Abstract:
:A new murine monoclonal antibody (MAb), E-9, has been raised using tissue-cultured human umbilical vein endothelial cells. The antigen recognized by this MAb is a peptide of 170 kDa under non-reducing conditions and 96 kDa under reducing conditions. MAb E-9 showed marked heterogeneity in its distribution in various tissues. The antigen recognized by it was present in vascular endothelial cells of all tumours, foetal organs and in regenerating and inflamed tissues. It stained a few normal tissues. However, with the exception of tonsils, staining tended to be weak and limited to a few blood vessels, as revealed by double staining using pan-endothelial antibody (CD31) and antibody to von Willebrand factor, another marker of vascular endothelium. Surprisingly, blood vessels within the placental villi were completely negative. The function of the antigen recognized by MAb E-9 is not known, but its evaluation and use should increase our understanding of angiogenesis.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Wang JM,Kumar S,Pye D,van Agthoven AJ,Krupinski J,Hunter RDdoi
10.1002/ijc.2910540303subject
Has Abstractpub_date
1993-05-28 00:00:00pages
363-70issue
3eissn
0020-7136issn
1097-0215journal_volume
54pub_type
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journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540302
更新日期:1993-05-28 00:00:00
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