Abstract:
:In this review, we evaluate key molecular pathways and markers of muscle-invasive bladder cancer (MIBC). Overexpression and activation of EGFR, p63, and EMT genes are suggestive of basal MIBC subtype generally responsive to chemotherapy. Alterations in PPARγ, ERBB2/3, and FGFR3 gene products and their signaling along with deregulated p53, cytokeratins KRT5/6/14 in combination with the cellular proliferation (Ki-67), and cell cycle markers (p16) indicate the need for more radical treatment protocols. Similarly, the "bell-shape" dynamics of Shh expression levels may suggest aggressive MIBC. A panel of diverse biological markers may be suitable for simulation studies of MIBC and development of an optimized treatment protocol. We conducted a critical evaluation of PubMed/Medline and SciFinder databases related to MIBC covering the period 2009-2015. The free-text search was extended by adding the following keywords and phrases: bladder cancer, metastatic, muscle-invasive, basal, luminal, epithelial-to-mesenchymal transition, cancer stem cell, mutations, immune response, signaling, biological markers, molecular markers, mathematical models, simulation, epigenetics, transmembrane, transcription factor, kinase, predictor, prognosis. The resulting selection of ca 500 abstracts was further analyzed in order to select the latest publications relevant to MIBC molecular markers of immediate clinical significance.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Kiselyov A,Bunimovich-Mendrazitsky S,Startsev Vdoi
10.1002/ijc.29918subject
Has Abstractpub_date
2016-06-01 00:00:00pages
2562-9issue
11eissn
0020-7136issn
1097-0215journal_volume
138pub_type
杂志文章,评审abstract::Multiple myeloma (MM) is the second most common hematologic malignancy characterized by the clonal expansion of plasma cells. Despite continuing advances, novel biomarkers are needed for diagnosis and prognosis of MM. In our study, we characterized the diagnostic and prognostic potential of circulating microRNAs (miRN...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29199
更新日期:2015-04-15 00:00:00
abstract::The effect of linoleic acid (LA) on growth and transformation of IEC6 intestinal cells was examined. IEC6 cells expressed mRNAs of 15-lipooxygenase (LOX15) and peroxisome proliferator-activated receptor (PPAR)gamma but not COX-2. Cell growth was suppressed by LA in a dose-dependent manner in IEC6 cells. Three-week tre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21393
更新日期:2006-02-01 00:00:00
abstract::Because of the absence of data on smoking history for patients in cancer registries, large population-based studies have been unable to directly assess the role of smoking in the risk of multiple primary cancers. In a random sample of 618 adults diagnosed with invasive cancer in 2002 and reported to the population-bas...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21786
更新日期:2006-07-01 00:00:00
abstract::The distribution of oestradiol in plasma from postmenopausal women with or without breast cancer has been measured and related to the metabolic clearance rates of oestradiol (MCR-E2). All measurements were carried out preoperatively. No difference in the free fraction of oestradiol was found between women with breast ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350407
更新日期:1985-04-15 00:00:00
abstract::The majority of lung cancer patients have tumor-derived genetic alterations in circulating plasma DNA that could be exploited as a diagnostic tool. We used fluorescent microsatellite analysis to detect alterations in plasma and tumor DNA in 34 patients who underwent bronchoscopy for lung cancer, including 11 small cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11079
更新日期:2003-06-20 00:00:00
abstract::A persistent increase in incidence of thyroid carcinoma (TC) has been reported worldwide. The aim of our study was to assess trends in incidence and mortality of TC in The Netherlands between 1989 and 2003 and to examine whether these trends correlate with changes in diagnostic practices such as changes in the number ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23678
更新日期:2008-10-01 00:00:00
abstract::The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2 to development of ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23360
更新日期:2008-05-01 00:00:00
abstract::Uveal melanoma is associated with a high tumor-related mortality due to the propensity to develop metastases. The mechanisms that are responsible for malignant dissemination are largely unknown and need to be explored to facilitate diagnosis and treatment of metastases. To identify molecules involved in dissemination,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11262
更新日期:2003-09-10 00:00:00
abstract::Female residents of six counties in Washington and Utah in whom a diagnosis of ovarian cancer was made during 1975-79 were interviewed concerning prior use of oral contraceptives. Interviews with a random sample of women drawn from these same counties were obtained for comparison. A smaller proportion of women with ep...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280602
更新日期:1981-12-01 00:00:00
abstract::Pheochromocytomas and paragangliomas (PPGLs) are catecholamine-producing chromaffin cell tumors with diverse phenotypic features reflecting mutations in numerous genes, including MYC-associated factor X (MAX). To explore whether phenotypic differences among PPGLs reflect a MAX-mediated mechanism and opposing influence...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28868
更新日期:2014-11-01 00:00:00
abstract::In order to update the findings of relative risk associated with cigarette smoking for lung cancer by histologic type in Japan, the data from a population-based cohort study of 91,738 men and women were analyzed. During 1990-1999, 422 lung cancer incident cases were identified. The relative risk for all incident cases...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10308
更新日期:2002-05-10 00:00:00
abstract::Epithelial ovarian carcinoma (EOC) is a leading cause of death from gynecologic malignancies, due mainly to the prevalence of undetected metastatic disease. The process of cell invasion during intraperitoneal anchoring of metastatic lesions requires concerted regulation of many processes, including modulation of adhes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24347
更新日期:2009-08-15 00:00:00
abstract::Persistent infection with high-risk human papillomavirus (HPV) is central to cervical carcinogenesis. Certain high-risk types, such as HPV16, may be more persistent than other HPV types, and type-specific HPV persistence may differ by HIV serostatus. This study evaluated the association between HPV type and clearance ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22015
更新日期:2006-10-01 00:00:00
