Analysis of human meningiomas for aberrations of the MADH2, MADH4, APM-1 and DCC tumor suppressor genes on the long arm of chromosome 18.


:We have previously reported that losses of genomic material from the long arm of chromosome 18 are frequent in atypical and anaplastic meningiomas but rare in benign meningiomas. In the present study, we have investigated a series of 37 meningiomas for mutation and expression of 4 tumor suppressor genes (MADH2, MADH4, APM-1 and DCC) located at 18q21. Comparative genomic hybridization or loss of heterozygosity analysis showed losses on chromosome 18 that included sequences from 18q21 in 15 of 37 tumors. Mutation analysis of APM-1 revealed a missense mutation (c. 1819G>A: G607S) in 1 atypical meningioma. None of the tumors showed mutations of MADH2 and MADH4 or loss of detectable transcripts from MADH2, MADH4, APM-1 and DCC. In contrast to human brain tissue, normal leptomeninges and meningiomas showed preferential expression of a DCC splice variant lacking 60 base pairs from exon 17. Taken together, our data do not support a significant role for MADH2, MADH4, APM-1 and DCC alterations in the pathogenesis of meningiomas. The targeted gene that is inactivated in most meningiomas with 18q losses remains to be identified.


Int J Cancer


Büschges R,Boström J,Wolter M,Blaschke B,Weber RG,Lichter P,Collins VP,Reifenberger G





Has Abstract


2001-05-15 00:00:00














  • Impact of an HPV6/11/16/18 L1 virus-like particle vaccine on progression to cervical intraepithelial neoplasia in seropositive women with HPV16/18 infection.

    abstract::The impact of a human papillomavirus (HPV) vaccine on development of cervical intraepithelial neoplasia grade 2-3 or adenocarcinoma in situ (CIN2-3/AIS) in women with ongoing HPV16 or 18 infections prevaccination is reported. Seventeen thousand six-hundred and twenty-two women aged 16-26 were enrolled in 1 of 2 random...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Haupt RM,Wheeler CM,Brown DR,Garland SM,Ferris DG,Paavonen JA,Lehtinen MO,Steben M,Joura EA,Giacoletti KE,Radley DR,James MK,Saah AJ,Sings HL,FUTURE I and II Investigators.

    更新日期:2011-12-01 00:00:00

  • Cell cycle-related kinase supports ovarian carcinoma cell proliferation via regulation of cyclin D1 and is a predictor of outcome in patients with ovarian carcinoma.

    abstract::Our previous study has suggested that the cell cycle-related kinase (CCRK) is a putative candidate oncogene in glioblastoma tumorigenesis. The potential oncogenic role of CCRK and its clinical/prognostic significance, however, in ovarian carcinoma are unclear. In this study, CCRK expression was examined by immunohisto...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wu GQ,Xie D,Yang GF,Liao YJ,Mai SJ,Deng HX,Sze J,Guan XY,Zeng YX,Lin MC,Kung HF

    更新日期:2009-12-01 00:00:00

  • Adolescent and mid-life diet and subsequent risk of thyroid cancer in the NIH-AARP diet and health study.

    abstract::Although thyroid cancer is suspected to have a nutritional etiology, prospective studies examining the relationship between diet and thyroid cancer are lacking. During 1996-1997, NIH-AARP Diet and Health Study participants, ages 51-72 years, completed a 37-item food frequency questionnaire about diet at ages 12-13 yea...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Braganza MZ,Potischman N,Park Y,Thompson FE,Hollenbeck AR,Kitahara CM

    更新日期:2015-11-15 00:00:00

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    abstract::The effects of prolonged administration of genistein, a tyrosine-kinase inhibitor, on sodium-chloride-enhanced induction of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tatsuta M,Iishi H,Baba M,Yano H,Uehara H,Nakaizumi A

    更新日期:1999-01-29 00:00:00

  • Increased LDL receptor mRNA expression in colon cancer is correlated with a rise in plasma cholesterol levels after curative surgery.

    abstract::It is currently under debate whether the low serum cholesterol levels that are frequently observed in cancer patients represent a risk factor for/or, rather, are a consequence of the tumour. We postulate that malignant tumours are directly involved in an increased catabolism of cholesterol-rich low-density lipoprotein...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Niendorf A,Nägele H,Gerding D,Meyer-Pannwitt U,Gebhardt A

    更新日期:1995-05-16 00:00:00

  • Impact of BCRP/MXR, MRP1 and MDR1/P-Glycoprotein on thermoresistant variants of atypical and classical multidrug resistant cancer cells.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Stein U,Lage H,Jordan A,Walther W,Bates SE,Litman T,Hohenberger P,Dietel M

    更新日期:2002-02-20 00:00:00

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    journal_title:International journal of cancer

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Culine S,Olofsson B,Gosselin S,Honore N,Tavitian A

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    journal_title:International journal of cancer

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McWhirter WR,Petroeschevsky AL

    更新日期:1990-06-15 00:00:00