Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.

abstract：:In a previous study, human ZNF312b was identified as a cell proliferation-associated oncogene via the K-ras/extracellular signal-regulated kinase cascade in gastric cancer. However, the mechanism concerning its transcriptional activation remains unknown. Here, we show that DNA methylation and histone acetylation of th...

journal_title：International journal of cancer

authors： Song IS,Ha GH,Kim JM,Jeong SY,Lee HC,Kim YS,Kim YJ,Kwon TK,Kim NS

更新日期：2011-11-01 00:00:00

abstract：:Colorectal cancer is among the commonest cancers worldwide. Dietary factors have been linked to colorectal cancer risk, however, few studies have evaluated the relationship between a priori dietary patterns and colorectal cancer risk. We evaluated the effect of adherence to a Mediterranean dietary pattern, as measured...

journal_title：International journal of cancer

authors： Agnoli C,Grioni S,Sieri S,Palli D,Masala G,Sacerdote C,Vineis P,Tumino R,Giurdanella MC,Pala V,Berrino F,Mattiello A,Panico S,Krogh V

更新日期：2013-03-15 00:00:00

abstract：:Angiogenesis and immunosuppression work hand-in-hand in the renal cell carcinoma (RCC) microenvironment. Tumor growth is associated with impaired antitumor immune response in RCC, which involves T cells, natural killer cells, dendritic cells (DCs) and macrophages. Vascular endothelial growth factor receptor (VEGFR), s...

journal_title：International journal of cancer

authors： Santoni M,Berardi R,Amantini C,Burattini L,Santini D,Santoni G,Cascinu S

更新日期：2014-06-15 00:00:00

abstract：:The natural history of human T-lymphotropic virus type I (HTLV-I) has been shown to differ markedly by geographic area. The differences include contrasting patterns of risk of adult T-cell lymphoma (ATL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP), which may be due in part to differences in...

journal_title：International journal of cancer

authors： Birmann BM,Breen EC,Stuver S,Cranston B,Martínez-Maza O,Falk KI,Okayama A,Hanchard B,Mueller N,Hisada M

更新日期：2009-02-01 00:00:00

abstract：:The granulin-epithelin precursor (GEP/PCDGF), a 68-88 kDa secreted glycoprotein, has been shown to be an important growth and survival factor for ovarian cancer cells. Furthermore, GEP expression is a predictor of patient survival in metastatic ovarian cancer cells. Up to this point, however, the molecular mechanisms ...

journal_title：International journal of cancer

authors： Pizarro GO,Zhou XC,Koch A,Gharib M,Raval S,Bible K,Jones MB

更新日期：2007-06-01 00:00:00

abstract：:Because renal-cell carcinoma (RCC) is considered relatively resistant to radio- and chemotherapy, RCC patients may benefit from new treatment modalities, e.g. immunotherapy. In vitro and in vivo studies suggest that combinations of cytokines such as interferon gamma or interferon alpha (IFN-gamma, IFN-alpha) and tumor...

journal_title：International journal of cancer

authors： van Dijk J,Uemura H,Beniers AJ,Peelen WP,Zegveld ST,Fleuren GJ,Warnaar SO,Oosterwijk E

更新日期：1994-01-15 00:00:00

abstract：:Fatty acids play a key role in cellular bioenergetics, membrane biosynthesis and intracellular signaling processes and thus may be involved in cancer development and progression. In the present study, we comprehensively assessed associations of 14,522 common single-nucleotide polymorphisms (SNPs) in 149 genes of the f...

journal_title：International journal of cancer

authors： Dai W,Liu H,Xu X,Ge J,Luo S,Zhu D,Amos CI,Fang S,Lee JE,Li X,Nan H,Li C,Wei Q

更新日期：2019-11-15 00:00:00

abstract：:Metastasis is a critical problem in the treatment of human lung cancer. Thus, a suitable animal model of metastasis of human lung cancer is required for in vivo biological and preclinical studies. In this study, we tried to establish a suitable model for this, using SCID mice. Neither human SCLC H69/VP cells (5 x 10(6...

journal_title：International journal of cancer

authors： Yano S,Nishioka Y,Izumi K,Tsuruo T,Tanaka T,Miyasaka M,Sone S

更新日期：1996-07-17 00:00:00

abstract：:Use of dietary supplements is rising in countries where colorectal cancer is prevalent. We conducted a systematic literature review and meta-analyses of prospective cohort studies on dietary supplement use and colorectal cancer risk. We identified relevant studies in Medline, Embase and Cochrane up to January 2013. Or...

journal_title：International journal of cancer

authors： Heine-Bröring RC,Winkels RM,Renkema JM,Kragt L,van Orten-Luiten AC,Tigchelaar EF,Chan DS,Norat T,Kampman E

更新日期：2015-05-15 00:00:00

abstract：:A human tumor clonogenic assay has been used to test the antiproliferative effect of recombinant human leukocyte interferon alpha 2 alone and in combination with each of 8 cytotoxic agents. Cell lines derived from 6 human tumors and primary tumor cells from 13 patients have been used in these clonogenic assay studies....