abstract::Human conventional renal cell carcinoma (CCC) remains resistant to current therapies. Focal Adhesion Kinase (FAK) is upregulated in many epithelial tumors and clearly implicated in nearly all facets of cancer. However, only few reports have assessed whether FAK may be associated with renal tumorigenesis. In this study...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29522
更新日期:2015-10-01 00:00:00
abstract::Biliary glycoprotein I (BGP I) is a member of carcinoembryonic antigen (CEA) gene family consisting of at least 11 related genes. The transcription of BGP I gene was analysed in malignant and non-malignant human liver tissues with a 396-bp 3'-untranslated region probe from a cDNA clone 4-13 which was newly isolated fr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450516
更新日期:1990-05-15 00:00:00
abstract::In vitro infection of EBV-negative lymphoma cell lines with immortalizing strains of Epstein-Barr virus induces the cell-surface expression of B-cell markers, such as the EBV receptor/CR2 (CD21) and the CD23 antigen. The non-immortalizing EBV variant, P3HRI, which carries a deletion encompassing the EBV nuclear antige...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460418
更新日期:1990-10-15 00:00:00
abstract::Parvoviruses of rodents are endowed with oncosuppressive properties. In particular, parvoviral infections protect host animals from spontaneous and chemical- or virus-induced tumour initiation in laboratory animals. The present study was undertaken to substantiate the capacity of parvovirus H-1 to inhibit therapeutica...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980209)75:4<584::aid-ijc
更新日期:1998-02-09 00:00:00
abstract::DCs hold promise for cancer immunotherapy due to their functional ambivalence: iDCs internalize antigens, then mDCs trigger naive T-cell activation. However, no consensus has been reached concerning the optimal mode of antigen acquisition for efficient cross-priming of TAA-specific CTLs, and this remains a field of in...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10605
更新日期:2002-09-20 00:00:00
abstract::The majority of intermediate-risk rhabdomyosarcoma (RMS) patients have gross residual disease (Group III) after their first operative procedure. It is currently not known if local control rates can be maintained when, following induction chemotherapy, the radiation therapy (RT) dose is decreased after a delayed primar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29351
更新日期:2015-07-01 00:00:00
abstract::It has been proposed that oxidative stress develops in tumors, with important consequences for growth and progression. To investigate this hypothesis, we measured low m.w. thiols, disulfides, protein-mixed disulfides and a pool of major anti-oxidant enzymes in renal-cortex as well as renal-cell carcinoma (RCC) specime...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010101)91:1<55::aid-ijc1006>3.
更新日期:2001-01-01 00:00:00
abstract::Aristolochic acid (AA), a naturally occurring nephrotoxin and carcinogen, has been associated with the development of urothelial cancer in humans. Understanding which human enzymes are involved in AA activation and/or detoxication is important in the assessment of an individual's susceptibility to this plant carcinoge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20564
更新日期:2005-01-10 00:00:00
abstract::Adenovirus early region 4 open reading frame 4 (E4orf4) protein is a novel cell death factor that selectively induces apoptosis in cancer cells. This study evaluated tumor inhibitory effects of a protein made by fusion E4orf4 and human epidermal growth factor (EGF). EGF was used to ensure the selective targeting of EG...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24415
更新日期:2009-09-01 00:00:00
abstract::Human papilloma virus is a causative factor in the etiology of cervical cancer with HPV16 being the most prevalent genotype associated with it. Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV 16 besides being of phylogenetic importance, are associated with risk of viral persistence and progressio...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.24322
更新日期:2009-07-01 00:00:00
abstract::Cancer survival among people with AIDS (PWA) has been described in developed countries, but there is lack of data from developing countries. The aim of this study was to evaluate survival after cancer diagnosis in PWA and compare it with people without AIDS (non-PWA) in São Paulo, Brazil. A probabilistic record linkag...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31081
更新日期:2018-02-01 00:00:00
abstract::Therapeutics targeting the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway initially produce potent antitumor effects, but resistance frequently occurs. Using a phosphoproteome analysis, we found that colorectal cancer (CRC) cells exhibit resistance against PI3K/mTOR inhibition through ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33047
更新日期:2020-11-15 00:00:00
abstract::Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. Th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31578
更新日期:2018-10-15 00:00:00
abstract::A specific chromosomal aberration was observed in 14 of 15 avian lymphoblastoid cell lines transformed with Marek's disease herpesvirus. This aberration, designated dup(1p)(p22-p23), appeared as an extra G-positive band and interband on the short arm of one chromosome I homolog. Using fluorescent in situ hybridization...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540426
更新日期:1993-06-19 00:00:00
abstract::The object of our multicenter retrospective study was to compare the new histologic World Health Organization (WHO) classification and the classical histologic Bernatz classification in terms of interobserver agreement and prognostic importance. The influence of coexisting diseases was also analyzed using the Charlson...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.10255
更新日期:2002-04-20 00:00:00
abstract::Although tumor-specific T lymphocytes recognize tumor-associated antigens (TAA) present on their cell surface via major histocompatibility complex (MHC) molecules, T cells require other activating signals. These are provided by costimulatory molecules, including B7-1 (CD80), B7-2 (CD86) and intercellular adhesive mole...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990827)82:5<714::aid-ijc
更新日期:1999-08-27 00:00:00
abstract::V-ATPases are proton-translocating enzymes, which are found not only in numerous intracellular organelles but also in the plasma membranes of many eukaryotic cells. Using differential display, we have identified one of the proton pump subunit genes, ATP6C, as a cisplatin-inducible gene. Northern blot analysis demonstr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1418
更新日期:2001-09-01 00:00:00