Histo-blotting: hybridization in situ detection of specific RNAs on tissue sections transferred on nitrocellulose.

abstract：:Bcl-2 expression is up-regulated in prostate cancer cells after androgen ablation and associated with development of androgen independence and chemoresistance. We recently reported that antisense Bcl-2 oligodeoxynucleotides (ODNs) delay progression to androgen independence in the androgen-dependent (AD) human LNCaP pr...

journal_title：International journal of cancer

authors： Leung S,Miyake H,Zellweger T,Tolcher A,Gleave ME

更新日期：2001-03-15 00:00:00

abstract：:The relationship between renal-cell cancer (RCC) and occupation was investigated in an international multicenter population-based case-control study. Study centers in Australia, Denmark, Germany, Sweden and the United States interviewed 1732 incident RCC cases and 2309 controls. Significant associations were found wit...

journal_title：International journal of cancer

authors： Mandel JS,McLaughlin JK,Schlehofer B,Mellemgaard A,Helmert U,Lindblad P,McCredie M,Adami HO

更新日期：1995-05-29 00:00:00

abstract：:The association of fruit and vegetable consumption and lung cancer incidence was evaluated using the most recent data from the European Prospective Investigation into Cancer and Nutrition (EPIC), applying a refined statistical approach (calibration) to account for measurement error potentially introduced by using food...

journal_title：International journal of cancer

authors： Linseisen J,Rohrmann S,Miller AB,Bueno-de-Mesquita HB,Büchner FL,Vineis P,Agudo A,Gram IT,Janson L,Krogh V,Overvad K,Rasmuson T,Schulz M,Pischon T,Kaaks R,Nieters A,Allen NE,Key TJ,Bingham S,Khaw KT,Amiano P,Bar

更新日期：2007-09-01 00:00:00

abstract：:Genomic instability plays a key role in hereditary nonpolyposis colorectal cancer and in a significant sub-set of non-hereditary colorectal tumors. Recent evidence suggests that microsatellite instability also occurs in various sub-sets of common, non-hereditary forms of extra-colorectal carcinoma. To investigate the ...

journal_title：International journal of cancer

authors： Contegiacomo A,Palmirotta R,De Marchis L,Pizzi C,Mastranzo P,Delrio P,Petrella G,Figliolini M,Bianco AR,Frati L

更新日期：1995-08-22 00:00:00

abstract：:GC-binding factor 2 (GCF2), a transcriptional repressor that decreases the activity of several genes is capable of binding directly to the GC-rich sequence of the EGFR promoter and repressing the transcriptional activity of EGFR. In addition to its function as a transcriptional repressor, GCF2 can directly interact wi...

journal_title：International journal of cancer

authors： Ohtsuka H,Oikawa M,Ariake K,Rikiyama T,Motoi F,Katayose Y,Unno M,Johnson AC

更新日期：2011-10-01 00:00:00

abstract：:Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...

journal_title：International journal of cancer

authors： Tomala J,Chmelova H,Strohalm J,Ulbrich K,Sirova M,Rihova B,Kovar M

更新日期：2011-10-15 00:00:00

abstract：:High BCAR1/p130Cas expression in primary breast tumour cytosol predicts a poor chance of response recurrent disease to tamoxifen treatment in patients with oestrogen receptor (ER)-positive breast carcinomas. In this study, we assessed whether BCAR1/p130Cas expression is altered during acquisition of anti-oestrogen res...

journal_title：International journal of cancer

authors： van der Flier S,Chan CM,Brinkman A,Smid M,Johnston SR,Dorssers LC,Dowsett M

更新日期：2000-09-20 00:00:00

abstract：:The miR-34 family members are direct transcriptional targets of tumor suppressor p53, and loss of miR-34 function can impair p53-mediated cell cycle arrest and apoptosis. A potentially functional SNP rs4938723 (T > C) was found in the promoter region of pri-miR-34b/c (423 bp from the transcription start site), located...

journal_title：International journal of cancer

authors： Xu Y,Liu L,Liu J,Zhang Y,Zhu J,Chen J,Liu S,Liu Z,Shi H,Shen H,Hu Z

更新日期：2011-01-15 00:00:00

abstract：:Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several arginine depletion strategies into early phase clinical trials. Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginos...

journal_title：International journal of cancer

authors： Fultang L,Vardon A,De Santo C,Mussai F

更新日期：2016-08-01 00:00:00

abstract：:In addition to antiviral effects, Type I interferons (IFN) have potent antiproliferative and immunomodulatory activities. Because of these properties IFNs have been evaluated as therapeutics for the treatment of a number of human diseases, including cancer. Currently, IFNs have been shown to be efficacious for the tre...

