Characteristic chromosomal abnormalities in biopsies and lymphoid-cell lines from patients with Burkitt and non-Burkitt lymphomas.

abstract：:Established cell lines derived from human malignant astrocytomas typically express a combination of platelet-derived growth factor (PDGF) and PDGF receptor which could form an autocrine loop. In this study, we screened for the essential components of a PDGF autocrine loop in fresh surgical isolates of human astrocytom...

journal_title：International journal of cancer

authors： Guha A,Dashner K,Black PM,Wagner JA,Stiles CD

更新日期：1995-01-17 00:00:00

abstract：:Immunohistochemical and/or indirect immunofluorescence analysis with monoclonal antibody (MAb) H19 demonstrated the expression of protectin (CD59) in 54 surgically removed metastatic melanoma lesions and on 8 out of 12 melanoma cell lines. CD59 expression had a low degree of intra- and intertumor heterogeneity. SDS-PA...

journal_title：International journal of cancer

authors： Brasoveanu LI,Altomonte M,Gloghini A,Fonsatti E,Coral S,Gasparollo A,Montagner R,Cattarossi I,Simonelli C,Cattelan A

更新日期：1995-05-16 00:00:00

abstract：:Using radioiodinated Staphylococcus aureus protein A [125I]SPA to measure syngeneic, allogeneic and heterogeneic IgG bound to murine tumor cells, we performed a serological analysis of surface antigens of 8 solid tumors and 2 leukemias of BALB/c mice (3 chemically-induced colon carcinomas, 3 chemically-induced sarcoma...

journal_title：International journal of cancer

authors： Cleveland PH,Belnap LP,Knotts FB,Nayak SK,Baird SM,Pilch YH

更新日期：1979-03-15 00:00:00

abstract：:Thermal injury resulting from drinking very hot beverages has been incriminated as a risk factor for oesophageal cancer, although no information is available on the lesions caused by this injury in human or experimental animals. The drinking of hot maté tea is very common in areas of moderately high incidence of oesop...

journal_title：International journal of cancer

authors： Muñoz N,Victora CG,Crespi M,Saul C,Braga NM,Correa P

更新日期：1987-06-15 00:00:00

abstract：:Apc gene-deficient Min and Apc(1309) mice feature a hyperlipidemic state with a markedly low expression level of lipoprotein lipase (LPL) compared to their wild-type counterparts. We previously showed that induction of LPL mRNA by peroxisome proliferator-activated receptor (PPAR) alpha and gamma agonists or an LPL sel...

journal_title：International journal of cancer

authors： Niho N,Mutoh M,Komiya M,Ohta T,Sugimura T,Wakabayashi K

更新日期：2007-10-15 00:00:00

abstract：:Chronic gastritis caused by Helicobacter pylori (H. pylori) infection could lead to the development of gastric cancer. The finding that multiple gastric cancers can develop synchronously and/or metachronously suggests the development of field cancerization in chronically inflamed, H. pylori-infected gastric mucosa. Th...

journal_title：International journal of cancer

authors： Mizuguchi A,Takai A,Shimizu T,Matsumoto T,Kumagai K,Miyamoto S,Seno H,Marusawa H

更新日期：2018-10-15 00:00:00

abstract：:Specific estrogen, progesterone and androgen receptors were determined in 19 well-characterized squamous-cell carcinoma (SCC) cell lines. Ten of the lines were derived from patients with SCC of the larynx and nine were from patients with SCC originating in other areas of the head and neck. Estrogen receptors (ER) were...

journal_title：International journal of cancer

authors： Virolainen E,Vanharanta R,Carey TE

更新日期：1984-01-15 00:00:00

abstract：:Wilms' tumor development, like most tumors, involves multiple genetic alterations affecting diverse genes. Only one of these has thus far been identified, the Wilms' tumor 1 (WT1) gene on 11p13, which functions as a tumor suppressor gene. We assessed the involvement of the WT1 gene constitutionally and somatically in ...

journal_title：International journal of cancer

authors： Nordenskjöld A,Friedman E,Sandstedt B,Söderhäll S,Anvret M

更新日期：1995-11-15 00:00:00

abstract：:To monitor recent trends in oral and pharyngeal cancer mortality in 38 European countries, we analyzed data provided by the World Health Organization over the period 1975-2004. Joinpoint analysis was used to identify significant changes in trends. In the European Union (EU), male mortality rates rose by 2.1% per year ...

journal_title：International journal of cancer

authors： Garavello W,Bertuccio P,Levi F,Lucchini F,Bosetti C,Malvezzi M,Negri E,La Vecchia C

更新日期：2010-07-01 00:00:00

abstract：:Osteolytic bone diseases are a prominent feature of multiple myeloma (MM), resulting from aberrant osteoclastic bone resorption that is uncoupled from osteoblastic bone formation. Myeloma stimulates osteoclastogenesis, which is largely dependent on an increase in receptor activator of NF-κB ligand (RANKL) and a decrea...

journal_title：International journal of cancer

authors： Ai LS,Sun CY,Wang YD,Zhang L,Chu ZB,Qin Y,Gao F,Yan H,Guo T,Chen L,Yang D,Hu Y

