Abstract：
:Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G transversion (Asp 148 Glu), was previously shown to be associated with risk of lung cancer, an association that was modified by cigarette smoking. To explore the association between APE1 genotype, smoking and bladder cancer risk, we examined data from an existing case-control study of bladder cancer patients (n = 239) and control individuals (n = 215) recruited from urology clinics at 2 hospitals in North Carolina. Genotype at the polymorphic site was determined using allele-specific primer extension reactions, followed by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. We found no overall association between APE1 genotype and bladder cancer risk. In stratified analyses, however, a positive association with risk was observed with an increasing number of Glu alleles among never smokers, but not among smokers (p-value for interaction = 0.005). We can speculate that small allelic differences that are apparent in never smokers are obscured by the large amount of DNA damage found in smokers. Given the lack of established biological mechanisms, and suboptimal numbers of subjects in some exposure categories, our findings should be interpreted cautiously.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Terry PD,Umbach DM,Taylor JAdoi
10.1002/ijc.21768keywords:
subject
Has Abstractpub_date
2006-06-15 00:00:00pages
3170-3issue
12eissn
0020-7136issn
1097-0215journal_volume
118pub_type
杂志文章,多中心研究abstract：:Some ovarian cancer cells in vivo are in a reversible quiescent state where they can contribute to cancer spread under favorable growth conditions. The serine/threonine kinase Mirk/dyrk1B was expressed in each of seven ovarian cancer cell lines and in 21 of 28 resected human ovarian cancers, and upregulated in 60% of ...
journal_title：International journal of cancer
pub_type： 杂志文章
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abstract：:This article describes the characteristics of 3 dominant features of breast cancer epidemiology. These characteristics include the association of disease risk with childbearing, its relationship to ovarian activity and its international variation (particularly as the latter differs in the years before and after menopa...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.21404
更新日期：2006-05-15 00:00:00
abstract：:We, and others, have recently shown that recombinant feline leukaemia viruses (FeLV) containing the myc gene (FeLV-myc) occur in up to 30% of naturally occurring cases of T-cell lymphosarcoma. Investigation of the disease spectrum of two FeLV-myc isolates showed that they induced clonal or oligoclonal T-cell tumours a...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910400108
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abstract：:The selective targets for HTLV-III/LAV, the causal infectious agent of AIDS and AIDS-related complex (ARC), are T4 cells, apparently because the virus receptor is associated with T4 antigen determinants. This accounts for T4 cell depletion in AIDS and for a decrease of IL-2 production by AIDS peripheral blood lymphocy...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910380507
更新日期：1986-11-15 00:00:00
abstract：:Reverse-transcriptase polymerase chain reaction has been used to analyze the expression of 2 latent genes (EBNA-1 and LMP-1) and one replicative gene (BZLF-1) of Epstein-Barr virus in mononuclear cells from bone marrow and peripheral blood of healthy donors. EBV-gene transcription was detected in 8 out of 15 bone-marr...
journal_title：International journal of cancer
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更新日期：1997-03-04 00:00:00
abstract：:The targeted radiotherapy of neuroblastoma with 131l-labelled metaiodobenzyl guanidine (mIBG) is now the subject of several clinical studies. The precise intracellular localization of mIBG, necessary for nuclear microdosimetry, has not previously been described. We report the use of electron-energy-loss spectroscopy a...
journal_title：International journal of cancer
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abstract：:We investigated whether the concentration of fibronectin (FN) in the cerebrospinal fluid (CSF) could be used for identifying patients with subclinical blast-cell infiltration in the central nervous system (CNS) and an increased risk of CNS relapse later in the course of their leukemia. Our series comprised 36 children...
journal_title：International journal of cancer
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abstract：:CXCR1 and CXCR2 are receptors for CXCL-8 and are differentially expressed on melanoma and endothelial cells. In this study, we determined the functional role of these receptors in melanoma progression. We stably knock-down the expression of CXCR1 and/or CXCR2 in A375-SM (SM; high metastatic) human melanoma cells by sh...
journal_title：International journal of cancer
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doi：10.1002/ijc.24714
更新日期：2010-01-15 00:00:00
abstract：:Mice transgenic for the carcinoembryonic (CEA) gene were used to study the biodistribution and tumor targeting of a radioiodinated monoclonal antibody (MAb), T84.66. The specificity of antibody uptake in tumors was assessed in mice bearing a CEA-transfected syngeneic tumor as well as the antigen-negative parental tumo...
journal_title：International journal of cancer
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更新日期：2000-03-15 00:00:00
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journal_title：International journal of cancer
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doi：10.1002/1097-0215(20010101)91:1<55::aid-ijc1006>3.
