Abstract:
:Tumors can induce the generation and accumulation of immunosuppressive cells such as myeloid-derived suppressor cells (MDSCs) in a tumor microenvironment, contributing to tumor escape from immunological attack. Although dendritic cell-based cancer vaccines can initiate antitumor immune responses, tumor-educated dendritic cells (TEDCs) involved in the tolerance induction have attracted much attention recently. In this study, we investigated the effect of β-glucan on TEDCs and found that β-glucan treatment could promote the maturation and migration of TEDCs and that the suppressive function of TEDCs was significantly decreased. Treatment with β-glucan drastically decreased the levels of regulatory T (Treg) cells but increased the infiltration of macrophages, granulocytes and DCs in tumor masses, thus elicited Th1 differentiation and cytotoxic T-lymphocyte responses and led to a delay in tumor progression. These findings reveal that β-glucan can inhibit the regulatory function of TEDCs, therefore revealing a novel function for β-glucan in immunotherapy and suggesting its potential clinical benefit. β-Glucan directly abrogated tumor-educated dendritic cells-associated immune suppression, promoted Th1 differentiation and cytotoxic T-lymphocyte priming and improved antitumor responses.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ning Y,Xu D,Zhang X,Bai Y,Ding J,Feng T,Wang S,Xu N,Qian K,Wang Y,Qi Cdoi
10.1002/ijc.30002subject
Has Abstractpub_date
2016-06-01 00:00:00pages
2713-23issue
11eissn
0020-7136issn
1097-0215journal_volume
138pub_type
杂志文章abstract::The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980130)75:3<396::aid-ijc
更新日期:1998-01-30 00:00:00
abstract::Target-specific acute myeloid leukemia (AML) immunotherapy requires selective cell-surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous studies, a chemically linked full-length anti-CD64 immunotoxin based on...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25766
更新日期:2011-09-01 00:00:00
abstract::Occupational X-ray examination programs have been conducted in many countries to screen for occupational and nonoccupational respiratory diseases, resulting in widespread exposure to X-radiation. We conducted a multicentre case-control study of lung cancer in the Czech Republic, Hungary, Poland, Romania, Russia and Sl...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.20854
更新日期:2005-06-10 00:00:00
abstract::Etiological risk factors for proximal (right-sided) colon cancers may be different to those of distal colon and rectal (left-sided) cancers if these tumors develop along distinct pathways. The CpG Island Methylator Phenotype (CIMP+) occurs in approximately 15% of colorectal cancers (CRC) and predominantly in the proxi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24324
更新日期:2009-07-01 00:00:00
abstract::Peripheral or tonsil lymphocyte populations of EBV-seropositive donors give rise to EBV-carrying LCLs upon in vitro explantation. Such lines can arise either by a 2-step mechanism, namely release of virus from some of the explanted cells followed by infection of previously uninfected B cells, or by direct outgrowth of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390411
更新日期:1987-04-15 00:00:00
abstract::Bcl-2 protein inhibits apoptosis, reduces the requirement for growth factors, and thereby extends the survival of cells. Recent findings of Bcl-2 in several solid tumors suggest that it might contribute to the genesis of some types of cancer. Over-expression of Bcl-2 might play a role in carcinogenesis and malignant p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980417)79:2<153::aid-ijc
更新日期:1998-04-17 00:00:00
abstract::Hybridomas producing syngeneic monoclonal antibodies (MAbs) were prepared by fusion of spleen cells of BALB/c mice, which were immunized with sublethal doses of RMB-I cells. This cell line originates from a Rauscher virus (R-MuLV)-induced myeloid leukemia and forms tumors when re-inoculated into mice. MAbs were charac...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420121
更新日期:1988-07-15 00:00:00
abstract::Ciclopirox olamine (CPX) is a synthetic antifungal agent clinically used to treat mycoses of the skin and nails. Here, we show that CPX inhibited tumor growth in human breast cancer MDA-MB-231 xenografts. To unveil the underlying mechanism, we further studied the antitumor activity of CPX in cell culture. The results ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25255
