当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CANCER期刊下所有文献 > T lymphocytes infiltrating renal cell carcinoma have a reduced expression of transferrin receptor.

T lymphocytes infiltrating renal cell carcinoma have a reduced expression of transferrin receptor.

Abstract：

:T-cell responses have been reported to be impaired in cancer patients, and lymphocytes infiltrating human tumors (T-TIL) appear to be more affected than those in the peripheral blood. T-TIL display a poor proliferative response when compared to peripheral blood T (T-PBL) cells that show a strong response to all stimuli. Here we report that T-TIL from patients with renal cell carcinoma (RCC) also have a defect in transferrin receptor (TfR) expression that is not present in T-PBL cells. Immunocytometry studies (dual staining for CD3 epsilon and TfR) demonstrated that autologous T cells from the peripheral blood but not from the tumor expressed TfR following stimulation with IL2, anti-CD3 or PHA. Expression of TfR correlated with the capacity of T cells from the blood and tumor to proliferate. Gene expression studies using reverse transcriptase-polymerase chain reaction (RT-PCR) demonstrated that TfR mRNA levels in T-TIL were undetectable or low relative to T-PBL following stimulation. The failure to detect TfR mRNA in T-TIL after stimulation was not due to a shift in kinetics of mRNA accumulation since TfR mRNA was not detectable at any of the times tested (4, 12, 24 and 36 hr). The defect in TfR gene expression is selective since IL2R alpha gene expression was induced in T-TIL. Because IL2 binding to its receptor results in TfR expression, the defect in TfR induction in T-TIL appears to be distal to IL2R alpha expression. Our studies illustrate another alteration in T-TIL that is not observed in T cells from the peripheral blood. The absence of TfR gene expression may contribute to the poor proliferative response of T cells from the tumor.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Kudoh S,Stanley J,Edinger MG,Tubbs RR,Klein E,Bukowski RM,Finke JH

doi

10.1002/ijc.2910580311

subject

Has Abstract

pub_date

1994-08-01 00:00:00

pages

369-75

issue

3

eissn

0020-7136

issn

1097-0215

journal_volume

58

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CANCER文献大全
  • High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma.

    abstract：:Embryonal tumors such as Wilms' tumor (WT), embryonal rhabdomyosarcoma (eRMS) and hepatoblastoma have been thought to have a common pathogenetic mechanism. H19 was found to be inactivated in WT and eRMS either by loss of heterozygosity or by hypermethylation of the maternal allele. We show here that the expression of ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19990812)82:4<490::aid-ijc

    authors： Fukuzawa R,Umezawa A,Ochi K,Urano F,Ikeda H,Hata J

    更新日期：1999-08-12 00:00:00

  • Comparisons of colon-cancer survival among European countries: The Eurocare Study.

    abstract：:Under the aegis of EUROCARE, a European Union project to assemble survival data from population-based cancer registries and analyze them according to standardized procedures, we have investigated and compared colon-cancer survival in 10 European countries. We analyzed 68,283 colon-cancer cases diagnosed between 1978 a...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ijc.2910630109

    authors： Sant M,Capocaccia R,Verdecchia A,Gatta G,Micheli A,Mariotto A,Hakulinen T,Berrino F

    更新日期：1995-09-27 00:00:00

  • Alterations of RB1, p53 and Wnt pathways in hepatocellular carcinomas associated with hepatitis C, hepatitis B and alcoholic liver cirrhosis.

    abstract：:Major etiologic factors associated with human hepatocellular carcinomas (HCCs) include infection with hepatitis C (HCV) and hepatitis B virus (HBV), excess alcohol intake and aflatoxin B(1) exposure. While the G-->T p53 mutation at codon 249 has been identified as a genetic hallmark of HCC caused by aflatoxin B(1), th...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ijc.11254

    authors： Edamoto Y,Hara A,Biernat W,Terracciano L,Cathomas G,Riehle HM,Matsuda M,Fujii H,Scoazec JY,Ohgaki H

    更新日期：2003-09-01 00:00:00

  • Long-term risk of colorectal cancer after screen-detected adenoma: Experiences from a Danish gFOBT-positive screening cohort.

    abstract：:Fecal occult blood test (FOBT) screening for colorectal cancer (CRC) is implemented in several countries. Approximately half of all FOBT-positive persons have screen-detected adenomas. Despite removal of these, patients with large/multiple adenomas have increased risk of later developing new advanced adenomas and CRC....

