GC-binding factor 2 interacts with dishevelled and regulates Wnt signaling pathways in human carcinoma cell lines.

abstract：:The prevalence of methylation of the p16, DAPK and RASSF1A genes was investigated in lung adenocarcinoma from smokers, former uranium miners and never smokers. The association between a common genetic alteration in adenocarcinoma, mutation of the K-ras gene and methylation of these genes, as well as survival was exami...

journal_title：International journal of cancer

authors： Divine KK,Pulling LC,Marron-Terada PG,Liechty KC,Kang T,Schwartz AG,Bocklage TJ,Coons TA,Gilliland FD,Belinsky SA

更新日期：2005-04-10 00:00:00

abstract：:Leukoplakia is an asymptomatic, potentially malignant change in the oral mucosa. Previous studies have reported that smoking and betel quid chewing are associated with increased risk of leukoplakia; few studies have reported on these associations in populations where betel quid does not contain tobacco. We conducted a...

journal_title：International journal of cancer

authors： Thomas SJ,Harris R,Ness AR,Taulo J,Maclennan R,Howes N,Bain CJ

更新日期：2008-10-15 00:00:00

abstract：:Human papillomavirus (HPV) is detected in nearly all cervical cancers and approximately half of vaginal cancers. However, vaginal cancer is an order of magnitude less common than cervical cancer, not only in the general population but also among women with HIV/AIDS. It is interesting therefore that recent studies foun...

journal_title：International journal of cancer

authors： D'Souza G,Burk RD,Zhong Y,Minkoff H,Massad LS,Xue X,Watts DH,Anastos K,Palefsky JM,Levine AM,Colie C,Castle PE,Strickler HD

更新日期：2012-09-15 00:00:00

abstract：:The relative expression of estrogen receptor (ER) and progesterone receptor (PR) mRNA transcripts was measured in 71 primary breast-cancer biopsies. ER and PR binding activity were estimated in parallel by the dextran-coated-charcoal method. There was a close correlation between the amount of ER mRNA and estradiol bin...

journal_title：International journal of cancer

authors： Nagai MA,Marques LA,Yamamoto L,Fujiyama CT,Brentani MM

更新日期：1994-11-01 00:00:00

abstract：:Crizotinib is an oral tyrosine kinase inhibitor approved for treating patients with non-small cell lung cancer (NSCLC) containing an anaplastic lymphoma kinase (ALK) rearrangement. We used knockout mice to study the roles of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) in plasma pharmacokinetics...

journal_title：International journal of cancer

authors： Tang SC,Nguyen LN,Sparidans RW,Wagenaar E,Beijnen JH,Schinkel AH

更新日期：2014-03-15 00:00:00

abstract：:The International Classification of Childhood Cancer (ICCC) updates the widely used Birch and Marsden classification scheme. ICCC is based on the second edition of the International Classification of Diseases for Oncology (ICD-O-2). The purpose of the new classification is to accommodate important changes in recogniti...

journal_title：International journal of cancer

authors： Kramárová E,Stiller CA

更新日期：1996-12-11 00:00:00

abstract：:The expression of the estrogen-regulated breast-cancer-associated pS2 gene was examined in 75 stomach resections taken from 45 patients. The 600-base pS2 mRNA was found in all of the 47 non-neoplastic samples at varying levels: in the histologically normal group we observed a Poisson-type distribution, whereas 79% of ...

journal_title：International journal of cancer

authors： Luqmani Y,Bennett C,Paterson I,Corbishley CM,Rio MC,Chambon P,Ryall G

更新日期：1989-11-15 00:00:00

abstract：:Using immunohistochemical methods, we analyzed the association between nuclear p53 overexpression and various clinicopathological parameters in patients with endometrial cancers. Formalin-fixed and paraffin-embedded tissue sections from 139 cases of endometrial cancer (endometrioid type, 126; serous papillary type, 12...

journal_title：International journal of cancer

authors： Inoue M,Okayama A,Fujita M,Enomoto T,Sakata M,Tanizawa O,Ueshima H

更新日期：1994-07-01 00:00:00

abstract：:Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression was examined by immunohisto...

journal_title：International journal of cancer

authors： Wu GQ,Xie D,Yang GF,Liao YJ,Mai SJ,Deng HX,Sze J,Guan XY,Zeng YX,Lin MC,Kung HF

更新日期：2009-12-01 00:00:00

abstract：:Circulating tumor DNA (ctDNA) is a new circulating tumor biomarker which might be used as a prognostic biomarker in a way similar to circulating tumor cells (CTCs). Here, we used the high prevalence of TP53 mutations in triple negative breast cancer (TNBC) to compare ctDNA and CTC detection rates and prognostic value ...

