Small interfering RNA-mediated CXCR1 or CXCR2 knock-down inhibits melanoma tumor growth and invasion.

abstract：:The impact of the ABC transporters breast cancer resistance protein/mitoxantrone resistance associated transporter (BCRP/MXR), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance gene-1/P-glycoprotein (MDR1/PGP) on the multidrug resistance (MDR) phenotype in chemoresistance and thermoresistance w...

journal_title：International journal of cancer

authors： Stein U,Lage H,Jordan A,Walther W,Bates SE,Litman T,Hohenberger P,Dietel M

更新日期：2002-02-20 00:00:00

abstract：:Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...

journal_title：International journal of cancer

authors： Santos L,Amaro T,Costa C,Pereira S,Bento MJ,Lopes P,Oliveira J,Criado B,Lopes C

更新日期：2003-06-10 00:00:00

abstract：:Although menopausal hormone therapy (MHT) seemingly increases the risk of ovarian cancer, evidence is insufficient whether the risk varies between various MHT formulations, regimens and administration modes. With the aim of filling these knowledge gaps, we investigated the effect of different MHT treatment options on ...

journal_title：International journal of cancer

authors： Simin J,Tamimi RM,Callens S,Engstrand L,Brusselaers N

更新日期：2020-07-01 00:00:00

abstract：:Primary cultures derived from pre-cancerous and cancerous human colon tissue are essential for understanding normal and abnormal growth function in the large intestine. Here presented are (i) the methodology for routine establishment of primary cultures of normal, adenoma- and carcinoma-derived cells, and (ii) data fo...

journal_title：International journal of cancer

authors： Tong WM,Bises G,Sheinin Y,Ellinger A,Genser D,Pötzi R,Wrba F,Wenzl E,Roka R,Neuhold N,Peterlik M,Cross HS

更新日期：1998-01-30 00:00:00

abstract：:Epithelial-mesenchymal transition (EMT) describes a process occurring during development and oncogenesis by which epithelial cells obtain fibroblast-like properties and show reduced cell adhesion and increased motility. In this report, we demonstrated typical EMT in human mammary epithelial MCF10A small interfering (s...

journal_title：International journal of cancer

authors： Tanaka H,Shirkoohi R,Nakagawa K,Qiao H,Fujita H,Okada F,Hamada J,Kuzumaki S,Takimoto M,Kuzumaki N

更新日期：2006-04-01 00:00:00

abstract：:To assess long-term trends in the prevalence of oncogenic human papillomavirus (HPV) infection, we performed a cross-sectional serosurvey of the seroprevalence of the major oncogenic HPV type, HPV16, among 3,512 pregnant women undergoing population-based serological screening at the first trimester of pregnancy in the...

journal_title：International journal of cancer

authors： af Geijersstam V,Wang Z,Lewensohn-Fuchs I,Eklund C,Schiller JT,Forsgren M,Dillner J

更新日期：1998-05-04 00:00:00

abstract：:Retinoids play essential roles in the regulation of cell differentiation and in the proliferation of various epithelial tissues, and atRA is one such active metabolite of retinoids. However, despite the known functions of atRA, its clinical applications are limited due to the induced metabolism by the specific cytochr...

journal_title：International journal of cancer

authors： Choi Y,Kim SY,Kim SH,Yang J,Park K,Byun Y

更新日期：2003-10-20 00:00:00

abstract：:We present data on test positivity, relative sensitivity, rates of detection and relative specificity for primary human papillomavirus (HPV) testing with different cutoff levels for test positivity, in comparison to conventional cytology. In 2003-2004, 18,438 women were screened primarily with Hybrid Capture 2 (HC 2) ...

journal_title：International journal of cancer

authors： Kotaniemi-Talonen L,Malila N,Nieminen P,Anttila A,Tarkkanen J,Laurila P,Hakama M

更新日期：2008-12-15 00:00:00

abstract：:We previously reported that some single nucleotide polymorphisms (SNPs) of candidate genes involved in the MTOR complex1 (MTORC1) were associated with risk of gastric cancer (GCa). In the present study, we further evaluated associations of eight potentially functional SNPs of MTOR, MLST8 and RPTOR with survival of 100...

journal_title：International journal of cancer

authors： Cheng L,Qiu L,Zhang R,Qian D,Wang M,Sun M,Zhu X,Wang Y,Guo W,Wei Q

更新日期：2019-01-15 00:00:00

abstract：:In order to define technical limitations of conventional external beam irradiation for clinically localized prostate cancer, we evaluated the impact of several reduced-field treatment factors, such as reduced-field (RF) irradiated volume, RF technique, photon energy of treatment, and dose on survival endpoints and loc...

journal_title：International journal of cancer

authors： Gagnon GJ,Harter KW,Berg CD,Lynch JH,Cornell DR,Kuettel MR,Dritschilo A

更新日期：2000-10-20 00:00:00

abstract：:To identify tumor-suppressor genes on chromosome 10 in non-small cell lung cancers, we isolated 10 types of splicing variant of the HELLS/SMARCA6 gene transcripts. HELLS/SMARCA6 is a novel member of SNF2 family, which is implicated in cellular functions like chromatin remodeling. Variant 1 was an alternatively spliced...

