Hemizygous or homozygous deletion of the chromosomal region containing the p16INK4a gene is associated with amplification of the EGF receptor gene in glioblastomas.


:The p16INK4a gene product acts as a negative regulator of the cell cycle by binding to cyclin-dependent kinases (CDKs) 4 and 6, thereby inhibiting the formation of an active CDK/cyclin D complex. Deletion of the p16 locus has been observed in tumor cell lines and, less frequently, in primary human neoplasms. We analyzed 31 glioblastomas and identified 6 cases with hemizygous and 6 with homozygous deletions of the p16 locus. Eight of these cases showed a concurrent amplification of the EGFR gene (epidermal growth factor receptor) while the overall frequency was 35%. This close correlation suggests that deletion of the p16 chromosomal region constitutes another genetic hallmark of the primary glioblastoma, which rapidly develops de novo, without a less malignant precursor lesion and for which EGFR amplification is a characteristic genetic change. The p16 protein was not detectable in 15 of 22 glioblastomas but only 4 of these showed homozygous deletion of the gene. The alternative transcript p16 beta, for which a growth-suppressing function has been suggested, was co-expressed with p16 alpha mRNA in most cases. Hypermethylation of CpG islands in the 5' region of the p16 gene was identified in only 1 case, suggesting that this alternative mechanism of gene silencing is rarely responsible for loss of p16 expression in glioblastomas. Likewise, only 1 glioblastoma carried a p16 mutation and in addition, unexpectedly, a homozygous deletion of p16 in approximately 80% of tumor cells. This mutation, Arg24Pro, has previously been identified in a melanoma kindred.


Int J Cancer


Hegi ME,zur Hausen A,Rüedi D,Malin G,Kleihues P




Has Abstract


1997-09-26 00:00:00














  • Cytogenetic abnormalities in benign lymphoid hyperplasia: a dual-parameter study using chromosome analysis and flow cytometry.

    abstract::This is a prospective study of lymphoid tissue showing benign reactive hyperplasia (18 lymph nodes and 2 tonsils), using cytogenetic analysis of cells stimulated with T- or B-cell mitogens. The reason for this study was the detection of an abnormal chromosomal population in cells from an enlarged lymph node excised fr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Grace J,Hall BE,Lew M,Singh S,Pittman S,Palmer AA,Zbroja R,Wass J,Vincent PC

    更新日期:1989-12-15 00:00:00

  • Association between progression-free survival and patients' quality of life in cancer clinical trials.

    abstract::Quality of life outcomes provide essential information for patients and physicians in oncology care. However, the validity of progression-free survival (PFS) as a surrogate for quality of life, and the inclusion and reporting of quality of life endpoints in clinical trials, is unclear. We performed a retrospective stu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hwang TJ,Gyawali B

    更新日期:2019-04-01 00:00:00

  • MHC-restricted responses of CD8+ and CD4+ T-cell clones from regional lymph nodes of melanoma patients.

    abstract::Regional lymph-node (LN) lymphocytes may constitute an important defence against the spread of human melanoma beyond regional LNs. The present study was directed to clonal analysis of lymphocytes cultured either directly from the LNs or after stimulation in cultures with autologous melanoma (MLTC). T-cell clones deriv...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen Q,Hersey P

    更新日期:1992-05-08 00:00:00

  • 7-Deoxynarciclasine shows promising antitumor efficacy by targeting Akt against hepatocellular carcinoma.

    abstract::Akt is a promising therapeutic target for cancer treatment. In our study, we have identified that 7-deoxynarciclasine (7-DONCS) is a potential inhibitor of Akt, which results in the repression of multiple oncogenic processes in hepatocellular carcinoma (HCC). We have found that 7-DONCS suppresses the growth of HCC by ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yin S,Qiu Y,Jin C,Wang R,Wu S,Liu H,Koo S,Han L,Zhang Y,Gao X,Pang X,Wang T,Yu H

    更新日期:2019-12-15 00:00:00

  • Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study.

    abstract::Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated wi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Pantavos A,Ruiter R,Feskens EF,de Keyser CE,Hofman A,Stricker BH,Franco OH,Kiefte-de Jong JC

    更新日期:2015-05-01 00:00:00

  • Farnesyl transferase inhibitor treatment of breast cancer cells leads to altered RhoA and RhoC GTPase activity and induces a dormant phenotype.

    abstract::Farnesyl transferase inhibitors (FTIs) were shown to be effective in modulating tumor growth in Ras-transformed tumor cells. Recent studies have focused on Rho GTPases as putative targets of FTI action. Previously, we demonstrated that FTIs were effective in inhibiting the growth and invasiveness of RhoC GTPase-overex...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chatterjee M,van Golen KL

