Augmentation of B16 melanoma lung colony formation in C57BL/6 mice having marked granulocytosis.

abstract：:Epidemiologic evidence is lacking for the association between alcohol consumption and the risk of breast cancer in Japanese women. We addressed this association in a prospective cohort study with an average follow-up of 7.6 years. At baseline (1988-1990), cohort participants completed a self-administered questionnaire...

journal_title：International journal of cancer

authors： Lin Y,Kikuchi S,Tamakoshi K,Wakai K,Kondo T,Niwa Y,Yatsuya H,Nishio K,Suzuki S,Tokudome S,Yamamoto A,Toyoshima H,Tamakoshi A

更新日期：2005-09-20 00:00:00

abstract：:The incidence of cutaneous melanoma in children aged 0-14 years was examined in Queensland, Australia. Details of notifications were collected from the population-based Australian Paediatric Cancer Registry. Between 1987 and 1994, the age-adjusted incidence rates of invasive cutaneous melanoma occurring in Queensland ...

journal_title：International journal of cancer

authors： Whiteman D,Valery P,McWhirter W,Green A

更新日期：1995-12-11 00:00:00

abstract：:The presence, concentration and selected molecular characteristics of the human mammary carcinoma glycoprotein molecule set MTGP, a trace and apparently tumor-specific molecule, were examined in fifteen cell cultures established from mammary carcinomas, tissue from seven mammary carcinomas and control cultures. Both c...

journal_title：International journal of cancer

authors： Leung JP,Nelson-Rees WA,Moore GE,Cailleau R,Edgington TS

更新日期：1981-07-15 00:00:00

abstract：:Hormone refractory prostate cancer poses a huge problem and standard of care chemotherapy has not been very successful. We used a novel strategy to combine properties of 2 well-studied class of compounds (selenium and COX-2 inhibitor) and examined the resulting effectiveness against prostate cancer. Bearing in mind th...

journal_title：International journal of cancer

authors： Desai D,Sinha I,Null K,Wolter W,Suckow MA,King T,Amin S,Sinha R

更新日期：2010-07-01 00:00:00

abstract：:The effects of prolonged administration of genistein, a tyrosine-kinase inhibitor, on sodium-chloride-enhanced induction of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wi...

journal_title：International journal of cancer

authors： Tatsuta M,Iishi H,Baba M,Yano H,Uehara H,Nakaizumi A

更新日期：1999-01-29 00:00:00

abstract：:Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemo...

journal_title：International journal of cancer

authors： Abdallah EA,Fanelli MF,Buim ME,Machado Netto MC,Gasparini Junior JL,Souza E Silva V,Dettino AL,Mingues NB,Romero JV,Ocea LM,Rocha BM,Alves VS,Araújo DV,Chinen LT

更新日期：2015-09-15 00:00:00

abstract：:Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was...

journal_title：International journal of cancer

authors： Lifsted T,Le Voyer T,Williams M,Muller W,Klein-Szanto A,Buetow KH,Hunter KW

更新日期：1998-08-12 00:00:00

abstract：:Endometriosis is a common gynecologic disease, which generally follows a benign course. Notwithstanding, several clinical and histologic studies as well as molecular data show that endometriosis could be a precursor of sporadic endometrioid and clear cell carcinomas at extrauterine loci. Several reports have implicate...

journal_title：International journal of cancer

authors： Martini M,Ciccarone M,Garganese G,Maggiore C,Evangelista A,Rahimi S,Zannoni G,Vittori G,Larocca LM

更新日期：2002-12-01 00:00:00

abstract：:Transforming growth factor-beta (TGF-beta) signaling is initiated following heterodimerization of the type II TGF-beta receptor (TbetaRII) with the type I TGF-beta receptor (TbetaRI). Both receptors are required for TGF-beta responsiveness. In the present study, we characterized the actions of TGF-beta1 in T3M4 human ...

journal_title：International journal of cancer

authors： Wagner M,Kleeff J,Lopez ME,Bockman I,Massaqué J,Korc M

更新日期：1998-10-05 00:00:00

abstract：:The prognostic role of inflammation index like neutrophil-to-lymphocyte ratio (NLR) in colorectal cancer (CRC) remains controversial. We conduct a meta-analysis to determine the predictable value of NLR in the clinical outcome of CRC patients. The analysis was carried out based on the data from 16 studies (19 cohorts)...

journal_title：International journal of cancer

authors： Li MX,Liu XM,Zhang XF,Zhang JF,Wang WL,Zhu Y,Dong J,Cheng JW,Liu ZW,Ma L,Lv Y

更新日期：2014-05-15 00:00:00

abstract：:Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...

journal_title：International journal of cancer

authors： Brasoveanu LI,Altomonte M,Gloghini A,Fonsatti E,Coral S,Gasparollo A,Montagner R,Cattarossi I,Simonelli C,Cattelan A