journal_title：International journal of cancer

authors： Madic J,Kiialainen A,Bidard FC,Birzele F,Ramey G,Leroy Q,Rio Frio T,Vaucher I,Raynal V,Bernard V,Lermine A,Clausen I,Giroud N,Schmucki R,Milder M,Horn C,Spleiss O,Lantz O,Stern MH,Pierga JY,Weisser M,Lebofsky R

更新日期：2015-05-01 00:00:00

abstract：:Carcinomatous meningitis is a devastating metastatic complication of systemic carcinoma, which may occur insidiously, accompanied by a confusing spectrum of clinical symptoms and signs. In the absence of reliable diagnostic tumour markers, the diagnosis is established by the demonstration of malignant cells within the...

journal_title：International journal of cancer

authors： Moseley RP,Oge K,Shafqat S,Moseley CM,Sullivan NM,Badley RA,Burchell J,Taylor-Papadimitriou J,Coakham HB

更新日期：1989-09-15 00:00:00

abstract：:We evaluated promoter hypermethylation of a panel of tumor suppressor genes as a means to detect epigenetic alterations in oral squamous cell carcinomas (OSCC) of Indian-origin and compare with North-American head and neck squamous cell carcinomas (HNSCC). Quantitative-methylation-specific PCR was used to investigate ...

journal_title：International journal of cancer

authors： Kaur J,Demokan S,Tripathi SC,Macha MA,Begum S,Califano JA,Ralhan R

更新日期：2010-11-15 00:00:00

abstract：:Angiogenesis in pancreatic ductal adenocarcinomas depends on the presence of angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) and is thought to be stimulated by hypoxia. We tested the angiogenic potential of 9 cell lines of pancreatic ductal carcinoma origi...

journal_title：International journal of cancer

authors： Sipos B,Weber D,Ungefroren H,Kalthoff H,Zühlsdorff A,Luther C,Török V,Klöppel G

更新日期：2002-12-20 00:00:00

abstract：:A diet high in linoleic acid (an ω-6 PUFA) increased the formation of miscoding etheno (ε)--DNA adducts in WBC-DNA of women, but not in men (Nair et al., Cancer Epidemiol Biomark Prev 1997;6:597-601). This gender specificity could result from an interaction between ω-6 PUFA intake and estrogen catabolism, via redox-cy...

journal_title：International journal of cancer

authors： Sun X,Nair J,Linseisen J,Owen RW,Bartsch H

更新日期：2012-11-01 00:00:00

abstract：:Polyclonal and monoclonal antibodies were used to characterize human milk fat globule (HMFG) membrane antigens, using gel filtration, ion exchange chromatography and western blotting. Although originally generated against HMFG, monoclonal antibodies also reacted with skim milk. In western blotting, several antigen mol...

journal_title：International journal of cancer

authors： Ashorn P,Krohn K

更新日期：1985-02-15 00:00:00

abstract：:Metabolic syndrome (MetS) and its components may link to pancreatic cancer risk; however, current epidemiological evidence is limited, and the potential mechanisms underlying the associations remain unclear. To investigate this, we carried out this prospective cohort study of 474 929 participants without a diagnosis o...

journal_title：International journal of cancer

authors： Xia B,He Q,Pan Y,Gao F,Liu A,Tang Y,Chong C,Teoh AYB,Li F,He Y,Zhang C,Yuan J

更新日期：2020-12-15 00:00:00

abstract：:WAVE3, an actin cytoskeleton remodeling protein, is highly expressed in advanced stages of breast cancer and influences tumor cell invasion. Loss of miR-31 has been associated with cancer progression and metastasis. Here, we show that the activity of WAVE3 to promote cancer cell invasion is regulated by miR-31. An inv...

journal_title：International journal of cancer

authors： Sossey-Alaoui K,Downs-Kelly E,Das M,Izem L,Tubbs R,Plow EF

更新日期：2011-09-15 00:00:00

abstract：:Numerous reports suggest that interleukin-6 (IL-6) promotes survival and proliferation of tumor cells through the phosphorylation of a cell-signaling protein, signal-transducer-and-activator-of-transcription-3 (STAT3). Constitutive activation of STAT3 in head and neck squamous cell carcinoma (HNSCC) and its role in pr...

journal_title：International journal of cancer

authors： Chakravarti N,Myers JN,Aggarwal BB

更新日期：2006-09-15 00:00:00

abstract：:Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...

journal_title：International journal of cancer

authors： Ziegler HW,Kay NE,Zarling JM

更新日期：1981-03-15 00:00:00

abstract：:The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly attractive target for chemotherapeutic drugs. However, these drugs are highly toxic, and so new approaches are required. One such strategy is to target topoisom...

journal_title：International journal of cancer

authors： Barker CR,Hamlett J,Pennington SR,Burrows F,Lundgren K,Lough R,Watson AJ,Jenkins JR