    更新日期:2011-07-01 00:00:00

  • Modification of the effect of C. parvum on macrophage activity and tumour growth by X-irradiation.

    abstract::The radiosensitivity of three forms of response to injection of C. parvum in mice has been investigated. The increase in phagocytin index evoked by IP or IV injection of 0.7 mg C. parvum (but not that evoked by 1.4 mg) was reduced but not abolished in mice given 350-500 rad whole-body irradiation 4 days before C. parv...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Woodruff MF,Ghaffar A,Whitehead VL

    更新日期:1976-05-15 00:00:00

  • A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens.

    abstract::Increasing evidence indicates that breast cancer pathogenesis is linked with DNA double-strand break (DSB) repair dysfunction. This conclusion is based on advances in the study of functions of breast cancer susceptibility genes such as BRCA1 and BRCA2, on the identification of breast cancer-associated changes regardin...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Keimling M,Kaur J,Bagadi SA,Kreienberg R,Wiesmüller L,Ralhan R

    更新日期:2008-08-01 00:00:00

  • Significance of the expression of major histocompatibility complex class II antigen, HLA-DR and -DQ, with recurrence of papillary thyroid cancer.

    abstract::Normal thyroid epithelial cells lack major histocompatibility complex (MHC) Class II antigen. Oncogenic kinases involved in papillary thyroid carcinoma (PTC) trigger the expression of Class II transactivator and MHC Class II complex. However, the relationship between MHC Class II antigen expression and clinical outcom...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jo YS,Lee JC,Li S,Choi YS,Bai YS,Kim YJ,Lee IS,Rha SY,Ro HK,Kim JM,Shong M

    更新日期:2008-02-15 00:00:00

  • Nicotine modulates the effects of retinoids on growth inhibition and RAR beta expression in lung cancer cells.

    abstract::Epidemiological and animal studies have demonstrated that vitamin A and its natural and synthetic derivatives, retinoids, are effective agents in preventing the development of tobacco-associated cancers. Unfortunately, clinical trials of retinoids on cigarette smokers have shown lack of efficacy in preventing lung can...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen GQ,Lin B,Dawson MI,Zhang XK

    更新日期:2002-05-10 00:00:00

  • Androgenic regulation of growth factor and growth factor receptor expression in the CWR22 model of prostatic adenocarcinoma.

    abstract::The effects of androgen manipulation on epidermal growth factor (EGF) receptor, p185erbB-2 and transforming growth factor-alpha (TGF-alpha) levels were examined in prostatic adenocarcinoma. Male nude mice were inoculated with the CWR22 androgen-dependent human prostatic tumor or an androgen-independent (CWR22R) deriva...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Myers RB,Oelschlager D,Manne U,Coan PN,Weiss H,Grizzle WE

    更新日期:1999-07-30 00:00:00

  • Pesticide exposure as risk factor for non-Hodgkin lymphoma including histopathological subgroup analysis.

    abstract::We report a population based case-control study of exposure to pesticides as risk factor for non-Hodgkin lymphoma (NHL). Male and female subjects aged 18-74 years living in Sweden were included during December 1, 1999, to April 30, 2002. Controls were selected from the national population registry. Exposure to differe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Eriksson M,Hardell L,Carlberg M,Akerman M

    更新日期:2008-10-01 00:00:00

  • Prediagnostic telomere length and risk of B-cell lymphoma-Results from the EPIC cohort study.

    abstract::Recent epidemiological investigations have reported on the association between telomere length (TL) and a number of malignancies, including B-cell lymphoma (BCL). The reported results for BCLs are however inconsistent. We carried out a nested case-control study to determine whether TL is associated with future risk of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hosnijeh FS,Matullo G,Russo A,Guarrera S,Modica F,Nieters A,Overvad K,Guldberg P,Tjønneland A,Canzian F,Boeing H,Aleksandrova K,Trichopoulou A,Lagiou P,Trichopoulos D,Tagliabue G,Tumino R,Panico S,Palli D,Olsen KS,

    更新日期:2014-12-15 00:00:00

  • Diabetes and risk of esophageal and gastric adenocarcinomas.

    abstract::Diabetes has been consistently associated with an increased risk of liver, pancreas and endometrial cancer and has been implicated as a risk factor for esophageal and gastric cancers, although this association has been less well studied. We sought to determine the role of diabetes in the etiology of esophageal, gastri...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jiang X,Bernstein L,Tseng CC,Wu AH