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32850

    authors： Bjerrum A,Lindebjerg J,Andersen O,Fischer A,Lynge E

    更新日期：2020-08-15 00:00:00

  • Nutritional factors and pancreatic cancer in the francophone community in Montréal, Canada.

    abstract：:In a population-based case-control study of dietary risk factors for pancreatic cancer, a total of 179 cases and 239 controls were interviewed between 1984 and 1988. This study demonstrated an increased risk of pancreas cancer associated with high levels of reported energy intake. After adjustment for age, sex, respon...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910470102

    authors： Ghadirian P,Simard A,Baillargeon J,Maisonneuve P,Boyle P

    更新日期：1991-01-02 00:00:00

  • Post-translationally modified S12, absent in transformed breast epithelial cells, is not associated with the 26S proteasome and is induced by proteasome inhibitor.

    abstract：:The 26S proteasome, consisting of the 20S core and 19S regulatory complexes, regulates intracellular protein concentration through proteolytic degradation of targeted substrates. Composition of the 19S regulatory complex as well as posttranslational modifications of the 19S subunits can effectively regulate the activi...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.20261

    authors： Thompson HG,Harris JW,Brody JP

    更新日期：2004-09-01 00:00:00

  • Involvement of nucleophosmin/B23 in the response of HeLa cells to UV irradiation.

    abstract：:The steady-state mRNA level of nucleophosmin/B23 in HeLa cells increased after UV irradiation. Nucleophosmin/B23 antisense transfection potentiated ultraviolet (UV)-induced cell killing. A block in G(2)/M phase, larger peak of apoptotic cells and higher caspase-3 in vitro activity were noted in nucleophosmin/B23 antis...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.1606

    authors： Wu MH,Chang JH,Chou CC,Yung BY

    更新日期：2002-01-20 00:00:00

  • In vivo anti-tumor effects of local adoptive transfer of mouse and human cultured lymphoid cells.

    abstract：:Mouse and human lymphoid cells were cultivated in the presence of T-cell growth factor (TCGF) and evaluated for their in vivo anti-tumor effect in mice. Cultured spleen cells of normal BALB/c mice or of mice bearing the M109 tumor had a high level of cytotoxic activity in vitro against a variety of tumor target cells ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910280208

    authors： Gorelik E,Kedar E,Sredni B,Herberman R

    更新日期：1981-08-15 00:00:00

  • Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation.

    abstract：:In the last decade, mitochondrial DNA (mtDNA) haplogroups have been associated with the occurrence of breast cancer. However, the underlying mechanism is not known. Combining a case-control study with a large cohort of women from Southern China with breast cancer and functional analyses with trans-mitochondrial techno...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.31207

    authors： Ma L,Fu Q,Xu B,Zhou H,Gao J,Shao X,Xiong J,Gu Q,Wen S,Li F,Shen L,Chen G,Fang H,Lyu J

    更新日期：2018-05-01 00:00:00

  • Incidence of childhood cancer in Cuba (1986-1990).

    abstract：:Cancer is an infrequent disease in childhood. However, it is responsible for 13.06% of child deaths between 1 and 14 years in Cuba. The aim of our work was to describe the incidence of childhood cancer in the period 1986 to 1990 using data reported to the National Cancer Registry (NCR) of Cuba. All cancer cases betwee...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19970807)72:4<551::aid-ijc

    authors： Martín AA,Alert JA,Renó JS,Lonchong M,Grueiro S

    更新日期：1997-08-07 00:00:00

  • Adolescent and mid-life diet and subsequent risk of thyroid cancer in the NIH-AARP diet and health study.