更新日期:2010-11-15 00:00:00
abstract::DCs hold promise for cancer immunotherapy due to their functional ambivalence: iDCs internalize antigens, then mDCs trigger naive T-cell activation. However, no consensus has been reached concerning the optimal mode of antigen acquisition for efficient cross-priming of TAA-specific CTLs, and this remains a field of in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10605
更新日期:2002-09-20 00:00:00
abstract::In mice as well as humans, cytotoxic T lymphocytes (CTL) specific for wild-type-sequence (wt) p53 peptides have been shown to react against a wide range of tumors, but not normal cells. As such, they are attractive candidates for developing broadly applicable cancer vaccines. Of particular interest is the potential of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20686
更新日期:2005-03-01 00:00:00
abstract::In a novel attempt to understand the variations in DNA sequences underlying HLA class I alleles associated with HPV16-related CaCx, we determined the alleles by reconstructing SNP-based haplotypes from resequencing of the most polymorphic exons 2 and 3 of HLA-A, HLA-B and HLA-C. We also determined the impact of SNPs a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30681
更新日期:2017-06-01 00:00:00
abstract::Trends in the incidence of stomach cancer among 52,604 patients notified to the National Swedish Cancer Registry in 1960 through 1984 were analysed. Age-standardized incidence rates declined throughout the period, from 47.1 to 24.6 per 10(5) in males and from 23.8 to 12.7 per 10(5) in females. Among males the decline ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470405
更新日期:1991-02-20 00:00:00
abstract::The insulin-like growth factors (IGF-I and IGF-II) play a key role in cellular proliferation and are involved in cellular transformation. The expression of the IGF-I receptor has been demonstrated in a variety of human tumor cell lines including ovarian cancer cells. Phosphorothioate antisense oligodeoxynucleotides (S...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980812)77:4<567::aid-ijc
更新日期:1998-08-12 00:00:00
abstract::Selenium is a promising chemopreventive agent for prostate cancer, possibly via an induction of apoptosis. Earlier studies have shown that selenite induces DNA single strand breaks (SSBs), reactive oxygen species (ROS), p53 Ser-15 phosphorylation and caspase-dependent and -independent apoptosis, whereas a methylseleno...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22480
更新日期:2007-05-01 00:00:00
abstract::Sprague-Dawley rats were given combinations of aminopyrine or oxytetracycline and sodium nitrite in drinking water. Of 30 animals receiving 0.1% (1,000 ppm) of aminopyrine and sodium nitrite for 30 weeks, 29 died with hemangioendothelial sarcomas of the liver. The same tumor caused death in 26 of 30 animals that recei...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910160203
更新日期:1975-08-15 00:00:00
abstract::Growth of a highly-deviated ascites hepatoma (Yoshida AH-130) in rats caused initial hyperplastic enlargement of the liver, followed by progressive reduction to a size lower than that seen in controls. The time-course of this biphasic change in liver weight roughly corresponded to the exponential and stationary phases...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440424
更新日期:1989-10-15 00:00:00
abstract::During malignant progression cancer cells undergo a series of changes, which promote their survival, invasiveness and metastatic process. One of them is a change in glucose metabolism. Unlike normal cells, which mostly rely on the tricarboxylic acid cycle (TCA), many cancer types rely on glycolysis. Pyruvate dehydroge...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31812
更新日期:2019-02-15 00:00:00
abstract::Intestinal mucositis is a common side effect of chemotherapy leading to diarrhea, abdominal pain and increased risk of infections. The intestinal microbiota has been recognized as a key regulator of mucosal immune responses. Therefore, we hypothesized that intestinal microbial changes would be associated with enterocy...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32942
更新日期:2020-10-01 00:00:00
abstract::Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro. Here, we investigated the effect on breast cancer survival of germline variation in these genes in 925 Finnish breast cancer patients and further analyzed five sing...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27884
