Effects of an inducible anti-sense c-myc gene transfer in a drug-resistant human small-cell-lung-carcinoma cell line.

abstract：:Our previous studies demonstrate that introduction of a approximately 70 cM region (now estimated at 63.75 Mb by the Human Genome Project) of human chromosome 12 into the highly metastatic Dunning rat prostate cancer cell line AT6.1 results in >30-fold (>/=90%) reduction in the number of overt metastases in spontaneou...

journal_title：International journal of cancer

authors： Jaeger EB,Chekmareva MA,Tennant TR,Luu HH,Hickson JA,Chen SL,Samant RS,Sokoloff MH,Rinker-Schaeffer CW

更新日期：2004-01-01 00:00:00

abstract：:Gliomas are the most common tumors of the central nervous system and have a grave prognosis. Deletion of chromosome 10p15 is one of the most common chromosomal alterations in gliomas. Recently, a candidate tumor suppressor gene, KLF6, which is mapped to chromosome 10p, was found to be frequently mutated in prostate ca...

journal_title：International journal of cancer

authors： Jeng YM,Hsu HC

更新日期：2003-07-10 00:00:00

abstract：:Mesothelin is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed on the cell surface of mesothelioma, ovarian cancer and other malignant tumors. The interaction between mesothelin and CA125 (also called MUC16) may facilitate the implantation and metastasis of tumors in the peritoneal cavity....

journal_title：International journal of cancer

authors： Ho M,Feng M,Fisher RJ,Rader C,Pastan I

更新日期：2011-05-01 00:00:00

abstract：:C57BL/6J mice immunized with devitalized Ehrlich tumor (ET) cells produce high serum levels of IgM antibodies to ET cell-surface carbohydrates that are critical in the observed resistance against this tumor. However, this response is not found in ET-bearing mice at any stage of tumor development. Since previous studie...

journal_title：International journal of cancer

authors： Viñuela JE,Rodriguez R,Gil J,Coll J,De la Concha EG,Subiza JL

更新日期：1991-01-02 00:00:00

abstract：:Leukoplakia is an asymptomatic, potentially malignant change in the oral mucosa. Previous studies have reported that smoking and betel quid chewing are associated with increased risk of leukoplakia; few studies have reported on these associations in populations where betel quid does not contain tobacco. We conducted a...

journal_title：International journal of cancer

authors： Thomas SJ,Harris R,Ness AR,Taulo J,Maclennan R,Howes N,Bain CJ

更新日期：2008-10-15 00:00:00

abstract：:Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic...

journal_title：International journal of cancer

authors： Huberman E,Bartsch H,Sachs L

更新日期：1975-10-15 00:00:00

abstract：:AKT/PKB is a central signaling molecule related to stimulation of cell proliferation and inhibition of apoptosis. Perturbations of AKT expression and function play an important role in tumor development and progression. We wanted to determine (a) whether AKT is overexpressed in human prostatic tumors, (b) whether AKT ...

journal_title：International journal of cancer

authors： Liao Y,Grobholz R,Abel U,Trojan L,Michel MS,Angel P,Mayer D

更新日期：2003-11-20 00:00:00

abstract：:Due to the large scale use of asbestos (more than 3.5 million tons produced or imported until its definitive banning in 1992), a specific national surveillance system of mesothelioma incident cases is active in Italy, with direct and individual anamnestic etiological investigation. In the period between 1993 and 2004,...

journal_title：International journal of cancer

authors： Marinaccio A,Binazzi A,Marzio DD,Scarselli A,Verardo M,Mirabelli D,Gennaro V,Mensi C,Riboldi L,Merler E,Zotti RD,Romanelli A,Chellini E,Silvestri S,Pascucci C,Romeo E,Menegozzo S,Musti M,Cavone D,Cauzillo G,Tumino

更新日期：2012-05-01 00:00:00

abstract：:Viruses that replicate selectively in cancer cells hold considerable promise as novel therapeutic agents for the treatment of malignancy. We report an orthotopic model of multi-focal colorectal cancer (CRC) metastases in the livers of syngeneic and immune-competent rats, which permitted rigorous testing of oncolytic v...

journal_title：International journal of cancer

authors： Shinozaki K,Ebert O,Woo SL

更新日期：2005-04-20 00:00:00

abstract：:Sulfotransferase (SULT) 1A1 detoxifies and bioactivates a broad spectrum of substrates including xenobiotics. It has been suggested that the SULT1A1 his (histidine) allele, which is caused by a his for arg (arginine) substitution due to a G-->A transition at codon 213, carries a significantly higher risk for women to ...

