Genetic features of multicentric/multifocal intramucosal gastric carcinoma.

abstract：:Mice transgenic for the carcinoembryonic (CEA) gene were used to study the biodistribution and tumor targeting of a radioiodinated monoclonal antibody (MAb), T84.66. The specificity of antibody uptake in tumors was assessed in mice bearing a CEA-transfected syngeneic tumor as well as the antigen-negative parental tumo...

journal_title：International journal of cancer

authors： Szalai G,Williams LE,Primus FJ

更新日期：2000-03-15 00:00:00

abstract：:We evaluated the therapeutic potential of the replication competent vector VA7-EGFP, which is based on the avirulent Semliki Forest virus (SFV) strain A7 (74) carrying the EGFP marker gene in an orthotopic lung cancer tumor model in nude mice. We have previously shown that this oncolytic vector destroys tumor cells ef...

journal_title：International journal of cancer

authors： Määttä AM,Mäkinen K,Ketola A,Liimatainen T,Yongabi FN,Vähä-Koskela M,Pirinen R,Rautsi O,Pellinen R,Hinkkanen A,Wahlfors J

更新日期：2008-10-01 00:00:00

abstract：:Cervical cancer is a public health concern as it represents the second cause of cancer death in women worldwide. High-risk human papillomaviruses (HPV) are the etiologic agents, and HPV E6 and/or E7 oncogene-specific therapeutic vaccines are under development to treat HPV-related lesions in women. Whether the use of m...

journal_title：International journal of cancer

authors： Decrausaz L,Domingos-Pereira S,Duc M,Bobst M,Romero P,Schiller JT,Jichlinski P,Nardelli-Haefliger D

更新日期：2011-08-01 00:00:00

abstract：:Marfe, G., Pucci, B., De Martino, L., Fiorito, F., Di Stefano, C., Indelicato, M., Aventaggiato, M., Russo, M. A. and Tafani, M. (2009), Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. Int. J. Cancer, 125: 2077-2085. doi: 10.1002/ijc.24572 The above article, published online o...

journal_title：International journal of cancer

authors：

更新日期：2019-08-15 00:00:00

abstract：:Although several studies have investigated the association of miRNAs with hepatocellular carcinoma (HCC), the data published so far are not concordant. A reason for these discrepancies may be the fact that most studies used the nontumorous tissue surrounding the HCC lesion as a control, which is almost invariably affe...

journal_title：International journal of cancer

authors： Diaz G,Melis M,Tice A,Kleiner DE,Mishra L,Zamboni F,Farci P

更新日期：2013-08-15 00:00:00

abstract：:Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...

journal_title：International journal of cancer

authors： Tomala J,Chmelova H,Strohalm J,Ulbrich K,Sirova M,Rihova B,Kovar M

更新日期：2011-10-15 00:00:00

abstract：:Vaccination strategies based on repeated injections of NY-ESO-1 protein formulated in ISCOMATRIX particles (NY-ESO-1 ISCOMATRIX) have shown to elicit combined NY-ESO-1 specific antibody and T cell responses. However, it remains unclear whether heterologous prime-boost strategies based on the combination with NY-ESO-1 ...

journal_title：International journal of cancer

authors： Chen JL,Dawoodji A,Tarlton A,Gnjatic S,Tajar A,Karydis I,Browning J,Pratap S,Verfaille C,Venhaus RR,Pan L,Altman DG,Cebon JS,Old LL,Nathan P,Ottensmeier C,Middleton M,Cerundolo V

更新日期：2015-03-15 00:00:00

abstract：:Animal and experimental data suggest that anti-Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case-control study of 302 ovarian cancer ca...

journal_title：International journal of cancer

authors： Jung S,Allen N,Arslan AA,Baglietto L,Barricarte A,Brinton LA,Egleston BL,Falk RT,Fortner RT,Helzlsouer KJ,Gao Y,Idahl A,Kaaks R,Krogh V,Merritt MA,Lundin E,Onland-Moret NC,Rinaldi S,Schock H,Shu XO,Sluss PM,Staa

更新日期：2018-01-15 00:00:00

abstract：:It is unclear which chromosome arms frequently show loss of heterozygosity (LOH) in adenocarcinoma of the uterine cervix. To identify such chromosomal arms, LOH on 52 different chromosome loci was examined using laser capture microdissection and PCR-LOH analysis in 25 common-type adenocarcinomas, comprising 13 cases o...

journal_title：International journal of cancer

authors： Tsuda H,Takarabe T,Okada S,Uchida H,Kasamatsu T,Yamada T,Tsunematsu R,Ohmi K,Hirohashi S

更新日期：2002-04-10 00:00:00

abstract：:Primary breast diffuse large B-cell lymphoma (DLBCL) is an extremely rare presentation of non-Hodgkin's lymphoma that has been associated with poorer clinical outcomes compared with nodal DLBCL in the pre-rituximab era. The aim of this study was to investigate the impact of rituximab on clinical outcomes in patients w...

