High frequency of inactivation of the imprinted H19 gene in "sporadic" hepatoblastoma.

abstract：:To investigate the genetic changes that occur during establishment of gastric cancer cell lines, 4 gastric cancer cell lines and their original tumor tissues were examined for microsatellite instability (MSI), loss of heterozygosity (LOH), and p53 mutation. MSI status did not change during the establishment, though th...

journal_title：International journal of cancer

authors： Bae SI,Park JG,Kim YI,Kim WH

更新日期：2000-08-15 00:00:00

abstract：:Photodynamic therapy using 5-aminolevulinic acid (5-ALA)-induced protoporphyrin IX is a promising tool in bladder-cancer therapy. However, little is known about the cellular mechanisms of phototoxicity. Our aim was to characterize the cellular damage and to optimize differential photodynamic effectiveness between tumo...

journal_title：International journal of cancer

authors： Seidl J,Rauch J,Krieg RC,Appel S,Baumgartner R,Knuechel R

更新日期：2001-06-01 00:00:00

abstract：:Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel drugs that can downregulate CXCR4/CXCL12 axis have a great potential in the treatment of metastatic...

journal_title：International journal of cancer

authors： Shanmugam MK,Manu KA,Ong TH,Ramachandran L,Surana R,Bist P,Lim LH,Kumar AP,Hui KM,Sethi G

更新日期：2011-10-01 00:00:00

abstract：:Micro RNAs (miR) are master regulators of cellular transcriptome. We aimed to investigate the role of miR regulation on tumor radiosensitivity and development of local tumor recurrence by a novel large-scale in vivo loss of function screen. For stable miR silencing, human A431 tumor cells were transduced with lentivir...

journal_title：International journal of cancer

authors： Fahim Golestaneh A,Lecker LSM,Schlegel J,Nowrouzi A,Schwager C,Meister S,Weichert W,Debus J,Abdollahi A

更新日期：2019-06-01 00:00:00

abstract：:Studies of colon cancer risk in males have reported strong positive associations with obesity, particularly with central adiposity. The association has been weaker and less consistent for women. In a prospective cohort study of women, body measurements were taken directly; fat mass and fat-free mass being estimated by...

journal_title：International journal of cancer

authors： MacInnis RJ,English DR,Hopper JL,Gertig DM,Haydon AM,Giles GG

更新日期：2006-03-15 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)-, matrix metall...

journal_title：International journal of cancer

authors： Farina AR,Coppa A,Tiberio A,Tacconelli A,Turco A,Colletta G,Gulino A,Mackay AR

更新日期：1998-03-02 00:00:00

abstract：:This work demonstrates the need for the continued presence of lipopolysaccharide (LPS) for tumor necrosis factor (TNF) production by thioglycollate-induced peritoneal macrophages. Removal of LPS at any time resulted in the abrupt cessation of further TNF production. The readdition of LPS resulted in further production...

journal_title：International journal of cancer

authors： Gifford GE,Lohmann-Matthes ML

更新日期：1986-07-15 00:00:00

abstract：:Exercise has been shown to reduce risk and improve prognosis of several types of cancers. Irisin is a myokine linked to exercise and lean body mass, which is thought to favorably alter metabolism systemically, potentially providing benefit for metabolic disease (including cancer). We evaluated the effects of various c...

journal_title：International journal of cancer

authors： Gannon NP,Vaughan RA,Garcia-Smith R,Bisoffi M,Trujillo KA

更新日期：2015-02-15 00:00:00

abstract：:Although the existence of a humoral response against tumor-associated antigens is well appreciated, a systematic analysis of its possible induction by the tumor remains missing. We compared the specific IgG response of Stage IV melanoma patients during vaccination. Patients had been treated within 2 clinical trials wi...

journal_title：International journal of cancer

authors： Ehlken H,Schadendorf D,Eichmüller S

更新日期：2004-01-10 00:00:00

abstract：:p16(INK4a), a cell cycle regulation protein, accumulates in abnormal epithelial cells infected with high-risk human papilloma virus (HPV). In immunostaining studies, p16(INK4a) has shown potential as a marker of high grade cervical intraepithelial neoplasia (CIN) and invasive cervical cancer. To evaluate its potential...

journal_title：International journal of cancer

authors： Mao C,Balasubramanian A,Yu M,Kiviat N,Ridder R,Reichert A,Herkert M,von Knebel Doeberitz M,Koutsky LA

更新日期：2007-06-01 00:00:00

abstract：:The aim of this study was to assess the diagnostic performance of breast imaging in the diagnosis of breast cancer in a non-screening population. In a consecutive set of patients referred for mammography in one year, the results of palpation and radiological breast imaging were scored on a 5-point grading scale and li...