journal_title：International journal of cancer

authors： Wu MT,Wang YT,Ho CK,Wu DC,Lee YC,Hsu HK,Kao EL,Lee JM

更新日期：2003-01-01 00:00:00

abstract：:Therapeutics targeting the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway initially produce potent antitumor effects, but resistance frequently occurs. Using a phosphoproteome analysis, we found that colorectal cancer (CRC) cells exhibit resistance against PI3K/mTOR inhibition through ...

journal_title：International journal of cancer

authors： Lee HS,Lee S,Cho KH

更新日期：2020-11-15 00:00:00

abstract：:Matrix metalloproteinase 2 (MMP-2) plays a crucial role in invasion and metastasis of malignant tumors. Membrane type 1-MMP (MT1-MMP) was originally identified as an activator of MMP-2. Tissue inhibitor of MMP-2 (TIMP-2) was identified as an inhibitor of MMP-2 and MT1-MMP. However, TIMP-2 was reported to be essential ...

journal_title：International journal of cancer

authors： Yoshizaki T,Maruyama Y,Sato H,Furukawa M

更新日期：2001-01-20 00:00:00

abstract：:Laser microdissection (LMD) and microarray were used to identify genes associated with colorectal cancer. Stanniocalcin 2 (STC2) expression and clinicopathological significance in 139 clinical colorectal cancer samples were specifically investigated using real-time quantitative reverse transcription-polymerase chain r...

journal_title：International journal of cancer

authors： Ieta K,Tanaka F,Yokobori T,Kita Y,Haraguchi N,Mimori K,Kato H,Asao T,Inoue H,Kuwano H,Mori M

更新日期：2009-08-15 00:00:00

abstract：:This is a prospective study of lymphoid tissue showing benign reactive hyperplasia (18 lymph nodes and 2 tonsils), using cytogenetic analysis of cells stimulated with T- or B-cell mitogens. The reason for this study was the detection of an abnormal chromosomal population in cells from an enlarged lymph node excised fr...

journal_title：International journal of cancer

authors： Grace J,Hall BE,Lew M,Singh S,Pittman S,Palmer AA,Zbroja R,Wass J,Vincent PC

更新日期：1989-12-15 00:00:00

abstract：:Detection of methylated free-circulating DNA (mfcDNA) for hyperplastic polyposis 1 (HPP1) in blood is correlated with a poor prognosis for patients with metastatic colorectal cancers (mCRC). Here, we analyzed the plasma levels of HPP1 mfcDNA in mCRC patients treated with a combination therapy containing a fluoropyrimi...

journal_title：International journal of cancer

authors： Herbst A,Vdovin N,Gacesa S,Ofner A,Philipp A,Nagel D,Holdt LM,Op den Winkel M,Heinemann V,Stieber P,Graeven U,Reinacher-Schick A,Arnold D,Ricard I,Mansmann U,Hegewisch-Becker S,Kolligs FT

更新日期：2017-05-01 00:00:00

abstract：:Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...

journal_title：International journal of cancer

authors： Hook RR Jr,Hamby CV,Millikan LE,Berkelhammer J,Stills HF Jr,Oxenhandler RW

更新日期：1983-05-15 00:00:00

abstract：:The heterogeneous nuclear ribonucleoprotein (hnRNP) K is an essential RNA and DNA binding protein involved in gene expression and signal transduction including DNA transcription, RNA splicing, RNA stability and translation. The role of hnRNP K in cancer is relatively understudied. However, several cellular functions s...

journal_title：International journal of cancer

authors： Zhou R,Shanas R,Nelson MA,Bhattacharyya A,Shi J

更新日期：2010-01-15 00:00:00

abstract：:It is well known that certain cancers have shown clustering in socioeconomic groups, but limited data are available on recent results and time trends in such clustering. We determined standardized incidence ratios (SIR) for cancer, adjusted for age, period, region, parity and age at first childbirth among men and wome...

journal_title：International journal of cancer

authors： Hemminki K,Zhang H,Czene K

更新日期：2003-07-10 00:00:00

abstract：:This study reports the induction of interferon (IFN) in human mononuclear cells (MNC) by hematopoietic tumor cells. Only 3 out of 15 cell lines were capable of inducing IFN in the mixed leukocyte/tumor-cell reaction (MLTR). K562, a pluripotent stem cell line and DUTKO-I, a hybrid between K562 and Daudi (Burkitt lympho...

journal_title：International journal of cancer

authors： Berger R,Knapp W,Kirchner H

更新日期：1984-07-15 00:00:00

abstract：:A triazene-xenogenized tumor sub-line was derived from the mouse mastocytoma cell line P815 following several transplant generations in vivo on DTIC. The highly immunogenic P815/DTIC variant line expressed new CTL-defined antigens. Novel antigens were also detected by antibodies in immunoprecipitation and by Western b...

