Expression and localization of human multidrug resistance protein (ABCC) family members in pancreatic carcinoma.

abstract：:Multiple myeloma (MM) is characterized by accumulation of monoclonal plasma cells in the bone marrow and progression of lytic bone lesions. The mechanisms of enhanced bone resorption in patients with myeloma are not fully defined. We have previously identified the role of brain-derived neurotrophic factor (BDNF) in pr...

journal_title：International journal of cancer

authors： Sun CY,Chu ZB,She XM,Zhang L,Chen L,Ai LS,Hu Y

更新日期：2012-02-15 00:00:00

abstract：:Oxaliplatin, which is widely used as chemotherapy for certain solid cancers, frequently causes peripheral neuropathy. Commonly described neuropathic symptoms include aberrant sensations such as mechanical allodynia (hypersensitivity to normally innocuous stimuli). Although oxaliplatin neuropathy is a dose-limiting tox...

journal_title：International journal of cancer

authors： Yamamoto S,Yamashita T,Ito M,Caaveiro JMM,Egashira N,Tozaki-Saitoh H,Tsuda M

更新日期：2019-10-15 00:00:00

abstract：:CA 50 is a new tumor marker based on a monoclonal antibody (MAb) against a human colorectal carcinoma cell line. The CA 50 antigen is similar, but not identical, to the tumor marker CA 19-9. The serum concentrations of CA 50 were measured by an immunoradiometric assay (CA 50 IRMA) in 95 patients with pancreatic cancer...

journal_title：International journal of cancer

authors： Haglund C,Kuusela P,Jalanko H,Roberts PJ

更新日期：1987-04-15 00:00:00

abstract：:Emerging reports now implicate alterations of arachidonic acid (AA) metabolism with prostate carcinogenesis. To test this hypothesis, androgen-primed benign hyperplastic (BHC) and malignant tumorigenic (MTC) cells derived from the Lobund-Wistar rat model of autochthonous prostate adenocarcinoma were incubated with (14...

journal_title：International journal of cancer

authors： Pham H,Banerjee T,Ziboh VA

更新日期：2004-08-20 00:00:00

abstract：:Neuroblastoma (NB) is the most common extracranial solid tumor of childhood. In advanced disease stages, prognosis is poor and treatments have limited efficacy, thus novel strategies are warranted. The synthetic retinoid Fenretinide (HPR) induces apoptosis in NB and melanoma cell lines. We reported an in vitro potenti...

journal_title：International journal of cancer

authors： Raffaghello L,Pagnan G,Pastorino F,Cosimo E,Brignole C,Marimpietri D,Montaldo PG,Gambini C,Allen TM,Bogenmann E,Ponzoni M

更新日期：2003-05-01 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated lymphoepithelioma. The aim of this study was to characterize the homogeneity and distinctness of the T-cell repertoires within and between primary and metastatic NPCs. We used ultra-deep sequencing of the hypervariably rearranged antigen-binding ...

journal_title：International journal of cancer

authors： Chung YL,Wu ML

更新日期：2018-08-01 00:00:00

abstract：:EPLIN is frequently downregulated or lost in various cancers. The purpose of this study was to evaluate the importance of EPLIN in prostate cancer progression, with particular focus on the mechanistic implications to elucidate EPLIN's tumor suppressive function in cancer. EPLIN expression was evaluated in prostate can...

journal_title：International journal of cancer

authors： Collins RJ,Morgan LD,Owen S,Ruge F,Jiang WG,Sanders AJ

更新日期：2018-11-15 00:00:00

abstract：:Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was...

journal_title：International journal of cancer

authors： Lifsted T,Le Voyer T,Williams M,Muller W,Klein-Szanto A,Buetow KH,Hunter KW

更新日期：1998-08-12 00:00:00

abstract：:We treated 72 patients with metastatic renal-cell cancer according to 2 protocols consisting of two 5-week induction cycles of continuous i.v. high-dose interleukin-2 (IL-2), i.m. interferon-alpha (IFN alpha) and ex vivo IL-2-activated lymphocytes, followed for patients with stable disease (SD), partial response (PR) ...

journal_title：International journal of cancer

authors： Gratama JW,Schmitz PI,Goey SH,Lamers CH,Stoter G,Bolhuis RL

更新日期：1996-01-17 00:00:00

abstract：:Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a carcinoma acquire an enhanced migratory phenotype in a process called epithelial-to-mesenchymal transition (EMT). This cellular pla...

journal_title：International journal of cancer

authors： Dhamija S,Diederichs S

更新日期：2016-07-15 00:00:00

abstract：:Three lymphoblastoid cell lines were established from splenic lymphocytes of a lymphomatous baboon (Papio hamadryas) by co-cultivation of the lymphocytes with X-irradiated cells of marmoset or baboon lymphoblastoid cell cultures; the baboon splenic lymphocytes failed to grow when cultured alone. A herpesvirus, associa...