journal_title：International journal of cancer

authors： Wagner TC,Velichko S,Chesney SK,Biroc S,Harde D,Vogel D,Croze E

更新日期：2004-08-10 00:00:00

abstract：:von Willebrand factor (vWF), a glycoprotein produced uniquely by endothelial cells and megakaryocytes, is routinely used to identify vessels in tissue sections. Vessel density in tumor specimens, as determined by immuno-histochemical staining for vWF or other endothelial cell markers, is a negative prognostic factor f...

journal_title：International journal of cancer

authors： Zanetta L,Marcus SG,Vasile J,Dobryansky M,Cohen H,Eng K,Shamamian P,Mignatti P

更新日期：2000-01-15 00:00:00

abstract：:A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occurring HPV infectio...

journal_title：International journal of cancer

authors： Giannoudis A,Graham DA,Southern SA,Herrington CS

更新日期：1999-09-24 00:00:00

abstract：:Familial risk of pancreatic cancer has been mainly assessed through case-control studies based on reported but not medically verified cancers in family members. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and 21,000 pancreatic cancers to calculate standardized incidence ratios (SI...

journal_title：International journal of cancer

authors： Hemminki K,Li X

更新日期：2003-02-10 00:00:00

abstract：:The t(14;19)(q32;q13) is a recurrent chromosomal translocation reported in a variety of B-cell leukemias and lymphomas, including chronic lymphocytic leukemia (CLL). CLL cases associated with t(14;19) often have atypical morphologic and immunophenotypic features and unmutated immunoglobulin heavy chain (IGH) variable ...

journal_title：International journal of cancer

authors： Schweighofer CD,Huh YO,Luthra R,Sargent RL,Ketterling RP,Knudson RA,Barron LL,Medeiros LJ,Keating MJ,Abruzzo LV

更新日期：2011-06-01 00:00:00

abstract：:The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer has been measured and related to the metabolic clearance rates of oestradiol (MCR-E2). All measurements were carried out preoperatively. No difference in the free fraction of oestradiol was found between women with breast ...

journal_title：International journal of cancer

authors： Reed MJ,Beranek PA,Cheng RW,Ghilchik MW,James VH

更新日期：1985-04-15 00:00:00

abstract：:Therapy-induced senescence (TIS) as a permanent growth arrest can be induced by various stimuli, including anticancer compounds. TIS emerged as a promising strategy to overcome resistance phenomena. However, senescent cancer cells might regain proliferation activity in vivo or even secrete tumor-promoting cytokines. T...

journal_title：International journal of cancer

authors： Weiland T,Lampe J,Essmann F,Venturelli S,Berger A,Bossow S,Berchtold S,Schulze-Osthoff K,Lauer UM,Bitzer M

更新日期：2014-01-01 00:00:00

abstract：:The enzyme alpha1,3galactosyltransferase synthesizes the alphaGal epitope, a carbohydrate structure (Galalpha1,3Galbeta1,4GlcNAc-R), on glycoconjugates in lower mammals. The enzyme is absent in humans but large amounts of natural antibodies that recognize alphaGal epitopes are present in human serum. It is likely that...

journal_title：International journal of cancer

authors： Aubert M,Crotte C,Bernard JP,Lombardo D,Sadoulet MO,Mas E

更新日期：2003-12-20 00:00:00

abstract：:The prevalence of methylation of the p16, DAPK and RASSF1A genes was investigated in lung adenocarcinoma from smokers, former uranium miners and never smokers. The association between a common genetic alteration in adenocarcinoma, mutation of the K-ras gene and methylation of these genes, as well as survival was exami...

journal_title：International journal of cancer

authors： Divine KK,Pulling LC,Marron-Terada PG,Liechty KC,Kang T,Schwartz AG,Bocklage TJ,Coons TA,Gilliland FD,Belinsky SA

更新日期：2005-04-10 00:00:00

abstract：:Numerous studies support a role for Sox2 to keep stem cells and progenitor cells in an immature and proliferative state. Coexpression of Sox2 and GFAP has been found in regions of the adult brain where neural stem cells are present and in human glioma cells. In our study, we have investigated the roles of Sox2 and its...

journal_title：International journal of cancer

authors： Ferletta M,Caglayan D,Mokvist L,Jiang Y,Kastemar M,Uhrbom L,Westermark B

更新日期：2011-07-01 00:00:00

abstract：:Etiological risk factors for proximal (right-sided) colon cancers may be different to those of distal colon and rectal (left-sided) cancers if these tumors develop along distinct pathways. The CpG Island Methylator Phenotype (CIMP+) occurs in approximately 15% of colorectal cancers (CRC) and predominantly in the proxi...

journal_title：International journal of cancer

authors： Iacopetta B,Heyworth J,Girschik J,Grieu F,Clayforth C,Fritschi L

更新日期：2009-07-01 00:00:00

abstract：:There is concern that hormone replacement therapy (HRT) increases the risk of breast cancer. We undertook a case-control study of this risk relationship within a cohort of 40- to 74-year-old women in Uppsala County, Sweden, who participated in mammography screening. Incident cases of breast cancer were ascertained dur...

journal_title：International journal of cancer

authors： Persson I,Thurfjell E,Bergstrom R,Holmberg L

更新日期：1997-09-04 00:00:00

abstract：:While dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on dietary antioxidants and its precursor Barrett's esophagus (BE) are limited. The present study extends previous work on BE by investigating risks of nondysplastic BE, dysplastic BE and EAC ass...

journal_title：International journal of cancer

authors： Ibiebele TI,Hughes MC,Nagle CM,Bain CJ,Whiteman DC,Webb PM,Study of Digestive Health and Australian Cancer Study.