journal_title：International journal of cancer

authors： Grohmann U,Fioretti MC,Binaglia L,Belladonna ML,Bianchi R,Puccetti P

更新日期：1993-09-09 00:00:00

abstract：:We previously reported that ganglioside GD1a, which is highly expressed in poorly metastatic FBJ-S1 cells, inhibits the serum-induced motility of FBJ-LL cells and that the metastatic potential of FBJ-LL cells is completely suppressed by enforced GD1a expression (Hyuga et al., Int J Cancer 1999;83:685-91). We recently ...

journal_title：International journal of cancer

authors： Hyuga S,Kawasaki N,Hyuga M,Ohta M,Shibayama R,Kawanishi T,Yamagata S,Yamagata T,Hayakawa T

更新日期：2001-11-01 00:00:00

abstract：:The relative expression of estrogen receptor (ER) and progesterone receptor (PR) mRNA transcripts was measured in 71 primary breast-cancer biopsies. ER and PR binding activity were estimated in parallel by the dextran-coated-charcoal method. There was a close correlation between the amount of ER mRNA and estradiol bin...

journal_title：International journal of cancer

authors： Nagai MA,Marques LA,Yamamoto L,Fujiyama CT,Brentani MM

更新日期：1994-11-01 00:00:00

abstract：:The melanosomal protein TRP2 expressed by melanocytes and most melanoma cells is an attractive, clinically relevant model antigen for the experimental development of melanoma immunotherapy in mice. A peptide shared by murine and human TRP2 can be recognized by melanoma-reactive CTL in C57BL/6 mice, as well as in human...

journal_title：International journal of cancer

authors： Steitz J,Brück J,Steinbrink K,Enk A,Knop J,Tüting T

更新日期：2000-04-01 00:00:00

abstract：:The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...

journal_title：International journal of cancer

authors： Menendez JA,Vellon L,Colomer R,Lupu R

更新日期：2005-05-20 00:00:00

abstract：:Biopsies were obtained from 12 patients suspected of having nasopharyngeal carcinoma (NPC). A portion of the tissue was submitted for histopathology and another for Western blotting using a murine monoclonal antibody (MAb), MA6. Touch smears of the tissues were also prepared immediately prior to extraction and Western...

journal_title：International journal of cancer

authors： Yip TC,Chan KH,Choy D,Chan CW,Ng MH

更新日期：1987-04-15 00:00:00

abstract：:To provide an up-to-date overview of recent trends in mortality from oral and pharyngeal cancer, we analyzed death certification data for 61 countries worldwide provided by the World Health Organization in 2010-2015, and, for selected most populous countries, over the period 1970-2016. For 12 largest countries, we ana...

journal_title：International journal of cancer

authors： Bosetti C,Carioli G,Santucci C,Bertuccio P,Gallus S,Garavello W,Negri E,La Vecchia C

更新日期：2020-08-15 00:00:00

abstract：:The occurrence of resistance to cytotoxic agents in tumor cells, associated with several phenotypic alterations, is one of the major obstacles to successful anticancer chemotherapy. A new strategy to overcome MDR of human cancer cells was studied, using BSAO, which generates cytotoxic products from spermine, H(2)O(2) ...

journal_title：International journal of cancer

authors： Calcabrini A,Arancia G,Marra M,Crateri P,Befani O,Martone A,Agostinelli E

更新日期：2002-05-01 00:00:00

abstract：:There is a well-established link between inflammation and cancer of various organs, but little data are available on inflammation-associated markers of diagnostic and prognostic clinical utility in pulmonary malignancy. Blood samples were prospectively collected from 75 resectable lung cancer patients before surgery a...

journal_title：International journal of cancer

authors： Infante M,Allavena P,Garlanda C,Nebuloni M,Morenghi E,Rahal D,Roncalli M,Cavuto S,Pesce S,Monari M,Valaperta S,Montanelli A,Solomon D,Bottoni E,Errico V,Voulaz E,Bossi M,Chiesa G,Passera E,Mantovani A,Alloisio M

更新日期：2016-02-15 00:00:00

abstract：:Renewed interest in the use of therapeutic enzymes combined with an improved knowledge of cancer cell metabolism, has led to the translation of several arginine depletion strategies into early phase clinical trials. Arginine auxotrophic tumors are reliant on extracellular arginine, due to the downregulation of arginos...

journal_title：International journal of cancer

authors： Fultang L,Vardon A,De Santo C,Mussai F

更新日期：2016-08-01 00:00:00

abstract：:We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...

journal_title：International journal of cancer

authors： Fukuyama R,Minoshima S,Ochiai A,Tahara E,Shimizu N

更新日期：1991-04-22 00:00:00