更新日期：1995-05-16 00:00:00

abstract：:EBNA-positive lymphoblast cells were detected in 0.1 to 0.9% of the T-cell-depleted lymphocytes obtained from peripheral blood samples of five patients with infectious mononucleosis (IM). The same blood specimens from four of the five patients contained cells that formed EBNA-positive colonies in soft agar containing ...

journal_title：International journal of cancer

authors： Katsuki T,Hinuma Y,Saito T,Yamamoto J,Hirashima Y,Sudoh H,Deguchi M,Motokawa M

更新日期：1979-06-15 00:00:00

abstract：:Polyamines are essential for cell growth and differentiation. Their specific uptake contributes to the regulation of intracellular polyamine levels. In this study, we describe the modulation of this transport mechanism in a rat tumoral pancreatic acinar cell line (AR4-2J) and analyze the transport system characteristi...

journal_title：International journal of cancer

authors： Nicolet T,Scemama JL,Pradayrol L,Berthélémy P,Seva C,Vaysse N

更新日期：1991-10-21 00:00:00

abstract：:CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...

journal_title：International journal of cancer

authors： Widenmeyer M,Griesemann H,Stevanović S,Feyerabend S,Klein R,Attig S,Hennenlotter J,Wernet D,Kuprash DV,Sazykin AY,Pascolo S,Stenzl A,Gouttefangeas C,Rammensee HG

更新日期：2012-07-01 00:00:00

abstract：:Gab2, a docking-type signaling protein with demonstrated oncogenic potential, is overexpressed in breast cancer, but its prognostic significance and role in disease evolution remain unclear. Immunohistochemical detection of Gab2 in a large cohort of primary human breast cancers of known outcome revealed that while Gab...

journal_title：International journal of cancer

authors： Fleuren ED,O'Toole S,Millar EK,McNeil C,Lopez-Knowles E,Boulghourjian A,Croucher DR,Schramek D,Brummer T,Penninger JM,Sutherland RL,Daly RJ

更新日期：2010-09-01 00:00:00

abstract：:APC10.1 is a new intestinal cell line derived from ApcMin/+ mice that retains both the heterozygous Apc genotype and a nonactivated Wnt signaling pathway and displays an early neoplastic phenotype. Although tumorigenic both in immunodepressed and in immunocompetent syngeneic mice, it requires a high cell dose and a lo...

journal_title：International journal of cancer

authors： De Giovanni C,Landuzzi L,Nicoletti G,Astolfi A,Croci S,Micaroni M,Nanni P,Lollini PL

更新日期：2004-03-20 00:00:00

abstract：:Cholera toxin (which increases intracellular cAMP levels) significantly (p less than 0.05) increased the growth of MCF-7, T47-D and Hs578T human breast carcinoma cells in vitro. The effect of cholera toxin on growth of MCF-7 and T47-D cells was more pronounced in the presence of 17 beta-estradiol (p less than 0.05), i...

journal_title：International journal of cancer

authors： Sheffield LG,Welsch CW

更新日期：1985-10-15 00:00:00

abstract：:A new cell line from a sporadic Wilms' tumor was established and extensively characterized. In nude mice, the tumor cells rapidly formed tumors which, in histological characteristics and extracellular-matrix (ECM) composition resembled sarcomatoid Wilms' tumor. The tumor cells produced B chains of laminin, but no A ch...

journal_title：International journal of cancer

authors： Talts JF,Aufderheide E,Sorokin L,Ocklind G,Mattsson R,Ekblom P

更新日期：1993-07-09 00:00:00

abstract：:Two genome-wide association studies (GWAS) have identified 5p15.33 (TERT-CLPTM1L) as one of the susceptible regions for glioma in European background. A replication research of our group highlighted the association signals in the TERT gene of this region in a Chinese Han population. To comprehensively explore the regi...

journal_title：International journal of cancer

authors： Zhao Y,Chen G,Zhao Y,Song X,Chen H,Mao Y,Lu D

更新日期：2012-10-01 00:00:00

abstract：:We have previously reported that losses of genomic material from the long arm of chromosome 18 are frequent in atypical and anaplastic meningiomas but rare in benign meningiomas. In the present study, we have investigated a series of 37 meningiomas for mutation and expression of 4 tumor suppressor genes (MADH2, MADH4,...

journal_title：International journal of cancer

authors： Büschges R,Boström J,Wolter M,Blaschke B,Weber RG,Lichter P,Collins VP,Reifenberger G

更新日期：2001-05-15 00:00:00

abstract：:Deletions on chromosomes 1p and 19q are associated with favorable prognosis in patients with oligodendroglial tumors. The aim of our study was to identify additional genomic aberrations linked to patient survival. We performed a genome-wide screen for genomic imbalances by comparative genomic hybridization on tumors f...

