Assessment of ovarian cancer conditions from exhaled breath.

abstract：:HtrA1, a member of serine protease family, has been previously found to be involved in resistance to chemotherapy in ovarian cancer although the underlying mechanism is not clear. Using mixture-based oriented peptide library approach, previously we identified X-linked inhibitor of apoptosis protein (XIAP), a member of...

journal_title：International journal of cancer

authors： He X,Khurana A,Maguire JL,Chien J,Shridhar V

更新日期：2012-03-01 00:00:00

abstract：:Epithelial ovarian cancer (EOC) is a complex disease comprising discrete histological and molecular subtypes, for which survival rates remain unacceptably low. Tailored approaches for this deadly heterogeneous disease are urgently needed. Efflux pumps belonging to the ATP-binding cassette (ABC) family of transporters ...

journal_title：International journal of cancer

authors： Jung M,Gao J,Cheung L,Bongers A,Somers K,Clifton M,Ramsay EE,Russell AJ,Valli E,Gifford AJ,George J,Kennedy CJ,Wakefield MJ,Topp M,Ho GY,Australian Ovarian Cancer Study.,Scott CL,Bowtell DD,deFazio A,Norris MD,Hab

更新日期：2020-10-15 00:00:00

abstract：:We have employed the DNA-mediated gene transfer method to introduce the allogenic major-histocompatibility-complex(MHC)-class-I gene H-2Kb into the K36.16 tumor cells, H-2k, in order to generate tumor-specific immunity. The acquisition of immunogenicity by the H-2Kb-transformed clones following gene transfer is associ...

journal_title：International journal of cancer

authors： Chia KY,Lim SP,Oei AA,Sabapathy TK,Hui KM

更新日期：1994-04-15 00:00:00

abstract：:Murine macrophages from different anatomical sites were compared for their ability to become tumoricidal and to secrete interleukin-1 (IL-1) and tumor necrosis factor (TNF) following stimulation in vitro by several biological response modifiers (BRM). Peritoneal macrophages (PM), alveolar macrophages (AM), and tumor-i...

journal_title：International journal of cancer

authors： Brunda MJ,Sulich V,Wright RB,Palleroni AV

更新日期：1991-07-09 00:00:00

abstract：:Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a c...

journal_title：International journal of cancer

authors： Murtola TJ,Karppa EK,Taari K,Talala K,Tammela TL,Auvinen A

更新日期：2016-06-15 00:00:00

abstract：:Angiogenesis inhibitors have been used to treat some cancers, but the therapeutic potential of these agents for gastric cancer has remained unclear. To investigate their therapeutic potential, we examined the effect of ZD6474, an agent that selectively targets vascular endothelial growth factor receptor-2 (VEGFR-2; KD...

journal_title：International journal of cancer

authors： Arao T,Yanagihara K,Takigahira M,Takeda M,Koizumi F,Shiratori Y,Nishio K

更新日期：2006-01-15 00:00:00

abstract：:A correlation analysis was performed on 125 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and mo...

journal_title：International journal of cancer

authors： Pandis N,Idvall I,Bardi G,Jin Y,Gorunova L,Mertens F,Olsson H,Ingvar C,Beroukas K,Mitelman F,Heim S

更新日期：1996-04-10 00:00:00

abstract：:Distribution of miscarriages, stillbirths and infant deaths in the families of a population-based series of children with soft-tissue sarcoma was examined in relation to index case histology (rhabdomyosarcoma or other soft-tissue sarcoma) and to the possible presence of genetic predisposition to cancer in the families...

journal_title：International journal of cancer

authors： Hartley AL,Birch JM,Blair V,Kelsey AM,Morris Jones PH

更新日期：1994-03-01 00:00:00

abstract：:Although aneuploidy is commonly observed in human cancers, the molecular mechanism underlying aneuploidization remains unclear. We used multiploid cancer model that had diploid and aneuploid cancer cells within the same cancerous tissue and attempted to detect specific epigenetic alterations associated with tumor cell...

journal_title：International journal of cancer

authors： Habano W,Sugai T,Jiao YF,Nakamura S

更新日期：2007-10-01 00:00:00

abstract：:Primary cultures derived from pre-cancerous and cancerous human colon tissue are essential for understanding normal and abnormal growth function in the large intestine. Here presented are (i) the methodology for routine establishment of primary cultures of normal, adenoma- and carcinoma-derived cells, and (ii) data fo...

journal_title：International journal of cancer

authors： Tong WM,Bises G,Sheinin Y,Ellinger A,Genser D,Pötzi R,Wrba F,Wenzl E,Roka R,Neuhold N,Peterlik M,Cross HS

更新日期：1998-01-30 00:00:00

abstract：:G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs...

journal_title：International journal of cancer

authors： Chan YT,Lai AC,Lin RJ,Wang YH,Wang YT,Chang WW,Wu HY,Lin YJ,Chang WY,Wu JC,Yu JC,Chen YJ,Yu AL

