Phosphoglycerate kinase 1-overexpressing lung cancer cells reduce cyclooxygenase 2 expression and promote anti-tumor immunity in vivo.

abstract：:To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...

journal_title：International journal of cancer

authors： Daino K,Ugolin N,Altmeyer-Morel S,Guilly MN,Chevillard S

更新日期：2009-08-01 00:00:00

abstract：:The subsets of small lymphocytes (surface Igm-positive or B, Thy-I-positive or T and "double-negative" or null) appearing within spontaneous mammary tumors of C3H retired breeder female mice and in various lymphoid organs of the host at different stages of tumor development were characterized directly using a radioaut...

journal_title：International journal of cancer

authors： Santer V,Mastromarino JH,Lala PK

更新日期：1980-01-15 00:00:00

abstract：:Breast cancer is heterogeneous in clinical behavior by subtypes; however, it is unclear how this heterogeneity is related to epidemiological factors. To evaluate the differences in epidemiological factors by breast tumor subtypes, we investigated the associations of epidemiological factors between tumor subtypes in Ko...

journal_title：International journal of cancer

authors： Song N,Choi JY,Sung H,Chung S,Song M,Park SK,Han W,Lee JW,Kim MK,Yoo KY,Ahn SH,Noh DY,Kang D

更新日期：2014-08-01 00:00:00

abstract：:A hospital-based case-control study of renal-cell carcinoma was conducted in France from 1987 to 1991. A total of 196 histologically confirmed cases (138 males and 58 females) and 347 controls (235 males and 112 females), matched for sex, age at interview, hospital and interviewer, were included. The risk of renal-cel...

journal_title：International journal of cancer

authors： Benhamou S,Lenfant MH,Ory-Paoletti C,Flamant R

更新日期：1993-08-19 00:00:00

abstract：:Leukemia stem cells (LSCs) might originate from malignant transformation of normal hematopoietic stem cells (HSCs), or alternatively, of progenitors in which the acquired mutations have re-installed a dysregulated self-renewal program. LSCs are on top of a hierarchy and generate leukemia cells with more differentiated...

journal_title：International journal of cancer

authors： Buss EC,Ho AD

更新日期：2011-11-15 00:00:00

abstract：:RB1 gene expression has been reported to be upregulated in colorectal carcinomas (CRC) at both the mRNA and protein levels when compared to normal colonic mucosa. However, allelic loss at the genomic level has been detected in CRC with widely differing frequencies ranging from 11.5% to 50%. To determine whether there ...

journal_title：International journal of cancer

authors： Lai PS,Cheah PY,Kadam P,Chua CL,Lie DK,Li HH,Eu KW,Seow-Choen F,Lee AS

更新日期：2006-09-01 00:00:00

abstract：:Withaferin A (WFA) is purified from the plant Withania somnifera and inhibits the vimentin cytoskeleton. Vimentin overexpression in cancer correlates with metastatic disease, induction of epithelial to mesenchymal transition and reduced patient survival. As vimentin functions in cell motility, we wanted to test the hy...

journal_title：International journal of cancer

authors： Thaiparambil JT,Bender L,Ganesh T,Kline E,Patel P,Liu Y,Tighiouart M,Vertino PM,Harvey RD,Garcia A,Marcus AI

更新日期：2011-12-01 00:00:00

abstract：:The antigen-induced leukocyte adherence inhibition (LAI) test is an assay of cellular immune reactivity which was expected to offer a promising adjunct to currently available diagnostic and monitoring procedures in cancer patients. We have applied this assay to (1) 83 inpatients clinically suspected of having breast c...

journal_title：International journal of cancer

authors： Fritze D,Fedra G,Kaufmann M

更新日期：1982-03-15 00:00:00

abstract：:Dietary patterns reflect combinations of dietary exposures, and here we examine these in relation to prostate cancer risk. In a case-control study, 80 incident primary prostate cancer cases and 334 urology clinic controls were enrolled from 1997 through 1999 in Kingston, Ontario, Canada. Food-frequency questionnaires ...

journal_title：International journal of cancer

authors： Walker M,Aronson KJ,King W,Wilson JW,Fan W,Heaton JP,MacNeily A,Nickel JC,Morales A

更新日期：2005-09-10 00:00:00

abstract：:Antibodies to HTLV-I have been detected in sera from 15 (2.0%) of 736 adult blood-donors in Nigeria, in 4 (20.0%) of 20 patients with chronic lymphatic leukaemia, 3 (10.0%) of 30 with non-Hodgkin's lymphoma, one of 12 with Burkitt's lymphoma and one of 7 with acute lymphoblastic leukaemia. The frequency of positivity ...

