Prenatal diethylstilbestrol exposure and mammographic density.

abstract：:Histone deacetylases (HDAC) extensively contribute to the c-Myc oncogenic program, pointing to their inhibition as an effective strategy against c-Myc-overexpressing cancers. We, thus, studied the therapeutic activity of the new-generation pan-HDAC inhibitor ITF2357 (Givinostat®) against c-Myc-overexpressing human B-c...

journal_title：International journal of cancer

authors： Zappasodi R,Cavanè A,Iorio MV,Tortoreto M,Guarnotta C,Ruggiero G,Piovan C,Magni M,Zaffaroni N,Tagliabue E,Croce CM,Zunino F,Gianni AM,Di Nicola M

更新日期：2014-11-01 00:00:00

abstract：:Second-line ipilimumab has been publicly funded in Ontario for metastatic melanoma (MM) since September 2012. We examined real-world toxicity of second-line ipilimumab compared to standard second-line treatments prior to funding. MM patients who received systemic treatment from April 2005 to March 2015 were included. ...

journal_title：International journal of cancer

authors： Dai WF,Beca J,Croxford R,Isaranuwatchai W,Menjak IB,Petrella TM,Mittmann N,Earle CC,Gavura S,Mercer RE,Hanna TP,Chan KKW

更新日期：2020-10-26 00:00:00

abstract：:Limited data are available on the carcinogenicity of smokeless tobacco products in organs other than the mouth. Snus is a smokeless tobacco product widely used in Norway. We studied 10,136 Norwegian men enrolled since 1966 in a prospective cohort study, 31.7% of whom were exposed to snus. The relative risk of pancreat...

journal_title：International journal of cancer

authors： Boffetta P,Aagnes B,Weiderpass E,Andersen A

更新日期：2005-05-10 00:00:00

abstract：:Primary cultures of rat microvascular endothelial cells were transformed, in vitro, by exposure to Rous sarcoma virus. Transformed cells were followed and evaluated cytogenetically through numerous passages. Highly specific karyotypic changes in karyotype (both structural and numerical) were documented. These changes ...

journal_title：International journal of cancer

authors： Tyrkus M,Diglio CA,Gohle N

更新日期：1983-10-15 00:00:00

abstract：:Risks of 2nd primary cancer were assessed in all patients with cutaneous melanoma (12,460) and all patients with ocular melanoma (2,018) incident in Denmark from 1943 to 1989 and followed for totals of 88,667 person-years and 16,045 person-years, respectively. After cutaneous melanoma, 972 2nd cancers occurred. The ri...

journal_title：International journal of cancer

authors： Swerdlow AJ,Storm HH,Sasieni PD

更新日期：1995-06-09 00:00:00

abstract：:Tumor cells of colorectal cancer (CRC) release exosomes into the circulation. These exosomes can mediate communication between cells and affect various tumor-related processes in their target cells. We present a quantitative proteomics analysis of the exosomes purified from serum of patients with CRC and normal volunt...

journal_title：International journal of cancer

authors： Chen Y,Xie Y,Xu L,Zhan S,Xiao Y,Gao Y,Wu B,Ge W

更新日期：2017-02-15 00:00:00

abstract：:The relationship between the biomarker of vitamin D status, 25(OH)D, and the risk for colorectal neoplasia is suggestive but equivocal. Questions remain regarding whether there are differential associations between 25(OH)D and colorectal adenoma by gender, colorectal subsite or features of baseline and recurrent adeno...

journal_title：International journal of cancer

authors： Jacobs ET,Hibler EA,Lance P,Sardo CL,Jurutka PW

更新日期：2013-12-15 00:00:00

abstract：:To test whether alloimmunization with H-2 or/and non-H-2 different normal tissues may increase the immunity to syngeneic tumors, groups of BALB/c (H-2d) mice were immunized with a series of allogeneic lymphoid cells and then challenged i.p. with syngeneic lymphoma cells. The outgrowth of otherwise lethal doses of the ...

journal_title：International journal of cancer

authors： Parmiani G,Sensi ML,Carbone G,Colombo M,Pierotti M,Ballinari D,Hilgers J,Hilkens J

更新日期：1982-03-15 00:00:00

abstract：:Altered microRNA (miRNA) expression has been found to promote carcinogenesis, but little is known about the role of miRNAs in esophageal cancer. In this study, we selected 10 miRNAs and analyzed their expression in 10 esophageal cancer cell lines and 158 tissue specimens using Northern blotting and in situ hybridizati...

journal_title：International journal of cancer

authors： Hu Y,Correa AM,Hoque A,Guan B,Ye F,Huang J,Swisher SG,Wu TT,Ajani JA,Xu XC

更新日期：2011-01-01 00:00:00

abstract：:Cytogenetic analysis of short-term cultures from 26 primary bronchial large cell carcinomas and 1 metastasis from a primary large cell carcinoma revealed clonal chromosome abnormalities in 20 tumors and a normal karyotype in 6. No outgrowth was obtained in 1 case. Simple aberrations were present in 3 tumors; in 1, the...

