Ganglioside GD1a inhibits HGF-induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c-Met.

abstract：:T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimul...

journal_title：International journal of cancer

authors： Kudoh S,Stanley J,Edinger MG,Tubbs RR,Klein E,Bukowski RM,Finke JH

更新日期：1994-08-01 00:00:00

abstract：:Telomerase, the enzyme responsible for maintenance of the telomeres, is absent from the vast majority of somatic cells but is present in most tumours. Little is known about how telomerase is activated in cancer, although it is thought vital for immortalisation to occur. The aim of our study was to identify genetic cha...

journal_title：International journal of cancer

authors： Loveday RL,Greenman J,Drew PJ,Monson JR,Kerin MJ

更新日期：1999-10-22 00:00:00

abstract：:We have previously shown that sensory nerve peptides contribute to the pathogenesis of pulmonary hypersensitivity reactions (HSRs) to paclitaxel in rats. Moreover, pemirolast, an antiallergic agent, reverses the HSRs to paclitaxel, although the mechanism is considered to result from the blockade of paclitaxel-induced ...

journal_title：International journal of cancer

authors： Yahata H,Saito M,Sendo T,Itoh Y,Uchida M,Hirakawa T,Nakano H,Oishi R

更新日期：2006-05-15 00:00:00

abstract：:The APTIMA HPV Assay (AHPV) allows detection of 14 high-risk human papillomavirus (HPV) RNA types in cervical specimens. Until present, the assay has been compared to HPV DNA tests only in triage settings. Herein, we compare AHPV with a DNA assay (Hybrid Capture 2; HC2) and liquid-based cytology (LBC; using PreservCyt...

journal_title：International journal of cancer

authors： Monsonego J,Hudgens MG,Zerat L,Zerat JC,Syrjänen K,Halfon P,Ruiz F,Smith JS

更新日期：2011-08-01 00:00:00

abstract：:C57BL/6J mice immunized with devitalized Ehrlich tumor (ET) cells produce high serum levels of IgM antibodies to ET cell-surface carbohydrates that are critical in the observed resistance against this tumor. However, this response is not found in ET-bearing mice at any stage of tumor development. Since previous studie...

journal_title：International journal of cancer

authors： Viñuela JE,Rodriguez R,Gil J,Coll J,De la Concha EG,Subiza JL

更新日期：1991-01-02 00:00:00

abstract：:In a population-based case-control study of dietary risk factors for pancreatic cancer, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. This study demonstrated an increased risk of pancreas cancer associated with high levels of reported energy intake. After adjustment for age, sex, respon...

journal_title：International journal of cancer

authors： Ghadirian P,Simard A,Baillargeon J,Maisonneuve P,Boyle P

更新日期：1991-01-02 00:00:00

abstract：:Neuroblastoma (NBL), one of the most common childhood solid tumors, has a distinct nature in different prognostic subgroups. However, the precise mechanism underlying this phenomenon remains largely unknown. To understand the molecular and genetic bases of neuroblastoma, we have generated its cDNA libraries and identi...

journal_title：International journal of cancer

authors： Kato C,Miyazaki K,Nakagawa A,Ohira M,Nakamura Y,Ozaki T,Imai T,Nakagawara A

更新日期：2004-11-10 00:00:00

abstract：:Generation of cytotoxic T lymphocytes (CTL) in vitro and tumor-rejection responses by sensitization of semi-syngeneic mice with tumor-antigen-reconstituted liposomes were investigated. Liposomes were prepared from a crude butanol extract (CBE) of BALBRVD leukemia cells and egg phosphatidylcholine (PC): 1,2-dimyristoyl...

journal_title：International journal of cancer

authors： Shibata R,Noguchi T,Sato T,Akiyoshi K,Sunamoto J,Shiku H,Nakayama E

更新日期：1991-05-30 00:00:00

abstract：:Cancer initiation is presumed to occur in utero for many childhood cancers and it has been hypothesized that advanced paternal age may have an impact due to the increasing number of mutations in the sperm DNA with increasing paternal age. We examined the association between paternal age and specific types of childhood...

journal_title：International journal of cancer

authors： Urhoj SK,Raaschou-Nielsen O,Hansen AV,Mortensen LH,Andersen PK,Nybo Andersen AM

更新日期：2017-06-01 00:00:00

abstract：:Cytokines and growth factors are powerful modulators of the immune response. Their aberrant expression either by the tumor cells or by the tumor infiltrating lymphocytes confers a selective advantage to the tumor to grow and suppress the cytotoxic activity of the infiltrating lymphocytes. Therefore, analysis of these ...