journal_title：International journal of cancer

authors： Falk L,Deinhardt F,Nonoyama M,Wolfe LG,Bergholz C

更新日期：1976-12-15 00:00:00

abstract：:A specific chromosomal aberration was observed in 14 of 15 avian lymphoblastoid cell lines transformed with Marek's disease herpesvirus. This aberration, designated dup(1p)(p22-p23), appeared as an extra G-positive band and interband on the short arm of one chromosome I homolog. Using fluorescent in situ hybridization...

journal_title：International journal of cancer

authors： Moore FR,Schat KA,Hutchison N,Leciel C,Bloom SE

更新日期：1993-06-19 00:00:00

abstract：:The androgen receptor (AR) gene is a transcription factor responsible for mediating the physiological effects of androgens. Evidence suggests that androgens and the androgen receptor are involved in uterine cell proliferation. A polymorphic CAG repeat in exon 1 of the AR gene encodes a polyglutamine tract that is inve...

journal_title：International journal of cancer

authors： McGrath M,Lee IM,Hankinson SE,Kraft P,Hunter DJ,Buring J,De Vivo I

更新日期：2006-03-01 00:00:00

abstract：:Although early detection and systemic therapies have improved the diagnosis and clinical cure rate of breast cancer, breast cancer remains the most frequently occurring malignant cancer in women due to a lack of sufficiently effective treatments. Thus, to develop potential targeted therapies and thus benefit more pati...

journal_title：International journal of cancer

authors： Liu ZH,Chen ML,Zhang Q,Zhang Y,An X,Luo YL,Liu XM,Liu SX,Liu Q,Yang T,Liu YM,Liu BL,Zhou AJ,Li MZ,Liu YJ,Liu ZX,Zhong Q

更新日期：2020-07-15 00:00:00

abstract：:The relation between physical activity and renal cell cancer is unclear. High occupational physical activity has been associated with a decreased risk of renal cell cancer among men-but not among women-in two previous studies, while no association has been found for leisure time physical activity. Our aim was to inves...

journal_title：International journal of cancer

authors： Bergström A,Terry P,Lindblad P,Lichtenstein P,Ahlbom A,Feychting M,Wolk A

更新日期：2001-04-01 00:00:00

abstract：:A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western b...

journal_title：International journal of cancer

authors： Grohmann U,Fioretti MC,Binaglia L,Belladonna ML,Bianchi R,Puccetti P

更新日期：1993-09-09 00:00:00

abstract：:We investigated whether the concentration of fibronectin (FN) in the cerebrospinal fluid (CSF) could be used for identifying patients with subclinical blast-cell infiltration in the central nervous system (CNS) and an increased risk of CNS relapse later in the course of their leukemia. Our series comprised 36 children...

journal_title：International journal of cancer

authors： Rautonen J,Koskiniemi M,Siimes MA,Salonen EM,Vaheri A

更新日期：1989-01-15 00:00:00

abstract：:To generate broad eating patterns, which could explain more adequately the breast cancer etiology, we conducted an exploratory factor analysis in Montevideo, Uruguay. The study included 442 newly diagnosed and microscopically confirmed cases with breast cancer and 442 hospitalized controls, with non-neoplastic disease...

journal_title：International journal of cancer

authors： Ronco AL,De Stefani E,Boffetta P,Deneo-Pellegrini H,Acosta G,Mendilaharsu M

更新日期：2006-10-01 00:00:00

abstract：:Several promising chemopreventive agents have for lung cancer emerged in preclinical models and in retrospective trials. These agents have been shown to modulate pathways altered in carcinogenesis and reduce markers of carcinogenesis in animal and cell culture models. Cancer-prone transgenic mice with oncogenic Kras e...

journal_title：International journal of cancer

authors： Unver N,Delgado O,Zeleke K,Cumpian A,Tang X,Caetano MS,Wang H,Katayama H,Yu H,Szabo E,Wistuba II,Moghaddam SJ,Hanash SM,Ostrin EJ

更新日期：2018-04-01 00:00:00

abstract：:Interleukin-11(rhIL-11) is a cytokine that has been shown to enhance the recovery of bone marrow and intestinal crypt cells after cytotoxic insult with radiation or anticancer drugs. The current study examined the effects of rhIL-11 on the response of CEM human lymphoblastic leukemia cells and on the EMT-6 murine mamm...

journal_title：International journal of cancer

authors： Teicher BA,Chen YN,Ara G,Emi Y,Kakeji Y,Maehara Y,Keyes S,Northey D

更新日期：1996-09-17 00:00:00

abstract：:Data from 1,916 cases of oral neoplasms occurring in the Sudan in a 16-year period, from January 1970 to December 1985, were retrieved and analysed. The study revealed a relatively high frequency of oral neoplasms in comparison with neighbouring countries. In this study, squamous-cell carcinoma was the most common ora...