journal_title：International journal of cancer

authors： Johansson M,Dietrich C,Mandahl N,Hambraeus G,Johansson L,Clausen PP,Mitelman F,Heim S

更新日期：1994-05-15 00:00:00

abstract：:Using antisera for two specific basement membrane (b.m.) antigens such as laminin and collagen type-IV, together with electron microscopy, we have shown that fully antigenic b.m. and morphologically typical basal lamina (b.l.) are associated with normal and transformed cells of the melanocyte lineage in different ways...

journal_title：International journal of cancer

authors： Natali PG,Nicotra MR,Bellocci M,Cavaliere R,Bigotti A

更新日期：1985-04-15 00:00:00

abstract：:In neuroblastoma (NB), genetic alterations in chromatin remodeling (CRGs) and epigenetic modifier genes (EMGs) have been described. We sought to determine their frequency and clinical impact. Whole exome (WES)/whole genome sequencing (WGS) data and targeted sequencing (TSCA®) of exonic regions of 33 CRGs/EMGs were ana...

journal_title：International journal of cancer

authors： Bellini A,Bessoltane-Bentahar N,Bhalshankar J,Clement N,Raynal V,Baulande S,Bernard V,Danzon A,Chicard M,Colmet-Daage L,Pierron G,Le Roux L,Planchon JM,Combaret V,Lapouble E,Corradini N,Thebaud E,Gambart M,Valteau-Cou

更新日期：2019-11-15 00:00:00

abstract：:The open reading frames of the phosphoprotein pp58 (BMRFI) and the deoxyribonuclease (BGLF5) of the Epstein-Barr-virus (EBV) strain M-ABA were cloned in the baculovirus expression vectors pAc373 and pAc360 and expressed in the Spodoptera frugiperda (SF158) insect cells. The recombinant phosphoprotein pp58 expressed in...

journal_title：International journal of cancer

authors： Chen HF,Sauter M,Haiss P,Müller-Lantzsch N

更新日期：1991-07-30 00:00:00

abstract：:The loss of E-cadherin expression and the translocation of beta-catenin to the nucleus are frequently associated with the metastatic conversion of epithelial cells. In the nucleus, beta-catenin binds to the TCF/LEF-1 (T-cell factor/ lymphoid enhancer factor) transcription factor family resulting in the activation of s...

journal_title：International journal of cancer

authors： Mestdagt M,Polette M,Buttice G,Noël A,Ueda A,Foidart JM,Gilles C

更新日期：2006-01-01 00:00:00

abstract：:High dietary intakes of calcium and dairy products have been hypothesized to enhance prostate cancer risk, but available prospective data regarding these associations are inconsistent. We examined dietary intakes of calcium and dairy products in relation to risk of prostate cancer in the Alpha-Tocopherol, Beta-Caroten...

journal_title：International journal of cancer

authors： Mitrou PN,Albanes D,Weinstein SJ,Pietinen P,Taylor PR,Virtamo J,Leitzmann MF

更新日期：2007-06-01 00:00:00

abstract：:In this review, we evaluate key molecular pathways and markers of muscle-invasive bladder cancer (MIBC). Overexpression and activation of EGFR, p63, and EMT genes are suggestive of basal MIBC subtype generally responsive to chemotherapy. Alterations in PPARγ, ERBB2/3, and FGFR3 gene products and their signaling along ...

journal_title：International journal of cancer

authors： Kiselyov A,Bunimovich-Mendrazitsky S,Startsev V

更新日期：2016-06-01 00:00:00

abstract：:By radioimmunoassay (RIA) mammary tumour virus (MTV) antigens were detected in individual milk samples of C3Hf mice, (female BALB/c X male C3Hf)F1 mice and (female C3Hf X male BALB/c)F1 mice; milk samples of BALB/c mice were negative. In the segregating backcross I population, female BALB/c X male (female BALB/c X mal...

journal_title：International journal of cancer

authors： van Nie R,Verstraeten AA

更新日期：1975-12-15 00:00:00

abstract：:Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversial. To clarify thi...

journal_title：International journal of cancer

authors： Shimizu Y,Zhu JJ,Han F,Ishikawa T,Oda H

更新日期：1999-07-19 00:00:00

abstract：:In a series of 87 primary breast tumors, somatostatin receptor (SSR) expression was detected by in vitro autoradiography in 58 tumors. In 41 tumors the SSR expression was homogeneous and in 17 it was heterogeneous. Although the tumors were not selected by the investigators upon entry in the study, examination of the t...

journal_title：International journal of cancer

authors： Bootsma AH,van Eijck C,Schouten KK,Reubi JC,Waser B,Foekens JA,van Pel R,Zwarthoff EC,Lamberts SW,de Klein A

