The involvement of the RET variant G691S in medullary thyroid carcinoma enlightened by a meta-analysis study.

abstract：:Tumor cells interact with endothelial cells during both intra- and extravasation. Understanding how these interactions are modulated could lead to the development of ways to alter the metastatic potential of tumor cells. Three pancreatic cancer cell lines, SW1990, CAPAN-2 and PANC-I, were examined for their ability to...

journal_title：International journal of cancer

authors： Sawada T,Ho JJ,Chung YS,Sowa M,Kim YS

更新日期：1994-06-15 00:00:00

abstract：:To identify characteristics of gastric cancer associated with hereditary non-polyposis colorectal cancer (HNPCC), we gathered clinical data and tumor samples relating to patients recorded in the Finnish HNPCC registry. Our series included 51 families with a characterized mutation and/or that met the Amsterdam criteria...

journal_title：International journal of cancer

authors： Aarnio M,Salovaara R,Aaltonen LA,Mecklin JP,Järvinen HJ

更新日期：1997-10-21 00:00:00

abstract：:CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...

journal_title：International journal of cancer

authors： Widenmeyer M,Griesemann H,Stevanović S,Feyerabend S,Klein R,Attig S,Hennenlotter J,Wernet D,Kuprash DV,Sazykin AY,Pascolo S,Stenzl A,Gouttefangeas C,Rammensee HG

更新日期：2012-07-01 00:00:00

abstract：:Since advanced melanoma remains practically incurable, early detection is an important step toward a reduction in mortality. High expectations are entertained for a technique known as dermoscopy or epiluminescence light microscopy; however, evaluation of pigmented skin lesions by this method is often extremely complex...

journal_title：International journal of cancer

authors： Rubegni P,Cevenini G,Burroni M,Perotti R,Dell'Eva G,Sbano P,Miracco C,Luzi P,Tosi P,Barbini P,Andreassi L

更新日期：2002-10-20 00:00:00

abstract：:The antigen K-1-2, detectable by a MAb is found in nevi and melanomas. It is associated with melanoma cells of low invasive and metastatic potential as shown by immunoperoxidase studies with cell lines, biopsies and autopsies: K-1-2 occurs in melanoma cell line SK-Mel 25, but not in cell line A-375. A-375 has a higher...

journal_title：International journal of cancer

authors： Suter L,Brüggen J,Bröcker EB,Sorg C

更新日期：1985-06-15 00:00:00

abstract：:In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and ...

journal_title：International journal of cancer

authors： Allday MJ,Kundu D,Finerty S,Griffin BE

更新日期：1990-06-15 00:00:00

abstract：:Carcinomatous meningitis is a devastating metastatic complication of systemic carcinoma, which may occur insidiously, accompanied by a confusing spectrum of clinical symptoms and signs. In the absence of reliable diagnostic tumour markers, the diagnosis is established by the demonstration of malignant cells within the...

journal_title：International journal of cancer

authors： Moseley RP,Oge K,Shafqat S,Moseley CM,Sullivan NM,Badley RA,Burchell J,Taylor-Papadimitriou J,Coakham HB

更新日期：1989-09-15 00:00:00

abstract：:With an increasing cancer rate worldwide, there is an urgent quest for the improvement of anticancer drugs. One of the main problems of present chemotherapy in treatment of tumor patients is the toxicity of drugs. Most of the existent anticancer drugs, unfortunately, attack also proliferating normal cells. In recent y...

journal_title：International journal of cancer

authors： Zhu JY,Lavrik IN,Mahlknecht U,Giaisi M,Proksch P,Krammer PH,Li-Weber M

更新日期：2007-10-15 00:00:00

abstract：:Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...

journal_title：International journal of cancer

authors： Franceschi S,Levi F,Randimbison L,La Vecchia C

更新日期：1996-07-03 00:00:00

abstract：:Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capaci...

journal_title：International journal of cancer

authors： Thomson DM

更新日期：1975-06-15 00:00:00

abstract：:Thrombin is now recognized as an important factor in many cancers. Here, we examined the expression and role of the recently discovered thrombin receptor PAR4, in human colon cancer cells. PAR4 mRNA was found in 10 out of 14 (71%) human colon cancer cell lines tested but not in epithelial cells isolated from normal hu...

