Frequent lack of translation of antigen presentation-associated molecules MHC class I, CD1a and Beta(2)-microglobulin in Reed-Sternberg cells.

abstract：:Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. To improve existing therapies and broaden the spectrum of cytotoxic agents that can be used in RMS treatment, we performed a phage-display-based screening for peptides that bind specifically to RMS cells. Two peptides binding to RMS and to othe...

journal_title：International journal of cancer

authors： Witt H,Hajdin K,Iljin K,Greiner O,Niggli FK,Schäfer BW,Bernasconi M

更新日期：2009-05-01 00:00:00

abstract：:Cetuximab is a human/mouse chimeric IgG1 monoclonal antibody (mAb) to epidermal growth factor receptor, approved for colorectal carcinoma treatment in combination with chemotherapy. The immune-mediated effects elicited by its human fraction of crystallization moiety might critically contribute to the overall anti-tumo...

journal_title：International journal of cancer

authors： Correale P,Botta C,Cusi MG,Del Vecchio MT,De Santi MM,Gori Savellini G,Bestoso E,Apollinari S,Mannucci S,Marra M,Abbruzzese A,Aquino A,Turriziani M,Bonmassar L,Caraglia M,Tagliaferri P

更新日期：2012-04-01 00:00:00

abstract：:By centrifuging total cellular DNA derived from human genital warts (condylomata acuminata) in CsCl-ethidium bromide gradients, supercoiled DNA was isolated. The molecular weight of this DNA was determined by agarose gel electrophoresis and amounted to 5.1 X 10(4). This DNA isolated from an individual genital wart was...

journal_title：International journal of cancer

authors： Gissmann L,zur Hausen H

更新日期：1980-05-15 00:00:00

abstract：:Although tumor-specific T lymphocytes recognize tumor-associated antigens (TAA) present on their cell surface via major histocompatibility complex (MHC) molecules, T cells require other activating signals. These are provided by costimulatory molecules, including B7-1 (CD80), B7-2 (CD86) and intercellular adhesive mole...

journal_title：International journal of cancer

authors： Joki T,Kikuchi T,Akasaki Y,Saitoh S,Abe T,Ohno T

更新日期：1999-08-27 00:00:00

abstract：:V-ATPases are proton-translocating enzymes, which are found not only in numerous intracellular organelles but also in the plasma membranes of many eukaryotic cells. Using differential display, we have identified one of the proton pump subunit genes, ATP6C, as a cisplatin-inducible gene. Northern blot analysis demonstr...

journal_title：International journal of cancer

authors： Murakami T,Shibuya I,Ise T,Chen ZS,Akiyama S,Nakagawa M,Izumi H,Nakamura T,Matsuo K,Yamada Y,Kohno K

更新日期：2001-09-01 00:00:00

abstract：:Epidemiologic evidence on the association of antioxidant intake and prostate cancer incidence is inconsistent. Total antioxidant intake and prostate cancer incidence have not previously been examined. Using the ferric-reducing antioxidant potential (FRAP) assay, the total antioxidant content (TAC) of diet and suppleme...

journal_title：International journal of cancer

authors： Russnes KM,Wilson KM,Epstein MM,Kasperzyk JL,Stampfer MJ,Kenfield SA,Smeland S,Blomhoff R,Giovannucci EL,Willett WC,Mucci LA

更新日期：2014-03-01 00:00:00

abstract：:Twin studies suggest a familial aggregation of bladder cancer but elements of this increased familial risk of bladder cancer are not well understood. To characterize familial risk of bladder cancer, we examined the relationship between family history of bladder and other types of cancer among first-degree relatives an...

journal_title：International journal of cancer

authors： Koutros S,Decker KL,Baris D,Pardo LA,Johnson A,Hosain GMM,Rothman N,Karagas MR,Schwenn MR,Silverman DT

更新日期：2021-01-27 00:00:00

abstract：:Biopsies were obtained from 12 patients suspected of having nasopharyngeal carcinoma (NPC). A portion of the tissue was submitted for histopathology and another for Western blotting using a murine monoclonal antibody (MAb), MA6. Touch smears of the tissues were also prepared immediately prior to extraction and Western...

journal_title：International journal of cancer

authors： Yip TC,Chan KH,Choy D,Chan CW,Ng MH

更新日期：1987-04-15 00:00:00

abstract：:We describe an innovative strategy to quantify risk of cancer associated with varying levels of exposure to chronic parasitic infection through the identification of asymptomatic cases of cholangiocarcinoma within a population-based survey of Opisthorchis viverrini infection. Stool samples from 12,311 adults over age ...

journal_title：International journal of cancer

authors： Haswell-Elkins MR,Mairiang E,Mairiang P,Chaiyakum J,Chamadol N,Loapaiboon V,Sithithaworn P,Elkins DB