更新日期：1993-05-28 00:00:00

abstract：:Homeobox-containing genes are a network of genes encoding DNA-binding proteins highly conserved throughout evolution. They are involved in the control of normal development as well as in the regulation of gene expression in adult differentiating systems, including hematopoiesis. Aberrant expression of homeobox-contain...

journal_title：International journal of cancer

authors： Celetti A,Barba P,Cillo C,Rotoli B,Boncinelli E,Magli MC

更新日期：1993-01-21 00:00:00

abstract：:Infection of (C57BL/6 X DBA/2)F1 (BDF1) mice with 2,500 FFU of Friend virus complex (FV) resulted in erythroleukemia followed by recovery, at which time virus could not be detected in the spleens of mice, and with splenomegaly (progressor mice) or without splenomegaly (regressor mice). Progressor and regressor mice de...

journal_title：International journal of cancer

authors： Yoosook C

更新日期：1982-06-15 00:00:00

abstract：:A simple and rapid variant of in situ hybridization on tissue sections (histo-blotting) usable for detection of specific RNA distribution among tissues is proposed. Tissue sections prepared with a cryostatic microtome are placed on nitrocellulose and these "histo-blots" are hybridized with labelled DNA or RNA probes u...

journal_title：International journal of cancer

authors： Gudkov AV,Kashkin KN,Zaitsevskaya TE,Troyanovsky SM

更新日期：1989-12-15 00:00:00

abstract：:BALB/cfC3H female mice which develop mammary tumor virus (MTV)-induced mammary tumors possess not only serun antibodies directed against virus-associated antigens which are expressed on mammary tumor cells but also antibodies directed against antigenic specificities which are unique to each tumor. The possible range o...

journal_title：International journal of cancer

authors： Blair PB,Lane ML

更新日期：1978-04-15 00:00:00

abstract：:Cancer stem cells (CSCs) are initiating cells in colorectal cancer (CRC). Colorectal tumours undergo epithelial to mesenchymal transition (EMT)-like processes at the invasive front, enabling invasion and metastasis, and recent studies have linked this process to the acquisition of stem cell-like properties. It is of f...

journal_title：International journal of cancer

authors： Sarkar D,Shields B,Davies ML,Müller J,Wakeman JA

更新日期：2012-01-15 00:00:00

abstract：:The topic of this review is the role of stromal-epithelial interactions in normal and malignant prostatic growth. Because cell-cell interactions and androgens play such key roles in the prostate, the goal of this review will be to apply endocrinologic and developmental concepts to the understanding of normal and malig...

journal_title：International journal of cancer

authors： Cunha GR,Hayward SW,Wang YZ,Ricke WA

更新日期：2003-10-20 00:00:00

abstract：:The knowledge that cervical neoplasia are caused by human papillomavirus (HPV) infection has led to the evaluation of its role in screening. We evaluated the accuracy of HPV testing by Hybrid capture II (HC II) method in detecting cervical intraepithelial neoplasia grade 2 and 3 (CIN 2 and 3) lesions in 4 cross-sectio...

journal_title：International journal of cancer

authors： Sankaranarayanan R,Chatterji R,Shastri SS,Wesley RS,Basu P,Mahe C,Muwonge R,Seigneurin D,Somanathan T,Roy C,Kelkar R,Chinoy R,Dinshaw K,Mandal R,Amin G,Goswami S,Pal S,Patil S,Dhakad N,Frappart L,Fontaniere B

更新日期：2004-11-01 00:00:00

abstract：:140.240, an IgG2a mouse monoclonal antibody raised against a cultured human melanoma cell line, was highly specific for melanoma cells as determined by direct and absorption analyses in a mixed hemadsorption assay. Supernatants of doubly cloned hybridomas producing antibody 140.240 reacted with all cultured and fresh ...

journal_title：International journal of cancer

authors： Liao SK,Clarke BJ,Khosravi M,Kwong PC,Brickenden A,Dent PB

更新日期：1982-11-15 00:00:00

abstract：:The intrauterine environment appears to play a role in the development of adult diseases, including several prominent cancers. Our study aims to characterize the relationship between birth weight, a measure of the intrauterine environment, and adult obesity. A population-based sample of women aged 50-79, living in the...

journal_title：International journal of cancer

authors： Leong NM,Mignone LI,Newcomb PA,Titus-Ernstoff L,Baron JA,Trentham-Dietz A,Stampfer MJ,Willett WC,Egan KM

更新日期：2003-03-01 00:00:00

abstract：:MicroRNAs (mirs) are small noncoding RNA molecules (~22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we screened for altered microRNA ex...

journal_title：International journal of cancer

authors： Chang SS,Jiang WW,Smith I,Poeta LM,Begum S,Glazer C,Shan S,Westra W,Sidransky D,Califano JA

更新日期：2008-12-15 00:00:00

abstract：:A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western b...

journal_title：International journal of cancer

authors： Grohmann U,Fioretti MC,Binaglia L,Belladonna ML,Bianchi R,Puccetti P

更新日期：1993-09-09 00:00:00