更新日期：2001-01-01 00:00:00
abstract：:Recurrent deletions of chromosome fragments observed in neoplasms are thought to participate in tumor development through the inactivation of tumor-suppressor genes. In gliomas, the most frequent deletions involve chromosome arms 9p, 10q, 17p, 19q and 22q. We have analysed deletions of chromosome 22 in gliomas by stud...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：1995-02-08 00:00:00
abstract：:Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 pati...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2002-09-01 00:00:00
abstract：:In order to understand the expression and modulation of adhesion molecules (AMs) on the surface of different gastric cancers, we studied 4 gastric-cancer cell lines including SC-M1, KATO-III, AGS and AZ-521. The expression of E-cadherin, integrins (beta1, beta2 and beta3), ICAMs (1 and 2), and CD11 (a, b and c) on the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960904)67:5<690::AID-IJC
更新日期：1996-09-04 00:00:00
abstract：:Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910310516
更新日期：1983-05-15 00:00:00
abstract：:Human papillomavirus (HPV) is an important factor for the development of tonsillar squamous cell carcinoma (TSCC). In addition, patients with HPV-positive TSCC have a better clinical outcome than patients with HPV-negative TSCC. Although, HPV is an important prognostic marker, additional biomarkers are needed to bette...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.27635
更新日期：2013-01-01 00:00:00
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journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20763
更新日期：2005-04-20 00:00:00
abstract：:Glioblastoma are notorious for their highly invasive growth, diffusely infiltrating adjacent brain structures that precludes complete resection, and is a major obstacle for cure. To characterize this "invisible" tumor part, we designed a high resolution multimodal imaging approach assessing in vivo the metabolism of i...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31299
更新日期：2018-07-01 00:00:00
abstract：:Anticancer drugs docetaxel and vinorelbine suppress cell growth by altering microtubule assembly and activating the proapoptotic signal pathway. Vinorelbine and docetaxel have been approved for treating several advanced cancers. However, their efficacy in the management of advanced hormone-refractory prostate cancer r...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11413
更新日期：2003-11-10 00:00:00
abstract：:Detectable post-therapy plasma Epstein-Barr virus (EBV) DNA predicts poor survival in non-metastatic nasopharyngeal carcinoma (NPC). However, some patients subsequently experience spontaneous remission of residual EBV DNA during follow-up and it was unclear whether these patients were still at high risk of disease fai...
journal_title：International journal of cancer
pub_type： 杂志文章
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更新日期：2019-05-01 00:00:00
abstract：:Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, treatment with the v...
journal_title：International journal of cancer
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更新日期：2013-01-01 00:00:00
abstract：:Insulin-like growth factor-binding protein 7 (IGFBP7) functions in several cellular processes including proliferation, senescence and apoptosis. This study analyzed IGFBP7 function in hepatocellular carcinoma (HCC) cells by gene manipulation and investigated the prognostic significance of IGFBP7 expression in clinical...
journal_title：International journal of cancer
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更新日期：2012-01-15 00:00:00
abstract：:The International Classification of Childhood Cancer (ICCC) updates the widely used Birch and Marsden classification scheme. ICCC is based on the second edition of the International Classification of Diseases for Oncology (ICD-O-2). The purpose of the new classification is to accommodate important changes in recogniti...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/(SICI)1097-0215(19961211)68:6<759::AID-IJC
更新日期：1996-12-11 00:00:00
abstract：:The effects of long-term treatment with mouse interferon on the phenotype of untransformed C3H/10T1/2 cells and cloned derivatives transformed by methylcholanthrene (MCA) and Simian virus 40 (SV40) were investigated. Continuous presence of interferon induced morphologic reversion, with the development of thick, submem...
journal_title：International journal of cancer
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更新日期：1984-07-15 00:00:00
abstract：:Although the combination of cisplatin and etoposide has been used as standard therapy for small-cell lung cancer, it is difficult to demonstrate combination effects between cisplatin and etoposide in vitro. We therefore adopted a 3-dimensional (3-D) model to analyze the combination effects of anticancer drugs, and com...
journal_title：International journal of cancer
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doi：10.1002/(sici)1097-0215(19970502)71:3<311::aid-ijc
更新日期：1997-05-02 00:00:00
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journal_title：International journal of cancer
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更新日期：1991-06-19 00:00:00
abstract：:In both the rat kidney and lung, inhalation of cigarette smoke diluted with air (1/15) for a limited period of time (15 min) specifically induces aryl hydrocarbon hydroxylase (AHH)2 in less than 4 h. Up to four successive inhalations administered at 2-h intervals activities. The maximal effect corresponds to about 10 ...
journal_title：International journal of cancer
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更新日期：1977-04-15 00:00:00
abstract：:The effect of EGF on the soft agar colony-forming ability of fresh human tumor cells was assessed in 40 specimens obtained from various types of carcinoma including those of the breast, endometrium ovary, and other sites. Cells from four established human tumor cell lines (three breast and one endometrial) were also i...
journal_title：International journal of cancer
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更新日期：1982-12-15 00:00:00
abstract：:Overuse of antibiotic drugs alters the composition of gut microbiota and has detrimental effects on the host. In our study, we investigated association of gut flora and antibiotics in the prognosis of patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospec...
journal_title：International journal of cancer
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更新日期：2019-11-15 00:00:00
abstract：:cis-Diamminedichloroplatinum(II) (CDDP) induced G2-phase arrest in PC-9 human cancer cells. To elucidate how CDDP acts on cell-cycle regulation, we analyzed the effect of CDDP on cell-cycle regulators such as p34cdc2 protein kinase. p34cdc2 protein kinase activity was maximum in G2 phase and decreased after G2/M trans...
journal_title：International journal of cancer
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更新日期：1993-10-21 00:00:00
abstract：:Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the most evidenced triages is outlined, as are challenges for implementation...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
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更新日期：2018-08-15 00:00:00
