Abstract:
:Chicken anemia virus viral protein 3 (VP3 or apoptin) localizes more efficiently in the nucleus of transformed than nontransformed cells. Although previous studies implicate the C-terminus of apoptin as being responsible, the molecular basis is controversial, and the extent to which altered nuclear transport efficiency in tumor cells may influence VP3 differential targeting unclear. Here we establish that the C-terminus of VP3 (residues 74-121), out of the context of the full-length protein, is indeed sufficient for tumor cell-enhanced nuclear targeting through phosphoinhibition of VP3 (74-121)-mediated nuclear export occurring exclusively in tumor cells. Importantly, we show that VP3 (74-121) is unique in showing tumor cell-enhanced nuclear targeting in that other NLS-containing proteins fail to show differential localization in human osteosarcoma cells compared to their normal isogenic counterparts. Thus, the C-terminus of VP3 represents a unique tumor cell-enhanced nuclear targeting module with potential application in tumor cell-specific drug delivery.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Kuusisto HV,Wagstaff KM,Alvisi G,Jans DAdoi
10.1002/ijc.23884subject
Has Abstractpub_date
2008-12-15 00:00:00pages
2965-9issue
12eissn
0020-7136issn
1097-0215journal_volume
123pub_type
杂志文章abstract::In the present study we examined the expression of concanavalin-A(Con-A)-like molecules on natural-killer (NK)-sensitive target cells and investigated their possible role in the human NK-cell phenomenon. The incubation of either peripheral-blood lymphocytes (PBL) or large granular lymphocytes (LGL) with swainsonine (S...
journal_title:International journal of cancer
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doi:10.1002/ijc.2910520428
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910420222
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2018-11-15 00:00:00
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journal_title:International journal of cancer
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doi:10.1002/ijc.30044
更新日期:2016-07-01 00:00:00
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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doi:10.1002/ijc.2910450428
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journal_title:International journal of cancer
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journal_title:International journal of cancer
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更新日期:2009-10-15 00:00:00
abstract::A deficit in colorectal cancer survival in Denmark and in the UK compared to Sweden, Norway and Finland was found in the EUROCARE studies. We set out to explore if these differences still exist. Patients diagnosed with colorectal cancer as their first invasive cancer at age 15-89 in the period 1994-2000 were identifie...
journal_title:International journal of cancer
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更新日期:2007-09-01 00:00:00
abstract::The antiproliferative effect of 2',5' A3 core and 2',5'-3'dA3 (cordycepin trimer) core was measured in 8 human tumor cell lines. Cells were treated in a dose-response manner for 72 hr and the concentration of drug necessary to inhibit cell growth 50% (GI50) was determined. A wide range of sensitivities to these drugs ...
journal_title:International journal of cancer
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doi:
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journal_title:International journal of cancer
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abstract::Dose-dense adjuvant chemotherapy is standard of care in high-risk early breast cancer patients. However, its role in HER2-positive patients is still uncertain. In this exploratory analysis of the GIM2 trial, we investigated the efficacy of dose-dense chemotherapy in HER2-positive breast cancer patients with or without...
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journal_title:International journal of cancer
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更新日期:2003-07-10 00:00:00
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journal_title:International journal of cancer
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