Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development.

abstract：:The human HBL-100 cell line harbours SV40 DNA integrated in tandem at a unique site. The SV40 T-antigen expressed in these cells is defective in a function essential to the replication of the viral genome. The integrated SV40 sequences were molecularly cloned in a bacteriophage, and a subclone (plasmid pSVHBI) contain...

journal_title：International journal of cancer

authors： Saint-Ruf C,Nardeux P,Cebrian J,Lacasa M,Lavialle C,Cassingena R

更新日期：1989-08-15 00:00:00

abstract：:The development of reliable gene expression profiling technology is having an increasing impact on our understanding of lung cancer biology. Our study aimed to determine any correlation between the phenotypic heterogeneity and genetic diversity of lung cancer. Microarray analysis was performed on a set of 46 tumor sam...

journal_title：International journal of cancer

authors： Sanchez-Palencia A,Gomez-Morales M,Gomez-Capilla JA,Pedraza V,Boyero L,Rosell R,Fárez-Vidal ME

更新日期：2011-07-15 00:00:00

abstract：:The ability of verapamil to overcome resistance to adriamycin in a multidrug-resistant derivative of the V79 cell line (LZ), grown as multicellular spheroids or as monolayers, was examined. Verapamil was much less effective in overcoming resistance to adriamycin in spheroids than in monolayers. Verapamil increased the...

journal_title：International journal of cancer

authors： Sakata K,Kwok TT,Gordon GR,Waleh NS,Sutherland RM

更新日期：1994-10-15 00:00:00

abstract：:Comparisons of patients receiving different cancer treatments reflect the effects of both treatment and patient selection. In breast cancer, however, if radiotherapy decisions are unrelated to laterality, comparisons of left-sided and right-sided cancers can demonstrate the causal effects of higher-versus-lower cardia...

journal_title：International journal of cancer

authors： Henson KE,McGale P,Darby SC,Parkin M,Wang Y,Taylor CW

更新日期：2020-09-01 00:00:00

abstract：:Neuroblastoma (NBL), one of the most common childhood solid tumors, has a distinct nature in different prognostic subgroups. However, the precise mechanism underlying this phenomenon remains largely unknown. To understand the molecular and genetic bases of neuroblastoma, we have generated its cDNA libraries and identi...

journal_title：International journal of cancer

authors： Kato C,Miyazaki K,Nakagawa A,Ohira M,Nakamura Y,Ozaki T,Imai T,Nakagawara A

更新日期：2004-11-10 00:00:00

abstract：:In our previous study on hepatocellular carcinoma (HCC) susceptibility genes in chronic hepatitis patients, we identified the MHC class I polypeptide-related sequence A (MICA). Natural killer cells eliminate various cancer cells, including HCC, by suppressing MICA shedding. Therefore, we investigated MICA sheddases an...

journal_title：International journal of cancer

authors： Arai J,Goto K,Tanoue Y,Ito S,Muroyama R,Matsubara Y,Nakagawa R,Kaise Y,Lim LA,Yoshida H,Kato N

更新日期：2018-11-15 00:00:00

abstract：:Tonsillar squamous cell carcinoma (TSCC) is frequently associated with human papillomavirus (HPV) and chromosome instability. Data from cellular model systems are, however, controversial concerning a relation between HPV and chromosome instability development. Here we studied this association in 77 primary TSCC with k...

journal_title：International journal of cancer

authors： Mooren JJ,Kremer B,Claessen SM,Voogd AC,Bot FJ,Peter Klussmann J,Huebbers CU,Hopman AH,Ramaekers FC,Speel EJ

更新日期：2013-04-15 00:00:00

abstract：:Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...

journal_title：International journal of cancer

authors： Cui Y,Whiteman MK,Flaws JA,Langenberg P,Tkaczuk KH,Bush TL

更新日期：2002-03-10 00:00:00

abstract：:Oligodeoxynucleotides containing CpG motifs (CpG-ODN) display broad immunostimulating activity and are currently under clinical trial in various malignancies, including recurrent glioblastomas. Combining CpG-ODN with another therapy that could induce antigen release might enhance tumor-specific immune response. We inv...

journal_title：International journal of cancer

authors： Meng Y,Carpentier AF,Chen L,Boisserie G,Simon JM,Mazeron JJ,Delattre JY

更新日期：2005-10-10 00:00:00

abstract：:In light of recent, strong inverse findings between lifetime red wine consumption and prostate cancer among younger men, we revisited our previous cohort analysis to more thoroughly investigate red wine consumption and prostate cancer in the Health Professionals Follow-up Study (HPFS). In 1986, HPFS participants repor...

journal_title：International journal of cancer

authors： Sutcliffe S,Giovannucci E,Leitzmann MF,Rimm EB,Stampfer MJ,Willett WC,Platz EA