更新日期:2013-05-01 00:00:00
abstract::Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall surv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31195
更新日期:2018-04-15 00:00:00
abstract::Malignant mesothelioma (MM) is an aggressive tumor associated with environmental or occupational exposure to asbestos fibers. Erionite is a fibrous zeolite, morphologically similar to asbestos and it is assumed to be even more carcinogenic. Onset and progression of MM has been suggested as the result of the cooperatio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22687
更新日期:2007-07-01 00:00:00
abstract::MAGE genes encoding tumor-rejection antigens recognized by cytotoxic T lymphocytes are expressed at the mRNA level in various malignant tumors. We have investigated the expression of genes MAGE-1, -2, -3/-6 and -4a/-4b at the mRNA level in malignant and non-malignant ovarian tumors as well as in normal ovaries by reve...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910640607
更新日期:1995-12-20 00:00:00
abstract::MicroRNA-9-1(miR-9-1) plays an important role in the mechanism that regulates the lineage fate of differentiating hematopoietic cells. Recent studies have shown that miR-9-1 is downregulated in t (8; 21) AML. However, the pathogenic mechanisms underlying miR-9-1 downregulation and the RUNX1-RUNX1T1 fusion protein, gen...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30481
更新日期:2017-02-01 00:00:00
abstract::Cultured cells derived from pregnancy-dependent mouse mammary tumors (plaques) when transplanted into the gland-free mammary fat pad display a heterogeneous developmental potential. They not only gave rise to plaques but also produced normal mammary gland, hyperplastic alvoelar nodules (HAN), and autonomous mammary tu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230520
更新日期:1979-05-15 00:00:00
abstract::Transfer of the herpes simplex virus type I thymidine kinase (HSV-TK) gene into tumor cells using virus-based vectors in conjunction with ganciclovir (GCV) exposure provides a potential gene therapy strategy for the treatment of cancer. The possibility of using a novel targetable Sindbis virus expression vector contai...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990105)80:1<110::aid-ijc
更新日期:1999-01-05 00:00:00
abstract::A simple and rapid variant of in situ hybridization on tissue sections (histo-blotting) usable for detection of specific RNA distribution among tissues is proposed. Tissue sections prepared with a cryostatic microtome are placed on nitrocellulose and these "histo-blots" are hybridized with labelled DNA or RNA probes u...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910440619
更新日期:1989-12-15 00:00:00
abstract::Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with canine transmissible venereal sarcoma (CTVS) at different stages of growth was determined by the tube LAI test. Tumors were classified at the time of excision into progressor, steady state, and regressor stages of growth. The LAI ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270314
更新日期:1981-03-15 00:00:00
abstract::To investigate the association between hysterectomy and thyroid cancer subtypes based on histopathology. They did a nationwide, population-based, cohort study from 1973 to 2009 in Sweden. All women above 18 years of age during the period between January 1, 1973 and December 31, 2009 from the Register of Population (n ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30606
更新日期:2017-04-15 00:00:00
abstract::Marked variation in phenotypic expression among BRCA1 and BRCA2 mutation carriers may be partly explained by modifier genes that influence mutation penetrance. Variation in CAG/CAA repeat lengths coding for stretches of glutamines in the C-terminus of the AIB1 protein (amplified in breast cancer 1, a steroid receptor ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21176
更新日期:2005-11-01 00:00:00
abstract::A hamster lymphoid cell line, HCT-2, transformed by human T-cell leukemia virus type I (HTLV-I) was serially transplanted for 9 passages in newborn hamsters. A total of 34 newborn hamsters inoculated intraperitoneally (i.p.) with 0.2-2 X 10(7) HCT-2 cells developed fatal lymphomas with dissemination to various organs ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410617
更新日期:1988-06-15 00:00:00