Establishment of a hepatocellular carcinoma patient-derived xenograft platform and its application in biomarker identification.

abstract：:A persistent increase in incidence of thyroid carcinoma (TC) has been reported worldwide. The aim of our study was to assess trends in incidence and mortality of TC in The Netherlands between 1989 and 2003 and to examine whether these trends correlate with changes in diagnostic practices such as changes in the number ...

journal_title：International journal of cancer

authors： Netea-Maier RT,Aben KK,Casparie MK,den Heijer M,Grefte JM,Slootweg P,Hermus A

更新日期：2008-10-01 00:00:00

abstract：:In order to analyze the mutational events and to understand the biological significance of the p53 gene in chemical carcinogenesis, we applied a new yeast-based p53 functional assay to ovarian tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA), as well as to transitional cell carcinomas of the urinary bladder in...

journal_title：International journal of cancer

authors： Yamamoto K,Nakata D,Tada M,Tonoki H,Nishida T,Hirai A,Ba Y,Aoyama T,Hamada J,Furuuchi K,Harada H,Hirai K,Shibahara N,Katsuoka Y,Moriuchi T

更新日期：1999-11-26 00:00:00

abstract：:Lymphoma EL-4 of B6 origin was inoculated into lethally-irradiated syngeneic B6 or resistant BD2F1 hybrid recipients. Marked impairment of lymphoma cell proliferation (i.e. hybrid resistance, HR) occurred in the spleen but not in the liver or lung of BD2F1 hosts. Treatment with DTIC at the optimal dose of 80 mg/kg i.p...

journal_title：International journal of cancer

authors： Iorio AM,Neri M,Enrico P,Goldin A,Bonmassar E

更新日期：1981-10-15 00:00:00

abstract：:Mutations of the p53 tumor-suppressor gene universally occur on exons 5-8 in human cancer. We analyzed these mutations in esophageal cancer tissue from 207 patients in China using 2 methods, single-strand conformation polymorphism (SSCP), one of the most frequently used methods, and the recently developed denaturing h...

journal_title：International journal of cancer

authors： Yamanoshita O,Kubota T,Hou J,Ping YM,Zhang XL,Li XP,Li SS,Li XX,Zhu DC,Fukushima Y,Nakajima T

更新日期：2005-03-10 00:00:00

abstract：:Family history of urogenital cancers has been associated with an increased risk of cancer at the same sites. To evaluate the risks of bladder, prostate and renal cell neoplasms for family history of urogenital cancers in first-degree relatives, we analysed data from a case-control study conducted in northern Italy bet...

journal_title：International journal of cancer

authors： Randi G,Pelucchi C,Negri E,Talamini R,Galeone C,Franceschi S,La Vecchia C

更新日期：2007-12-15 00:00:00

abstract：:To identify molecular markers for the progression of head-and-neck squamous cell carcinoma (HNSCC), we used RNA arbitrarily primed (RAP) PCR to determine the qualitative and quantitative differences in gene expression between normal epithelial cells, those derived from dysplastic oral mucosa and invasive and metastati...

journal_title：International journal of cancer

authors： Patel V,Aldridge K,Ensley JF,Odell E,Boyd A,Jones J,Gutkind JS,Yeudall WA

更新日期：2002-06-01 00:00:00

abstract：:To assess the relation between air pollution with airway irritants, including sulfuric acid and lung cancer, a case-control study was performed near an industry producing sulfuric acid and fertilizers in Kedainiai county, central Lithuania. The county had the highest lung cancer rates of the country among men. Between...

journal_title：International journal of cancer

authors： Petrauskaite R,Pershagen G,Gurevicius R

更新日期：2002-05-01 00:00:00

abstract：:The aim of our study was to investigate the protection afforded to the bone marrow by Goralatide (AcSDKP), an inhibitor of hemopoietic stem cell proliferation, when administered alone or in combination with a growth factor (granulocyte/macrophage colony-stimulating factor [GM-CSF]) during iterative cycles of Ara-C (cy...

journal_title：International journal of cancer

authors： Bogden AE,Moreau JP,Gamba-Vitalo C,Deschamps de Paillette E,Tubiana M,Frindel E,Carde P

更新日期：1998-03-30 00:00:00

abstract：:We have recently shown in the BDII rat model of human endometrial adenocarcinoma (EAC), rat chromosome 10 (RNO10) is frequently involved in chromosomal aberrations. In the present study, we investigated the association between RNO10 deletions, allelic imbalance (AI) at RNO10q24 and Tp53 mutation in 27 rat EAC tumors. ...

journal_title：International journal of cancer

authors： Nordlander C,Karlsson S,Karlsson A,Sjöling A,Winnes M,Klinga-Levan K,Behboudi A

更新日期：2007-04-01 00:00:00

abstract：:Telomerase activity is considered to be a diagnostic marker of malignancy since most malignant cells express this activity and most somatic cells do not. However, the detection of telomerase activity is rather complicated and is affected by many factors. Recently, human telomerase components were cloned and found to c...

