Effects of an inducible anti-sense c-myc gene transfer in a drug-resistant human small-cell-lung-carcinoma cell line.

abstract：:It has been established that the Hedgehog (Hh) and epithelial-mesenchymal transition (EMT) signals act on morphogenesis of embryonic and adult tissues. Recently, both signals have been involved in tumor malignancy. However, little is known as to whether Hh and EMT signals act on normal and malignant epithelial cells i...

journal_title：International journal of cancer

authors： Isohata N,Aoyagi K,Mabuchi T,Daiko H,Fukaya M,Ohta H,Ogawa K,Yoshida T,Sasaki H

更新日期：2009-09-01 00:00:00

abstract：:Cervical cancer screening test performance has been hampered by either lack of sensitivity of Pap cytology or lack of specificity of Human Papillomavirus (HPV) testing. This uncertainty can lead to unnecessary referral and treatment, which is disturbing for patients and increases costs for health care providers. The i...

journal_title：International journal of cancer

authors： Bergeron C,Ronco G,Reuschenbach M,Wentzensen N,Arbyn M,Stoler M,von Knebel Doeberitz M

更新日期：2015-06-15 00:00:00

abstract：:Maspin is a Class II tumor suppressor protein and plays a role in tumor growth by inhibiting cellular invasion and motility. It is a member of the serpin family of protease inhibitors and has been shown to reduce angiogenesis. Maspin gene expression can be upregulated by the tumor suppressor p53. We tested 7 p53-relat...

journal_title：International journal of cancer

authors： Spiesbach K,Tannapfel A,Mössner J,Engeland K

更新日期：2005-04-20 00:00:00

abstract：:Microspheres containing cisplatin (CDDP) embedded in poly-d,l-lactic acid (PLA) and polyethylene glycol acid (CDDP-PPMS) were developed to improve treatment of malignant effusions. In vitro studies demonstrated that CDDP was released continuously for more than 4 weeks from CDDP-PPMS without initial burst. CDDP-PPMS wa...

journal_title：International journal of cancer

authors： Tokuda K,Natsugoe S,Shimada M,Kumanohoso T,Baba M,Takao S,Nakamura K,Yamada K,Yoshizawa H,Hatate Y,Aikou T

更新日期：1998-05-29 00:00:00

abstract：:Immunochromatographical fecal occult blood tests were shown to have higher sensitivity for detecting colorectal neoplasms than the commonly used guaiac-based test. However, positivity rates, sensitivity and specificity vary widely. We aimed to assess the reasons for this heterogeneity. Six dichotomous (qualitative) im...

journal_title：International journal of cancer

authors： Brenner H,Haug U,Hundt S

更新日期：2010-10-01 00:00:00

abstract：:MicroRNAs (miRNAs) play an important role in the regulation of a variety of cellular processes, including cell growth, differentiation, apoptosis and carcinogenesis. The purpose of this study was to elucidate the molecular mechanisms by which miR-148b acts as a tumor suppressor in colorectal cancer. The expression of ...

journal_title：International journal of cancer

authors： Song Y,Xu Y,Wang Z,Chen Y,Yue Z,Gao P,Xing C,Xu H

更新日期：2012-09-01 00:00:00

abstract：:Renal-cell carcinomas (RCC) are clinically, histologically and cytogenetically very heterogeneous. The present histological WHO classification shows no clear correlation between histologic subtypes and specific chromosomal abnormalities. In 1986, a new classification was proposed by Thoenes and Störkel based on the ce...

journal_title：International journal of cancer

authors： van den Berg E,van der Hout AH,Oosterhuis JW,Störkel S,Dijkhuizen T,Dam A,Zweers HM,Mensink HJ,Buys CH,de Jong B

更新日期：1993-09-09 00:00:00

abstract：:The aim of this study was to determine whether the skin-sensitizing agent 2,4-dinitrofluorobenzene (DNFB) would elicit the same morphological and biochemical events that are characteristic of 12-O-tetradecanoylphorbol-13-acetate (TPA). While single applications of 0.1% or 0.2% DNFB produced only mild epidermal hyperpl...

journal_title：International journal of cancer

authors： Maldve RE,Fischer SM

更新日期：1995-02-08 00:00:00

abstract：:The enzyme nitroreductase from E. coli can reduce the weak, monofunctional alkylating agent 5-(aziridin-1-yl)-2, 4-dinitrobenzamide (CB1954) to a potent cytotoxic species that generates interstrand crosslinks in DNA. Nitroreductase therefore has potential as a "suicide enzyme" for cancer gene therapy, as cells that ex...

journal_title：International journal of cancer

authors： Weedon SJ,Green NK,McNeish IA,Gilligan MG,Mautner V,Wrighton CJ,Mountain A,Young LS,Kerr DJ,Searle PF

