Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas.


:The karyotypes of cells from 10 Burkitt lymphoma (BL) biopsies, eight cell lines established from BL and nine cell lines from non-BL sources were studied by chromosome banding techniques. With the exception of the BL-derived cell lines BJAB, GC-BJAB, Maku and U-8691 all biopsies and lines of Burkitt origin contained an extra band at the distal region of the long arm of one chromosome 14. An extra band on chromosome 14 was also found in cells of one non-BL biopsy, in cells from a lymphosarcoma-derived cell line and in a long-established cell line derived from the pleural exudate of a patient with Hodgkin's disease. A distal region at the long arm of one chromosome 8 was missing in all metaphase figures of good technical quality in the same material. The size, morphology and stain-ability of the missing region corresponded fairly well to the extra region at chromosome 14. We therefore suggest that the chromosome 14 marker represents a translocation between chromosomes 8 and 14,t (8q-; 14q+). The translocation was present neither in lymphocytes of the peripheral blood of five Burkitt patients nor in five lymphoblastoid cell lines of non-BL origin. Trisomy 7 was found in two of the 10 BL biopsies, in two BL-derived cell lines, in one non-BL biopsy, in two lymphosarcoma-derived cell lines and in one cell line derived from a patient with Hodgkin's disease.


Int J Cancer


Zech L,Haglund U,Nilsson K,Klein G




Has Abstract


1976-01-15 00:00:00












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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rangan SR,Martin LN,Bozelka BE,Wang N,Gormus BJ

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  • Redundancy of autocrine loops in human osteosarcoma cells.

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    authors: Benini S,Baldini N,Manara MC,Chano T,Serra M,Rizzi S,Lollini PL,Picci P,Scotlandi K

    更新日期:1999-02-09 00:00:00

  • Dissecting the journey to breast cancer diagnosis in sub-Saharan Africa: Findings from the multicountry ABC-DO cohort study.

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Foerster M,McKenzie F,Zietsman A,Galukande M,Anele A,Adisa C,Parham G,Pinder L,Schüz J,McCormack V,Dos-Santos-Silva I

    更新日期:2021-01-15 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nicolet T,Scemama JL,Pradayrol L,Berthélémy P,Seva C,Vaysse N

    更新日期:1991-10-21 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Murray JC,Clauss M,Denekamp J,Stern D

    更新日期:1991-09-09 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Weiland T,Lampe J,Essmann F,Venturelli S,Berger A,Bossow S,Berchtold S,Schulze-Osthoff K,Lauer UM,Bitzer M

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    journal_title:International journal of cancer

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    authors: Reber S,Matzku S,Günthert U,Ponta H,Herrlich P,Zöller M

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    journal_title:International journal of cancer

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    authors: Jin T,Branch DR,Zhang X,Qi S,Youngson B,Goss PE

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  • RAB27A promotes melanoma cell invasion and metastasis via regulation of pro-invasive exosomes.

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    authors: Guo D,Lui GYL,Lai SL,Wilmott JS,Tikoo S,Jackett LA,Quek C,Brown DL,Sharp DM,Kwan RYQ,Chacon D,Wong JH,Beck D,van Geldermalsen M,Holst J,Thompson JF,Mann GJ,Scolyer RA,Stow JL,Weninger W,Haass NK,Beaumont KA

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    authors: Swerdlow AJ,Storm HH,Sasieni PD

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    pub_type: 杂志文章,meta分析


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    authors: Adami HO,Bergström R,Möhner M,Zatoński W,Storm H,Ekbom A,Tretli S,Teppo L,Ziegler H,Rahu M

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    authors: Ramberg H,Grytli HH,Nygård S,Wang W,Ögren O,Zhao S,Løvf M,Katz B,Skotheim RI,Bjartell A,Eri LM,Berge V,Svindland A,Taskén KA

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    journal_title:International journal of cancer

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    journal_title:International journal of cancer

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    authors: Han SS,Ten Haaf K,Hazelton WD,Munshi VN,Jeon J,Erdogan SA,Johanson C,McMahon PM,Meza R,Kong CY,Feuer EJ,de Koning HJ,Plevritis SK

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    journal_title:International journal of cancer

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Domann FE,Rice JC,Hendrix MJ,Futscher BW

    更新日期:2000-03-15 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tchipysheva TA,Guelstein VI,Bannikov GA

    更新日期:1977-09-15 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McMichael AJ,McCall MG,Hartshorne JM,Woodings TL

    更新日期:1980-04-15 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yeo JH,Yoon SY,Kim SJ,Oh SB,Lee JH,Beitz AJ,Roh DH

    更新日期:2016-05-15 00:00:00