journal_title：International journal of cancer

authors： Sumida T,Hamakawa H,Sogawa K,Sugita A,Tanioka H,Ueda N

更新日期：1999-01-05 00:00:00

abstract：:We analyzed the biodistribution of the 111In-labelled murine anti-tenascin-C MAb BC-2 after intralesional injection in 15 glioblastoma patients. The activated ligand DTPA was conjugated via the isothiocyanato-benzyl group onto BC-2. Conjugates were labelled with 111In, displaying immunoreactivity greater than 90% and ...

journal_title：International journal of cancer

authors： Merlo A,Jermann E,Hausmann O,Chiquet-Ehrismann R,Probst A,Landolt H,Maecke HR,Mueller-Brand J,Gratzl O

更新日期：1997-05-29 00:00:00

abstract：:A new murine monoclonal antibody (MAb), E-9, has been raised using tissue-cultured human umbilical vein endothelial cells. The antigen recognized by this MAb is a peptide of 170 kDa under non-reducing conditions and 96 kDa under reducing conditions. MAb E-9 showed marked heterogeneity in its distribution in various ti...

journal_title：International journal of cancer

authors： Wang JM,Kumar S,Pye D,van Agthoven AJ,Krupinski J,Hunter RD

更新日期：1993-05-28 00:00:00

abstract：:We compared and contrasted intracranial (i.c.) and subcutaneous (s.c.) heterotransplantation of small-cell carcinoma of the lung (SCCL) into athymic nude mice. Fresh human SCCL tumor specimens, tumor colonies grown in soft agarose and continuous cell lines were used. Tumors induced by the three types of specimens were...

journal_title：International journal of cancer

authors： Gazdar AF,Carney DN,Sims HL,Simmons A

更新日期：1981-12-01 00:00:00

abstract：:The interactions which occur between antigenic tumor cells and normal or immune lymphoid cells in a 3-day in vitro culture, have been studied with a murine sarcoma virus (MSV)-induced tumor. The 3H-thymidine incorporation of lymphoma cells growing in suspension, and the radioactive-chromium release of freshly sampled ...

journal_title：International journal of cancer

authors： Senik A,Hebrero FP,Levy JP

更新日期：1975-12-15 00:00:00

abstract：:Over-expression of the c-erbB-2 (HER-2/neu) gene product p185 occurs in 30% of breast and ovarian cancers. The p185 protein might serve as a target for serotherapy in that antibodies against different epitopes on the extracellular domain of p185 can inhibit growth of tumor cells in the absence of cellular or humoral e...

journal_title：International journal of cancer

authors： Xu F,Lupu R,Rodriguez GC,Whitaker RS,Boente MP,Berchuck A,Yu Y,DeSombre KA,Boyer CM,Bast RC Jr

更新日期：1993-02-01 00:00:00

abstract：:Up to 30% of stage II patients with curatively resected colorectal cancer (CRC) will develop disease recurrence. We evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. Lymph nodes (n = 780) from 36 CRC patients who had developed disease re...

journal_title：International journal of cancer

authors： Doekhie FS,Mesker WE,Kuppen PJ,van Leeuwen GA,Morreau H,de Bock GH,Putter H,Tanke HJ,van de Velde CJ,Tollenaar RA

更新日期：2010-06-01 00:00:00

abstract：:Breast cancer is a common malignancy with current biological therapies tailored to steroid hormone (ER, PR) and HER2 receptor status. Understanding the biological basis of resistance to current targeted therapies and the identification of new potential therapeutic targets is an ongoing challenge. The PI3K pathway is a...

journal_title：International journal of cancer

authors： López-Knowles E,O'Toole SA,McNeil CM,Millar EK,Qiu MR,Crea P,Daly RJ,Musgrove EA,Sutherland RL

更新日期：2010-03-01 00:00:00

abstract：:We have previously shown that anti-Ly-6C monoclonal antibody (MAb) 2B6-F2 identifies a subset of (CBA +/- C57BL/6)F1 splenic NK-1.1+ natural T (NT) cells which kill the NK-sensitive YAC-1 target in vitro. Furthermore, these Ly-6C+ cells are responsible for 40-50% of in vitro YAC-1 killing in all mouse strains tested. ...

journal_title：International journal of cancer

authors： Martiniello R,Burton RC,Smart YC

更新日期：1996-05-16 00:00:00

abstract：:Incidence rates in the United States show clear racial/ethnic disparities for colorectal cancer. We examined the extent to which ethnic differences in risk factors could explain the age-adjusted variation in the risk of colorectal cancer, overall and by stage at diagnosis, among 165,711 African Americans, Japanese Ame...

journal_title：International journal of cancer

authors： Ollberding NJ,Nomura AM,Wilkens LR,Henderson BE,Kolonel LN

更新日期：2011-10-15 00:00:00

abstract：:Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression was examined by immunohisto...

journal_title：International journal of cancer

authors： Wu GQ,Xie D,Yang GF,Liao YJ,Mai SJ,Deng HX,Sze J,Guan XY,Zeng YX,Lin MC,Kung HF

