Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas.

Abstract:

:The karyotypes of cells from 10 Burkitt lymphoma (BL) biopsies, eight cell lines established from BL and nine cell lines from non-BL sources were studied by chromosome banding techniques. With the exception of the BL-derived cell lines BJAB, GC-BJAB, Maku and U-8691 all biopsies and lines of Burkitt origin contained an extra band at the distal region of the long arm of one chromosome 14. An extra band on chromosome 14 was also found in cells of one non-BL biopsy, in cells from a lymphosarcoma-derived cell line and in a long-established cell line derived from the pleural exudate of a patient with Hodgkin's disease. A distal region at the long arm of one chromosome 8 was missing in all metaphase figures of good technical quality in the same material. The size, morphology and stain-ability of the missing region corresponded fairly well to the extra region at chromosome 14. We therefore suggest that the chromosome 14 marker represents a translocation between chromosomes 8 and 14,t (8q-; 14q+). The translocation was present neither in lymphocytes of the peripheral blood of five Burkitt patients nor in five lymphoblastoid cell lines of non-BL origin. Trisomy 7 was found in two of the 10 BL biopsies, in two BL-derived cell lines, in one non-BL biopsy, in two lymphosarcoma-derived cell lines and in one cell line derived from a patient with Hodgkin's disease.

journal_name

Int J Cancer

authors

Zech L,Haglund U,Nilsson K,Klein G

doi

10.1002/ijc.2910170108

subject

Has Abstract

pub_date

1976-01-15 00:00:00

pages

47-56

issue

1

eissn

0020-7136

issn

1097-0215

journal_volume

17

pub_type

杂志文章
  • Epstein-Barr virus-related herpesvirus from a rhesus monkey (Macaca mulatta) with malignant lymphoma.

    abstract::A herpesvirus (RhEBV) was isolated from a lymphoblastoid cell line (LCL) that became established from a malignant lymphoma in a rhesus monkey. The predominant cell marker in the LCL was that of B lymphocytes. RhEBV-induced viral capsid (VCA) and nuclear antigens (NA) in the LCL were serologically related to similar an...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910380319

    authors: Rangan SR,Martin LN,Bozelka BE,Wang N,Gormus BJ

    更新日期:1986-09-15 00:00:00

  • Redundancy of autocrine loops in human osteosarcoma cells.

    abstract::With the aim of identifying innovative therapeutic strategies for osteosarcoma patients who are refractory to conventional chemotherapy, we analyzed the in vitro effects of the blockage of autocrine circuits. Since the insulin-like growth factor-I receptor (IGF-IR)-mediated loop is relevant to the growth of osteosarco...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990209)80:4<581::aid-ijc

    authors: Benini S,Baldini N,Manara MC,Chano T,Serra M,Rizzi S,Lollini PL,Picci P,Scotlandi K

    更新日期:1999-02-09 00:00:00

  • Dissecting the journey to breast cancer diagnosis in sub-Saharan Africa: Findings from the multicountry ABC-DO cohort study.

    abstract::Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.33209

    authors: Foerster M,McKenzie F,Zietsman A,Galukande M,Anele A,Adisa C,Parham G,Pinder L,Schüz J,McCormack V,Dos-Santos-Silva I

    更新日期:2021-01-15 00:00:00

  • Putrescine and spermidine uptake is regulated by proliferation and dexamethasone treatment in AR4-2J cells.

    abstract::Polyamines are essential for cell growth and differentiation. Their specific uptake contributes to the regulation of intracellular polyamine levels. In this study, we describe the modulation of this transport mechanism in a rat tumoral pancreatic acinar cell line (AR4-2J) and analyze the transport system characteristi...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910490418

    authors: Nicolet T,Scemama JL,Pradayrol L,Berthélémy P,Seva C,Vaysse N

    更新日期:1991-10-21 00:00:00

  • Down-regulation of BiP/GRP78 sensitizes resistant prostate cancer cells to gene-therapeutic overexpression of REIC/Dkk-3.

    abstract::We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.24764

    authors: Tanimoto R,Sakaguchi M,Abarzua F,Kataoka K,Kurose K,Murata H,Nasu Y,Kumon H,Huh NH

    更新日期:2010-04-01 00:00:00

  • Evaluation of genetic melanoma vaccines in cdk4-mutant mice provides evidence for immunological tolerance against authochthonous melanomas in the skin.

    abstract::We evaluated the efficacy of a candidate melanoma vaccine approach in mice genetically prone to develop melanoma due to the introduction of an oncogenic mutation (R24C) in the germline sequence of the cyclin-dependent kinase 4 (cdk4), a protein critically involved in cell cycle regulation. Melanomas were induced in cd...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.21349

    authors: Steitz J,Büchs S,Tormo D,Ferrer A,Wenzel J,Huber C,Wölfel T,Barbacid M,Malumbres M,Tüting T