journal_title：International journal of cancer

authors： Fleming AF,Maharajan R,Abraham M,Kulkarni AG,Bhusnurmath SR,Okpara RA,Williams E,Akinsete I,Schneider J,Bayer H

更新日期：1986-12-15 00:00:00

abstract：:V-ATPases are proton-translocating enzymes, which are found not only in numerous intracellular organelles but also in the plasma membranes of many eukaryotic cells. Using differential display, we have identified one of the proton pump subunit genes, ATP6C, as a cisplatin-inducible gene. Northern blot analysis demonstr...

journal_title：International journal of cancer

authors： Murakami T,Shibuya I,Ise T,Chen ZS,Akiyama S,Nakagawa M,Izumi H,Nakamura T,Matsuo K,Yamada Y,Kohno K

更新日期：2001-09-01 00:00:00

abstract：:The present studies investigated the expression of the platelet-derived growth factor (PDGF) and PDGF-receptor genes in human meningiomas. Northern blot analysis demonstrated that all meningiomas examined expressed both the c-sis/PDGF-2 proto-oncogene and the PDGF-receptor gene. In situ hybridization localized the c-s...

journal_title：International journal of cancer

authors： Maxwell M,Galanopoulos T,Hedley-Whyte ET,Black PM,Antoniades HN

更新日期：1990-07-15 00:00:00

abstract：:Protectin (CD59) inhibits homologous complement-mediated cytolysis by preventing formation of the membrane attack complex at the point of insertion and polymerization of C9 into cell membranes. The present study investigated the expression and function of CD59 on human prostatic tumor cells in situ and on 5 human pros...

journal_title：International journal of cancer

authors： Jarvis GA,Li J,Hakulinen J,Brady KA,Nordling S,Dahiya R,Meri S

更新日期：1997-06-11 00:00:00

abstract：:Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) in a tumor microenvironment, contributing to tumor escape from immunological attack. Although dendritic cell-based cancer vaccines can initiate antitumor immune responses, tumor-educated dendri...

journal_title：International journal of cancer

authors： Ning Y,Xu D,Zhang X,Bai Y,Ding J,Feng T,Wang S,Xu N,Qian K,Wang Y,Qi C

更新日期：2016-06-01 00:00:00

abstract：:The interactions of MCF-7 tumor cells with human vascular endothelial cells (EC) and subendothelial extracellular matrices (ECM) were morphologically observed by electron microscopy and quantitatively evaluated by labelling tumor cells with 111Indium-oxine. MCF-7 tumor cells adhered more rapidly to ECM than to the api...

journal_title：International journal of cancer

authors： Abecassis J,Millon-Collard R,Klein-Soyer C,Nicora F,Fricker JP,Beretz A,Eber M,Muller D,Cazenave JP

更新日期：1987-10-15 00:00:00

abstract：:Molecular characterization has been extensively studied in serrated polyps but very little is known in serrated adenocarcinomas (SACs). We analyzed the incidence of KRAS, BRAF and PIK3CA mutations, microsatellite instability (MSI) status and loss of the DNA repair proteins MLH1, MSH2, MSH6 and MGMT in a series of 89 S...

journal_title：International journal of cancer

authors： García-Solano J,Conesa-Zamora P,Carbonell P,Trujillo-Santos J,Torres-Moreno D D,Pagán-Gómez I,Rodríguez-Braun E,Pérez-Guillermo M

更新日期：2012-10-15 00:00:00

abstract：:Data from 1,916 cases of oral neoplasms occurring in the Sudan in a 16-year period, from January 1970 to December 1985, were retrieved and analysed. The study revealed a relatively high frequency of oral neoplasms in comparison with neighbouring countries. In this study, squamous-cell carcinoma was the most common ora...

journal_title：International journal of cancer

authors： Idris AM,Ahmed HM,Mukhtar BI,Gadir AF,el-Beshir EI

更新日期：1995-04-10 00:00:00

abstract：:Ornithine decarboxylase may be a useful biomarker for risk of neoplasia in colorectal tissues. Investigators have reported enzyme activities varying by as much as 10- to 20-fold using variations of the usual 14CO2 release assay. We have examined the effect of different methodologic factors on calculated ornithine deca...

journal_title：International journal of cancer

authors： Garewal HS,Sloan D,Sampliner RE,Fennerty B

更新日期：1992-09-30 00:00:00

abstract：:Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

journal_title：International journal of cancer

authors： Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

更新日期：1996-07-03 00:00:00

abstract：:The targeted radiotherapy of neuroblastoma with 131l-labelled metaiodobenzyl guanidine (mIBG) is now the subject of several clinical studies. The precise intracellular localization of mIBG, necessary for nuclear microdosimetry, has not previously been described. We report the use of electron-energy-loss spectroscopy a...

