppressor gene universally occur on exons 5-8 in human cancer. We analyzed these mutations in esophageal cancer tissue from 207 patients in China using 2 methods, single-strand conformation polymorphism (SSCP), one of the most frequently used methods, and the recently developed denaturing h...

journal_title：International journal of cancer

authors： Yamanoshita O,Kubota T,Hou J,Ping YM,Zhang XL,Li XP,Li SS,Li XX,Zhu DC,Fukushima Y,Nakajima T

更新日期：2005-03-10 00:00:00

abstract：:Both epigallocatechin gallate (EGCG) and curcumin have shown efficacy in various in vivo and in vitro models of cancer. This study was designed to determine the efficacy of these naturally derived polyphenolic compounds in vitro and in vivo, when given in combination. Studies in MDA-MB-231 cells demonstrated that EGCG...

journal_title：International journal of cancer

authors： Somers-Edgar TJ,Scandlyn MJ,Stuart EC,Le Nedelec MJ,Valentine SP,Rosengren RJ

更新日期：2008-05-01 00:00:00

abstract：:The sensitivity of human tissues and tumors to infection with type C adenoviruses correlates with the expression of the human coxsackie B- and adenovirus receptor, hCAR. HCAR is heterogeneously expressed in various tissues and types of human cancer cells, which has implications for the use of adenoviruses as vectors i...

journal_title：International journal of cancer

authors： Fuxe J,Liu L,Malin S,Philipson L,Collins VP,Pettersson RF

更新日期：2003-03-01 00:00:00

abstract：:Gliomas represents more than 80% of all malignant brain tumors. However, the etiology still remains largely unknown. Human WW domain-containing oxidoreductase (WWOX), which is located at 16q23.1-16q23.2, the common fragile site 16D (FRA16D), an area with a high frequency of gene deletions or chromosomal alterations, h...

journal_title：International journal of cancer

authors： Yu K,Fan J,Ding X,Li C,Wang J,Xiang Y,Wang QS

更新日期：2014-10-01 00:00:00

abstract：:Inactivation of the tumor-suppressor gene p16 (MTS1/ CDKN2/INK4a) has been described in various human malignancies. Although p16 deletion has been found in various ovarian tumor cell lines, p16 inactivation by homozygous deletion or mutation has been reported only sporadically in primary ovarian carcinomas. In a compr...

journal_title：International journal of cancer

authors： Milde-Langosch K,Ocon E,Becker G,Löning T

更新日期：1998-02-20 00:00:00

abstract：:Previously, the induction of pancreatic carcinogenesis in the rat using azaserine has involved a multiple-dose treatment protocol. The objective of the present study was to determine the effect of multiple azaserine treatments on pancreatic DNA synthesis and to develop a protocol for a single-dose initiation of pancre...

journal_title：International journal of cancer

authors： Yager JD Jr,Roebuck BD,Zurlo J,Longnecker DS,Weselcouch EO,Wilpone SA

更新日期：1981-11-15 00:00:00

abstract：:Paclitaxel has antiangiogenic properties, but the mechanisms for the enhanced sensitivity of endothelial cells (ECs) to this drug are not established. The aims of our study were to compare the distribution of paclitaxel into ECs with other cell types, to assess the effects of low doses of paclitaxel on Cox-2 expressio...

journal_title：International journal of cancer

authors： Merchan JR,Jayaram DR,Supko JG,He X,Bubley GJ,Sukhatme VP

更新日期：2005-01-20 00:00:00

abstract：:Lysine-specific demethylase 1 (LSD1), a histone lysine demethylase with the main specificity for H3K4me2, has been shown to be overexpressed in rhabdomyosarcoma (RMS) tumor samples. However, its role in RMS biology is not yet well understood. Here, we identified a new role of LSD1 in regulating adhesion of RMS cells. ...

journal_title：International journal of cancer

authors： Haydn T,Kehr S,Willmann D,Metzger E,Schüle R,Fulda S

更新日期：2020-06-15 00:00:00

abstract：:In the setting of breast cancer screening, 5-9% of needle core biopsies are diagnosed as lesions of uncertain malignant potential (B3). The management of these lesions is potentially problematic as the data on their outcome remains limited. In our study, we aim to assess the outcome of screen-detected lesions diagnose...

