Abstract:
:Growth of a highly-deviated ascites hepatoma (Yoshida AH-130) in rats caused initial hyperplastic enlargement of the liver, followed by progressive reduction to a size lower than that seen in controls. The time-course of this biphasic change in liver weight roughly corresponded to the exponential and stationary phases of tumour growth. Histologically, scattered small foci of perilobular necrosis were observed during the hyperplastic phase and these were consistently associated with a moderate elevation of glutamate-pyruvate transaminase (GPT) activity in the blood plasma. By contrast, signs of necrosis were absent and plasma GTP levels had returned to normal during the phase of hepatic involution, which was characterized by enhanced apoptosis, a type of single-cell death known to be involved in the regulation of tissue size under both normal and pathological conditions. Biochemically, alterations in liver protein mass resulted from changed rates of tissue protein degradation. The apoptotic bodies could either be lost from the liver via blood, lymph and bile, or phagocytosed and degraded by adjacent cells. Disposal of the apoptotic bodies is likely to account, at least in part, for the enhanced rates of liver protein turnover that characterize hepatic involution.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Tessitore L,Valente G,Bonelli G,Costelli P,Baccino FMdoi
10.1002/ijc.2910440424subject
Has Abstractpub_date
1989-10-15 00:00:00pages
697-700issue
4eissn
0020-7136issn
1097-0215journal_volume
44pub_type
杂志文章abstract::The karyotypes of cells from 10 Burkitt lymphoma (BL) biopsies, eight cell lines established from BL and nine cell lines from non-BL sources were studied by chromosome banding techniques. With the exception of the BL-derived cell lines BJAB, GC-BJAB, Maku and U-8691 all biopsies and lines of Burkitt origin contained a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170108
更新日期:1976-01-15 00:00:00
abstract::MAGE genes are frequently expressed in several types of human malignancy and code for antigens recognized by cytotoxic T lymphocytes. We have previously described a monoclonal antibody (MAb), named 6C1, that recognizes the MAGE-1 protein and cross-reacts with a 72-kDa protein present in lysates of melanoma cells such ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990909)82:6<901::aid-ijc
更新日期:1999-09-09 00:00:00
abstract::It is currently under debate whether the low serum cholesterol levels that are frequently observed in cancer patients represent a risk factor for/or, rather, are a consequence of the tumour. We postulate that malignant tumours are directly involved in an increased catabolism of cholesterol-rich low-density lipoprotein...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910610405
更新日期:1995-05-16 00:00:00
abstract::PDT has been reported to induce cancer cell expression of cytokines, such as IL-6 and TNF-alpha, but it has been unclear whether cytokine expression by cancer cells is directly related to the antitumor effect of PDT. We treated Lewis lung carcinoma (LLC) cells with a new photosensitizer, mono-L-aspartyl chlorin e6 (NP...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1374
更新日期:2001-08-15 00:00:00
abstract::Protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. In this study...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28448
更新日期:2014-03-01 00:00:00
abstract::Ganglioside GM2 is expressed on cell surface membranes of a variety of human malignant cells and has been demonstrated to be immunogenic in humans. We have assessed the role of the antigen GM2 on melanoma cells as a recognition structure for lymphokine-activated killer (LAK) cells. LAK cells were generated by stimulat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430520
更新日期:1989-05-15 00:00:00
abstract::The present experiments were performed to investigate the possibility of inhibiting tumor growth in vivo with syngeneic lymphocytes sensitized in vitro on monolayers of the tumor under test, and to study the effect of a thymic humoral factor (THF) in this sensitization process. Monolayers of fibrosarcoma cells were us...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150612
更新日期:1975-06-15 00:00:00
abstract::The role of MHC-class-I-antigen expression in intracerebral anti-tumor natural resistance was examined using MHC-positive Lym+ and MHC-negative Lym- lymphoma cell lines. Lym+ was sensitive to MHC-class-I-restricted CTL-mediated lysis, while lym- was resistant. Both lines were susceptible to NK-cell-mediated lysis. The...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19960729)67:3<365::AID-IJC
更新日期:1996-07-29 00:00:00
abstract::As part of a collaborative study of risk factors for childhood brain tumours, the effects of the mother's smoking and her potential for passive smoking exposure during the pregnancy were assessed in a case-control study. Parents of 91 cases and 321 population controls from Northern Italy, matched for age, sex and resi...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.2910570602
更新日期:1994-06-15 00:00:00
abstract::Ninety-seven Japanese patients with so-called primary non-Hodgkin's lymphoma of the central nervous system (CNS-NHL), unrelated to the acquired immunodeficiency syndrome (AIDS) or organ transplantation, were reviewed. The patients' ages ranged from 1 to 87 years (median: 58 years) with a male to female ratio of 1.77:1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450410
更新日期:1990-04-15 00:00:00
abstract::We previously reported that some single nucleotide polymorphisms (SNPs) of candidate genes involved in the MTOR complex1 (MTORC1) were associated with risk of gastric cancer (GCa). In the present study, we further evaluated associations of eight potentially functional SNPs of MTOR, MLST8 and RPTOR with survival of 100...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31656
更新日期:2019-01-15 00:00:00
abstract::Hybridomas producing syngeneic monoclonal antibodies (MAbs) were prepared by fusion of spleen cells of BALB/c mice, which were immunized with sublethal doses of RMB-I cells. This cell line originates from a Rauscher virus (R-MuLV)-induced myeloid leukemia and forms tumors when re-inoculated into mice. MAbs were charac...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420121
更新日期:1988-07-15 00:00:00
abstract::We have previously reported that the negative signaling regulator Similar Expression to FGF (hSef) is downregulated in prostate cancer and its loss is associated with clinical metastasis. Here, we explored the mechanistic basis of this finding. We first confirmed our clinical observation by testing hSef manipulation i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30604