journal_title：International journal of cancer

authors： Gaze MN,Huxham IM,Mairs RJ,Barrett A

更新日期：1991-04-01 00:00:00

abstract：:Extracts were made from Walker 256 carcinoma, spontaneous rat mammary adenocarcinoma, Wilms' tumour, human neuroblastoma and human haemangioma. Chromatography of the extracts on Sephadex G-100 yielded four fractions, A, B, C and D. Injection of fractions B and C resulted in the growth of new capillaries in the subcuta...

journal_title：International journal of cancer

authors： Phillips P,Steward JK,Kumar S

更新日期：1976-05-15 00:00:00

abstract：:Immunochromatographical fecal occult blood tests were shown to have higher sensitivity for detecting colorectal neoplasms than the commonly used guaiac-based test. However, positivity rates, sensitivity and specificity vary widely. We aimed to assess the reasons for this heterogeneity. Six dichotomous (qualitative) im...

journal_title：International journal of cancer

authors： Brenner H,Haug U,Hundt S

更新日期：2010-10-01 00:00:00

abstract：:There is a great need to identify new and better prognostic and predictive biomarkers to stratify prostate cancer patients for optimal treatment. The aims of this study were to characterize the expression profile of pre-B cell leukemia homeobox (PBX) transcription factors in prostate cancer with an emphasis on investi...

journal_title：International journal of cancer

authors： Ramberg H,Grytli HH,Nygård S,Wang W,Ögren O,Zhao S,Løvf M,Katz B,Skotheim RI,Bjartell A,Eri LM,Berge V,Svindland A,Taskén KA

更新日期：2016-10-15 00:00:00

abstract：:In normal somatic cells, the methylation pattern of DNA is stably maintained by DNA (cytosine-5-)-methyltransferase (DNA methyltransferase). Increased expression of DNA methyltransferase has been detected in many types of human cancer and has been thought to play an important role in tumorigenesis. In our study, we de...

journal_title：International journal of cancer

authors： Chen B,Liu X,Savell VH,Dilday BR,Johnson MW,Jenkins JJ,Parham DM

更新日期：1999-09-24 00:00:00

abstract：:To provide an up-to-date overview of recent trends in mortality from oral and pharyngeal cancer, we analyzed death certification data for 61 countries worldwide provided by the World Health Organization in 2010-2015, and, for selected most populous countries, over the period 1970-2016. For 12 largest countries, we ana...

journal_title：International journal of cancer

authors： Bosetti C,Carioli G,Santucci C,Bertuccio P,Gallus S,Garavello W,Negri E,La Vecchia C

更新日期：2020-08-15 00:00:00

abstract：:Cancer survival varies by place of residence, but it remains uncertain whether this reflects differences in tumour, patient and treatment characteristics (including tumour stage, indicators of socioeconomic status (SES), comorbidity and information on received surgery and radiotherapy) or possibly regional differences...

journal_title：International journal of cancer

authors： Skyrud KD,Bray F,Eriksen MT,Nilssen Y,Møller B

更新日期：2016-05-01 00:00:00

abstract：:The effects of three monoclonal antibodies (B3/25, 43/31, and 42/6) reactive with human transferrin (Tf) receptors on growth of normal and malignant myeloid cells were examined using in vitro culture techniques. When added directly to cultures, all three antibodies caused dose-dependent inhibition of normal granulocyt...

journal_title：International journal of cancer

authors： Taetle R,Honeysett JM,Trowbridge I

更新日期：1983-09-15 00:00:00

abstract：:Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also ...

journal_title：International journal of cancer

authors： Copeland BT,Bowman MJ,Boucheix C,Ashman LK

更新日期：2013-10-15 00:00:00

abstract：:In order to isolate and characterize genes whose expression may be altered in breast malignancy, we screened a cDNA library with a polyclonal anti-serum against breast-cancer-metastasis membranes and isolated several immunopositive clones. One of these, AJ1, was analyzed in detail and found to be expressed at varying ...

journal_title：International journal of cancer

authors： Jameel A,Skilton RA,Campbell TA,Chander SK,Coombes RC,Luqmani YA

更新日期：1992-02-01 00:00:00

abstract：:Cervical carcinogenesis is a consequence of persistent infection with high-risk human papillomaviruses (HPVs). Recent studies indicate that HPV-transformed cells actively instruct their microenvironment to promote carcinogenesis. Here, we demonstrate that cervical cancer cells activate monocytes to produce their own C...

journal_title：International journal of cancer

authors： Pahne-Zeppenfeld J,Schröer N,Walch-Rückheim B,Oldak M,Gorter A,Hegde S,Smola S

更新日期：2014-05-01 00:00:00