journal_title：International journal of cancer

authors： Marrogi AJ,Munshi A,Merogi AJ,Ohadike Y,El-Habashi A,Marrogi OL,Freeman SM

更新日期：1997-10-21 00:00:00

abstract：:Malignant gliomas recur even after extensive surgery and chemo-radiotherapy. Although a relatively novel chemotherapeutic agent, temozolomide (TMZ), has demonstrated promising activity against gliomas, the effects last only a few months and drug resistance develops thereafter in many cases. It has been acknowledged th...

journal_title：International journal of cancer

authors： Zhuang D,Liu Y,Mao Y,Gao L,Zhang H,Luan S,Huang F,Li Q

更新日期：2012-01-15 00:00:00

abstract：:The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...

journal_title：International journal of cancer

authors： Bartel F,Meye A,Würl P,Kappler M,Bache M,Lautenschläger C,Grünbaum U,Schmidt H,Taubert H

更新日期：2001-05-20 00:00:00

abstract：:The putative tumor suppressors RASSF1A and BLU are mapped adjacent to one another on chromosome 3p21.3, a region frequently deleted in lung cancer. These genes are often inactivated by promoter hypermethylation, but the association of this inactivation with clinical features of the disease or with carcinogen exposure ...

journal_title：International journal of cancer

authors： Marsit CJ,Kim DH,Liu M,Hinds PW,Wiencke JK,Nelson HH,Kelsey KT

更新日期：2005-03-20 00:00:00

abstract：:The effects of long-term treatment with mouse interferon on the phenotype of untransformed C3H/10T1/2 cells and cloned derivatives transformed by methylcholanthrene (MCA) and Simian virus 40 (SV40) were investigated. Continuous presence of interferon induced morphologic reversion, with the development of thick, submem...

journal_title：International journal of cancer

authors： Brouty-Boyé D,Wybier-Franqui J,Calvo C,Feunteun J,Gresser I

更新日期：1984-07-15 00:00:00

abstract：:A diet high in linoleic acid (an ω-6 PUFA) increased the formation of miscoding etheno (ε)--DNA adducts in WBC-DNA of women, but not in men (Nair et al., Cancer Epidemiol Biomark Prev 1997;6:597-601). This gender specificity could result from an interaction between ω-6 PUFA intake and estrogen catabolism, via redox-cy...

journal_title：International journal of cancer

authors： Sun X,Nair J,Linseisen J,Owen RW,Bartsch H

更新日期：2012-11-01 00:00:00

abstract：:Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...

journal_title：International journal of cancer

authors： Ekblom P,Thesleff I,Lehto VP,Virtanen I

更新日期：1983-01-15 00:00:00

abstract：:Telomerase activity is involved in the maintenance of telomere length and is thought to be required for cellular immortality and oncogenesis. Three major subunits composing telomerase, human telomerase RNA (hTR), telomerase-associated protein (TPI) and human telomerase catalytic subunit (hTERT), have been identified. ...

journal_title：International journal of cancer

authors： Kyo S,Kanaya T,Takakura M,Tanaka M,Yamashita A,Inoue H,Inoue M

更新日期：1999-03-15 00:00:00

abstract：:Infection by oncogenic human papillomavirus (HPV) is a necessary but not sufficient cause of cervical carcinoma. Several host genetic and viral factors have been reported to increase the risk of carcinoma development given an HPV infection. In our study, we have analysed the contribution of HPV 16 E6 sequence subtype ...

journal_title：International journal of cancer

authors： Beskow AH,Engelmark MT,Magnusson JJ,Gyllensten UB

更新日期：2005-11-20 00:00:00

abstract：:Thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) are important enzymes of DNA de novo synthesis and the salvage pathway in cancer cells, respectively. Intratumoral TS and DPD gene expressions were evaluated to determine the correlation between the expression of the 2 genes in both normal stromal tis...

journal_title：International journal of cancer

authors： Ichikawa W,Takahashi T,Suto K,Nihei Z,Shirota Y,Shimizu M,Sasaki Y,Hirayama R

更新日期：2004-12-20 00:00:00

abstract：:Sperm protein 17 (Sp17) is an antigenic protein highly expressed in spermatozoa. Sp17 expression was demonstrated recently in multiple myeloma, suggesting that it may be a novel cancer-testis antigen. Expression of Sp17 mRNA and protein was examined in human ovarian tumors. Sp17 mRNA was evaluated by reverse transcrip...

journal_title：International journal of cancer

authors： Straughn JM Jr,Shaw DR,Guerrero A,Bhoola SM,Racelis A,Wang Z,Chiriva-Internati M,Grizzle WE,Alvarez RD,Lim SH,Strong TV