journal_title：International journal of cancer

authors： Yano M,Ouchida M,Shigematsu H,Tanaka N,Ichimura K,Kobayashi K,Inaki Y,Toyooka S,Tsukuda K,Shimizu N,Shimizu K

更新日期：2004-10-20 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer-related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment and play an important role in the onset and progression of HCC through the secretion of g...

journal_title：International journal of cancer

authors： Ruan Q,Wang H,Burke LJ,Bridle KR,Li X,Zhao CX,Crawford DHG,Roberts MS,Liang X

更新日期：2020-09-15 00:00:00

abstract：:Expression levels of hTERT mRNA were investigated by RT-PCR in tissue specimens of patients with (Group A) and without (Group B) clinically overt bronchial carcinoma, respectively. Bronchial carcinoma (n = 9) and distant normal (n = 9) specimens were analyzed in Group A. The chance of carcinoma seemed to increase with...

journal_title：International journal of cancer

authors： Snijders PJ,Breuer RH,Sutedja TG,Egging M,Voorhorst FJ,Steenbergen RD,van der Linden HC,Risse EK,Berkhof J,de Vries EG,van der Zee AG,Postmus PE,Meijer CJ,Smit EF

更新日期：2004-04-10 00:00:00

abstract：:In addition to the known function in the glycolytic pathway, phosphoglycerate kinase 1 (PGK-1) promotes reduction of plasmin disulfide bonds leading to angiostatin formation and inhibition of tumor angiogenesis. In this study, the effects of PGK-1 on anti- tumor immunity against lung cancer were evaluated using the Te...

journal_title：International journal of cancer

authors： Tang SJ,Ho MY,Cho HC,Lin YC,Sun GH,Chi KH,Wang YS,Jhou RS,Yang W,Sun KH

更新日期：2008-12-15 00:00:00

abstract：:The 1100delC mutation of the cell cycle checkpoint kinase 2 (CHEK2) gene confers an increased risk for breast cancer, but the clinical impact of other CHEK2 gene variants remains unclear. We determined the frequency of two functionally relevant CHEK2 gene mutations, I157T and IVS2+1G > A, in two large series of breast...

journal_title：International journal of cancer

authors： Bogdanova N,Enssen-Dubrowinskaja N,Feshchenko S,Lazjuk GI,Rogov YI,Dammann O,Bremer M,Karstens JH,Sohn C,Dörk T

更新日期：2005-08-20 00:00:00

abstract：:The most recent data available demonstrate a 120-fold difference between the lowest and highest incidence rates of prostatic cancer, the disease being very common in North America, particularly among Blacks, and in Scandinavia, while it is rare in Japan and other oriental countries. The highest mortality for prostatic...

journal_title：International journal of cancer

authors： Zaridze DG,Boyle P,Smans M

更新日期：1984-02-15 00:00:00

abstract：:Inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), is known to play an important role in the development of sporadic clear cell renal cell carcinomas (ccRCCs). Even if available targeted therapies for metastatic RCCs (mRCCs) have helped to improve progression-free survival rates, they have no durable ...

journal_title：International journal of cancer

authors： Bouhamdani N,Joy A,Barnett D,Cormier K,Léger D,Chute IC,Lamarre S,Ouellette R,Turcotte S

更新日期：2017-08-15 00:00:00

abstract：:Paraffin sections from 190 epithelial ovarian tumours, including 159 malignant and 31 benign epithelial tumours, were analysed immunohistochemically for expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16INK4A (p16). Most benign tumours showed no p16 expression in the tumour cells, whereas only...

journal_title：International journal of cancer

authors： Dong Y,Walsh MD,McGuckin MA,Gabrielli BG,Cummings MC,Wright RG,Hurst T,Khoo SK,Parsons PG

更新日期：1997-02-20 00:00:00

abstract：:Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WT1 deletions/mutations and loss of heterozygosity (LOH) on 11p and 11q in a large number of WTs and compared our findings with those from 4 series of Caucasian WTs. Incidence rates of the subtl...

journal_title：International journal of cancer

authors： Nakadate H,Yokomori K,Watanabe N,Tsuchiya T,Namiki T,Kobayshi H,Suita S,Tsunematsu Y,Horikoshi Y,Hatae Y,Endo M,Komada Y,Eguchi H,Toyoda Y,Kikuta A,Kobayashi R,Kaneko Y

更新日期：2001-11-01 00:00:00

abstract：:The occurrence of resistance to cytotoxic agents in tumor cells, associated with several phenotypic alterations, is one of the major obstacles to successful anticancer chemotherapy. A new strategy to overcome MDR of human cancer cells was studied, using BSAO, which generates cytotoxic products from spermine, H(2)O(2) ...