    更新日期:2006-01-15 00:00:00

  • Selective induction of endothelial cell tissue factor in the presence of a tumour-derived mediator: a potential mechanism of flavone acetic acid action in tumour vasculature.

    abstract::Flavone acetic acid (FAA) is a potentially useful anti-tumour agent which has been reported to induce changes in tumour vasculature, in particular loss of bloodflow. This led us to examine whether endothelium could be a cellular target of FAA action, with resultant modulation of cell-surface coagulant properties leadi...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910490219

    authors: Murray JC,Clauss M,Denekamp J,Stern D

    更新日期:1991-09-09 00:00:00

  • Enhanced killing of therapy-induced senescent tumor cells by oncolytic measles vaccine viruses.

    abstract::Therapy-induced senescence (TIS) as a permanent growth arrest can be induced by various stimuli, including anticancer compounds. TIS emerged as a promising strategy to overcome resistance phenomena. However, senescent cancer cells might regain proliferation activity in vivo or even secrete tumor-promoting cytokines. T...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.28350

    authors: Weiland T,Lampe J,Essmann F,Venturelli S,Berger A,Bossow S,Berchtold S,Schulze-Osthoff K,Lauer UM,Bitzer M

    更新日期:2014-01-01 00:00:00

  • Retardation of metastatic tumor growth after immunization with metastasis-specific monoclonal antibodies.

    abstract::The influence of 4 murine monoclonal antibodies (MAbs) directed against surface determinants of a metastasizing rat adenocarcinoma (BSp73ASML) on metastatic spread was evaluated and compared to their in vivo binding as well as to the induction of a humoral anti-MAb response, especially with respect to the development ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910460528

    authors: Reber S,Matzku S,Günthert U,Ponta H,Herrlich P,Zöller M

    更新日期:1990-11-15 00:00:00

  • Examination of POU homeobox gene expression in human breast cancer cells.

    abstract::Abnormal expression of homeobox genes may lead to the development of leukemias, lymphomas, and solid tumors. Expression of homeobox genes in mammary glands, however, has not been studied actively until recently. We have examined the expression of POU homeobox genes in human breast cancer cell lines and human breast ti...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990331)81:1<104::aid-ijc

    authors: Jin T,Branch DR,Zhang X,Qi S,Youngson B,Goss PE

    更新日期:1999-03-31 00:00:00

  • RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.

    abstract::Despite recent advances in targeted and immune-based therapies, advanced stage melanoma remains a clinical challenge with a poor prognosis. Understanding the genes and cellular processes that drive progression and metastasis is critical for identifying new therapeutic strategies. Here, we found that the GTPase RAB27A ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32064

    authors: Guo D,Lui GYL,Lai SL,Wilmott JS,Tikoo S,Jackett LA,Quek C,Brown DL,Sharp DM,Kwan RYQ,Chacon D,Wong JH,Beck D,van Geldermalsen M,Holst J,Thompson JF,Mann GJ,Scolyer RA,Stow JL,Weninger W,Haass NK,Beaumont KA

    更新日期:2019-06-15 00:00:00

  • Risks of second primary malignancy in patients with cutaneous and ocular melanoma in Denmark, 1943-1989.

    abstract::Risks of 2nd primary cancer were assessed in all patients with cutaneous melanoma (12,460) and all patients with ocular melanoma (2,018) incident in Denmark from 1943 to 1989 and followed for totals of 88,667 person-years and 16,045 person-years, respectively. After cutaneous melanoma, 972 2nd cancers occurred. The ri...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910610606

    authors: Swerdlow AJ,Storm HH,Sasieni PD

    更新日期:1995-06-09 00:00:00

  • Folate intake and colorectal cancer risk: a meta-analytical approach.

    abstract::Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,meta分析

    doi:10.1002/ijc.20648

    authors: Sanjoaquin MA,Allen N,Couto E,Roddam AW,Key TJ

    更新日期:2005-02-20 00:00:00

  • Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.

    abstract::The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated association...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.28512

    authors: Zhang C,Sturgis EM,Zheng H,Song X,Wei P,Jin L,Chao L,Wei Q,Li G

    更新日期:2014-04-15 00:00:00

  • Serum concentration of thyroid hormones in abnormal and euthyroid ranges and breast cancer risk: A cohort study.