更新日期：2020-03-15 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is among the top 10 causes of death from cancer in industrialized countries. In comparison with other gastrointestinal malignancies, pancreatic cancer is one of the tumors most resistant to chemotherapy. An important mechanism of tumor multidrug resistance is increased drug efflux medi...

journal_title：International journal of cancer

authors： König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D

更新日期：2005-06-20 00:00:00

abstract：:Cervical cancer and many other anogenital and oropharyngeal carcinomas are strongly associated with high-risk human papillomavirus (HPV) persistent infections. HPV E7 oncoprotein is the major viral transforming factor, emerging as a natural candidate for immunotherapy, since it is constitutively expressed in HPV-induc...

journal_title：International journal of cancer

authors： Cerutti ML,Alonso LG,Tatti S,de Prat-Gay G

更新日期：2012-04-15 00:00:00

abstract：:The majority of lung cancer patients have tumor-derived genetic alterations in circulating plasma DNA that could be exploited as a diagnostic tool. We used fluorescent microsatellite analysis to detect alterations in plasma and tumor DNA in 34 patients who underwent bronchoscopy for lung cancer, including 11 small cel...

journal_title：International journal of cancer

authors： Beau-Faller M,Gaub MP,Schneider A,Ducrocq X,Massard G,Gasser B,Chenard MP,Kessler R,Anker P,Stroun M,Weitzenblum E,Pauli G,Wihlm JM,Quoix E,Oudet P

更新日期：2003-06-20 00:00:00

abstract：:Several lines of evidence suggest that long-term treatment with non-steroidal anti-inflammatory drugs may reduce the risk of colon cancer and the size and number of colonic polyps in patients with familial adenomatous polyposis. Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to...

journal_title：International journal of cancer

authors： Ricchi P,Pignata S,Di Popolo A,Memoli A,Apicella A,Zarrilli R,Acquaviva AM

更新日期：1997-12-10 00:00:00

abstract：:CD95/Fas is a cell surface protein that belongs to the tumor necrosis factor receptor family. Signals through CD95/Fas are able to induce apoptosis in sensitive cells. Therefore, modalities to regulate the CD95/Fas expression level in tumor cells are called for. In the present study, we show that sublethal doses of ar...

journal_title：International journal of cancer

authors： Woo SH,Park IC,Park MJ,An S,Lee HC,Jin HO,Park SA,Cho H,Lee SJ,Gwak HS,Hong YJ,Hong SI,Rhee CH

更新日期：2004-11-20 00:00:00

abstract：:The early arrest patterns of a methylcholanthrene-induced fibrosarcoma were determined after injection of 125IUdR-labelled cells into the systemic circulation of mice bearing transplanted lymphosarcomas, and of normal animals. Similar experiments were performed using radiolabelled lymphosarcoma cells and normal or fib...

journal_title：International journal of cancer

authors： Weiss L,Glaves D

更新日期：1976-12-15 00:00:00

abstract：:Epigenetic silencing of MLH1 is the most common cause of defective DNA mismatch repair in endometrial and colorectal cancers. We hypothesized that variation in the MLH1 gene might contribute to the risk for MLH1 methylation and epigenetic silencing. We undertook a case-control study to test for the association between...

journal_title：International journal of cancer

authors： Chen H,Taylor NP,Sotamaa KM,Mutch DG,Powell MA,Schmidt AP,Feng S,Hampel HL,de la Chapelle A,Goodfellow PJ

更新日期：2007-04-15 00:00:00

abstract：:Caspase recruitment domain-containing protein 9 (CARD9) is an adaptor protein and highly expressed in myeloid cells. Our previous study demonstrates a critical protective effect of CARD9 in the development of colitis-associated colon cancer. Nevertheless, the effect of CARD9 in lung cancer remains unclear. Here, using...

journal_title：International journal of cancer

authors： Qu J,Liu L,Xu Q,Ren J,Xu Z,Dou H,Shen S,Hou Y,Mou Y,Wang T

更新日期：2019-10-15 00:00:00

abstract：:Osteosacarcoma (OS) lung metastases are often resistant to chemotherapy. Most anticancer drugs are administered systemically. In many cases this is followed by dose-dependent toxicity, which may not allow the achievement of therapeutic levels in lungs to eradicate metastases. We determined the efficacy of gemcitabine ...

journal_title：International journal of cancer

authors： Koshkina NV,Kleinerman ES

更新日期：2005-09-01 00:00:00

abstract：:Human papillomavirus (HPV) genomes usually persist as episomal molecules in HPV associated preneoplastic lesions whereas they are frequently integrated into the host cell genome in HPV-related cancers cells. This suggests that malignant conversion of HPV-infected epithelia is linked to recombination of cellular and vi...