更新日期：2013-09-01 00:00:00

abstract：:Several observational epidemiological studies have reported inconsistent results on the association between the use of benzodiazepine and the risk of cancer. We investigated the association by using a meta-analysis. We searched PubMed, EMBASE, and the bibliographies of relevant articles to locate additional publicatio...

journal_title：International journal of cancer

authors： Kim HB,Myung SK,Park YC,Park B

更新日期：2017-02-01 00:00:00

abstract：:Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 microm UCF1-C immediately and reversibly inhibited growth in these cells, without modifyin...

journal_title：International journal of cancer

authors： Servais P,Gulbis B,Fokan D,Galand P

更新日期：1998-05-18 00:00:00

abstract：:MicroRNA (miRNA) expression is frequently altered in human cancers. To search for epigenetically silenced miRNAs in non-small-cell lung cancer (NSCLC), we mapped human miRNAs on autosomal chromosomes and selected 55 miRNAs in silico. We treated six NSCLC cell lines with the DNA methylation inhibitor 5-aza-2'-deoxycyti...

journal_title：International journal of cancer

authors： Watanabe K,Emoto N,Hamano E,Sunohara M,Kawakami M,Kage H,Kitano K,Nakajima J,Goto A,Fukayama M,Nagase T,Yatomi Y,Ohishi N,Takai D

更新日期：2012-06-01 00:00:00

abstract：:The modifying effects of a Kunitz trypsin inhibitor (KTI) and a Bowman-Birk trypsin inhibitor (BBI), purified from soybean trypsin inhibitor, as dietary supplements on experimental and spontaneous pulmonary metastasis of murine Lewis lung carcinoma 3LL cells as well as peritoneal disseminated metastasis model in human...

journal_title：International journal of cancer

authors： Kobayashi H,Fukuda Y,Yoshida R,Kanada Y,Nishiyama S,Suzuki M,Kanayama N,Terao T

更新日期：2004-11-10 00:00:00

abstract：:Identification of loss of heterozygosity on specific genetic loci is crucial for understanding the pathogenesis of prostate cancer at the molecular level. This is especially important because the deleted regions may contain putative tumor suppressor genes. Chromosome 3p loss appears to be frequently associated with va...

journal_title：International journal of cancer

authors： Dahiya R,McCarville J,Hu W,Lee C,Chui RM,Kaur G,Deng G

更新日期：1997-03-28 00:00:00

abstract：:The UBE1L gene isolated from the chromosome 3p21 region has an extremely reduced level of mRNA in lung cancer. Sequence analysis showed a 45% homology to the human ubiquitin-activating enzyme E1 at the amino acid level. To further characterize the protein product, we generated UBE1L protein-specific antibodies. Immuno...

journal_title：International journal of cancer

authors： McLaughlin PM,Helfrich W,Kok K,Mulder M,Hu SW,Brinker MG,Ruiters MH,de Leij LF,Buys CH

更新日期：2000-03-15 00:00:00

abstract：:NDRG3 belongs to the N-myc down-regulated gene (NDRG) family that contains 4 paralogs: NDRG1, -2, -3 and -4. The function of NDRG3 and its relationship to cancer has not been studied. We herein report our examination of the expression and biological roles of NDRG3 in prostate cancers. We showed that NDRG3 expression i...

journal_title：International journal of cancer

authors： Wang W,Li Y,Li Y,Hong A,Wang J,Lin B,Li R

更新日期：2009-02-01 00:00:00

abstract：:Sera from 526 Old-World monkeys and apes, representing 50 species and 20 genera and living in US zoos and vivaria, were screened for antibodies to HTLV-I, HTLV-III/LAV, and simian-AIDS retrovirus, type I (SRV-I). Sera were screened initially by ELISA, and ELISA-positive sera, as well as ELISA-negative sera from cage c...

journal_title：International journal of cancer

authors： Lowenstine LJ,Pedersen NC,Higgins J,Pallis KC,Uyeda A,Marx P,Lerche NW,Munn RJ,Gardner MB

更新日期：1986-10-15 00:00:00

abstract：:The ability of verapamil to overcome resistance to adriamycin in a multidrug-resistant derivative of the V79 cell line (LZ), grown as multicellular spheroids or as monolayers, was examined. Verapamil was much less effective in overcoming resistance to adriamycin in spheroids than in monolayers. Verapamil increased the...

journal_title：International journal of cancer

authors： Sakata K,Kwok TT,Gordon GR,Waleh NS,Sutherland RM

更新日期：1994-10-15 00:00:00

abstract：:A correlation analysis was performed on 125 cytogenetically characterized breast cancer cases to assess the relationship between the tumor karyotype and clinicopathologic features. The carcinomas of young women had a higher modal chromosome number than those of older women. The number of chromosomal aberrations and mo...

journal_title：International journal of cancer

authors： Pandis N,Idvall I,Bardi G,Jin Y,Gorunova L,Mertens F,Olsson H,Ingvar C,Beroukas K,Mitelman F,Heim S