更新日期：2000-06-15 00:00:00

abstract：:IL-15 is an immunostimulatory cytokine with IL-2-like activities. To exploit the potential role of IL-15 in cancer immuno-/gene therapy, we engineered murine TS/A cells with different IL-15 cDNA constructs. Significant IL-15 secretion was achieved only by the use of a modified cDNA encoding for an IL-15 pre-protein be...

journal_title：International journal of cancer

authors： Meazza R,Lollini PL,Nanni P,De Giovanni C,Gaggero A,Comes A,Cilli M,Di Carlo E,Ferrini S,Musiani P

更新日期：2000-08-15 00:00:00

abstract：:Interval breast cancer (IC) has a more aggressive phenotype and higher mortality than screen-detected cancer (SDC). In this case-case study, we investigated whether the size of longitudinal fluctuations in mammographic percent density (PD fluctuation) was associated with the ratio of IC versus SDC among screened women...

journal_title：International journal of cancer

authors： Strand F,Humphreys K,Eriksson M,Li J,Andersson TM,Törnberg S,Azavedo E,Shepherd J,Hall P,Czene K

更新日期：2017-01-01 00:00:00

abstract：:We previously produced evidence that the human mammary-carcinoma cell line 8701-BC expresses several metalloproteinases (MMP-1, -2, -9, and -10) and their tissue inhibitors). In order to obtain a better understanding of the environmental control over gelatinolytic activities, we have tested the enzyme production of 87...

journal_title：International journal of cancer

authors： Minafra S,Giambelluca C,Andriolo M,Pucci-Minafra I

更新日期：1995-09-15 00:00:00

abstract：:Epithelial ovarian carcinoma (EOC) is a leading cause of death from gynecologic malignancies, due mainly to the prevalence of undetected metastatic disease. The process of cell invasion during intraperitoneal anchoring of metastatic lesions requires concerted regulation of many processes, including modulation of adhes...

journal_title：International journal of cancer

authors： Barbolina MV,Adley BP,Kelly DL,Shepard J,Fought AJ,Scholtens D,Penzes P,Shea LD,Stack MS

更新日期：2009-08-15 00:00:00

abstract：:Retinoids modulate several cell functions and especially inhibit the growth of a wide variety of cells including breast cancer. Retinoic acid receptor-gamma (RAR-gamma) has been shown to mediate the antiproliferative activity of retinoids. To further test this hypothesis we examined the effects of different RAR-gamma ...

journal_title：International journal of cancer

authors： Widschwendter M,Daxenbichler G,Culig Z,Michel S,Zeimet AG,Mörtl MG,Widschwendter A,Marth C

更新日期：1997-05-02 00:00:00

abstract：:A polymorphism at codon 72 of the p53 gene, resulting in either an arginine or a proline residue in the protein, has been reported to affect the susceptibility of p53 to human papillomavirus (HPV) E6-mediated degradation in cultured cells. However, the relevance of this polymorphism to naturally occurring HPV infectio...

journal_title：International journal of cancer

authors： Giannoudis A,Graham DA,Southern SA,Herrington CS

更新日期：1999-09-24 00:00:00

abstract：:Recent analyses have suggested decreases over time in colorectal cancer incidence at older ages (≥55 years) but increases at younger ages (20-54 years). Understanding the geographic heterogeneity of incidence facilitates resource allocation for potential interventions and advances our knowledge of differential etiolog...

journal_title：International journal of cancer

authors： Chernyavskiy P,Kennerley VM,Jemal A,Little MP,Rosenberg PS

更新日期：2019-04-15 00:00:00

abstract：:Ovarian cancer is the fourth most common cause of cancer deaths among females in the western world after cancer of the breast, colon and lung. The inability to control the disease within the peritoneal cavity is the major cause of treatment failure in patients with ovarian cancer. The majority of ovarian carcinomas ex...

journal_title：International journal of cancer

authors： Dijkgraaf I,Kruijtzer JA,Frielink C,Corstens FH,Oyen WJ,Liskamp RM,Boerman OC

更新日期：2007-02-01 00:00:00

abstract：:Paraffin sections from 190 epithelial ovarian tumours, including 159 malignant and 31 benign epithelial tumours, were analysed immunohistochemically for expression of cyclin-dependent kinase inhibitor 2 (CDKN2A) gene product p16INK4A (p16). Most benign tumours showed no p16 expression in the tumour cells, whereas only...

journal_title：International journal of cancer

authors： Dong Y,Walsh MD,McGuckin MA,Gabrielli BG,Cummings MC,Wright RG,Hurst T,Khoo SK,Parsons PG

更新日期：1997-02-20 00:00:00

abstract：:The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of ...

journal_title：International journal of cancer

authors： Kang S,Kim JW,Kang GH,Lee S,Park NH,Song YS,Park SY,Kang SB,Lee HP

更新日期：2006-05-01 00:00:00

abstract：:Drug-induced DNA demethylation in normal human cells and inherited localized hypomethylation in mitogen-stimulated lymphocytes from patients with a rare recessive disease (ICF: immunodeficiency, centromeric region instability, facial anomalies) are associated with karyotypic instability. This chromosomal recombination...