    abstract：:Although thyroid cancer is suspected to have a nutritional etiology, prospective studies examining the relationship between diet and thyroid cancer are lacking. During 1996-1997, NIH-AARP Diet and Health Study participants, ages 51-72 years, completed a 37-item food frequency questionnaire about diet at ages 12-13 yea...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.29600

    authors： Braganza MZ,Potischman N,Park Y,Thompson FE,Hollenbeck AR,Kitahara CM

    更新日期：2015-11-15 00:00:00

  • Tumor targeting with radiolabeled antibodies in a human carcinoembryonic antigen transgenic mouse model.

    abstract：:Mice transgenic for the carcinoembryonic (CEA) gene were used to study the biodistribution and tumor targeting of a radioiodinated monoclonal antibody (MAb), T84.66. The specificity of antibody uptake in tumors was assessed in mice bearing a CEA-transfected syngeneic tumor as well as the antigen-negative parental tumo...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(20000315)85:6<751::aid-ijc

    authors： Szalai G,Williams LE,Primus FJ

    更新日期：2000-03-15 00:00:00

  • Multiple births and risk of breast cancer.

    abstract：:Data from a large, multicenter, population-based case-control study were analyzed to investigate the relation between multiple birth pregnancies and subsequent breast-cancer risk in the gravidas. Women less than 75 years old who had breast cancer were identified from statewide tumor registries in Wisconsin, western Ma...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ijc.2910620209

    authors： Dietz AT,Newcomb PA,Storer BE,Longnecker MP,Mittendorf R

    更新日期：1995-07-17 00:00:00

  • Neuropilin-2 and its ligand VEGF-C predict treatment response after transurethral resection and radiochemotherapy in bladder cancer patients.

    abstract：:The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role in the...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.28987

    authors： Keck B,Wach S,Taubert H,Zeiler S,Ott OJ,Kunath F,Hartmann A,Bertz S,Weiss C,Hönscheid P,Schellenburg S,Rödel C,Baretton GB,Sauer R,Fietkau R,Wullich B,Krause FS,Datta K,Muders MH

    更新日期：2015-01-15 00:00:00

  • Adhesion of human breast cancer cell line MCF-7 to human vascular endothelial cells in culture. Enhancement by activated platelets.

    abstract：:The interactions of MCF-7 tumor cells with human vascular endothelial cells (EC) and subendothelial extracellular matrices (ECM) were morphologically observed by electron microscopy and quantitatively evaluated by labelling tumor cells with 111Indium-oxine. MCF-7 tumor cells adhered more rapidly to ECM than to the api...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910400416

    authors： Abecassis J,Millon-Collard R,Klein-Soyer C,Nicora F,Fricker JP,Beretz A,Eber M,Muller D,Cazenave JP

    更新日期：1987-10-15 00:00:00

  • Reducing overtreatment associated with overdiagnosis in cervical cancer screening-A model-based benefit-harm analysis for Austria.

    abstract：:A general concern exists that cervical cancer screening using human papillomavirus (HPV) testing may lead to considerable overtreatment. We evaluated the trade-off between benefits and overtreatment among different screening strategies differing by primary tests (cytology, p16/Ki-67, HPV alone or in combinations), int...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32849

    authors： Sroczynski G,Esteban E,Widschwendter A,Oberaigner W,Borena W,von Laer D,Hackl M,Endel G,Siebert U

    更新日期：2020-08-15 00:00:00

  • Determinants of cervical cancer rates in developing countries.