journal_title：International journal of cancer

authors： Trost D,Ehrler M,Fimmers R,Felsberg J,Sabel MC,Kirsch L,Schramm J,Wiestler OD,Reifenberger G,Weber RG

更新日期：2007-06-01 00:00:00

abstract：:The p53 tumor suppressor pathway is impaired in more than 90% of cervical cancers and cancer-derived cell lines as a result of infection by human papillomavirus (HPV). The HPV E6 oncoprotein forms complexes with p53 and promotes its degradation via ubiquitin-dependent mechanism. In our study, we attempted to improve t...

journal_title：International journal of cancer

authors： Wang H,Song X,Zhang H,Zhang J,Shen X,Zhou Y,Fan X,Dai L,Qian G,Hoffman AR,Hu JF,Ge S

更新日期：2012-01-15 00:00:00

abstract：:Triple-negative breast cancer [TNBC, which is negative for the estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2] is a high-risk form of the disease without a specific therapy. DNA microarray and immunohistochemical analyses have shown that most TNBCs fall within the basal-lik...

journal_title：International journal of cancer

authors： Arima Y,Hayashi N,Hayashi H,Sasaki M,Kai K,Sugihara E,Abe E,Yoshida A,Mikami S,Nakamura S,Saya H

更新日期：2012-06-01 00:00:00

abstract：:The aim of this study was to compare the seasonal variation in performance of a faecal immunochemical test for haemoglobin (FIT) and a guaiac test (gFOBT) for colorectal cancer screening. From June 2009 to May 2011, 18,290 screening participants (50-74 years old) performed OC-SENSOR quantitative FIT (1 sample) and Hem...

journal_title：International journal of cancer

authors： Chausserie S,Levillain R,Puvinel J,Ferrand O,Ruiz A,Raginel T,Lantieri O,Launoy G,Guittet L

更新日期：2015-04-15 00:00:00

abstract：:In advanced stages of malignant melanoma (MM), metastases to the CNS are frequently observed. Few results are available on trophic factors and immunological features involved in the process of invasion and adhesion of circulating metastatic cells into the CNS. A direct comparison of remote metastases found in differen...

journal_title：International journal of cancer

authors： Geertsen R,Zenklusen R,Kamarashev J,Burg G,Dummer R

更新日期：1999-09-24 00:00:00

abstract：:An important goal in prostate cancer research is to define specific molecular and cellular alterations that are associated with malignant progression. The mouse prostate reconstitution model is a relevant and useful system as it allows the study of early events in cancer progression under conditions where oncogene-ini...

journal_title：International journal of cancer

authors： Greene DR,Taylor SR,Aihara M,Yoshida K,Egawa S,Park SH,Timme TL,Yang G,Scardino PT,Thompson TC

更新日期：1995-01-27 00:00:00

abstract：:Normal thyroid epithelial cells lack major histocompatibility complex (MHC) Class II antigen. Oncogenic kinases involved in papillary thyroid carcinoma (PTC) trigger the expression of Class II transactivator and MHC Class II complex. However, the relationship between MHC Class II antigen expression and clinical outcom...

journal_title：International journal of cancer

authors： Jo YS,Lee JC,Li S,Choi YS,Bai YS,Kim YJ,Lee IS,Rha SY,Ro HK,Kim JM,Shong M

更新日期：2008-02-15 00:00:00

abstract：:Our study explored the drug interaction of all-trans retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells. RAD001 (10 nM) significantly enhanced the ATRA-induced growth arrest and differentiation of these...

journal_title：International journal of cancer

authors： Nishioka C,Ikezoe T,Yang J,Gery S,Koeffler HP,Yokoyama A

更新日期：2009-10-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) are involved in the pathology of colorectal cancer (CRC). Current efforts to eradicate CRC predominantly focused on targeting the proliferation of rapidly growing cancer epithelial cells. This is largely ineffective with resistance arising in most tumors after exposure to chemotherapy. De...

journal_title：International journal of cancer

authors： Deng X,Ruan H,Zhang X,Xu X,Zhu Y,Peng H,Zhang X,Kong F,Guan M

更新日期：2020-03-15 00:00:00

abstract：:In EBV-immortalized lymphoblastoid cell lines (LCLs) a small number of "latent" proteins are expressed. These are the EBV nuclear antigens, EBNAs 1-6, and a latent membrane protein, LMP. We have investigated the expression of these proteins in a variety of EBV-associated tumours and cell lines. Whereas transplant and ...

journal_title：International journal of cancer

authors： Allday MJ,Kundu D,Finerty S,Griffin BE

更新日期：1990-06-15 00:00:00