更新日期：2013-07-01 00:00:00

abstract：:To assess the relation between air pollution with airway irritants, including sulfuric acid and lung cancer, a case-control study was performed near an industry producing sulfuric acid and fertilizers in Kedainiai county, central Lithuania. The county had the highest lung cancer rates of the country among men. Between...

journal_title：International journal of cancer

authors： Petrauskaite R,Pershagen G,Gurevicius R

更新日期：2002-05-01 00:00:00

abstract：:Partial or total loss of chromosome 22 is often associated with tumors of the central nervous system and in particular with meningiomas. As in the case of other tumors, the ganglioside pattern is modified in transformed tissues. Cytogenetic analysis of 30 human meningiomas has been performed and the results compared t...

journal_title：International journal of cancer

authors： Berra B,Papi L,Bigozzi U,Serino D,Morichi R,Mennonna P,Rapelli S,Cogliati T,Montali E

更新日期：1991-02-01 00:00:00

abstract：:Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Tumor recurrence occurs in ∼20% of PTCs and some reach advanced stages. Promoter mutation in the telomerase reverse transcriptase (TERT) gene is identified to be a prognostic marker in PTC. However, the contribution of TERT promoter mutation ...

journal_title：International journal of cancer

authors： Bu R,Siraj AK,Divya SP,Kong Y,Parvathareddy SK,Al-Rasheed M,Al-Obaisi KAS,Victoria IG,Al-Sobhi SS,Al-Dawish M,Al-Dayel F,Al-Kuraya KS

更新日期：2018-05-15 00:00:00

abstract：:The findings of mutations and the development of targeted therapies have improved lung cancer management. Still, the prognosis remains poor, and we need to know more about the genetic and epigenetic alterations in lung cancer. MicroRNAs are involved in crucial biological processes like carcinogenesis by regulating gen...

journal_title：International journal of cancer

authors： Bjaanaes MM,Halvorsen AR,Solberg S,Jørgensen L,Dragani TA,Galvan A,Colombo F,Anderlini M,Pastorino U,Kure E,Børresen-Dale AL,Brustugun OT,Helland A

更新日期：2014-10-15 00:00:00

abstract：:Immunosuppressed patients who develop non-Hodgkin's lymphoma (NHL) have abnormal antibody responses against the Epstein-Barr virus (EBV) prior to the diagnosis of malignancy. To see if this is also true of "spontaneous" cases in the general population, we undertook a collaborative serologic case-control study. From 4 ...

journal_title：International journal of cancer

authors： Mueller N,Mohar A,Evans A,Harris NL,Comstock GW,Jellum E,Magnus K,Orentreich N,Polk BF,Vogelman J

更新日期：1991-09-30 00:00:00

abstract：:Studies of the MLTI were performed in a primary MSV-induced tumor system. Reactivity against mitomycin-C-treated RBL-5 cells could be detected during a limited period at about 14 days after virus injection. The degree of reactivity of MSV 14 spleen cells was quite variable; stimulation indices ranged from 2.2 to 9.4. ...

journal_title：International journal of cancer

authors： Kirchner H,Glaser M,Holden HT,Herberman RB

更新日期：1976-03-15 00:00:00

abstract：:Human epidemiological studies suggest that 1,25(OH)2 D3 deficiency might increase cancer incidence, but no spontaneous tumors have been reported in mice lacking 1,25(OH)2 D3 or deficient in its receptor. In our study, we detected, for the first time, diverse types of spontaneous tumors in l,25(OH)2 D3 deficient mice m...

journal_title：International journal of cancer

authors： Chen L,Yang R,Qiao W,Yuan X,Wang S,Goltzman D,Miao D

更新日期：2018-07-15 00:00:00

abstract：:Retinoic acid (RA) and its natural and synthetic analogs, the retinoids, regulate many biological processes, including development, differentiation, cell growth, morphogenesis, metabolism and homeostasis. Retinoid effects are mediated by specific nuclear receptors, the RARs and RXRs. Because of their ability to contro...

journal_title：International journal of cancer

authors： Lu XP,Fanjul A,Picard N,Shroot B,Pfahl M

更新日期：1999-01-18 00:00:00