journal_title：International journal of cancer

authors： Welander CE,Morgan TM,Homesley HD,Trotta PP,Spiegel RJ

更新日期：1985-06-15 00:00:00

abstract：:Both epigallocatechin gallate (EGCG) and curcumin have shown efficacy in various in vivo and in vitro models of cancer. This study was designed to determine the efficacy of these naturally derived polyphenolic compounds in vitro and in vivo, when given in combination. Studies in MDA-MB-231 cells demonstrated that EGCG...

journal_title：International journal of cancer

authors： Somers-Edgar TJ,Scandlyn MJ,Stuart EC,Le Nedelec MJ,Valentine SP,Rosengren RJ

更新日期：2008-05-01 00:00:00

abstract：:The secretion of antibody by hybridoma cells allows the growth of individual cells to be measured by a hemolytic plaque assay. Similarly, plaque reduction assays were sensitive indicators of tumor immunity. A series of strains of hybridoma have been isolated from an original isolate which is sensitive to cytotoxic T c...

journal_title：International journal of cancer

authors： Ezaki T,Marbrook J

更新日期：1985-01-15 00:00:00

abstract：:We tested the efficacy of gefitinib in the prevention of HER2/neu-mediated breast cancer development in BALB-NeuT transgenic mice. Oral administration of gefitinib to female transgenic mice from 5 to 14 weeks of age reduced tumor multiplicity from 9.6 +/- 0.82 to 0.58 +/- 1.1 (83%). We observed a decrease in the numbe...

journal_title：International journal of cancer

authors： Piechocki MP,Dibbley SK,Lonardo F,Yoo GH

更新日期：2008-04-15 00:00:00

abstract：:The present study was undertaken to define the gene(s) of importance on the long arm of chromosome 18 (chromosome 18q) in endometrial carcinomas. We analyzed loss of heterozygosity (LOH) at 3 loci on chromosome 18q and DCC gene expression by the reverse-transcriptase/polymerase chain reaction (RT-PCR) method. Among 61...

journal_title：International journal of cancer

authors： Gima T,Kato H,Honda T,Imamura T,Sasazuki T,Wake N

更新日期：1994-05-15 00:00:00

abstract：:In combination with xenogeneic immune RNA (l-RNA) and tumor antigen (TA), syngeneic spleen cells inhibited the growth of a N-methyl-N-nitrosourethane-induced colon carcinoma (CT-26) in BALB/c mice. The sequential administration of 1 X 10(7) spleen cells, l mg of anti-CT-26 l-RNA and 0.4 mg of CT-26 TA resulted in a 20...

journal_title：International journal of cancer

authors： Fukushima M,Colmerauer ME,Nayak SK,Koziol JA,Pilch YH

更新日期：1982-01-15 00:00:00

abstract：:Dietary patterns reflect combinations of dietary exposures, and here we examine these in relation to prostate cancer risk. In a case-control study, 80 incident primary prostate cancer cases and 334 urology clinic controls were enrolled from 1997 through 1999 in Kingston, Ontario, Canada. Food-frequency questionnaires ...

journal_title：International journal of cancer

authors： Walker M,Aronson KJ,King W,Wilson JW,Fan W,Heaton JP,MacNeily A,Nickel JC,Morales A

更新日期：2005-09-10 00:00:00

abstract：:An antiserum to SF antigen was shown to be selectively cytotoxic to two human fibroblast lines, while two tumor cell lines (one melanoma and one Hela cell line) were resistant. The selective cytotoxicity was also demonstrable in mixtures of fibroblasts and tumor cells. The cytotoxic effect was abrogated by admixture o...

journal_title：International journal of cancer

authors： Ruoslahti E,Sjögren HO

更新日期：1976-09-15 00:00:00

abstract：:Family history of urogenital cancers has been associated with an increased risk of cancer at the same sites. To evaluate the risks of bladder, prostate and renal cell neoplasms for family history of urogenital cancers in first-degree relatives, we analysed data from a case-control study conducted in northern Italy bet...

journal_title：International journal of cancer

authors： Randi G,Pelucchi C,Negri E,Talamini R,Galeone C,Franceschi S,La Vecchia C

更新日期：2007-12-15 00:00:00

abstract：:With metastatic disease at diagnosis for 70% of patients, ovarian cancer represents the most lethal gynecological malignancy. Ovarian carcinomas are aggressive malignancies that can evade immune surveillance and frequently develop into metastases. The tumor microenvironment is decisive for preventing immune attack but...

journal_title：International journal of cancer

authors： Martinet L,Poupot R,Mirshahi P,Rafii A,Fournié JJ,Mirshahi M,Poupot M

更新日期：2010-05-01 00:00:00

abstract：:Our previous studies demonstrate that introduction of a approximately 70 cM region (now estimated at 63.75 Mb by the Human Genome Project) of human chromosome 12 into the highly metastatic Dunning rat prostate cancer cell line AT6.1 results in >30-fold (>/=90%) reduction in the number of overt metastases in spontaneou...