    更新日期:2012-09-15 00:00:00

  • Comparison of assay methods for detection of circulating tumor cells in metastatic breast cancer: AdnaGen AdnaTest BreastCancer Select/Detect™ versus Veridex CellSearch™ system.

    abstract::The detection of CTCs prior to and during therapy is an independent and strong prognostic marker, and it is predictive of poor treatment outcome. A major challenge is that different technologies are available for isolation and characterization of CTCs in peripheral blood (PB). We compare the CellSearch system and Adna...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Andreopoulou E,Yang LY,Rangel KM,Reuben JM,Hsu L,Krishnamurthy S,Valero V,Fritsche HA,Cristofanilli M

    更新日期:2012-04-01 00:00:00

  • Analysis of T-cell-receptor beta-chain-gene usage in peripheral-blood and tumor-infiltrating lymphocytes from human non-small-cell lung carcinomas.

    abstract::Non-small-cell lung cancers (NSCLC) are often infiltrated by T lymphocytes. It is postulated that the presence of tumor-infiltrating lymphocytes (TIL) reflects a local host immune response against autologous tumors. To identify the nature of NSCLC TIL, we have characterized the molecular structure of the TCRbeta chain...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章


    authors: Echchakir H,Asselin-Paturel C,Dorothee G,Vergnon I,Grunenwald D,Chouaib S,Mami-Chouaib F

    更新日期:1999-04-12 00:00:00

  • Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats.

    abstract::Parathyroid hormone-related protein (PTHrP) is a causative factor of humoral hypercalcemia in malignancy. However, it is difficult to explain the mechanism of anorexia/cachexia with PTHrP secretion in detail. Previously, we demonstrated that the expressions of orexigenic peptides increased and anorexigenic peptides de...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Suzuki H,Hashimoto H,Kawasaki M,Watanabe M,Otsubo H,Ishikura T,Fujihara H,Ohnishi H,Onuma E,Yamada-Okabe H,Takuwa Y,Ogata E,Nakamura T,Ueta Y

    更新日期:2011-05-01 00:00:00

  • Survival of cervix cancer patients in Harare, Zimbabwe, 1995-1997.

    abstract::The survival experience of 284 patients with cancer of the cervix uteri registered by the population-based Zimbabwe National Cancer Registry in 1995-1997 is described. The vital status of these subjects was established by linkage with death registration and by retrieval of patient files from medical records department...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chokunonga E,Ramanakumar AV,Nyakabau AM,Borok MZ,Chirenje ZM,Sankila R,Parkin DM

    更新日期:2004-03-20 00:00:00

  • ALDH1A1 in patient-derived bladder cancer spheroids activates retinoic acid signaling leading to TUBB3 overexpression and tumor progression.

    abstract::Acquired chemoresistance is a critical issue for advanced bladder cancer patients during long-term treatment. Recent studies reveal that a fraction of tumor cells with enhanced tumor-initiating potential, or cancer stem-like cells (CSCs), may particularly contribute to acquired chemoresistance and recurrence. Thus, CS...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Namekawa T,Ikeda K,Horie-Inoue K,Suzuki T,Okamoto K,Ichikawa T,Yano A,Kawakami S,Inoue S

    更新日期:2020-02-15 00:00:00

  • Clinicopathological and prognostic significance of circulating tumor cells in patients with gastric cancer: a meta-analysis.

    abstract::The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane d...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析


    authors: Huang X,Gao P,Sun J,Chen X,Song Y,Zhao J,Xu H,Wang Z

    更新日期:2015-01-01 00:00:00

  • Expression of multidrug-resistance-associated protein (MRP) and chemosensitivity in human gastric cancer.

    abstract::Evidence has accumulated that, in addition to the MDR1 gene-coded P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP) also mediates the multidrug resistance (MDR) of various human tumors. In the case of gastric cancer, there is little or no involvement of P-glycoprotein, and the mechanisms of MDR remai...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Endo K,Maehara Y,Kusumoto T,Ichiyoshi Y,Kuwano M,Sugimachi K

    更新日期:1996-11-04 00:00:00

  • Long-term results of neoadjuvant radiation therapy for breast cancer.

    abstract::Our aim was to determine the long-term outcome and the possible role of neoadjuvant (preoperative) radiation therapy for breast cancers unsuitable for primary conservative surgery. From 1977 to 1992, 75 unifocal non-inflammatory and non-metastatic T2 and T3 breast cancers were treated in our department. All these pati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Calitchi E,Kirova YM,Otmezguine Y,Feuilhade F,Piedbois Y,Le Bourgeois JP

