Abstract:
:Parvoviruses of rodents are endowed with oncosuppressive properties. In particular, parvoviral infections protect host animals from spontaneous and chemical- or virus-induced tumour initiation in laboratory animals. The present study was undertaken to substantiate the capacity of parvovirus H-1 to inhibit therapeutically the growth of established tumours originating from human carcinoma cells implanted in recipient mice. To this end, quickly growing s.c. carcinomas were established by injection of human cervical carcinoma cells (HeLa) into immunodeficient (SCID) mice. Tumour-bearing mice subsequently were inoculated with H-1 at various multiplicities of infection. H-1 virus infection led to regression of tumours, the onset and efficiency of which were dose-dependent.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Faisst S,Guittard D,Benner A,Cesbron JY,Schlehofer JR,Rommelaere J,Dupressoir Tdoi
10.1002/(sici)1097-0215(19980209)75:4<584::aid-ijcsubject
Has Abstractpub_date
1998-02-09 00:00:00pages
584-9issue
4eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(19980209)75:4<584::AID-IJCjournal_volume
75pub_type
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