journal_title：International journal of cancer

authors： Gratio V,Walker F,Lehy T,Laburthe M,Darmoul D

更新日期：2009-04-01 00:00:00

abstract：:In a hospital-based case-control study of esophageal cancer undertaken in Athens (1989-1991), 43 patients with incident esophageal squamous-cell carcinoma and 56 patients with incident esophageal adenocarcinoma were compared to 200 injury patients. Personal interviews were conducted in the hospital setting, and dietar...

journal_title：International journal of cancer

authors： Tzonou A,Lipworth L,Garidou A,Signorello LB,Lagiou P,Hsieh C,Trichopoulos D

更新日期：1996-11-04 00:00:00

abstract：:A population-based case-control study of incident primary brain tumors in adults was carried out in Adelaide, Australia in the period 1987 through 1990. It included 110 subjects with newly diagnosed primary glioma, 60 subjects with meningioma and 417 controls selected from the Australian Electoral Roll and frequency-m...

journal_title：International journal of cancer

authors： Ryan P,Lee MW,North B,McMichael AJ

更新日期：1992-04-22 00:00:00

abstract：:We examined the effect of parity on breast cancer risk on the basis of information from 107,146 married female nurses followed prospectively between 1976-1980. For everparous women, a significant protective effect against breast cancer was observed with increasing parity (chi 12 for trend = 14.2, p less than 0.001). A...

journal_title：International journal of cancer

authors： Pathak DR,Speizer FE,Willett WC,Rosner B,Lipnick RJ

更新日期：1986-01-15 00:00:00

abstract：:Ferric nitrilotriacetate (Fe-NTA) causes renal proximal tubular necrosis, a consequence of iron ion-mediated free-radical-associated damage, that finally leads to a high incidence of renal adenocarcinoma in male rats and mice. We have investigated the levels of typical hydroxyl radical-induced DNA base modifications i...

journal_title：International journal of cancer

authors： Toyokuni S,Mori T,Dizdaroglu M

更新日期：1994-04-01 00:00:00

abstract：:Oncogenes of the myc family c-raf-1 and K-ras have been reported to modulate radiosensitivity. We examined the possible relationship between in vivo radiosensitivity to single-dose irradiation with 3-10 Gy, and activity of these proto-oncogenes in 2 sets of small-cell lung cancer (SCLC) xenografts, the CPH and the GLC...

journal_title：International journal of cancer

authors： Rygaard K,Slebos RJ,Spang-Thomsen M

更新日期：1991-09-09 00:00:00

abstract：:Dietary intake of many fruits and vegetables has been shown to be associated with reduced risk of cancer. We investigated the in vivo efficacy of grape seed extract (GSE, patented as Traconol) against prostate cancer (PCA) and associated molecular events. Athymic nude mice were implanted with hormone-refractory human ...

journal_title：International journal of cancer

authors： Singh RP,Tyagi AK,Dhanalakshmi S,Agarwal R,Agarwal C

更新日期：2004-02-20 00:00:00

abstract：:Oncolytic adenoviruses are being developed as novel anticancer therapeutics and currently undergoing clinical trials. We previously demonstrated that telomerase-specific replication-competent adenovirus (Telomelysin: OBP-301), in which the human telomerase reverse transcriptase (hTERT) promoter regulates viral replica...

journal_title：International journal of cancer

authors： Fujiwara T,Kagawa S,Kishimoto H,Endo Y,Hioki M,Ikeda Y,Sakai R,Urata Y,Tanaka N,Fujiwara T

更新日期：2006-07-15 00:00:00

abstract：:The melanosomal protein TRP2 expressed by melanocytes and most melanoma cells is an attractive, clinically relevant model antigen for the experimental development of melanoma immunotherapy in mice. A peptide shared by murine and human TRP2 can be recognized by melanoma-reactive CTL in C57BL/6 mice, as well as in human...

journal_title：International journal of cancer

authors： Steitz J,Brück J,Steinbrink K,Enk A,Knop J,Tüting T

更新日期：2000-04-01 00:00:00

abstract：:MEK1/2 inhibitors like U0126 can potentiate or antagonize the antitumor activity of cytotoxic agents such as cisplatin, paclitaxel or vinblastine, depending on the drug or the target cells. We now investigated whether U0126, differentially regulates melanoma signaling in response to UV radiation or betulinic acid, a d...