journal_title：International journal of cancer

authors： Flobbe K,van der Linden ES,Kessels AG,van Engelshoven JM

更新日期：2001-05-15 00:00:00

abstract：:We show that siRNA-mediated suppression of protein tyrosine phosphatase alpha (PTP alpha) reduces Src activity 2 to 4-fold in breast, colon and other human cancer cell lines. Src and PTP alpha RNAi induced apoptosis in estrogen receptor (ER)-negative breast cancer and colon cancer cells, but not in immortalized noncan...

journal_title：International journal of cancer

authors： Zheng X,Resnick RJ,Shalloway D

更新日期：2008-05-01 00:00:00

abstract：:The purpose was to evaluate alternative cytological screening methods in population-based screening for cervical cancer up to cancer incidence and mortality outcome. Automation-assisted screening was compared to conventional cytological screening in a randomized design. The study was based on follow-up of 503,391 wome...

journal_title：International journal of cancer

authors： Anttila A,Pokhrel A,Kotaniemi-Talonen L,Hakama M,Malila N,Nieminen P

更新日期：2011-03-01 00:00:00

abstract：:We have established a number of cell lines from Merkel cell carcinoma (MCC) of the skin. In many respects these cell lines resemble those established from small cell lung cancer (SCLC) and it is difficult to differentiate between metastatic MCC and SCLC on morphological or histochemical criteria. Both are thought to b...

journal_title：International journal of cancer

authors： Thomson JA,Leonard JH,McGregor K,Sturm RA,Parsons PG

更新日期：1994-07-15 00:00:00

abstract：:The cellular tumor suppressor p16 is strongly overexpressed in cervical cancers and precancers. We have previously demonstrated that infiltrating T lymphocytes reactive against p16 can be found in cervical cancer patients. Here, we analyzed whether p16 induces humoral immune responses. Sera of patients with cervical c...

journal_title：International journal of cancer

authors： Reuschenbach M,Waterboer T,Wallin KL,Einenkel J,Dillner J,Hamsikova E,Eschenbach D,Zimmer H,Heilig B,Kopitz J,Pawlita M,Doeberitz Mv,Wentzensen N

更新日期：2008-12-01 00:00:00

abstract：:The Epstein-Barr virus nuclear antigen I (EBNA I) is the only latent EBV antigen consistently expressed in malignant tissues of the nasopharynx. A 20-amino-acid synthetic peptide, p107 contains a major epitope of EBNA I. We tested sera from 210 patients with nasopharyngeal carcinoma (NPC) and from 128 normal individua...

journal_title：International journal of cancer

authors： Foong YT,Cheng HM,Sam CK,Dillner J,Hinderer W,Prasad U

更新日期：1990-06-15 00:00:00

abstract：:The MYH gene has recently been shown to be associated with a recessive form of colorectal adenomatous polyposis. Two common mutations in the MYH gene have been identified that lend themselves to rapid screening. We have examined a series of 302 individuals comprising 120 control subjects, 120 patients diagnosed with a...

journal_title：International journal of cancer

authors： Kairupan CF,Meldrum CJ,Crooks R,Milward EA,Spigelman AD,Burgess B,Groombridge C,Kirk J,Tucker K,Ward R,Williams R,Scott RJ

更新日期：2005-08-10 00:00:00

abstract：:A series of 111 human bladder tumors were screened using oligonucleotide mutant specific probes, restriction enzyme analysis and single-stranded confirmation polymorphism (SSCP) for the presence of H-ras activation events. Thirty-three tumors were found to harbor H-ras mutations where a glycine to valine (G-->T) chang...

journal_title：International journal of cancer

authors： Levesque P,Ramchurren N,Saini K,Joyce A,Libertino J,Summerhayes IC

更新日期：1993-11-11 00:00:00

abstract：:Regression of EB-virus-induced transformation occurs exclusively in cultures of leukocytes from seropositive donors. Studies have shown that the strength of regression could be assayed in terms of the proportion of T cells which must be added to the autologous EB virus-infected T-cell-depleted population in order to e...

journal_title：International journal of cancer

authors： Rickinson AB,Moss DJ,Pope JH

更新日期：1979-05-15 00:00:00

abstract：:DU-PAN-2 is a high-molecular-weight glycoprotein defined by a murine monoclonal antibody (MAb) against a pancreatic ductal adenocarcinoma cell line. In order to evaluate the usefulness of this antigen as a tumor marker, we determined the serum level of the antigen by competitive inhibition radioimmunoassay in sera fro...

journal_title：International journal of cancer

authors： Sawabu N,Toya D,Takemori Y,Hattori N,Fukui M

更新日期：1986-05-15 00:00:00

abstract：:A diet high in linoleic acid (an ω-6 PUFA) increased the formation of miscoding etheno (ε)--DNA adducts in WBC-DNA of women, but not in men (Nair et al., Cancer Epidemiol Biomark Prev 1997;6:597-601). This gender specificity could result from an interaction between ω-6 PUFA intake and estrogen catabolism, via redox-cy...