更新日期:2017-04-15 00:00:00
abstract::Head and neck squamous cell carcinoma (HNSCC) is a morbid cancer with poor outcomes. Statins possess anticancer properties such as immunomodulatory and anti-inflammatory effects. The objective of our study is to identify the association between statin use among untreated HNSCC patients and overall death, disease-speci...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33441
更新日期:2020-12-15 00:00:00
abstract::A series of 722 lung carcinomas, surgically resected and typed some years ago according to the 1967 WHO classification, was independently reviewed by 2 observers in order to test the reproducibility of histopathological typing when using the criteria of the 1981 WHO classification. Typing was fully agreed upon in 87% ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910530205
更新日期:1993-01-21 00:00:00
abstract::Benzo(a)pyrene and benz(a) anthrancene which, in contrast to the K-region epoxides benzo(a)pyrene 4,5-oxide and benz(a)anthracene 5,6-oxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparations, were activated by liver microsomes from C3H mice, which had not received any ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180408
更新日期:1976-10-15 00:00:00
abstract::Previous studies have shown that macrophage cell lines retained the ability to phagocytize, to secrete lysosomal enzymes, and to function as effector cells in antibody-dependent cellular cytoxicity. In this paper, the cytolytic activity of murine macrophage cell lines against tumor target cells was assessed using an 1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260110
更新日期:1980-07-15 00:00:00
abstract::By transmission and scanning electron microscopic studies of MC-29 virus-infected CEC cultures, C-type virus particles were detected in the medium of infected cultures, in infected cells and in intracellular vacuoles. Virus budding was also observed. In the scanning electron microscope (SEM) so-called blebs appeared o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910180419
更新日期:1976-10-15 00:00:00
abstract::We have studied the in vitro invasive properties of 3 cell lines derived from the co-transfection of rat embryo fibroblasts (REF) with EIA genes deficient in exon 2 and T24-ras. All 3 cell lines showed invasive properties at passage 10 after isolation. Invasive cells expressed elevated levels of stromelysin-1 and redu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510516
更新日期:1992-07-09 00:00:00
abstract::Rabbits were immunized with extracts of primary or grafted intestinal adeno-carcinomas induced by carcinogenic drugs in inbred rats. After absorption with normal tissue extracts, the antisera were able to recognize three tumor-associated antigens. Two of them were glycoproteins, present in cancer cells but also, in tr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910150117
更新日期:1975-01-15 00:00:00
abstract::Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25859
更新日期:2011-10-15 00:00:00
abstract::Cervical cancer screening will rely, increasingly, on HPV testing as a primary screen. The requirement for triage tests which can delineate clinically significant infection is thus prescient. In this EUROGIN 2017 roadmap, justification behind the most evidenced triages is outlined, as are challenges for implementation...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.31261
更新日期:2018-08-15 00:00:00
abstract::The case-fatality rate following a diagnosis of prostate cancer is higher for Black men compared to White men. How this elevated rate arises is uncertain, with differences in disease biology, presentation, treatment and comorbidity having been suggested. A systematic search was conducted for articles that reported eth...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析,评审
doi:10.1002/ijc.23500
更新日期:2008-07-15 00:00:00
abstract::Occupational data from 5 case-control studies in the United States involving 2,973 male cases and 3,210 controls were analyzed to estimate the percentage of lung cancer attributable to well-known and suspected lung carcinogens. The studies were conducted in areas heterogeneous in terms of industrial activities. The pe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420610
更新日期:1988-12-15 00:00:00
abstract::Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25072
更新日期:2010-08-01 00:00:00
abstract::Deregulation of cell survival pathways and resistance to apoptosis are widely accepted to be fundamental aspects of tumorigenesis. As in many tumours, the aberrant growth and survival of colorectal tumour cells is dependent upon a small number of highly activated signalling pathways, the inhibition of which elicits po...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22917
更新日期:2007-11-15 00:00:00
abstract::Although tumor heterogeneity is widely accepted, the existence of cancer stem cells (CSCs) and their proposed role in tumor maintenance has always been challenged and remains a matter of debate. Recently, a path-breaking chapter was added to this saga when three independent groups reported the in vivo existence of CSC...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28804
更新日期:2015-05-01 00:00:00
abstract::Telomerase activity is involved in the maintenance of telomere length and is thought to be required for cellular immortality and oncogenesis. Three major subunits composing telomerase, human telomerase RNA (hTR), telomerase-associated protein (TPI) and human telomerase catalytic subunit (hTERT), have been identified. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990315)80:6<804::aid-ijc
更新日期:1999-03-15 00:00:00
abstract::Thymidylate synthase (TYMS) is an important enzyme for 5-fluorouracil (5-FU) metabolism in metastatic colorectal cancer (mCRC) patients. The search for this enzyme in circulating tumor cells (CTCs) can be a powerful tool to follow-up cancer patients. mCRC patients were enrolled before the beginning of 5-FU-based chemo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29495
更新日期:2015-09-15 00:00:00
abstract::The human tumor line LOX was established as an s.c. xenograft in nude mice from a lymph-node metastasis of a patient with malignant melanoma. I.v. injection into adult nude mice of single-cell suspensions prepared from xenografts resulted in progressively growing lung tumor colonies that killed the animals. No differe...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410322
更新日期:1988-03-15 00:00:00