更新日期：2006-06-01 00:00:00

abstract：:This review is one of two complementary reviews that have been prepared in the framework of the Eurogin Roadmap 2015 to evaluate how knowledge about HPV is changing practices in HPV infection and disease control through vaccination and screening. In this review of HPV vaccine knowledge, we present the most significant...

journal_title：International journal of cancer

authors： Brotherton JM,Jit M,Gravitt PE,Brisson M,Kreimer AR,Pai SI,Fakhry C,Monsonego J,Franceschi S

更新日期：2016-08-01 00:00:00

abstract：:The CpG island methylator phenotype (CIMP) is a distinct form of epigenomic instability. Many CIMP-high colorectal cancers (CRCs) with BRAF mutation are considered to arise from serrated pathway. We recently reported that microRNA-31 (miR-31) is associated with BRAF mutation in colorectal tumors. Emerging new approach...

journal_title：International journal of cancer

authors： Ito M,Mitsuhashi K,Igarashi H,Nosho K,Naito T,Yoshii S,Takahashi H,Fujita M,Sukawa Y,Yamamoto E,Takahashi T,Adachi Y,Nojima M,Sasaki Y,Tokino T,Baba Y,Maruyama R,Suzuki H,Imai K,Yamamoto H,Shinomura Y

更新日期：2014-12-01 00:00:00

abstract：:The effect that polymorphonuclear leukocytes (PMN) may have on the metastatic colonization of tumor cells is controversial: some laboratories have reported that PMN can inhibit metastasis whereas others have shown an augmentation effect. We have exploited our finding that a particular fibrosarcoma (BMT-11) transplante...

journal_title：International journal of cancer

authors： Ishikawa M,Koga Y,Hosokawa M,Kobayashi H

更新日期：1986-06-15 00:00:00

abstract：:Chicken anemia virus viral protein 3 (VP3 or apoptin) localizes more efficiently in the nucleus of transformed than nontransformed cells. Although previous studies implicate the C-terminus of apoptin as being responsible, the molecular basis is controversial, and the extent to which altered nuclear transport efficienc...

journal_title：International journal of cancer

authors： Kuusisto HV,Wagstaff KM,Alvisi G,Jans DA

更新日期：2008-12-15 00:00:00

abstract：:During malignant progression cancer cells undergo a series of changes, which promote their survival, invasiveness and metastatic process. One of them is a change in glucose metabolism. Unlike normal cells, which mostly rely on the tricarboxylic acid cycle (TCA), many cancer types rely on glycolysis. Pyruvate dehydroge...

journal_title：International journal of cancer

authors： Golias T,Kery M,Radenkovic S,Papandreou I

更新日期：2019-02-15 00:00:00

abstract：:Regulatory T cells (Treg) mediate amelioration of disease and immune homeostasis by inhibiting immune activation and maintaining peripheral immune tolerance. The suppressive mechanisms and clinical significance of Treg have not been completely elucidated in patients with acute myeloid leukemia (AML). Here, we demonstr...

journal_title：International journal of cancer

authors： Shenghui Z,Yixiang H,Jianbo W,Kang Y,Laixi B,Yan Z,Xi X

更新日期：2011-09-15 00:00:00

abstract：:Target-specific acute myeloid leukemia (AML) immunotherapy requires selective cell-surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous studies, a chemically linked full-length anti-CD64 immunotoxin based on...

journal_title：International journal of cancer

authors： Tur MK,Huhn M,Jost E,Thepen T,Brümmendorf TH,Barth S

更新日期：2011-09-01 00:00:00

abstract：:Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most human breast cance...

journal_title：International journal of cancer

authors： Domann FE,Rice JC,Hendrix MJ,Futscher BW

更新日期：2000-03-15 00:00:00

abstract：:TK is a pyrimidine metabolic pathway enzyme involved in salvage DNA synthesis. What roles TK may play in epithelial ovarian cancer and the relationships between TK and the other pyrimidine pathway enzymes remain unclear. We examined TK1 gene expression by RT-PCR and related it to gene expression of TS, TP and DPD in 6...

journal_title：International journal of cancer

authors： Fujiwaki R,Hata K,Nakayama K,Moriyama M,Iwanari O,Katabuchi H,Okamura H,Sakai E,Miyazaki K

更新日期：2002-05-20 00:00:00

abstract：:The role of STAT2 in mediating the antigrowth effects of type I interferon (IFN) is well-documented in vitro. Yet evidence of IFN-activated STAT2 as having tumor suppressor function in vivo and participation in antitumor immunity is lacking. Here we show in a syngeneic tumor transplantation model that STAT2 reduces tu...

journal_title：International journal of cancer

authors： Yue C,Xu J,Tan Estioko MD,Kotredes KP,Lopez-Otalora Y,Hilliard BA,Baker DP,Gallucci S,Gamero AM

更新日期：2015-01-01 00:00:00