journal_title：International journal of cancer

authors： Rakha EA,Lee AH,Jenkins JA,Murphy AE,Hamilton LJ,Ellis IO

更新日期：2011-09-15 00:00:00

abstract：:Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

journal_title：International journal of cancer

authors： Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

更新日期：2018-11-15 00:00:00

abstract：:Human malignant mesothelioma (HMM) is resistant to many anticancer drugs, including doxorubicin. Mevastatin and simvastatin, 2 inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMGCoA) reductase, potentiated the intracellular accumulation and the cytotoxicity of doxorubicin in HMM cells constitutively expressing P-...

journal_title：International journal of cancer

authors： Riganti C,Orecchia S,Pescarmona G,Betta PG,Ghigo D,Bosia A

更新日期：2006-07-01 00:00:00

abstract：:The survival experience of 284 patients with cancer of the cervix uteri registered by the population-based Zimbabwe National Cancer Registry in 1995-1997 is described. The vital status of these subjects was established by linkage with death registration and by retrieval of patient files from medical records department...

journal_title：International journal of cancer

authors： Chokunonga E,Ramanakumar AV,Nyakabau AM,Borok MZ,Chirenje ZM,Sankila R,Parkin DM

更新日期：2004-03-20 00:00:00

abstract：:XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XI...

journal_title：International journal of cancer

authors： Bilim V,Kasahara T,Hara N,Takahashi K,Tomita Y

更新日期：2003-01-01 00:00:00

abstract：:The application of glucocorticoids (GC3) in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.R1-R5, isolated from the GC-sensitive human acute-T-cell-leukemic line, CCRF-CEM-C7, by se...

journal_title：International journal of cancer

authors： Hala M,Hartmann BL,Böck G,Geley S,Kofler R

更新日期：1996-11-27 00:00:00

abstract：:During malignant progression cancer cells undergo a series of changes, which promote their survival, invasiveness and metastatic process. One of them is a change in glucose metabolism. Unlike normal cells, which mostly rely on the tricarboxylic acid cycle (TCA), many cancer types rely on glycolysis. Pyruvate dehydroge...

journal_title：International journal of cancer

authors： Golias T,Kery M,Radenkovic S,Papandreou I

更新日期：2019-02-15 00:00:00

abstract：:Physiological concentrations of insulin support the in vitro growth of LB T-cell lymphoma. We could not detect similar insulin dependence in other tumor cell lines. This study reports that insulin also enhances the growth of LB cells in vivo. Mice treated with Streptozotocin (SZ) developed partial resistance to LB lym...

journal_title：International journal of cancer

authors： Sharon R,Pillemer G,Ish-Shalom D,Kalman R,Ziv E,Berry EM,Naor D

更新日期：1993-03-12 00:00:00

abstract：:Loss of heterozygosity on chromosome arm 16q frequently occurs in human breast carcinomas regardless of the histological grade or type. To reveal whether the status of chromosome 16 corresponds to the histology of breast carcinomas, we examined the signal number of 16cen, 16q breakpoints and 1;16 fusions in the interp...

journal_title：International journal of cancer

authors： Tsuda H,Takarabe T,Hirohashi S

更新日期：1999-08-20 00:00:00

abstract：:Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the most evidenced triages is outlined, as are challenges for implementation...

journal_title：International journal of cancer

authors： Cuschieri K,Ronco G,Lorincz A,Smith L,Ogilvie G,Mirabello L,Carozzi F,Cubie H,Wentzensen N,Snijders P,Arbyn M,Monsonego J,Franceschi S

更新日期：2018-08-15 00:00:00

abstract：:We have separated subpopulations of macrophages from an immunogenic fibrosarcoma by the technique of unit gravity velocity sedimentation. The activation state of these subpopulations was determined by measurement of the Fc receptor avidity of adherent cells, and by their 5' nucleotidase and acid phosphatase activity. ...

journal_title：International journal of cancer

authors： Moore K,McBride WH

更新日期：1980-11-15 00:00:00

abstract：:Preparations of stress protein gp96 from tumor cells are active as tumor vaccines by eliciting immune responses against mixtures of individual tumor peptide antigens which are complexed to gp96. Due to the individual antigenicity of tumors, a vaccine consisting of tumor-derived gp96 has to be prepared individually for...