更新日期：2009-12-01 00:00:00

abstract：:Deregulation of cell survival pathways and resistance to apoptosis are widely accepted to be fundamental aspects of tumorigenesis. As in many tumours, the aberrant growth and survival of colorectal tumour cells is dependent upon a small number of highly activated signalling pathways, the inhibition of which elicits po...

journal_title：International journal of cancer

authors： Greenhough A,Patsos HA,Williams AC,Paraskeva C

更新日期：2007-11-15 00:00:00

abstract：:To investigate the genetic changes that occur during establishment of gastric cancer cell lines, 4 gastric cancer cell lines and their original tumor tissues were examined for microsatellite instability (MSI), loss of heterozygosity (LOH), and p53 mutation. MSI status did not change during the establishment, though th...

journal_title：International journal of cancer

authors： Bae SI,Park JG,Kim YI,Kim WH

更新日期：2000-08-15 00:00:00

abstract：:Chemotherapy is a well-established risk factor for acute myeloid leukemia (AML) but little is known about other prescription drugs and AML risk. We report data from a population-based Los Angeles County study in which 299 matched case-control pairs had complete data on prescription drug use and 88% of cases were subty...

journal_title：International journal of cancer

authors： Pogoda JM,Katz J,McKean-Cowdin R,Nichols PW,Ross RK,Preston-Martin S

更新日期：2005-04-20 00:00:00

abstract：:Apigenin is a plant flavonoid that is thought to play a role in the prevention of carcinogenesis. However, its mechanism of action has not yet been elucidated. Because of the importance of angiogenesis in tumor growth, we investigated the effect of apigenin on endothelial and smooth-muscle cells in an in vitro model. ...

journal_title：International journal of cancer

authors： Trochon V,Blot E,Cymbalista F,Engelmann C,Tang RP,Thomaïdis A,Vasse M,Soria J,Lu H,Soria C

更新日期：2000-03-01 00:00:00

abstract：:Human papillomavirus (HPV) causes oropharyngeal squamous cell carcinoma (OPSCC), although strongly divergent results have been reported regarding the prevalence of HPV16 in different countries, whether this represents important differences in etiology remains unclear. Applying rigorous protocols for sample processing,...

journal_title：International journal of cancer

authors： Anantharaman D,Abedi-Ardekani B,Beachler DC,Gheit T,Olshan AF,Wisniewski K,Wunsch-Filho V,Toporcov TN,Tajara EH,Levi JE,Moyses RA,Boccia S,Cadoni G,Rindi G,Ahrens W,Merletti F,Conway DI,Wright S,Carreira C,Renard H

更新日期：2017-05-01 00:00:00

abstract：:There are approximately 100 genes which when mutated are known to predispose to one or more forms of cancer. Currently, genetic testing is offered for many of these, either as single genes or as multi-gene panels. Features of hereditary cancer include a positive family history of cancer, early age of onset and the app...

journal_title：International journal of cancer

authors： Cybulski C,Nazarali S,Narod SA

更新日期：2014-10-15 00:00:00

abstract：:Barrett's esophagus (BE) is a metaplastic condition caused by chronic gastroesophageal reflux which represents an early step in the development of esophageal adenocarcinoma (EAC). Single-nucleotide polymorphism microarray (SNP-chip) analysis is a novel, precise, high-throughput approach to examine genomic alterations ...

journal_title：International journal of cancer

authors： Akagi T,Ito T,Kato M,Jin Z,Cheng Y,Kan T,Yamamoto G,Olaru A,Kawamata N,Boult J,Soukiasian HJ,Miller CW,Ogawa S,Meltzer SJ,Koeffler HP

更新日期：2009-11-15 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) is the causative agent of adult T-cell leukemia/lymphoma (ATLL). It has been postulated that ATLL cells might act as regulatory T cells (T(regs)) which, in common with ATLL cells, express both CD25 and FoxP3, and so contribute to the severe immune suppression typical of ATLL....

journal_title：International journal of cancer

authors： Toulza F,Nosaka K,Takiguchi M,Pagliuca T,Mitsuya H,Tanaka Y,Taylor GP,Bangham CR

更新日期：2009-11-15 00:00:00

abstract：:Idiotypic protein (Id) produced by myeloma cells is clone-specific and may be a suitable tumor-specific antigen for immune targeting. Advances in dendritic cell (DC) technology suggest the opportunity for using this potent antigen presentation system to deliver myeloma Id to the autologous host to elicit anti-tumor im...

journal_title：International journal of cancer

authors： Lim SH,Bailey-Wood R

更新日期：1999-10-08 00:00:00

abstract：:The Glypican (GPC) family is a prototypical member of the cell-surface heparan sulfate proteoglycans (HSPGs). The HSPGs have been demonstrated to interact with growth factors, act as coreceptors and modulate growth factor activity. Here we show that based on oligonucleotide array analysis, GPC3 was upregulated in hepa...

journal_title：International journal of cancer

authors： Midorikawa Y,Ishikawa S,Iwanari H,Imamura T,Sakamoto H,Miyazono K,Kodama T,Makuuchi M,Aburatani H

更新日期：2003-02-10 00:00:00