    更新日期:2001-08-20 00:00:00

  • Circulating enterolactone and risk of endometrial cancer.

    abstract::It has been suggested that phytoestrogens protect against hormone-dependent cancers. Lignans are the main class of phytoestrogens in Western diets. We conducted a prospective study of endometrial cancer and circulating levels of the main human lignan, enterolactone. The design was a case-control study nested within 3 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Zeleniuch-Jacquotte A,Lundin E,Micheli A,Koenig KL,Lenner P,Muti P,Shore RE,Johansson I,Krogh V,Lukanova A,Stattin P,Afanasyeva Y,Rinaldi S,Arslan AA,Kaaks R,Berrino F,Hallmans G,Toniolo P,Adlercreutz H

    更新日期:2006-11-15 00:00:00

  • Loss of hSef promotes metastasis through upregulation of EMT in prostate cancer.

    abstract::We have previously reported that the negative signaling regulator Similar Expression to FGF (hSef) is downregulated in prostate cancer and its loss is associated with clinical metastasis. Here, we explored the mechanistic basis of this finding. We first confirmed our clinical observation by testing hSef manipulation i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hori S,Wadhwa K,Pisupati V,Zecchini V,Ramos-Montoya A,Warren AY,Neal DE,Gnanapragasam VJ

    更新日期:2017-04-15 00:00:00

  • Risk of second malignant neoplasms among lymphoma patients with a family history of cancer.

    abstract::Radiotherapy and chemotherapy are known risk factors for second cancers after lymphoma. The role of genetic influences, however, remains largely unknown. We assessed risk of second cancers associated with family history of any cancer in 41,181 patients with Hodgkin lymphoma (HL) (n = 7,476), non-Hodgkin lymphoma (NHL)...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Landgren O,Pfeiffer RM,Stewart L,Gridley G,Mellemkjaer L,Hemminki K,Goldin LR,Travis LB

    更新日期:2007-03-01 00:00:00

  • Flow cytometric analysis of the expression of 9A3 antigen, E-cadherin and EGF receptor in TMK-1 stomach cancer cells.

    abstract::We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fukuyama R,Minoshima S,Ochiai A,Tahara E,Shimizu N

    更新日期:1991-04-22 00:00:00

  • GPER-induced signaling is essential for the survival of breast cancer stem cells.

    abstract::G protein-coupled estrogen receptor-1 (GPER), a member of the G protein-coupled receptor (GPCR) superfamily, mediates estrogen-induced proliferation of normal and malignant breast epithelial cells. However, its role in breast cancer stem cells (BCSCs) remains unclear. Here we showed greater expression of GPER in BCSCs...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chan YT,Lai AC,Lin RJ,Wang YH,Wang YT,Chang WW,Wu HY,Lin YJ,Chang WY,Wu JC,Yu JC,Chen YJ,Yu AL

    更新日期:2020-03-15 00:00:00

  • Specific antigen of murine erythroblasts.

    abstract::A new antigan has been revealed by means of antisera against Rauscher virus in mice with Rauscher virus-induced leukemia. This antigen appears to be different from both Rauscher type-specific antigen and MULV-gs-1 (p-30), as shown by studies of electrophoretic mobility and immunochemical specificity. Except in leukemi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ievleva ES,Engelhardt NV,Abelev GI

    更新日期:1976-06-15 00:00:00

  • Novel ovarian cancer maintenance therapy targeted at mortalin and mutant p53.

    abstract::Current ovarian cancer maintenance therapy is limited by toxicity and no proven impact on overall survival. To study a maintenance strategy targeted at missense mutant p53, we hypothesized that the release of mutant p53 from mortalin inhibition by the SHetA2 drug combined with reactivation of mutant p53 with the PRIMA...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ramraj SK,Elayapillai SP,Pelikan RC,Zhao YD,Isingizwe ZR,Kennedy AL,Lightfoot SA,Benbrook DM

    更新日期:2020-08-15 00:00:00

  • Elevated expression of ICAM1 (CD54) and minimal expression of LFA3 (CD58) in Epstein-Barr-virus-positive nasopharyngeal carcinoma cells.

    abstract::Undifferentiated nasopharyngeal carcinoma (NPC) is a remarkable entity among human tumors because of its constant association with the Epstein-Barr virus (EBV). Malignant epithelial cells harbor the EBV genome and often express at least 2 species of latent EBV protein (EBNA1 and LMP1). Despite the massive presence of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Busson P,Zhang Q,Guillon JM,Gregory CD,Young LS,Clausse B,Lipinski M,Rickinson AB,Tursz T

    更新日期:1992-04-01 00:00:00