更新日期：1994-11-15 00:00:00

abstract：:3-Nitrobenzanthrone (3-NBA) is an environmental pollutant and suspected human carcinogen found in emissions from diesel and gasoline engines and on the surface of ambient air particulate matter; human exposure to 3-NBA is likely to occur primarily via the respiratory tract. In our study female Sprague Dawley rats were...

journal_title：International journal of cancer

authors： Bieler CA,Cornelius MG,Klein R,Arlt VM,Wiessler M,Phillips DH,Schmeiser HH

更新日期：2005-10-10 00:00:00

abstract：:Phenotypic and functional characteristics of tumor-infiltrating lymphocytes (TIL) obtained from human primary and metastatic liver tumors were studied. Lymphocytes isolated from 18 tumors and autologous (A) peripheral blood (6 cases) were phenotyped by 2-color flow cytometry and cloned in a limiting dilution system, w...

journal_title：International journal of cancer

authors： Shimizu Y,Iwatsuki S,Herberman RB,Whiteside TL

更新日期：1990-11-15 00:00:00

abstract：:The importance of tumor associated neutrophils (TANs) in cancer development is in the meantime well established. Numerous of clinical data document the adverse prognostic effects of neutrophil infiltration in solid tumors. However, certain tumor therapies need functional neutrophils to be effective, suggesting altered...

journal_title：International journal of cancer

authors： Andzinski L,Kasnitz N,Stahnke S,Wu CF,Gereke M,von Köckritz-Blickwede M,Schilling B,Brandau S,Weiss S,Jablonska J

更新日期：2016-04-15 00:00:00

abstract：:Peripheral blood lymphocytes from 32 patients with malignant melanoma were tested for cell-mediated cytotoxicity (CMC) against cultured autologous melanoma cells. Effector cells were prepared from venous blood by defibrination, gel sedimentation, nylon column filtration, and lysis of remaining erythrocytes with NH4Cl....

journal_title：International journal of cancer

authors： Livingston PO,Shiku H,Bean MA,Pinsky CM,Oettgen HF,Old LJ

更新日期：1979-07-15 00:00:00

abstract：:Several lines of evidence have demonstrated that IFNs could be relevant in the treatment of certain neoplastic diseases such as carcinomas. In particular, IFN-alpha, in addition to the anti-proliferative and cytostatic effects, was demonstrated to be capable of inducing cell death by apoptosis both in vivo and in vitr...

journal_title：International journal of cancer

authors： Matarrese P,Giandomenico V,Fiorucci G,Rivabene R,Straface E,Romeo G,Affabris E,Malorni W

更新日期：1998-05-18 00:00:00

abstract：:Statins are widely used for the treatment of hypercholesterolemia. However, their inhibitory action on HMG-CoA reductase also results in the depletion of intermediate biosynthetic products, which importantly contribute to cell proliferation. The aim of the present study was to compare the effects of the individual com...

journal_title：International journal of cancer

authors： Gbelcová H,Lenícek M,Zelenka J,Knejzlík Z,Dvoráková G,Zadinová M,Poucková P,Kudla M,Balaz P,Ruml T,Vítek L

更新日期：2008-03-15 00:00:00

abstract：:Cancer Procoagulant (CP), a cysteine proteinase which triggers blood coagulation by directly activating Factor X (FX) in the absence of Factor VII (F VII), has recently been isolated from rabbit V2 carcinoma and biochemically characterized. We have studied the procoagulant activity of tissue extracts from 4 murine exp...

journal_title：International journal of cancer

authors： Falanga A,Bolognese Dalessandro AP,Casali B,Roncaglioni MC,Donati MB

更新日期：1987-06-15 00:00:00

abstract：:Activating Ras mutations are involved in a significant fraction of human tumors. A suppressor screen using a retroviral mouse fibroblast cDNA library was performed to identify novel factors in Ras-mediated transformation. We identified a novel potent inhibitor of Ras-mediated morphological transformation encoded by a ...

journal_title：International journal of cancer

authors： Bjørndal B,Myklebust LM,Rosendal KR,Myromslien FD,Lorens JB,Nolan G,Bruland O,Lillehaug JR

更新日期：2007-03-01 00:00:00

abstract：:Using a method optimized in hepatocellular carcinoma (HCC), we established patient-derived xenograft (PDX) models with an increased take rate (42.2%) and demonstrated that FBS +10% dimethyl sulfoxide exhibited the highest tumor take rate efficacy. Among 254 HCC patients, 103 stably transplantable xenograft lines that ...

journal_title：International journal of cancer

authors： Hu B,Li H,Guo W,Sun YF,Zhang X,Tang WG,Yang LX,Xu Y,Tang XY,Ding GH,Qiu SJ,Zhou J,Li YX,Fan J,Yang XR

更新日期：2020-03-15 00:00:00

abstract：:Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated in ovarian cancer cells. Therefore, we examined the mechanisms of the upregulation of S100A4 expression in ovarian carcinoma cells, with par...