journal_title：International journal of cancer

authors： Yhim HY,Kim JS,Kang HJ,Kim SJ,Kim WS,Choi CW,Eom HS,Kim JA,Lee JH,Won JH,Shim H,Huh J,Lee DH,Suh C,Kwak JY

更新日期：2012-07-01 00:00:00

abstract：:An inverse association between smoking and endometrial cancer has generally been observed, primarily among current smokers. To assess this association, we analyzed data from the prospective Nurses' Health Study. From 1976 to 2000, 702 cases of invasive endometrial cancer were identified during 1.8 million person-years...

journal_title：International journal of cancer

authors： Viswanathan AN,Feskanich D,De Vivo I,Hunter DJ,Barbieri RL,Rosner B,Colditz GA,Hankinson SE

更新日期：2005-05-10 00:00:00

abstract：:The expression of the estrogen-regulated breast-cancer-associated pS2 gene was examined in 75 stomach resections taken from 45 patients. The 600-base pS2 mRNA was found in all of the 47 non-neoplastic samples at varying levels: in the histologically normal group we observed a Poisson-type distribution, whereas 79% of ...

journal_title：International journal of cancer

authors： Luqmani Y,Bennett C,Paterson I,Corbishley CM,Rio MC,Chambon P,Ryall G

更新日期：1989-11-15 00:00:00

abstract：:We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...

journal_title：International journal of cancer

authors： Fukuyama R,Minoshima S,Ochiai A,Tahara E,Shimizu N

更新日期：1991-04-22 00:00:00

abstract：:The enhanced oncogenicity of particular human papillomavirus type 16 (HPV16) E6 variants is population-dependent, implying the involvement of additional genetic cofactors. This study was designed to investigate the association between E6 variants and human leukocyte antigen (HLA) polymorphism within a Japanese populat...

journal_title：International journal of cancer

authors： Matsumoto K,Yasugi T,Nakagawa S,Okubo M,Hirata R,Maeda H,Yoshikawa H,Taketani Y

更新日期：2003-10-10 00:00:00

abstract：:The effects of three monoclonal antibodies (B3/25, 43/31, and 42/6) reactive with human transferrin (Tf) receptors on growth of normal and malignant myeloid cells were examined using in vitro culture techniques. When added directly to cultures, all three antibodies caused dose-dependent inhibition of normal granulocyt...

journal_title：International journal of cancer

authors： Taetle R,Honeysett JM,Trowbridge I

更新日期：1983-09-15 00:00:00

abstract：:Epidermodysplasia verruciformis (EV) is considered as a model of genetic cancer due to unusual susceptibility to EV-specific human papillomaviruses (HPVs). We established an in vivo experimental system for long-term propagation of EV tissue which should facilitate the study of tumor progression in EV. Skin fragments f...

journal_title：International journal of cancer

authors： Majewski S,Breitburd F,Skopinska M,Croissant O,Jablonska S,Orth G

更新日期：1994-03-01 00:00:00

abstract：:Apigenin is a plant flavonoid that is thought to play a role in the prevention of carcinogenesis. However, its mechanism of action has not yet been elucidated. Because of the importance of angiogenesis in tumor growth, we investigated the effect of apigenin on endothelial and smooth-muscle cells in an in vitro model. ...

journal_title：International journal of cancer

authors： Trochon V,Blot E,Cymbalista F,Engelmann C,Tang RP,Thomaïdis A,Vasse M,Soria J,Lu H,Soria C

更新日期：2000-03-01 00:00:00

abstract：:Cytotoxic antibodies against glioblastoma-associated antigen(s) have been sought for in glioma patient sera. Complement-dependent cytotoxicity (CDC) I and antibody-dependent cell-mediated cytotoxicity (ADCC) assays were used to test sera from 80 patients using 51 Cr labelled target cells derived from eight different g...

journal_title：International journal of cancer

authors： Martin-Achard A,Diserens AC,de Tribolet N,Carrel S

更新日期：1980-02-15 00:00:00

abstract：:There are few published estimates of the risk of developing breast or ovarian cancer in women with a strong family history of ovarian cancer. As these women commonly present to family cancer clinics, accurate cancer risk estimates are needed. We have estimated these risks in women from families with 2 or more confirme...

journal_title：International journal of cancer

authors： Sutcliffe S,Pharoah PD,Easton DF,Ponder BA

更新日期：2000-07-01 00:00:00

abstract：:OK-432, a streptococcal preparation, and BCG effectively inhibited splenomegaly in Friend leukemia virus (FLV)-infected mice. Divided drug dosage resulted in stronger inhibition than single administration. When the second dose was fixed at the 3rd pre-infection day, the best timing for the first dose was approximately...

journal_title：International journal of cancer

authors： Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y

更新日期：1980-01-15 00:00:00

abstract：:Maspin is a Class II tumor suppressor protein and plays a role in tumor growth by inhibiting cellular invasion and motility. It is a member of the serpin family of protease inhibitors and has been shown to reduce angiogenesis. Maspin gene expression can be upregulated by the tumor suppressor p53. We tested 7 p53-relat...