journal_title：International journal of cancer

authors： Calcabrini A,Arancia G,Marra M,Crateri P,Befani O,Martone A,Agostinelli E

更新日期：2002-05-01 00:00:00

abstract：:Multidrug resistance, the phenomenon by which cells treated with a drug become resistant to the cytotoxic effect of a variety of other structurally and functionally unrelated drugs, is often associated with the expression of P-glycoprotein, an efflux membrane pump coded by the MDR1 (ABCB1) gene. Transcription from MDR...

journal_title：International journal of cancer

authors： Raguz S,Randle RA,Sharpe ER,Foekens JA,Sieuwerts AM,Meijer-van Gelder ME,Melo JV,Higgins CF,Yagüe E

更新日期：2008-03-01 00:00:00

abstract：:We used a cross-sectional survey to examine short-term anxiety and distress in women receiving different results following routine human papillomavirus (HPV) primary testing at cervical screening. Participants were women aged 24-65 (n = 1,127) who had attended screening at one of five sites piloting HPV primary screen...

journal_title：International journal of cancer

authors： McBride E,Marlow LAV,Forster AS,Ridout D,Kitchener H,Patnick J,Waller J

更新日期：2020-04-15 00:00:00

abstract：:There is concern that hormone replacement therapy (HRT) increases the risk of breast cancer. We undertook a case-control study of this risk relationship within a cohort of 40- to 74-year-old women in Uppsala County, Sweden, who participated in mammography screening. Incident cases of breast cancer were ascertained dur...

journal_title：International journal of cancer

authors： Persson I,Thurfjell E,Bergstrom R,Holmberg L

更新日期：1997-09-04 00:00:00

abstract：:The genetic events underlying the development of prostate cancer are poorly defined. c-Myc is often activated in tumors that have progressed to metastatic status, so events that promote this process may be important. Bin1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor that was identified th...

journal_title：International journal of cancer

authors： Ge K,Minhas F,Duhadaway J,Mao NC,Wilson D,Buccafusca R,Sakamuro D,Nelson P,Malkowicz SB,Tomaszewski J,Prendergast GC

更新日期：2000-04-15 00:00:00

abstract：:Cytokines and growth factors are powerful modulators of the immune response. Their aberrant expression either by the tumor cells or by the tumor infiltrating lymphocytes confers a selective advantage to the tumor to grow and suppress the cytotoxic activity of the infiltrating lymphocytes. Therefore, analysis of these ...

journal_title：International journal of cancer

authors： Marrogi AJ,Munshi A,Merogi AJ,Ohadike Y,El-Habashi A,Marrogi OL,Freeman SM

更新日期：1997-10-21 00:00:00

abstract：:The present studies investigated the expression of the platelet-derived growth factor (PDGF) and PDGF-receptor genes in human meningiomas. Northern blot analysis demonstrated that all meningiomas examined expressed both the c-sis/PDGF-2 proto-oncogene and the PDGF-receptor gene. In situ hybridization localized the c-s...

journal_title：International journal of cancer

authors： Maxwell M,Galanopoulos T,Hedley-Whyte ET,Black PM,Antoniades HN

更新日期：1990-07-15 00:00:00

abstract：:The Insulin-like growth factor (IGF)/IGF-receptor pathway with its scaffolding proteins Insulin Receptor Substrate (IRS)1 and IRS2 are crucial regulators of metabolism and progression in metastatic colorectal cancer (mCRC). The goal of the study was the identification of predictive and prognostic markers among IRS1, I...

journal_title：International journal of cancer

authors： Schirripa M,Zhang W,Heinemann V,Cao S,Okazaki S,Yang D,Loupakis F,Berger MD,Ning Y,Miyamoto Y,Suenaga M,Gopez RF,West JD,Hanna D,Barzi A,Falcone A,Stintzing S,Lenz HJ

更新日期：2017-07-15 00:00:00

abstract：:Antibodies to the 27 kDa heat shock protein (hsp27) are present in some women with ovarian and endometrial cancers but not in women with nonmalignant conditions or healthy women. The appearance of these antibodies suggests that the corresponding protein (hsp27) may be present in an extracellular form in gynecologic ca...

journal_title：International journal of cancer

authors： Korneeva I,Caputo TA,Witkin SS

更新日期：2002-12-10 00:00:00

abstract：:High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...

journal_title：International journal of cancer

authors： Smida Rezgui S,Honore S,Rognoni JB,Martin PM,Penel C

更新日期：2000-08-01 00:00:00

abstract：:The influence of polyunsaturated fatty acids (PUFAs) on risk of colorectal cancer precursors remains largely unknown. We examined the associations of erythrocyte PUFAs, including n-3 and n-6 PUFAs, with risk of colorectal conventional adenomas and serrated polyps in 4517 participants from three US prospective cohorts ...

journal_title：International journal of cancer

authors： Wang L,Hang D,He X,Lo CH,Wu K,Chan AT,Ogino S,Giovannucci EL,Song M

更新日期：2021-01-01 00:00:00