    abstract：:Although cervical cancer (CC) is a leading cause of cancer-related deaths in developing countries, incidence rates vary considerably, ranging from 3 to 61 per 10(5) females. Identifying determinants of high vs. low rates may suggest population-level prevention strategies. CC rates for 175 countries were obtained from ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.10453

    authors： Drain PK,Holmes KK,Hughes JP,Koutsky LA

    更新日期：2002-07-10 00:00:00

  • APE1 genotype and risk of bladder cancer: evidence for effect modification by smoking.

    abstract：:Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G tr...

    journal_title：International journal of cancer

    pub_type： 杂志文章,多中心研究

    doi：10.1002/ijc.21768

    authors： Terry PD,Umbach DM,Taylor JA

    更新日期：2006-06-15 00:00:00

  • Patterns of growth and differentiation in the colon carcinoma cell line LIM 1863.

    abstract：:The LIM 1863 colon carcinoma cell line grows in the form of morphologically and functionally organized organoids. Cells are arranged around a central lumen with a brush border and nuclei are polarized to the periphery. The organoids contain 3 morphological cell types (columnar, goblet and caveolated cells). By agar cl...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910500515

    authors： Hayward IP,Whitehead RH

    更新日期：1992-03-12 00:00:00

  • Breast-cancer incidence in relation to height, weight and body-fat distribution in the Dutch "DOM" cohort.

    abstract：:In a cohort of 11,663 participants in a breast-cancer screening program, height, weight, waist circumference and hip circumference were measured, and information about menstrual and reproductive history was obtained by questionnaire. After exclusion of 83 women with unclear menopausal status, the subjects were divided...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19980529)76:5<647::aid-ijc

    authors： Kaaks R,Van Noord PA,Den Tonkelaar I,Peeters PH,Riboli E,Grobbee DE

    更新日期：1998-05-29 00:00:00

  • Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor models.

    abstract：:Clinical trials utilizing strategies to manipulate tumor oxygenation, blood flow and angiogenesis are under way, although limited quantitative information exists regarding basic tumor pathophysiology. The current study utilized murine KHT fibrosarcomas, spontaneous mammary carcinomas and first-generation spontaneous t...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.1401

    authors： Fenton BM,Lord EM,Paoni SF

    更新日期：2001-09-01 00:00:00

  • Next-generation sequencing reveals a novel role of lysine-specific demethylase 1 in adhesion of rhabdomyosarcoma cells.

    abstract：:Lysine-specific demethylase 1 (LSD1), a histone lysine demethylase with the main specificity for H3K4me2, has been shown to be overexpressed in rhabdomyosarcoma (RMS) tumor samples. However, its role in RMS biology is not yet well understood. Here, we identified a new role of LSD1 in regulating adhesion of RMS cells. ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32806

    authors： Haydn T,Kehr S,Willmann D,Metzger E,Schüle R,Fulda S

    更新日期：2020-06-15 00:00:00

  • Expression of Epstein-Barr virus in cutaneous T-cell lymphoma including mycosis fungoides.

    abstract：:Cutaneous T-Cell lymphoma (CTCL) is a non-Hodgkin's lymphoma of unknown pathogenesis. Mycosis fungoides (MF) is a clinically determined subset of CTCL with intensive infiltration of lymphoma cells into the epidermis. To determine whether Epstein-Barr virus (EBV) is associated with these lymphoma cells, we performed mR...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0215(200102)9999:9999<::aid-ijc1172>3

    authors： Shimakage M,Sasagawa T,Kawahara K,Yutsudo M,Kusuoka H,Kozuka T

    更新日期：2001-04-15 00:00:00

  • Unexpected paracrine action of prostate cancer cells harboring a new class of androgen receptor mutation--a new paradigm for cooperation among prostate tumor cells.

    abstract：:The emergence of mutations in the androgen receptor (AR) gene is a recurrent event during progression of prostate cancer (PCa) on androgen ablation therapy. In this study, we show that nonsense mutations that lead to carboxyl-terminal end truncated ARs are found at high frequency in metastatic PCas. Transcriptional ac...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.22830

    authors： Lapouge G,Erdmann E,Marcias G,Jagla M,Monge A,Kessler P,Serra S,Lang H,Jacqmin D,Bergerat JP,Céraline J