journal_title：International journal of cancer

authors： Narayan A,Ji W,Zhang XY,Marrogi A,Graff JR,Baylin SB,Ehrlich M

更新日期：1998-09-11 00:00:00

abstract：:Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadia...

journal_title：International journal of cancer

authors： Srour B,Plancoulaine S,Andreeva VA,Fassier P,Julia C,Galan P,Hercberg S,Deschasaux M,Latino-Martel P,Touvier M

更新日期：2018-11-15 00:00:00

abstract：:Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult-o...

journal_title：International journal of cancer

authors： Shang Y,Kakinuma S,Yamauchi K,Morioka T,Kokubo T,Tani S,Takabatake T,Kataoka Y,Shimada Y

更新日期：2014-09-01 00:00:00

abstract：:With the aim of identifying innovative therapeutic strategies for osteosarcoma patients who are refractory to conventional chemotherapy, we analyzed the in vitro effects of the blockage of autocrine circuits. Since the insulin-like growth factor-I receptor (IGF-IR)-mediated loop is relevant to the growth of osteosarco...

journal_title：International journal of cancer

authors： Benini S,Baldini N,Manara MC,Chano T,Serra M,Rizzi S,Lollini PL,Picci P,Scotlandi K

更新日期：1999-02-09 00:00:00

abstract：:ErbB-2 and EGF receptors are often co-expressed in human tumors and have been shown to synergize in the transformation of cells in experimental model systems. Transactivation of ErbB-2 can occur via ligand-induced heterodimerization with EGF receptor or other members of the ErbB family of receptor tyrosine kinases. We...

journal_title：International journal of cancer

authors： Schmidt M,Hynes NE,Groner B,Wels W

更新日期：1996-02-08 00:00:00

abstract：:RAS, TP53 (p53) and MYC are among the most frequently altered driver genes in cancer. Thus, RAS is the most frequently mutated oncogene, MYC the most frequently amplified gene and TP53 the most frequently mutated tumor suppressor gene and overall the most frequently mutated gene in cancer. Theoretically, therefore, th...

journal_title：International journal of cancer

authors： Duffy MJ,Crown J

更新日期：2021-01-01 00:00:00

abstract：:Insulin-like growth factor binding protein-3 (IGFBP-3) inhibits the mitogenic and antiapoptotic activity of insulin-like growth factor (IGF) by blocking the binding of IGF to its receptor. However, under certain circumstances, IGFBP-3 can enhance the activity of IGF by protecting IGF from degradation. More than half o...

journal_title：International journal of cancer

authors： Moon JW,Chang YS,Ahn CW,Yoo KN,Shin JH,Kong JH,Kim YS,Chang J,Kim SK,Kim HJ,Kim SK

更新日期：2006-01-15 00:00:00

abstract：:Deletions on chromosomes 1p and 19q are associated with favorable prognosis in patients with oligodendroglial tumors. The aim of our study was to identify additional genomic aberrations linked to patient survival. We performed a genome-wide screen for genomic imbalances by comparative genomic hybridization on tumors f...

journal_title：International journal of cancer

authors： Trost D,Ehrler M,Fimmers R,Felsberg J,Sabel MC,Kirsch L,Schramm J,Wiestler OD,Reifenberger G,Weber RG

更新日期：2007-06-01 00:00:00

abstract：:Circulating tumor DNA (ctDNA) is a new circulating tumor biomarker which might be used as a prognostic biomarker in a way similar to circulating tumor cells (CTCs). Here, we used the high prevalence of TP53 mutations in triple negative breast cancer (TNBC) to compare ctDNA and CTC detection rates and prognostic value ...

journal_title：International journal of cancer

authors： Madic J,Kiialainen A,Bidard FC,Birzele F,Ramey G,Leroy Q,Rio Frio T,Vaucher I,Raynal V,Bernard V,Lermine A,Clausen I,Giroud N,Schmucki R,Milder M,Horn C,Spleiss O,Lantz O,Stern MH,Pierga JY,Weisser M,Lebofsky R

更新日期：2015-05-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) results from the cumulative effects of deregulated tumor suppressor genes and oncogenes. The tumor suppressor and oncogenes commonly affected include growth factors, receptors and their downstream signaling pathway components. The overexpression of transforming growth factor alpha (TGF-a...

journal_title：International journal of cancer

authors： Baek JY,Morris SM,Campbell J,Fausto N,Yeh MM,Grady WM

更新日期：2010-09-01 00:00:00

abstract：:Several mouse models studying the MLL fusion-induced leukemic transformation showed that a myeloproliferation stage precedes leukemia or occurred as the only phenotype of hematological disorder in mice. We established 6 MLL/AF10(OM-LZ)-immortalized cell lines by retrovirally transducing the fusion gene into bone marro...

journal_title：International journal of cancer

authors： Fu JF,Hsu CL,Shih LY

更新日期：2010-04-01 00:00:00