    abstract::The impact of variations in serum thyroid hormone concentration within the euthyroid range on breast cancer risk remains unclear. We investigated the effect of serum thyrotropin (TSH) and thyroid hormone concentration on breast cancer risk. This cohort study involved 62,546 Korean women, aged ≥40 years, who were free ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.32283

    authors: Kim EY,Chang Y,Lee KH,Yun JS,Park YL,Park CH,Ahn J,Shin H,Ryu S

    更新日期:2019-12-15 00:00:00

  • Testicular cancer in nine northern European countries.

    abstract::The incidence of testicular cancer was examined in the Nordic and Baltic countries, Poland and Germany by collaboration among 10 cancer registries. Population-based registers were used to analyze a total of 34,309 cases, diagnosed from the start of registration (varying from 1943 in Denmark to 1980 in Latvia and Lithu...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910590108

    authors: Adami HO,Bergström R,Möhner M,Zatoński W,Storm H,Ekbom A,Tretli S,Teppo L,Ziegler H,Rahu M

    更新日期:1994-10-01 00:00:00

  • PBX3 is a putative biomarker of aggressive prostate cancer.

    abstract::There is a great need to identify new and better prognostic and predictive biomarkers to stratify prostate cancer patients for optimal treatment. The aims of this study were to characterize the expression profile of pre-B cell leukemia homeobox (PBX) transcription factors in prostate cancer with an emphasis on investi...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30220

    authors: Ramberg H,Grytli HH,Nygård S,Wang W,Ögren O,Zhao S,Løvf M,Katz B,Skotheim RI,Bjartell A,Eri LM,Berge V,Svindland A,Taskén KA

    更新日期:2016-10-15 00:00:00

  • Molecular characteristics and physical state of human papillomavirus DNA change with progressing malignancy: studies in a patient with epidermodysplasia verruciformis.

    abstract::In order to establish the role of human papillomavirus (HPV) in carcinogenesis of epidermodysplasia verruciformis (EV), the presence, the molecular characteristics and the physical state of HPV DNA in a benign lesion, a primary carcinoma and a metastatic carcinoma developing in the same EV patient were studied and com...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910430611

    authors: Yabe Y,Tanimura Y,Sakai A,Hitsumoto T,Nohara N

    更新日期:1989-06-15 00:00:00

  • Deficiency in surface expression of E-selectin ligand promotes lung colonization in a mouse model of breast cancer.

    abstract::Expression of sialyl Lewis(x) (sLe(x)) and sLe(a) on tumor cells is thought to facilitate metastasis by promoting cell adhesion to selectins on vascular endothelial cells. Experiments supporting this concept usually bypass the early steps of the metastatic process by employing tumor cells that are injected directly in...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.21192

    authors: Monzavi-Karbassi B,Whitehead TL,Jousheghany F,Artaud C,Hennings L,Shaaf S,Slaughter A,Korourian S,Kelly T,Blaszczyk-Thurin M,Kieber-Emmons T

    更新日期:2005-11-10 00:00:00

  • IGFBP7 downregulation is associated with tumor progression and clinical outcome in hepatocellular carcinoma.

    abstract::Insulin-like growth factor-binding protein 7 (IGFBP7) functions in several cellular processes including proliferation, senescence and apoptosis. This study analyzed IGFBP7 function in hepatocellular carcinoma (HCC) cells by gene manipulation and investigated the prognostic significance of IGFBP7 expression in clinical...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.25994

    authors: Tomimaru Y,Eguchi H,Wada H,Kobayashi S,Marubashi S,Tanemura M,Umeshita K,Kim T,Wakasa K,Doki Y,Mori M,Nagano H

    更新日期:2012-01-15 00:00:00

  • Real-world, population-based cohort study of toxicity and resource utilization of second-line ipilimumab for metastatic melanoma in Ontario, Canada.

    abstract::Second-line ipilimumab has been publicly funded in Ontario for metastatic melanoma (MM) since September 2012. We examined real-world toxicity of second-line ipilimumab compared to standard second-line treatments prior to funding. MM patients who received systemic treatment from April 2005 to March 2015 were included. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.33357

    authors: Dai WF,Beca J,Croxford R,Isaranuwatchai W,Menjak IB,Petrella TM,Mittmann N,Earle CC,Gavura S,Mercer RE,Hanna TP,Chan KKW

    更新日期:2020-10-26 00:00:00

  • Tamoxifen and toremifene treatment of breast cancer and risk of subsequent endometrial cancer: a population-based case-control study.