journal_title：International journal of cancer

authors： Heike M,Frenzel C,Meier D,Galle PR

更新日期：2000-05-15 00:00:00

abstract：:The light microscopic distinction between complex atypical hyperplasia (CAH) and invasive endometrioid carcinoma (UEC) on endometrial sampling is problematic and often has significant clinical implications. Using mouse models of endometrial tumorigenesis based on two of the most common molecular alterations found in p...

journal_title：International journal of cancer

authors： Wang H,Joshi A,Iaconis L,Solomon GJ,Xiang Z,Verhage HG,Douglas W,Ronnett BM,Ellenson LH

更新日期：2009-03-15 00:00:00

abstract：:Chimeric bcr/abl fusion proteins are thought to be the molecular 'pathogen' of chronic myelogenous leukaemia (CML). Expression levels of the respective fusion RNAs reflect disease progression as well as remission upon therapeutic intervention in CML patients. However, there is no quick and reliable method that would a...

journal_title：International journal of cancer

authors： Kreuzer KA,Lass U,Nagel S,Ellerbrok H,Pauli G,Pawlaczyk-Peter B,Siegert W,Huhn D,Schmidt CA

更新日期：2000-06-01 00:00:00

abstract：:Four human colon cancer cell lines (SW620, LS 180, DLD-I, and HCT-15) and Adriamycin-resistant sub-lines with varying degrees of P-glycoprotein expression were studied to evaluate the reversibility of Adriamycin resistance in human colon cancer. Two groups of cell lines were studied. In the first, including a series o...

journal_title：International journal of cancer

authors： Lai GM,Chen YN,Mickley LA,Fojo AT,Bates SE

更新日期：1991-11-11 00:00:00

abstract：:It has been suggested that smoking is associated with estrogen-negative breast cancer but not with estrogen-positive breast cancer. A population-based case-control study was conducted in Geneva, Switzerland, to determine the relation of passive and active smoking to breast cancer when the referent unexposed category c...

journal_title：International journal of cancer

authors： Morabia A,Bernstein M,Ruiz J,Héritier S,Diebold Berger S,Borisch B

更新日期：1998-01-30 00:00:00

abstract：:mTOR inhibition led to activation of upstream receptor tyrosine kinases (RTKs) and AKT, which may attenuate the efficacy of mTOR kinase inhibitors. We sought to discover efficient drug combination with mTOR inhibitors by elucidating the survival feedback loops induced by mTOR inhibition in breast cancer. The feedback ...

journal_title：International journal of cancer

authors： Chen SM,Guo CL,Shi JJ,Xu YC,Chen Y,Shen YY,Su Y,Ding J,Meng LH

更新日期：2014-11-15 00:00:00

abstract：:Since most intracellular proteins are expressed with their ligands, ligands of cancer-testis (CT) antigens may also be CT in their distribution. Applying Sperm protein 17 (Sp17) as the bait in a yeast 2-hybrid system of a testicular cDNA library, 17 interacting clones were isolated and all encoded Ropporin, a spermato...

journal_title：International journal of cancer

authors： Li Z,Li W,Meklat F,Wang Z,Zhang J,Zhang Y,Lim SH

更新日期：2007-10-01 00:00:00

abstract：:G-banding analyses of 14 independently derived B-cell lymphomas showed the frequent occurrence of chromosome 15 trisomy. It was present in seven of nine spontaneous B-cell lymphomas, but in company with other trisomies, monosomies and marker chromosomes. In five carcinogen-induced primary B-cell leukemias, trisomy 15 ...

journal_title：International journal of cancer

authors： Wiener F,Babonits M,Spira J,Bregula U,Klein G,Merwin RM,Asofsky R,Lynes M,Haughton G

更新日期：1981-01-15 00:00:00

abstract：:Interleukin-11(rhIL-11) is a cytokine that has been shown to enhance the recovery of bone marrow and intestinal crypt cells after cytotoxic insult with radiation or anticancer drugs. The current study examined the effects of rhIL-11 on the response of CEM human lymphoblastic leukemia cells and on the EMT-6 murine mamm...

journal_title：International journal of cancer

authors： Teicher BA,Chen YN,Ara G,Emi Y,Kakeji Y,Maehara Y,Keyes S,Northey D

更新日期：1996-09-17 00:00:00