journal_title：International journal of cancer

authors： Idris AM,Ahmed HM,Mukhtar BI,Gadir AF,el-Beshir EI

更新日期：1995-04-10 00:00:00

abstract：:Kaposi's sarcoma (KS) is a frequent complication of the acquired immunodeficiency syndrome (AIDS) in homosexual men. Risk factors for developing this malignancy are uncertain, other than immunosuppression and coinfection with human herpesvirus 8 (HHV-8). We therefore examined factors associated with KS in a cross-sect...

journal_title：International journal of cancer

authors： Nawar E,Mbulaiteye SM,Gallant JE,Wohl DA,Ardini M,Hendershot T,Goedert JJ,Rabkin CS,AIDS Cancer Cohort (ACC) Study Collaborators.

更新日期：2005-06-10 00:00:00

abstract：:Carcinomatous meningitis is a devastating metastatic complication of systemic carcinoma, which may occur insidiously, accompanied by a confusing spectrum of clinical symptoms and signs. In the absence of reliable diagnostic tumour markers, the diagnosis is established by the demonstration of malignant cells within the...

journal_title：International journal of cancer

authors： Moseley RP,Oge K,Shafqat S,Moseley CM,Sullivan NM,Badley RA,Burchell J,Taylor-Papadimitriou J,Coakham HB

更新日期：1989-09-15 00:00:00

abstract：:The recently described PGM-2 leukemia displays a hierarchical structure with bipotential stem cells, B-lymphocyte and macrophage progenitor cells, and post-mitotic end cells. Because the different cell types can easily be identified in vitro by clonal culture assays and simple staining procedures, this leukemia is a u...

journal_title：International journal of cancer

authors： Dührsen U,Knieling G,Hossfeld DK

更新日期：1995-03-03 00:00:00

abstract：:Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Understanding which human enzymes are involved in AA activation and/or detoxication is important in the assessment of an individual's susceptibility to this plant carcinoge...

journal_title：International journal of cancer

authors： Stiborová M,Frei E,Hodek P,Wiessler M,Schmeiser HH

更新日期：2005-01-10 00:00:00

abstract：:The mechanism of tumor cell killing by OXI4503 was investigated by studying vascular functional and morphological changes post drug administration. SCID mice bearing MHEC5-T hemangioendothelioma were given a single dose of OXI4503 at 100 mg/kg. Tumor blood flow, measured by microsphere fluorescence, was reduced by 50%...

journal_title：International journal of cancer

authors： Sheng Y,Hua J,Pinney KG,Garner CM,Kane RR,Prezioso JA,Chaplin DJ,Edvardsen K

更新日期：2004-09-10 00:00:00

abstract：:Tumor cells of colorectal cancer (CRC) release exosomes into the circulation. These exosomes can mediate communication between cells and affect various tumor-related processes in their target cells. We present a quantitative proteomics analysis of the exosomes purified from serum of patients with CRC and normal volunt...

journal_title：International journal of cancer

authors： Chen Y,Xie Y,Xu L,Zhan S,Xiao Y,Gao Y,Wu B,Ge W

更新日期：2017-02-15 00:00:00

abstract：:Using antisera for two specific basement membrane (b.m.) antigens such as laminin and collagen type-IV, together with electron microscopy, we have shown that fully antigenic b.m. and morphologically typical basal lamina (b.l.) are associated with normal and transformed cells of the melanocyte lineage in different ways...

journal_title：International journal of cancer

authors： Natali PG,Nicotra MR,Bellocci M,Cavaliere R,Bigotti A

更新日期：1985-04-15 00:00:00

abstract：:The utility of EBV load as a tumor marker in nasopharyngeal carcinoma (NPC) patients suggests that it might also serve as a screening test for individuals who are at high risk for developing NPC. We previously demonstrated that unaffected individuals from high-risk families had elevated anti-EBV antibody levels compar...

journal_title：International journal of cancer

authors： Yang X,Goldstein AM,Chen CJ,Rabkin CS,Chen JY,Cheng YJ,Hsu WL,Sun B,Diehl SR,Liu MY,Walters M,Shao W,Ortiz-Conde BA,Whitby D,Elmore SH,Gulley ML,Hildesheim A

更新日期：2006-02-01 00:00:00

abstract：:Although there are several hypotheses explaining the mechanisms of immune-privileged status of malignant tumor, the exact pathway has yet to be explored. Cyclooxygenase (COX)-2 plays a vital role in prognosis of cancer patients in terms of contribution to neoangiogenesis and apoptosis inhibition; however, the impact o...

journal_title：International journal of cancer

authors： Ohno Y,Ohno S,Suzuki N,Kamei T,Inagawa H,Soma G,Inoue M

更新日期：2005-05-01 00:00:00