journal_title：International journal of cancer

authors： Spiesbach K,Tannapfel A,Mössner J,Engeland K

更新日期：2005-04-20 00:00:00

abstract：:Little is known about age-dependent variation in outcomes of cervical cytology with modern technologies. This population-based study evaluated age-dependent changes after routine implementation of ThinPrep and SurePath technology in two independent laboratories, and controlled for time trends in a third laboratory usi...

journal_title：International journal of cancer

authors： Rask J,Lynge E,Franzmann M,Hansen B,Hjortebjerg A,Rygaard C,Schledermann D,Wåhlin A,Rebolj M

更新日期：2014-05-01 00:00:00

abstract：:PCNA and esophagin have been implicated in the multistep process of carcinogenesis, but simultaneous characterization of these proteins in the early stages of esophageal neoplastic progression has yet to be undertaken. In morphologically normal esophageal epithelium, esophagin stains the granular layer cells, principa...

journal_title：International journal of cancer

authors： Kimos MC,Wang S,Borkowski A,Yang GY,Yang CS,Perry K,Olaru A,Deacu E,Sterian A,Cottrell J,Papadimitriou J,Sisodia L,Selaru FM,Mori Y,Xu Y,Yin J,Abraham JM,Meltzer SJ

更新日期：2004-09-01 00:00:00

abstract：:Cancers of the stomach, pancreas, colon and rectum are increasingly regarded as being diet-influenced. Migrants to Australia from England, Scotland, Ireland, Poland, Yugoslavia, Greece, and Italy have come from countries with varied dietary backgrounds and gastrointestinal cancer risks. Age-standardized cancer death r...

journal_title：International journal of cancer

authors： McMichael AJ,McCall MG,Hartshorne JM,Woodings TL

更新日期：1980-04-15 00:00:00

abstract：:HER3 (ERBB3) is a catalytically inactive pseudokinase of the HER receptor tyrosine kinase family, frequently overexpressed in prostate and other cancers. Aberrant expression and mutations of 2 other members of the family, EGFR and HER2, are key carcinogenic events in several types of tumors, and both are well- validat...

journal_title：International journal of cancer

authors： Soler M,Mancini F,Meca-Cortés O,Sánchez-Cid L,Rubio N,López-Fernández S,Lozano JJ,Blanco J,Fernández PL,Thomson TM

更新日期：2009-12-01 00:00:00

abstract：:The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role in the...

journal_title：International journal of cancer

authors： Keck B,Wach S,Taubert H,Zeiler S,Ott OJ,Kunath F,Hartmann A,Bertz S,Weiss C,Hönscheid P,Schellenburg S,Rödel C,Baretton GB,Sauer R,Fietkau R,Wullich B,Krause FS,Datta K,Muders MH

更新日期：2015-01-15 00:00:00

abstract：:The pharmacokinetics of methotrexate (MX) and 7-OH methotrexate (MXOH) was studied in 18 cancer patients treated with 6-hr intravenous (i.v.) infusion of 100 mg/kg (A), 80 mg/kg preceded by 20 mg/kg i.v. loading dose (B), and 70 mg/kg preceded by 30 mg/kg i.v. loading dose (C). Simultaneous analysis of MX and MXOH was...

journal_title：International journal of cancer

authors： el-Yazigi A,Amer M,Al-Saleh I,Martin C

更新日期：1986-12-15 00:00:00

abstract：:The site-specific relationship between melanoma and sun exposure was investigated in the high-risk region of New Zealand. Age and latitude of residence were used as biological and geographical proxy measures of exposure for the 16,117 newly incident cases and 3,150 death records reported between 1968 and 1993. Age-sta...

journal_title：International journal of cancer

authors： Bulliard JL

更新日期：2000-03-01 00:00:00

abstract：:MART-1/MelanA and Pmel17/gp100 are melanoma-associated antigens (MAAs) that can be recognized by tumor-infiltrating lymphocytes (TILs) capable of mediating successful adoptive therapy in vivo. Analysis of melanoma cell lines in vitro has demonstrated that heterogeneous antigen expression in the context of class I MHC ...

journal_title：International journal of cancer

authors： Cormier JN,Hijazi YM,Abati A,Fetsch P,Bettinotti M,Steinberg SM,Rosenberg SA,Marincola FM

更新日期：1998-02-09 00:00:00

abstract：:Infection with human papillomavirus-16 (HPV-16) is the cause of most anogenital carcinomas. This virus is also detected in about 20% of all head and neck squamous cell carcinomas. While there is strong evidence for a causal etiological role in the case of tonsillar carcinomas, causal association with malignant lesions...

journal_title：International journal of cancer

authors： Balderas-Loaeza A,Anaya-Saavedra G,Ramirez-Amador VA,Guido-Jimenez MC,Kalantari M,Calleja-Macias IE,Bernard HU,Garcia-Carranca A

更新日期：2007-05-15 00:00:00