journal_title：International journal of cancer

authors： Horiuchi A,Hayashi T,Kikuchi N,Hayashi A,Fuseya C,Shiozawa T,Konishi I

更新日期：2012-10-15 00:00:00

abstract：:Telomerase activity is considered to be a diagnostic marker of malignancy since most malignant cells express this activity and most somatic cells do not. However, the detection of telomerase activity is rather complicated and is affected by many factors. Recently, human telomerase components were cloned and found to c...

journal_title：International journal of cancer

authors： Sumida T,Hamakawa H,Sogawa K,Sugita A,Tanioka H,Ueda N

更新日期：1999-01-05 00:00:00

abstract：:Up to 2016, low- and middle-income countries mostly introduced routine human papillomavirus (HPV) vaccination for just a single age-cohort of girls each year. However, high-income countries have reported large reductions in HPV prevalence following "catch-up" vaccination of multiple age-cohorts in the year of HPV vacc...

journal_title：International journal of cancer

authors： Jit M,Brisson M

更新日期：2018-07-15 00:00:00

abstract：:CD16 surface antigens represent activatory molecules in CD3-16+ NK cells. In order to target NK cells against relatively NK-resistant ovarian carcinomas, we used an anti-CD16 monoclonal antibody (MAb) (VD4), together with an anti-ovarian carcinoma-associated antigen (MOV19), to construct biMAbs. To this end, hybrid hy...

journal_title：International journal of cancer

authors： Ferrini S,Prigione I,Miotti S,Ciccone E,Cantoni C,Chen Q,Colnaghi MI,Moretta L

更新日期：1991-05-10 00:00:00

abstract：:We sought to analyze utilization and survival outcomes of cytoreductive nephrectomy (CN) in patients with metastatic renal cell carcinoma (RCC) before and after introduction of targeted therapy. We identified patients with metastatic RCC between 1993 and 2010 in the SEER registry and examined temporal trends in utiliz...

journal_title：International journal of cancer

authors： Conti SL,Thomas IC,Hagedorn JC,Chung BI,Chertow GM,Wagner TH,Brooks JD,Srinivas S,Leppert JT

更新日期：2014-05-01 00:00:00

abstract：:The aim of this study was to construct bispecific F(ab')2 [anti-CD3 x anti-BCL1 idiotype (Id)] Abs (BsAbs) which would enable lymphokine-activated killer (LAK) T cells to kill Id+ mouse BCL1 lymphoma cells, and to determine the mechanism(s) underlying cell death. Using 4-day activated LAK T cells from either perforin-...

journal_title：International journal of cancer

authors： Armstrong JM,Vitetta ES

更新日期：1996-12-11 00:00:00

abstract：:Cells of the human lymphoblastoid non-producer line Raji were cloned in soft agar. Individual colonies were isolated and analyzed for their inducibility of the Epstein-Barr virus-associated early antigen (EA). The induction of EA by the tumor promoter TPA varied among the different cell clones. Clones with very high a...

journal_title：International journal of cancer

authors： Bister K,Yamamoto N,zur Hausen H

更新日期：1979-06-15 00:00:00

abstract：:Expression of the monocyte chemoattractant protein-1 (MCP-1) was examined in human central nervous system tumours (glioblastomas and astrocytomas) and normal human brain. Northern blot analysis demonstrated constitutive expression of MCP-1 mRNA in 6 of 12 glioblastoma cell lines. Expression could be stimulated by inte...

journal_title：International journal of cancer

authors： Desbaillets I,Tada M,de Tribolet N,Diserens AC,Hamou MF,Van Meir EG

更新日期：1994-07-15 00:00:00

abstract：:The present study was undertaken to determine the role of the metalloproteinase MMP-9 in the invasive phenotype of squamous-cell carcinoma of the oral cavity and the regulation of its expression. Zymographic analysis of conditioned medium from 2 highly invasive squamous-cell-carcinoma cell lines indicated large amount...

journal_title：International journal of cancer

authors： Juarez J,Clayman G,Nakajima M,Tanabe KK,Saya H,Nicolson GL,Boyd D

更新日期：1993-08-19 00:00:00

abstract：:LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...

journal_title：International journal of cancer

authors： To MD,Faseruk SA,Gokgoz N,Pinnaduwage D,Done SJ,Andrulis IL

更新日期：2005-07-01 00:00:00

abstract：:BALB/c peritoneal plasmacytomas induced by a variety of agents are invariably associated with a c-myc translocation. In contrast, naturally arising bone marrow plasma cell tumors in C57BL/KaLwRij mice lack this translocation. This difference has led to the suggestion that these are 2 fundamentally different plasma cel...

journal_title：International journal of cancer

authors： Pumphrey JG,Hausner P,Rudikoff S

更新日期：1997-09-04 00:00:00

abstract：:Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...

journal_title：International journal of cancer

authors： Okamura R,Kurzrock R,Mallory RJ,Fanta PT,Burgoyne AM,Clary BM,Kato S,Sicklick JK

更新日期：2021-02-01 00:00:00