journal_title：International journal of cancer

authors： Jaeger EB,Chekmareva MA,Tennant TR,Luu HH,Hickson JA,Chen SL,Samant RS,Sokoloff MH,Rinker-Schaeffer CW

更新日期：2004-01-01 00:00:00

abstract：:Data from immunocytochemical assessment of estrogen receptor (ER) regulation in MCF-7 cells under estrogenic and anti-estrogenic stimulation were compared with those obtained by enzyme immunoassay (Abbott ER-EIA). Similar trends were observed, although ER level variations were less marked when assessed immunocytochemi...

journal_title：International journal of cancer

authors： Seo HS,Larsimont D,Querton G,El Khissiin A,Laios I,Legros N,Leclercq G

更新日期：1998-12-09 00:00:00

abstract：:A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3'UTR, and is associated with an increased risk for breast cancer in Asian women. Here, we explo...

journal_title：International journal of cancer

authors： Pan JW,Zabidi MMA,Chong BK,Meng MY,Ng PS,Hasan SN,Sandey B,Bahnu S,Rajadurai P,Yip CH,Rueda OM,Caldas C,Chin SF,Teo SH

更新日期：2021-01-07 00:00:00

abstract：:Receptors for the third component of complement (C3) were demonstrated on the surface of established human lymphoid cell lines by a membrane fluorescence test with FITC- or TRITC-conjugated antibodies against human C3. Two-color fluorescence staining of EBV receptors and C3 receptors showed complete overlapping of gre...

journal_title：International journal of cancer

authors： Yefenof E,Klein G,Jondal M,Oldstone MB

更新日期：1976-06-15 00:00:00

abstract：:Multiple myeloma (MM) is the second most common hematologic malignancy characterized by the clonal expansion of plasma cells. Despite continuing advances, novel biomarkers are needed for diagnosis and prognosis of MM. In our study, we characterized the diagnostic and prognostic potential of circulating microRNAs (miRN...

journal_title：International journal of cancer

authors： Hao M,Zang M,Wendlandt E,Xu Y,An G,Gong D,Li F,Qi F,Zhang Y,Yang Y,Zhan F,Qiu L

更新日期：2015-04-15 00:00:00

abstract：:Elevated platelet counts in patients diagnosed with malignant tumors were first described more than 100 years ago. Today it is well known that in many types of solid tumors, thrombocytosis at the time of diagnosis is associated with shorter survival. From this well-documented clinical correlation between platelet coun...

journal_title：International journal of cancer

authors： Buergy D,Wenz F,Groden C,Brockmann MA

更新日期：2012-06-15 00:00:00

abstract：:Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) ...

journal_title：International journal of cancer

authors： Gao GF,Roth MJ,Wei WQ,Abnet CC,Chen F,Lu N,Zhao FH,Li XQ,Wang GQ,Taylor PR,Pan QJ,Chen W,Dawsey SM,Qiao YL

更新日期：2006-09-15 00:00:00

abstract：:In this review, we evaluate key molecular pathways and markers of muscle-invasive bladder cancer (MIBC). Overexpression and activation of EGFR, p63, and EMT genes are suggestive of basal MIBC subtype generally responsive to chemotherapy. Alterations in PPARγ, ERBB2/3, and FGFR3 gene products and their signaling along ...

journal_title：International journal of cancer

authors： Kiselyov A,Bunimovich-Mendrazitsky S,Startsev V

更新日期：2016-06-01 00:00:00

abstract：:An epithelioid cell line, started from a human pancreatic carcinoma of ductal cell origin, has been maintained in culture for over 2 years and has been subcultured more than 40 times. The PANC-1 cell line has a doubling time of 52 h and G6PD activity of the slow mobility of B type. Chromosome studies show a modal numb...

journal_title：International journal of cancer

authors： Lieber M,Mazzetta J,Nelson-Rees W,Kaplan M,Todaro G

更新日期：1975-05-15 00:00:00

abstract：:p16(INK4a), a cell cycle regulation protein, accumulates in abnormal epithelial cells infected with high-risk human papilloma virus (HPV). In immunostaining studies, p16(INK4a) has shown potential as a marker of high grade cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. To evaluate its potential...

journal_title：International journal of cancer

authors： Mao C,Balasubramanian A,Yu M,Kiviat N,Ridder R,Reichert A,Herkert M,von Knebel Doeberitz M,Koutsky LA

更新日期：2007-06-01 00:00:00

abstract：:There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternati...

journal_title：International journal of cancer

authors： Luu HN,Neelakantan N,Geng TT,Wang R,Goh GB,Clemente JC,Jin A,van Dam RM,Jia W,Behari J,Koh WP,Yuan JM

更新日期：2020-10-31 00:00:00