Abstract:
:Antibodies to HTLV-I have been detected in sera from 15 (2.0%) of 736 adult blood-donors in Nigeria, in 4 (20.0%) of 20 patients with chronic lymphatic leukaemia, 3 (10.0%) of 30 with non-Hodgkin's lymphoma, one of 12 with Burkitt's lymphoma and one of 7 with acute lymphoblastic leukaemia. The frequency of positivity was higher (3.6%) in the blood-donors from the guinea and wooded savanna of northern Nigeria than in those from the rain-forest and mangrove swamps of southern Nigeria (1.8% in Lagos and 0.7% in Calabar). Two of the 3 seropositive patients with lymphoma had clinical presentation and courses similar to those of Japanese and Caribbean patients with adult T-cell leukaemia/lymphoma.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Fleming AF,Maharajan R,Abraham M,Kulkarni AG,Bhusnurmath SR,Okpara RA,Williams E,Akinsete I,Schneider J,Bayer Hdoi
10.1002/ijc.2910380605subject
Has Abstract,Author List Incompletepub_date
1986-12-15 00:00:00pages
809-13issue
6eissn
0020-7136issn
1097-0215journal_volume
38pub_type
杂志文章abstract::Previous studies have proved that a certain acidic isoform of ferritin is specifically synthesized by the placenta and breast-cancer tissue. In this context it has been further reported that the determination of this so-called placental isoferritin (PLF) on the surface of a subset of peripheral lymphocytes is highly s...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910520213
更新日期:1992-09-09 00:00:00
abstract::PGP9.5 is a controversial molecule from an oncologic point of view. We recently identified frequent methylation of PGP9.5 gene exclusively in primary head and neck squamous cell carcinoma (HNSCC), suggesting that it could be a tumor suppressor gene. On the other hand, PGP9.5 was reported to be overexpressed in a subse...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23354
更新日期:2008-08-15 00:00:00
abstract::The 9p21-23 chromosome region harbors a number of known and putative tumor-suppressor genes (TSGs). The best characterized gene in this area is p16(INK4A) (CDKN2A). Alterations of its product have been observed in various malignancies, including non-small-cell lung carcinomas (NSCLCs). We earlier investigated the mech...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000320)89:2<133::aid-ijc
更新日期:2000-03-20 00:00:00
abstract::Endothelial lipase (LIPG) is a cell surface associated lipase that displays phospholipase A1 activity towards phosphatidylcholine present in high-density lipoproteins (HDL). LIPG was recently reported to be expressed in breast cancer and to support proliferation, tumourigenicity and metastasis. Here we show that sever...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32138
更新日期:2019-08-15 00:00:00
abstract::The sister chromatid exchange (SCE) rates of cell lines derived from patients with different malignant and premalignant disease were studied before and after intracerebral inoculation into nude mice and were compared to the SCE frequencies of cell lines from healthy controls. Lymphoma lines characterized by chromosoma...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280408
更新日期:1981-10-15 00:00:00
abstract::Early detection, clinical management and disease recurrence monitoring are critical areas in cancer treatment in which specific biomarker panels are likely to be very important in each of these key areas. We have previously demonstrated that levels of alpha-2-heremans-schmid-glycoprotein (AHSG), complement component C...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26462
更新日期:2012-08-15 00:00:00
abstract::The application of glucocorticoids (GC3) in human leukemia is based on apoptosis induction but is often hampered by GC resistance. To delineate resistance mechanisms, we examined 5 GC-resistant leukemic cell lines, termed CEM-C7.R1-R5, isolated from the GC-sensitive human acute-T-cell-leukemic line, CCRF-CEM-C7, by se...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19961127)68:5<663::AID-IJC
更新日期:1996-11-27 00:00:00
abstract::Infection with a simian retrovirus (STLV-I) closely related to human T-lymphotropic virus type I (HTLV-I) was investigated in non-human primates living in their native countries in Africa and Asia. Serum antibodies cross-reacting with HTLV-I antigens were detected in 85 of 567 non-human primates of 30 species. Seropos...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400219
更新日期:1987-08-15 00:00:00
abstract::Transcriptional profiling was performed on 452 RNA preparations isolated from various types of pancreatic tissue from tumour patients and healthy donors, with a particular focus on peritumoral samples. Pancreatic ductal adenocarcinomas (PDAC) and cystic tumours were most different in these non-tumorous tissues surroun...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31087
更新日期:2018-03-01 00:00:00
abstract::Heme oxygenase (HO)-1 catalyzes the degradation of cytotoxic heme into biliverdin and blocks antitumor immune responses, thus protecting cancer against host defense. Whether this scenario also applies to neuroblastoma (NB), the most common extracranial solid childhood tumor, is not known. Here, we demonstrate for the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29933
更新日期:2016-04-15 00:00:00
abstract::A population-based case-control study of risk factors for renal-cell carcinoma was conducted in Denmark from 1989 to 1992. A total of 368 histologically verified cases and 396 controls were included. Information on weight, height, physical activity and reproductive factors were collected in a structured interview, alo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560113
更新日期:1994-01-02 00:00:00
abstract::Primary cultures of rat microvascular endothelial cells were transformed, in vitro, by exposure to Rous sarcoma virus. Transformed cells were followed and evaluated cytogenetically through numerous passages. Highly specific karyotypic changes in karyotype (both structural and numerical) were documented. These changes ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320416
更新日期:1983-10-15 00:00:00
abstract::Messenger RNA differential display was used to study liver-gene expression in paired tumor and non-tumor tissues from hepatocellular carcinoma (HCC) patients. mRNA differential display and Northern-blot analyses showed that a 0.8-kb cDNA fragment was diminished or absent from the tumorous tissues of 7 HCC patients. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980302)75:5<787::aid-ijc
更新日期:1998-03-02 00:00:00