    更新日期：2007-09-15 00:00:00

  • CDKN2A is not the principal target of deletions on the short arm of chromosome 9 in neuroendocrine (Merkel cell) carcinoma of the skin.

    abstract：:The majority of small-cell lung cancers (SCLCs) express p16 but not pRb. Given our previous study showing loss of pRb in Merkel cell carcinoma (MCC)/neuroendocrine carcinoma of the skin and the clinicopathological similarities between SCLC and MCC, we wished to determine if this was also the case in MCC. Twenty-nine M...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.1352

    authors： Cook AL,Pollock PM,Welch J,Walsh MD,Bowman RV,Baumann KC,Hayward NK,Leonard JH

    更新日期：2001-08-01 00:00:00

  • Metallothionein gene expression and resistance to cisplatin in human ovarian cancer.

    abstract：:Intracellular thiols have been proposed as mediators of resistance to alkylating agents and cisplatin. As metallothionein is the predominant protein thiol, we examined its relationship to cisplatin resistance in human ovarian cancer cell lines. A human ovarian carcinoma cell line, A2780, derived from an untreated pati...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910450306

    authors： Schilder RJ,Hall L,Monks A,Handel LM,Fornace AJ Jr,Ozols RF,Fojo AT,Hamilton TC

    更新日期：1990-03-15 00:00:00

  • Increased incidence of mouse mammary tumor virus-related antigen in Tunisian patients with breast cancer.

    abstract：:Biopsies obtained from 74 Tunisian women with breast cancer (33 cases), benign breast disease (17 cases), and cervical cancer (24 cases) were assayed for the presence of an antigen cross-reacting with gp52 of the mouse mammary tumor virus (MMTV) in order to determine the frequency and possible prognostic significance ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910330305

    authors： Levine PH,Mesa-Tejada R,Keydar I,Tabbane F,Spiegelman S,Mourali N

    更新日期：1984-03-15 00:00:00

  • Qualitative and quantitative differences between Burkitt lymphoma and lymphoblastoid cell lines in the expression of membrane ecto-nucleotidases and in the response to agonists of the A2-type adenosine receptor.

    abstract：:The activity of ecto-nucleotidases has been determined on intact cells from Burkitt lymphoma (BL) and lymphoblastoid cell lines established in vitro (LCLs). BL cells never express ecto-5'-nucleotidase (5'-N) and exhibit only low levels of ecto-ATPase activity, whereas LCL-cells usually express both enzymes to varying ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910410321

    authors： Gutensohn W,Jahn H

    更新日期：1988-03-15 00:00:00

  • Modulation of pentose phosphate pathway during cell cycle progression in human colon adenocarcinoma cell line HT29.

    abstract：:Cell cycle regulation is dependent on multiple cellular and molecular events. Cell proliferation requires metabolic sources for the duplication of DNA and cell size. However, nucleotide reservoirs are not sufficient to support cell duplication and, therefore, biosynthetic pathways should be upregulated during cell cyc...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.24262

    authors： Vizán P,Alcarraz-Vizán G,Díaz-Moralli S,Solovjeva ON,Frederiks WM,Cascante M

    更新日期：2009-06-15 00:00:00

  • Receptors for hormones and growth factors and (onco)-gene amplification in human ovarian cancer.

    abstract：:Receptor status and gene amplification were studied in advanced human ovarian adenocarcinoma tissues, borderline and benign ovarian tumours and normal ovarian tissues. Sixty-five percent (53/82) of ovarian adenocarcinomas, 57% (8/14) of benign/borderline tumours and only 31% (5/16) of normal ovarian tissues studied sh...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910520211

    authors： Berns EM,Klijn JG,Henzen-Logmans SC,Rodenburg CJ,van der Burg ME,Foekens JA

    更新日期：1992-09-09 00:00:00