journal_title：International journal of cancer

authors： Luft F,Klaes R,Nees M,Dürst M,Heilmann V,Melsheimer P,von Knebel Doeberitz M

更新日期：2001-04-01 00:00:00

abstract：:Multiple myeloma (MM) is a B lymphocyte malignancy that remains incurable despite extensive research efforts. This is due, in part, to frequent disease recurrences associated with the persistence of myeloma cancer stem cells (mCSCs). Bone marrow mesenchymal stromal cells (BMSCs) play critical roles in supporting mCSCs...

journal_title：International journal of cancer

authors： Choi DS,Stark DJ,Raphael RM,Wen J,Su J,Zhou X,Chang CC,Zu Y

更新日期：2015-03-01 00:00:00

abstract：:Marfe, G., Pucci, B., De Martino, L., Fiorito, F., Di Stefano, C., Indelicato, M., Aventaggiato, M., Russo, M. A. and Tafani, M. (2009), Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. Int. J. Cancer, 125: 2077-2085. doi: 10.1002/ijc.24572 The above article, published online o...

journal_title：International journal of cancer

authors：

更新日期：2019-08-15 00:00:00

abstract：:Invasive pituitary adenomas (PAs) are generally refractory to conventional therapy and salvage treatment with temozolomide (TMZ). In addition to antiprotozoan effects, pyrimethamine (PYR) has recently shown its strong antitumor activity as an antineoplastic agent or in combination with TMZ in metastatic melanoma cells...

journal_title：International journal of cancer

authors： Dai C,Zhang B,Liu X,Guo K,Ma S,Cai F,Yang Y,Yao Y,Feng M,Bao X,Deng K,Jiao Y,Wei Z,Junji W,Xing B,Lian W,Wang R

更新日期：2013-10-15 00:00:00

abstract：:Interferon-beta (IFN-beta) has been used as an antitumor drug against human glioma, melanoma and medulloblastoma since the 1980s. Recently, we developed a new gene therapy using the IFN-beta gene against malignant gliomas and then began clinical trials in 2000. Since stimulation of immune system was one mechanism of a...

journal_title：International journal of cancer

authors： Saito R,Mizuno M,Nakahara N,Tsuno T,Kumabe T,Yoshimoto T,Yoshida J

更新日期：2004-09-20 00:00:00

abstract：:Immunogenicity of a long 20-mer NY-ESO-1f peptide vaccine was evaluated in a lung cancer patient TK-f01, immunized with the peptide with Picibanil OK-432 and Montanide ISA-51. We showed that internalization of the peptide was necessary to present CD8 T-cell epitopes on APC, contrasting with the direct presentation of ...

journal_title：International journal of cancer

authors： Eikawa S,Kakimi K,Isobe M,Kuzushima K,Luescher I,Ohue Y,Ikeuchi K,Uenaka A,Nishikawa H,Udono H,Oka M,Nakayama E

更新日期：2013-01-15 00:00:00

abstract：:Gliomas are aggressive tumors of the central nervous system originating from proliferating neural cells. Regulators of neural stem or progenitor cells biology may thus influence aspects of brain tumorigenesis, such as the maintenance of tumor-propagating potential. We investigated the role of Pax6, a neurogenic transc...

journal_title：International journal of cancer

authors： Appolloni I,Calzolari F,Barilari M,Terrile M,Daga A,Malatesta P

更新日期：2012-10-01 00:00:00

abstract：:The open reading frames of the phosphoprotein pp58 (BMRFI) and the deoxyribonuclease (BGLF5) of the Epstein-Barr-virus (EBV) strain M-ABA were cloned in the baculovirus expression vectors pAc373 and pAc360 and expressed in the Spodoptera frugiperda (SF158) insect cells. The recombinant phosphoprotein pp58 expressed in...

journal_title：International journal of cancer

authors： Chen HF,Sauter M,Haiss P,Müller-Lantzsch N

更新日期：1991-07-30 00:00:00

abstract：:We describe a new, spontaneously occurring BALB/c-derived murine T-cell leukemia. The leukemic cells, designated LB, grow rapidly and progressively in the syngeneic host with no signs of effective immunological resistance. LB cells expressed the Thy-1+, Lyt-2+, L3T4-, CD3- class-I+, CD25+ (IL-2 receptor, IL-2R), class...

journal_title：International journal of cancer

authors： Lugasi H,Hajos S,Murphy JR,Strom TB,Nichols J,Peñarroja C,Naor D

更新日期：1990-01-15 00:00:00

abstract：:The peripheral blood monocyte is the reactive cell in the tube LAI assay. The monocyte loses its properties of adherence to glass upon exposure to specific antigen. Two different experiments to determine if lymphocytes, when they reacted with tumour, released mediators that were responsible for inhibiting monocyte gla...

journal_title：International journal of cancer

authors： Marti JH,Grosser N,Thomson DM

更新日期：1976-07-15 00:00:00