abstract::In order to analyze the mutational events and to understand the biological significance of the p53 gene in chemical carcinogenesis, we applied a new yeast-based p53 functional assay to ovarian tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA), as well as to transitional cell carcinomas of the urinary bladder in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19991126)83:5<700::aid-ijc
更新日期:1999-11-26 00:00:00
abstract::As the most abundant noncoding RNA in cells, tRNA plays an important role in tumorigenesis and development. The report of tRNA on the pathogenesis of lung adenocarcinoma is rare. It is of great clinical significance to explore the relationship between tRNA expression and prognosis of lung adenocarcinoma. The expressio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32250
更新日期:2019-10-01 00:00:00
abstract::A deficit in colorectal cancer survival in Denmark and in the UK compared to Sweden, Norway and Finland was found in the EUROCARE studies. We set out to explore if these differences still exist. Patients diagnosed with colorectal cancer as their first invasive cancer at age 15-89 in the period 1994-2000 were identifie...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22737
更新日期:2007-09-01 00:00:00
abstract::Incidence rates in the United States show clear racial/ethnic disparities for colorectal cancer. We examined the extent to which ethnic differences in risk factors could explain the age-adjusted variation in the risk of colorectal cancer, overall and by stage at diagnosis, among 165,711 African Americans, Japanese Ame...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25822
更新日期:2011-10-15 00:00:00
abstract::Cancer is associated with epigenetic (i.e., histone hypoacetylation) and metabolic (i.e., aerobic glycolysis) alterations. Levels of N-acetyl-L-aspartate (NAA), the primary storage form of acetate in the brain, and aspartoacylase (ASPA), the enzyme responsible for NAA catalysis to generate acetate, are reduced in glio...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28465
更新日期:2014-03-15 00:00:00
abstract::Genomic instability plays a key role in hereditary nonpolyposis colorectal cancer and in a significant sub-set of non-hereditary colorectal tumors. Recent evidence suggests that microsatellite instability also occurs in various sub-sets of common, non-hereditary forms of extra-colorectal carcinoma. To investigate the ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910640409
更新日期:1995-08-22 00:00:00
abstract::Medullary thyroid carcinoma (MTC) is a rare tumor, partially explained by mutations in the rearranged during transfection (RET) proto-oncogene. The nonsynonymous RET polymorphism G691S has been reported as associated with MTC, but findings are discordant. We sought to clarify the role of G691S in MTCs through in silic...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.27967
更新日期:2013-06-15 00:00:00
abstract::Spontaneous tumor development and primary oncogenesis were compared in a large number of NK4-deficient, homozygous C57Bl/6-bg/bg mice and their NK normal, heterozygous +/bg littermate controls. In a group of 167 retired breeders followed for spontaneous tumors, the probability of survival for mice eventually dying wit...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350414
更新日期:1985-04-15 00:00:00
abstract::By using a functional complementation approach, suppression of tumorigenicity was observed after transfer of intact or truncated copies of chromosome 3 into a nasopharyngeal carcinoma (NPC) HONE1 cell line. The extra exogenous chromosome 3 in the microcell hybrids (MCHs) significantly extended the lag period of tumor ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23528
更新日期:2008-07-15 00:00:00
abstract::Marked variation in phenotypic expression among BRCA1 and BRCA2 mutation carriers may be partly explained by modifier genes that influence mutation penetrance. Variation in CAG/CAA repeat lengths coding for stretches of glutamines in the C-terminus of the AIB1 protein (amplified in breast cancer 1, a steroid receptor ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21176
更新日期:2005-11-01 00:00:00
abstract::von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor specimens, as determined by immuno-histochemical staining for vWF or other endothelial cell markers, is a negative prognostic factor f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000115)85:2<281::aid-ijc
更新日期:2000-01-15 00:00:00
abstract::E-cadherin mutations are found in 50% of diffuse-type gastric carcinoma, but not in intestinal gastric carcinoma. Because cell-cell adhesion mediated by E-cadherin plays an important role in epithelial cell survival, E-cadherin mutations could alter the apoptotic behavior of tumor cells. p53 and Bcl-2 family members a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10879
更新日期:2003-03-10 00:00:00
abstract::A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing gene in the Eker rat model. In this study, we searched ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980911)77:6<895::aid-ijc
更新日期:1998-09-11 00:00:00
abstract::Regional lymph-node (LN) lymphocytes may constitute an important defence against the spread of human melanoma beyond regional LNs. The present study was directed to clonal analysis of lymphocytes cultured either directly from the LNs or after stimulation in cultures with autologous melanoma (MLTC). T-cell clones deriv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510209
更新日期:1992-05-08 00:00:00
abstract::The recently discovered human polyomavirus (MCPyV) is frequently found in Merkel cell carcinoma (MCC) tissue and is believed to be causally linked to MCC pathogenesis. While cell lines established from MCC represent a valuable tool to study the contribution of MCPyV to MCC pathogenesis, hitherto only 1 MCPyV-positive ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24877
更新日期:2010-05-01 00:00:00
abstract::Recent reports suggest that autoantibodies directed to aberrantly glycosylated mucins, in particular MUC1 and MUC4, are found in patients with colorectal cancer. There is, however, limited information on the autoantibody levels before clinical diagnosis, and their utility in cancer screening in the general population....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28538
更新日期:2014-05-01 00:00:00
abstract::We characterized 8 human hepatocellular-carcinoma cell lines established from the primary tumors of Korean patients. All lines showed substrate adherence and one line from anaplastic tumor also grew as floating aggregates. Most cultured cells maintained many morphological characteristics of the original tumors from wh...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910620308
更新日期:1995-07-28 00:00:00