更新日期：1996-04-10 00:00:00

abstract：:In recent years, Akt signaling has gained recognition for its functional role in more aggressive, therapy-resistant malignancies. As it is frequently constitutively active in cancer cells, several drugs are being investigated for their ability to inhibit Akt signaling. The purpose of this study is to determine effect ...

journal_title：International journal of cancer

authors： Srinivasan S,Koduru S,Kumar R,Venguswamy G,Kyprianou N,Damodaran C

更新日期：2009-08-15 00:00:00

abstract：:Gliomas are the most common tumors of the central nervous system and have a grave prognosis. Deletion of chromosome 10p15 is one of the most common chromosomal alterations in gliomas. Recently, a candidate tumor suppressor gene, KLF6, which is mapped to chromosome 10p, was found to be frequently mutated in prostate ca...

journal_title：International journal of cancer

authors： Jeng YM,Hsu HC

更新日期：2003-07-10 00:00:00

abstract：:Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...

journal_title：International journal of cancer

authors： Tonn JC,Kerkau S,Hanke A,Bouterfa H,Mueller JG,Wagner S,Vince GH,Roosen K

更新日期：1999-03-01 00:00:00

abstract：:NY-ESO-1 antigen is a prototype of a class of cancer/testis antigens. We carried out a clinical trial using NY-ESO-1 whole protein as a cancer vaccine for 13 advanced cancer patients. We have recently reported that vaccine elicited humoral and cellular immune responses in 9 cancer patients including 4 esophageal cance...

journal_title：International journal of cancer

authors： Wada H,Sato E,Uenaka A,Isobe M,Kawabata R,Nakamura Y,Iwae S,Yonezawa K,Yamasaki M,Miyata H,Doki Y,Shiku H,Jungbluth AA,Ritter G,Murphy R,Hoffman EW,Old LJ,Monden M,Nakayama E

更新日期：2008-11-15 00:00:00

abstract：:IL-15 is an immunostimulatory cytokine with IL-2-like activities. To exploit the potential role of IL-15 in cancer immuno-/gene therapy, we engineered murine TS/A cells with different IL-15 cDNA constructs. Significant IL-15 secretion was achieved only by the use of a modified cDNA encoding for an IL-15 pre-protein be...

journal_title：International journal of cancer

authors： Meazza R,Lollini PL,Nanni P,De Giovanni C,Gaggero A,Comes A,Cilli M,Di Carlo E,Ferrini S,Musiani P

更新日期：2000-08-15 00:00:00

abstract：:A large genotyping project within the Breast Cancer Association Consortium (BCAC) recently identified 41 associations between single nucleotide polymorphisms (SNPs) and overall breast cancer (BC) risk. We investigated whether the effects of these 41 SNPs, as well as six SNPs associated with estrogen receptor (ER) nega...

journal_title：International journal of cancer

authors： Rudolph A,Milne RL,Truong T,Knight JA,Seibold P,Flesch-Janys D,Behrens S,Eilber U,Bolla MK,Wang Q,Dennis J,Dunning AM,Shah M,Munday HR,Darabi H,Eriksson M,Brand JS,Olson J,Vachon CM,Hallberg E,Castelao JE,Carrac

更新日期：2015-03-15 00:00:00

abstract：:The p16INK4 gene is a candidate tumour-suppressor gene which maps to the genomic locus 9p21, and mutations of this gene are associated with melanoma and other cancers. Biochemical studies suggest that p16INK4 mediates its effects by specifically inhibiting the G1 cyclin-dependent kinases CDK4 and CDK6, thereby regulat...

journal_title：International journal of cancer

authors： Lilischkis R,Sarcevic B,Kennedy C,Warlters A,Sutherland RL

更新日期：1996-04-10 00:00:00

abstract：:The major goal in cancer immunotherapy is the induction of tumor-specific T lymphocytes capable of killing tumor cells. As both dendritic cells (DCs) and interleukin-12 (IL-12) can play immunostimulatory roles in vivo, the use of a combination of these has become a promising approach. In the present study, we used a m...

journal_title：International journal of cancer

authors： Furumoto K,Arii S,Yamasaki S,Mizumoto M,Mori A,Inoue N,Isobe N,Imamura M

更新日期：2000-09-01 00:00:00

abstract：:Loss of imprinting (LOI) of insulin-like growth factor 2 (IGF2) is a common event in many cancers and typically activates the maternally silenced allele. The resulting biallelic IGF2 expression correlates strongly with the hypomethylation of a differentially methylated region (DMR) near its promoter. It has also been ...

journal_title：International journal of cancer

authors： Cheng YW,Idrees K,Shattock R,Khan SA,Zeng Z,Brennan CW,Paty P,Barany F

更新日期：2010-08-01 00:00:00

abstract：:Polyclonal and monoclonal antibodies were used to characterize human milk fat globule (HMFG) membrane antigens, using gel filtration, ion exchange chromatography and western blotting. Although originally generated against HMFG, monoclonal antibodies also reacted with skim milk. In western blotting, several antigen mol...

journal_title：International journal of cancer

authors： Ashorn P,Krohn K

更新日期：1985-02-15 00:00:00