更新日期：2004-03-01 00:00:00

abstract：:Six oncogenic cell lines were established from primary sarcomas that had been induced in thymectomized, aged, BALB/cSt mice by the injection of 3-methylcholanthrene. Of these lines, three produced B-tropic murine leukemia virus (MuLV), i.e. MuLV that would patently infect fibroblasts of BALB/c origin but not those fro...

journal_title：International journal of cancer

authors： Gillespie GY,Jensen FC,Russell SW

更新日期：1978-02-15 00:00:00

abstract：:Polymorphism of DNA base excision repair (BER) genes affects DNA repair capacity and may alter sensitivity to platinum-based chemotherapy regimens. This study investigated polymorphisms of OGG1 Ser326Cys, APE1 Asp148Glu APE1-141T/G and XRCC1 Arg399Gln for association with clinical outcome in 235 advanced inoperable no...

journal_title：International journal of cancer

authors： Peng Y,Li Z,Zhang S,Xiong Y,Cun Y,Qian C,Li M,Ren T,Xia L,Cheng Y,Wang D

更新日期：2014-12-01 00:00:00

abstract：:Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...

journal_title：International journal of cancer

authors： Kitahara CM,Preston DL,Neta G,Little MP,Doody MM,Simon SL,Sigurdson AJ,Alexander BH,Linet MS

更新日期：2018-11-01 00:00:00

abstract：:The present experiments were performed to investigate the possibility of inhibiting tumor growth in vivo with syngeneic lymphocytes sensitized in vitro on monolayers of the tumor under test, and to study the effect of a thymic humoral factor (THF) in this sensitization process. Monolayers of fibrosarcoma cells were us...

journal_title：International journal of cancer

authors： Small M,Trainin N

更新日期：1975-06-15 00:00:00

abstract：:Ether-linked glycerophospholipids (ether lipids, EL) are selectively toxic and anti-proliferative agents against cancer cells in vitro. The reason for such selectivity is not completely clear. Their mechanism of action is mediated through an interaction with the plasma membrane and the membrane lipid composition may m...

journal_title：International journal of cancer

authors： Diomede L,Piovani B,Modest EJ,Noseda A,Salmona M

更新日期：1991-09-30 00:00:00

abstract：:Target-specific acute myeloid leukemia (AML) immunotherapy requires selective cell-surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous studies, a chemically linked full-length anti-CD64 immunotoxin based on...

journal_title：International journal of cancer

authors： Tur MK,Huhn M,Jost E,Thepen T,Brümmendorf TH,Barth S

更新日期：2011-09-01 00:00:00

abstract：:Histone deacetylase inhibitors, such as phenylbutyrate, are currently undergoing clinical trials as potential anticancer agents. Phenylbutyrate can induce cell differentiation and apoptosis in a number of cancer cell types and can act in synergy with ionizing radiation and chemotherapy to induce apoptosis. We used the...

journal_title：International journal of cancer

authors： Dyer ES,Paulsen MT,Markwart SM,Goh M,Livant DL,Ljungman M

更新日期：2002-10-10 00:00:00

abstract：:During 1984-88 a population-based case-control study was carried out in The Netherlands in collaboration with the International Agency for Research on Cancer in order to further explore the possible relationship between diet and exocrine pancreatic carcinoma. Past habitual dietary intake was assessed in 164 cases and ...

journal_title：International journal of cancer

authors： Bueno de Mesquita HB,Moerman CJ,Runia S,Maisonneuve P

更新日期：1990-09-15 00:00:00

abstract：:Southern blot analyses of surgical specimens of cervical carcinoma from Japanese patients showed that 3/9 samples contained human papillomavirus (HPV) type-16 DNA sequences, and 2 contained HPV type-18 DNA sequences. By Northern blot analyses, RNA transcripts of HPV DNA sequences were demonstrated in some of the tissu...

journal_title：International journal of cancer

authors： Tsunokawa Y,Takebe N,Nozawa S,Kasamatsu T,Gissmann L,zur Hausen H,Terada M,Sugimura T

更新日期：1986-04-15 00:00:00

abstract：:Murine mammary aplastic carcinoma, when it is passed from one alloxan-diabetic animal to another, after several passages becomes conditioned to hypoinsulinemia by secreting its own substance(s) immunologically cross-reactive with insulin (SICRI). Although not cytotoxic, the total daily dose of 2.5 mg of synthetic line...

journal_title：International journal of cancer

authors： Vuk-Pavlović S,Bozikov V,Pavelić K

更新日期：1982-06-15 00:00:00