更新日期：2007-04-01 00:00:00

abstract：:In order to target NK cells against the Hodgkin's-derived cell line L540, we developed bispecific monoclonal antibodies (Bi-MAbs) by somatic hybridization of the 2 mouse hybridoma cell line HRS-3 and A9 which produce monoclonal antibodies (MAbs) with reactivity against the Hodgkin and Reed-Sternberg cell-associated CD...

journal_title：International journal of cancer

authors： Hombach A,Jung W,Pohl C,Renner C,Sahin U,Schmits R,Wolf J,Kapp U,Diehl V,Pfreundschuh M

更新日期：1993-11-11 00:00:00

abstract：:To better understand the molecular basis of radiation-induced osteosarcoma (OS), we performed global gene expression profiling of rat OS tumors induced by the bone-seeking alpha emitter (238)Pu, and the expression profiles were compared with those of normal osteoblasts (OB). The expressions of 72 genes were significan...

journal_title：International journal of cancer

authors： Daino K,Ugolin N,Altmeyer-Morel S,Guilly MN,Chevillard S

更新日期：2009-08-01 00:00:00

abstract：:Paclitaxel exerts its cytotoxic effect by kinetic suppression of microtubules that block cells in the G2/M phase of the cell cycle and trigger apoptosis. To investigate apoptosis induced by paclitaxel in nasopharyngeal carcinoma (NPC), and its possible molecular mechanism of action, the human NPC cell lines HNE-1 (bea...

journal_title：International journal of cancer

authors： Tan G,Heqing L,Jiangbo C,Ming J,Yanhong M,Xianghe L,Hong S,Li G

更新日期：2002-01-10 00:00:00

abstract：:The presence of androgen receptor variant 7 (AR-V7) variants becomes a significant hallmark of castration-resistant prostate cancer (CRPC) relapsed from hormonal therapy and is associated with poor survival of CRPC patients because of lacking a ligand-binding domain. Currently, it still lacks an effective agent to tar...

journal_title：International journal of cancer

authors： Wang B,Lo UG,Wu K,Kapur P,Liu X,Huang J,Chen W,Hernandez E,Santoyo J,Ma SH,Pong RC,He D,Cheng YQ,Hsieh JT

更新日期：2017-11-15 00:00:00

abstract：:Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC versus SDC among screened women...

journal_title：International journal of cancer

authors： Strand F,Humphreys K,Eriksson M,Li J,Andersson TM,Törnberg S,Azavedo E,Shepherd J,Hall P,Czene K

更新日期：2017-01-01 00:00:00

abstract：:Several lines of evidence have demonstrated that IFNs could be relevant in the treatment of certain neoplastic diseases such as carcinomas. In particular, IFN-alpha, in addition to the anti-proliferative and cytostatic effects, was demonstrated to be capable of inducing cell death by apoptosis both in vivo and in vitr...

journal_title：International journal of cancer

authors： Matarrese P,Giandomenico V,Fiorucci G,Rivabene R,Straface E,Romeo G,Affabris E,Malorni W

更新日期：1998-05-18 00:00:00

abstract：:Alterations of gene expression in squamous cell carcinoma (SCC) cell lines derived from the larynx and keratinocytes derived from adjacent normal mucosa of the larynx have been studied using the mRNA differential display technique. Lane-to-lane comparison of reverse transcribed mRNA showed a strong repression of a 148...

journal_title：International journal of cancer

authors： Görögh T,Rudert H,Lippert BM,Gottschlich S,Maune S,Heidorn K,Maass J,Hoffmann M,Meyer JE,Rathcke IO,Folz BJ,Hortobagyi T,Werner JA

更新日期：1999-12-10 00:00:00

abstract：:Normal transcription displays a high degree of flexibility over the choice, timing and magnitude of mRNA expression levels that tend to oscillate and cycle. These processes allow for combinatorial actions, feedback control and fine-tuning. A central role has emerged for the transcriptional co-repressor proteins such a...

journal_title：International journal of cancer

authors： Battaglia S,Maguire O,Campbell MJ

更新日期：2010-06-01 00:00:00

abstract：:Although some authorities consider smoking to be an established risk factor for colorectal cancer, the international literature is not entirely consistent. Further, only 1 study has addressed the association with smokeless tobacco and none with Scandinavian moist snuff (snus). This retrospective cohort study included ...

journal_title：International journal of cancer

authors： Nordenvall C,Nilsson PJ,Ye W,Nyrén O

更新日期：2011-01-01 00:00:00

abstract：:Carcinoma-associated fibroblasts (CAFs) play a key onco-supportive role during prostate cancer (PCa) development and progression. We previously reported that the reactive oxygen species (ROS)-producing enzyme NADPH oxidase 4 (Nox4) is essential for TGFβ1-mediated activation of primary prostate human fibroblasts to a C...