    abstract::A population-based case-control study was performed to evaluate the risk of endometrial cancer related to tamoxifen or toremifene treatment. All patients with breast cancer diagnosis since 1980 in Finland who subsequently developed an endometrial cancer by the end of 1995 and 3 matched controls were identified among t...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.10454

    authors: Pukkala E,Kyyrönen P,Sankila R,Holli K

    更新日期:2002-07-20 00:00:00

  • The impact of overdiagnosis on the selection of efficient lung cancer screening strategies.

    abstract::The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low-dose computed tomography (LDCT) for lung cancer (LC) screening through age 80. However, the risk of overdiagnosis among older populations is a concern. Using four comparative models from the C...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.30602

    authors: Han SS,Ten Haaf K,Hazelton WD,Munshi VN,Jeon J,Erdogan SA,Johanson C,McMahon PM,Meza R,Kong CY,Feuer EJ,de Koning HJ,Plevritis SK

    更新日期:2017-06-01 00:00:00

  • Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro.

    abstract::Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(19990301)80:5<764::aid-ijc

    authors: Tonn JC,Kerkau S,Hanke A,Bouterfa H,Mueller JG,Wagner S,Vince GH,Roosen K

    更新日期:1999-03-01 00:00:00

  • Regulation of deleted in liver cancer 1 tumor suppressor by protein-protein interactions and phosphorylation.

    abstract::The deleted in liver cancer 1 (DLC1) tumor suppressor is an important RhoGTP activating protein (RhoGAP) that plays a crucial role in many types of human cancers. Small GTPases regulate normal cellular processes but aberrant expression and activation of GTPases contribute to tumorigenesis. RhoGAP suppresses Rho activi...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审

    doi:10.1002/ijc.28505

    authors: Ko FC,Ping Yam JW

    更新日期:2014-07-15 00:00:00

  • Epigenetic silencing of maspin gene expression in human breast cancers.

    abstract::Maspin is a tumor suppressor whose expression is lost in many advanced breast cancers. Maspin has been shown to inhibit cell motility, invasion and metastasis; however, its precise role in normal mammary epithelium remains to be elucidated. Although expression of maspin mRNA is low or absent in most human breast cance...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0215(20000315)85:6<805::aid-ijc

    authors: Domann FE,Rice JC,Hendrix MJ,Futscher BW

    更新日期:2000-03-15 00:00:00

  • alpha-fetoprotein-containing cells in the early stages of liver carcinogenesis induced by 3'-methyl-4-dimethyl-aminoazobenzene and 2-acetylaminofluorene.

    abstract::The morphology of rat liver cells containing alpha-feto-protein (AFP) during early stages of carcinogenesis induced by 3'methyl-4-dimethylaminoazobenzene and 2-acetylaminofluorene was investigated. Indirect immunofluorescence was used to detect AFP. AFP was not found in the cells of hyperplastic nodules but was presen...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910200310

    authors: Tchipysheva TA,Guelstein VI,Bannikov GA

    更新日期:1977-09-15 00:00:00

  • Promiscuous survivin peptide induces robust CD4+ T-cell responses in the majority of vaccinated cancer patients.

    abstract::CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.26365

    authors: Widenmeyer M,Griesemann H,Stevanović S,Feyerabend S,Klein R,Attig S,Hennenlotter J,Wernet D,Kuprash DV,Sazykin AY,Pascolo S,Stenzl A,Gouttefangeas C,Rammensee HG

    更新日期:2012-07-01 00:00:00

  • Patterns of gastro-intestinal cancer in European migrants to Australia: the role of dietary change.

    abstract::Cancers of the stomach, pancreas, colon and rectum are increasingly regarded as being diet-influenced. Migrants to Australia from England, Scotland, Ireland, Poland, Yugoslavia, Greece, and Italy have come from countries with varied dietary backgrounds and gastrointestinal cancer risks. Age-standardized cancer death r...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.2910250402

    authors: McMichael AJ,McCall MG,Hartshorne JM,Woodings TL

    更新日期:1980-04-15 00:00:00

  • Clonidine, an alpha-2 adrenoceptor agonist relieves mechanical allodynia in oxaliplatin-induced neuropathic mice; potentiation by spinal p38 MAPK inhibition without motor dysfunction and hypotension.

    abstract::Cancer chemotherapy with platinum-based antineoplastic agents including oxaliplatin frequently results in a debilitating and painful peripheral neuropathy. We evaluated the antinociceptive effects of the alpha-2 adrenoceptor agonist, clonidine on oxaliplatin-induced neuropathic pain. Specifically, we determined if (i)...

    journal_title:International journal of cancer

    pub_type: 杂志文章

    doi:10.1002/ijc.29980

    authors: Yeo JH,Yoon SY,Kim SJ,Oh SB,Lee JH,Beitz AJ,Roh DH

    更新日期:2016-05-15 00:00:00