journal_title：International journal of cancer

authors： Rieber M,Rieber MS

更新日期：2006-03-01 00:00:00

abstract：:Evidence from randomized controlled trials suggests that calcium may protect against recurrence of colorectal adenomas, which could lead to the subsequent prevention of cancer. Yet the trials used only a large single dose and were of small sizes, and thus, knowledge of the dose-response relationship and influence on h...

journal_title：International journal of cancer

authors： Keum N,Lee DH,Greenwood DC,Zhang X,Giovannucci EL

更新日期：2015-04-01 00:00:00

abstract：:The role of IL-33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer model we demonstrate time-dependent increase of endogenous IL-33 at both the mRNA and protein levels in primary tumors and metastatic lungs during cancer progression. Administration of IL-33 accelerated tumor growth and development...

journal_title：International journal of cancer

authors： Jovanovic IP,Pejnovic NN,Radosavljevic GD,Pantic JM,Milovanovic MZ,Arsenijevic NN,Lukic ML

更新日期：2014-04-01 00:00:00

abstract：:Like the majority of tumor cells, ovarian cancer cell growth is critically dependent on their neovascularization. Adhesion molecules and cellular events that lead to ovarian tumor cell interactions with endothelial extracellular matrix surrounding the vasculature are poorly identified. To understand the role of alphav...

journal_title：International journal of cancer

authors： Carreiras F,Thiébot B,Leroy-Dudal J,Maubant S,Breton MF,Darbeida H

更新日期：2002-06-20 00:00:00

abstract：:We have used differential-display PCR (DD-PCR) to compare renal-cell carcinoma (RCC) and normal kidney gene expression with the aim of identifying genes specifically associated with RCC. Using a modified DD-PCR approach, which was non-radioactive, quicker and simpler than the conventional method, 24 cDNA samples were ...

journal_title：International journal of cancer

authors： Rae FK,Stephenson SA,Nicol DL,Clements JA

更新日期：2000-12-01 00:00:00

abstract：:In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort o...

journal_title：International journal of cancer

authors： Strohsnitter WC,Bertrand KA,Troisi R,Scott CG,Cheville AL,Hoover RN,Palmer JR,Vachon CM

更新日期：2018-09-15 00:00:00

abstract：:Cancer incidence disparities exist among specific Asian American populations. However, the existing reports exclude data from large metropoles like Chicago, Houston and New York. Moreover, incidence rates by subgroup have been underestimated due to the exclusion of Asians with unknown subgroup. Cancer incidence data f...

journal_title：International journal of cancer

authors： Jin H,Pinheiro PS,Xu J,Amei A

更新日期：2016-05-01 00:00:00

abstract：:Management of oral leukoplakia-a potentially malignant disorder-is currently not evidence-based. Of the few randomized trials that have been reported, most have negative data. Therefore, a multi-centre, randomized, double-blind controlled trial (RCT) was undertaken to evaluate the use of low-dose beta-carotene combine...

journal_title：International journal of cancer

authors： Nagao T,Warnakulasuriya S,Nakamura T,Kato S,Yamamoto K,Fukano H,Suzuki K,Shimozato K,Hashimoto S

更新日期：2015-04-01 00:00:00

abstract：:E-cadherin mutations are found in 50% of diffuse-type gastric carcinoma, but not in intestinal gastric carcinoma. Because cell-cell adhesion mediated by E-cadherin plays an important role in epithelial cell survival, E-cadherin mutations could alter the apoptotic behavior of tumor cells. p53 and Bcl-2 family members a...

journal_title：International journal of cancer

authors： Fricke E,Keller G,Becker I,Rosivatz E,Schott C,Plaschke S,Rudelius M,Hermannstädter C,Busch R,Höfler H,Becker KF,Luber B

更新日期：2003-03-10 00:00:00

abstract：:Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet coun...

journal_title：International journal of cancer

authors： Buergy D,Wenz F,Groden C,Brockmann MA

更新日期：2012-06-15 00:00:00

abstract：:Docetaxel (DOC), a member of the taxane family of anticancer drugs, binds to tubulin and produces unnaturally stable microtubules that induce cell death. DOC is used clinically alone or in combination with other compounds to treat advanced stages of cancer. We have treated the human lung cancer cell lines A549 and H12...

journal_title：International journal of cancer

authors： Chang JT,Chang GC,Ko JL,Liao HY,Liu HJ,Chen CC,Su JM,Lee H,Sheu GT

更新日期：2006-01-15 00:00:00