journal_title：International journal of cancer

authors： Sampson N,Brunner E,Weber A,Puhr M,Schäfer G,Szyndralewiez C,Klocker H

更新日期：2018-07-15 00:00:00

abstract：:Ras expression induces increased expression and altered targeting of lysosomal proteases in multiple cell types, but the specific downstream cytoplasmic signaling pathways mediating these changes have not been identified. In this study, we compared the involvement of 3 major Ras effectors, Raf, phosphatidylinositol 3-...

journal_title：International journal of cancer

authors： Collette J,Ulku AS,Der CJ,Jones A,Erickson AH

更新日期：2004-11-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma is among the top 10 causes of death from cancer in industrialized countries. In comparison with other gastrointestinal malignancies, pancreatic cancer is one of the tumors most resistant to chemotherapy. An important mechanism of tumor multidrug resistance is increased drug efflux medi...

journal_title：International journal of cancer

authors： König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D

更新日期：2005-06-20 00:00:00

abstract：:It has become axiomatic that critical windows of susceptibility to genotoxins exist and that genetic damage in utero may be a trigger for later life cancers. Data supporting this critical window hypothesis are remarkably few. This study provides a quantitative bridge between DNA damage by the liver carcinogen aflatoxi...

journal_title：International journal of cancer

authors： Chawanthayatham S,Thiantanawat A,Egner PA,Groopman JD,Wogan GN,Croy RG,Essigmann JM

更新日期：2015-03-15 00:00:00

abstract：:Improved biomarkers for prostate cancer (PC) risk stratification are urgently needed. Here, we aimed to develop a novel multimarker model for prediction of biochemical recurrence (BCR) after curatively intended radical prostatectomy (RP), based on minimally invasive sampling of blood and urine. We initially measured t...

journal_title：International journal of cancer

authors： Fredsøe J,Rasmussen AKI,Mouritzen P,Borre M,Ørntoft T,Sørensen KD

更新日期：2019-11-01 00:00:00

abstract：:Our previous studies demonstrate that introduction of a approximately 70 cM region (now estimated at 63.75 Mb by the Human Genome Project) of human chromosome 12 into the highly metastatic Dunning rat prostate cancer cell line AT6.1 results in >30-fold (>/=90%) reduction in the number of overt metastases in spontaneou...

journal_title：International journal of cancer

authors： Jaeger EB,Chekmareva MA,Tennant TR,Luu HH,Hickson JA,Chen SL,Samant RS,Sokoloff MH,Rinker-Schaeffer CW

更新日期：2004-01-01 00:00:00

abstract：:The authors analyzed the HER2 status in early-stage nonrecurrent and recurrent breast cancer groups following breast-conserving treatment. Retrospective analyses of a group of 36 invasive early breast cancer (IBC) patients who developed a local recurrence as a first event and of a random control group of 69 IBC patien...

journal_title：International journal of cancer

authors： López-Guerrero JA,Llombart-Cussac A,Noguera R,Navarro S,Pellin A,Almenar S,Vazquez-Alvadalejo C,Llombart-Bosch A

更新日期：2006-04-01 00:00:00

abstract：:Childhood cancers (age at diagnosis: 0-14 years) comprise a variety of malignancies, with incidence varying worldwide by age, sex, ethnicity and geography, that provide insights into cancer etiology. A total of 1,334 childhood cancers registered in population-based cancer registry, Chennai, India, during 1990-2001 and...

journal_title：International journal of cancer

authors： Swaminathan R,Rama R,Shanta V

更新日期：2008-06-01 00:00:00

abstract：:Small-cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often correlated with poor pro...

journal_title：International journal of cancer

authors： Van Waardenburg RC,Meijer C,Burger H,Nooter K,De Vries EG,Mulder NH,De Jong S

更新日期：1997-11-14 00:00:00

abstract：:Results of epidemiologic studies of physical activity and ovarian cancer risk are inconsistent. Few have attempted to measure physical activity over the lifetime or in specific age windows, which may better capture etiologically relevant exposures. We examined participation in moderate-to-vigorous recreational physica...

journal_title：International journal of cancer

authors： Grundy A,Ho V,Abrahamowicz M,Parent MÉ,Siemiatycki J,Arseneau J,Gilbert L,Gotlieb WH,Provencher DM,Koushik A

更新日期：2020-04-01 00:00:00

abstract：:A simple and rapid variant of in situ hybridization on tissue sections (histo-blotting) usable for detection of specific RNA distribution among tissues is proposed. Tissue sections prepared with a cryostatic microtome are placed on nitrocellulose and these "histo-blots" are hybridized with labelled DNA or RNA probes u...

journal_title：International journal of cancer

authors： Gudkov AV,Kashkin KN,Zaitsevskaya TE,Troyanovsky SM

更新日期：1989-12-15 00:00:00