journal_title：International journal of cancer

authors： Sun X,Nair J,Linseisen J,Owen RW,Bartsch H

更新日期：2012-11-01 00:00:00

abstract：:The effect of linoleic acid (LA) on growth and transformation of IEC6 intestinal cells was examined. IEC6 cells expressed mRNAs of 15-lipooxygenase (LOX15) and peroxisome proliferator-activated receptor (PPAR)gamma but not COX-2. Cell growth was suppressed by LA in a dose-dependent manner in IEC6 cells. Three-week tre...

journal_title：International journal of cancer

authors： Sasaki T,Yoshida K,Shimura H,Ichiba M,Sasahira T,Shimomoto T,Denda A,Kuniyasu H

更新日期：2006-02-01 00:00:00

abstract：:Ten patients with bulky brain glioblastoma, recurring after surgery, radiotherapy or chemotherapy, underwent direct intralesional radioimmunotherapy (RIT) using a monoclonal antibody (MAb), BC-2, raised against tenascin and labelled with 131I. Tenascin, the BC-2-recognized glycoprotein, is an antigen expressed by the ...

journal_title：International journal of cancer

authors： Riva P,Arista A,Sturiale C,Moscatelli G,Tison V,Mariani M,Seccamani E,Lazzari S,Fagioli L,Franceschi G

更新日期：1992-04-22 00:00:00

abstract：:LiSa-2 is a stable cell line derived from a poorly differentiated, pleomorphic liposarcoma. In serum-containing medium, LiSa-2 cells are fibroblastoid and rapidly dividing. In a serum-free, chemically defined culture medium containing physiological concentrations of insulin, triiodothyronine and cortisol, LiSa-2 cells...

journal_title：International journal of cancer

authors： Wabitsch M,Brüderlein S,Melzner I,Braun M,Mechtersheimer G,Möller P

更新日期：2000-12-15 00:00:00

abstract：:The variants within the human melanocortin 1 receptor (MC1R) gene are associated with an increased risk of different skin cancers. In this study, we genotyped by direct sequencing, 529 cases of basal cell carcinoma of the skin (BCC) and 533 healthy controls for polymorphisms in the entire MC1R gene. In addition to 10 ...

journal_title：International journal of cancer

authors： Scherer D,Bermejo JL,Rudnai P,Gurzau E,Koppova K,Hemminki K,Kumar R

更新日期：2008-04-15 00:00:00

abstract：:High dietary intakes of calcium and dairy products have been hypothesized to enhance prostate cancer risk, but available prospective data regarding these associations are inconsistent. We examined dietary intakes of calcium and dairy products in relation to risk of prostate cancer in the Alpha-Tocopherol, Beta-Caroten...

journal_title：International journal of cancer

authors： Mitrou PN,Albanes D,Weinstein SJ,Pietinen P,Taylor PR,Virtamo J,Leitzmann MF

更新日期：2007-06-01 00:00:00

abstract：:Antibodies to HTLV-I have been detected in sera from 15 (2.0%) of 736 adult blood-donors in Nigeria, in 4 (20.0%) of 20 patients with chronic lymphatic leukaemia, 3 (10.0%) of 30 with non-Hodgkin's lymphoma, one of 12 with Burkitt's lymphoma and one of 7 with acute lymphoblastic leukaemia. The frequency of positivity ...

journal_title：International journal of cancer

authors： Fleming AF,Maharajan R,Abraham M,Kulkarni AG,Bhusnurmath SR,Okpara RA,Williams E,Akinsete I,Schneider J,Bayer H

更新日期：1986-12-15 00:00:00

abstract：:We have previously reported a complete allelotype study of 86 primary breast carcinomas, in which each non-acrocentric chromosome arm was studied with at least one polymorphic DNA-marker for the presence of allelic imbalance (AI, allelic loss or allelic gain) in the tumor. Here we report the statistical analysis of th...

journal_title：International journal of cancer

authors： Cornelisse CJ,Kuipers-Dijkshoorn N,van Vliet M,Hermans J,Devilee P

更新日期：1992-02-20 00:00:00

abstract：:Use of herbal preparations containing Aristolochia species has led to progressive nephropathy and urothelial cancer in humans. Analysis of DNA adducts formed in human target tissues and studies in animal models have pointed out a major role of the secondary plant metabolites, aristolochic acids, in these effects. Only...

journal_title：International journal of cancer

authors： Meinl W,Pabel U,Osterloh-Quiroz M,Hengstler JG,Glatt H

更新日期：2006-03-01 00:00:00

abstract：:In 584 consecutive patients with no previous history of cancer or polypectomy, 769 adenomas were excised endoscopically and classified retrospectively according to the following parameters: macroscopic growth pattern, size, histological type, grade of dysplasia, anatomical site, presence of adenocarcinoma (ADK), numbe...

journal_title：International journal of cancer

authors： Gatteschi B,Costantini M,Bruzzi P,Merlo F,Torcoli R,Nicolo G

更新日期：1991-10-21 00:00:00