Abstract:
:This work demonstrates the need for the continued presence of lipopolysaccharide (LPS) for tumor necrosis factor (TNF) production by thioglycollate-induced peritoneal macrophages. Removal of LPS at any time resulted in the abrupt cessation of further TNF production. The readdition of LPS resulted in further production of TNF but the yield was limited to the amount that would have been produced had the LPS not been removed.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Gifford GE,Lohmann-Matthes MLdoi
10.1002/ijc.2910380121subject
Has Abstractpub_date
1986-07-15 00:00:00pages
135-7issue
1eissn
0020-7136issn
1097-0215journal_volume
38pub_type
杂志文章abstract::Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN). Additionally, regulatory T (Treg) cells are increasingly understoo...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.24117
更新日期:2009-03-15 00:00:00
abstract::Up to 30% of stage II patients with curatively resected colorectal cancer (CRC) will develop disease recurrence. We evaluated whether examination of lymph nodes by multilevel sectioning and immunohistochemical staining can improve prognostication. Lymph nodes (n = 780) from 36 CRC patients who had developed disease re...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24817
更新日期:2010-06-01 00:00:00
abstract::Although tobacco smoking, pan chewing and alcohol drinking are important risk factors for head and neck cancer (HNC), the HNC risks conferred by products available in Nepal for these habits are unknown. We assessed the associations of tobacco smoking, chewing habits, and alcohol drinking with HNC risk in Nepal. A case...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32823
更新日期:2020-08-01 00:00:00
abstract::Because renal-cell carcinoma (RCC) is considered relatively resistant to radio- and chemotherapy, RCC patients may benefit from new treatment modalities, e.g. immunotherapy. In vitro and in vivo studies suggest that combinations of cytokines such as interferon gamma or interferon alpha (IFN-gamma, IFN-alpha) and tumor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560220
更新日期:1994-01-15 00:00:00
abstract::A wide variety of primary and metastatic human neoplasms express somatostatin receptors (SS-Rs). We evaluated the SS-R status of malignant lymphomas that had been surgically removed from 31 patients by use of in vitro SS-R autoradiography with the SS analog 125I-[Tyr3]-octreotide as radioligand. Of 11 low-grade-malign...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500613
更新日期:1992-04-01 00:00:00
abstract::Combretastatin A4 (CA4) is a novel vascular disrupting agent that has promising clinical efficacy because of its ability to inhibit microtubule assembly and subsequently disrupt tumor blood flow. In this study, we demonstrate that mitogen-activated protein kinases (MAPKs) are critically involved in the cytotoxicity of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23262
更新日期:2008-04-15 00:00:00
abstract::Human papillomavirus (HPV) genomes usually persist as episomal molecules in HPV associated preneoplastic lesions whereas they are frequently integrated into the host cell genome in HPV-related cancers cells. This suggests that malignant conversion of HPV-infected epithelia is linked to recombination of cellular and vi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2001-04-01 00:00:00
abstract::Cigarette smoking and alcohol consumption were examined as potential risk factors in a case-control study of primary liver cancer (PLC). A total of 165 PLC cases and 465 matched controls from several US hospitals were studied. A weak but statistically significant (p less than 0.05) dose-response relationship was obser...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420304
更新日期:1988-09-15 00:00:00
abstract::The aim of this study was to test the utility of AIMP3, an upstream regulator of DNA damage response following genotoxic stress, as a clinical biomarker in muscle-invasive bladder cancer (MIBC). AIMP3 was identified from a meta-analysis of a global gene-expression dataset. AIMP3 protein expression was determined by im...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.29022
更新日期:2015-02-01 00:00:00
abstract::In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis characterized by cell shrinkage and cell membrane scrambling. Eryptotic erythrocytes are rapidly cleared from circulating blood and may adhere to the vascular wall. Stimulation of eryptosis thus impairs microcirculation and leads to anemia as...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30800
更新日期:2017-10-15 00:00:00
abstract::CD22 antibodies (Abs) bound to B-cell lymphomas are known to be internalized and catabolized rapidly. Therefore, it would be expected that use of CD22 as a target for radioimmunotherapy should be enhanced by the use of "residualizing" radiolabels, which are trapped within the cell after catabolism of the Ab to which t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970502)71:3<429::aid-ijc
更新日期:1997-05-02 00:00:00
abstract::XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XI...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10776
更新日期:2003-01-01 00:00:00
abstract::Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in variety of cancer cells without affecting most normal cells, which makes it a promising agent for cancer therapy. However, TRAIL therapy is clinically not effective due to resistance induction. To identify novel regulators of TRAIL th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31079
更新日期:2018-02-01 00:00:00
abstract::Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33453
更新日期:2020-12-21 00:00:00
abstract::Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29680
更新日期:2016-01-01 00:00:00
abstract::MART-1/MelanA and Pmel17/gp100 are melanoma-associated antigens (MAAs) that can be recognized by tumor-infiltrating lymphocytes (TILs) capable of mediating successful adoptive therapy in vivo. Analysis of melanoma cell lines in vitro has demonstrated that heterogeneous antigen expression in the context of class I MHC ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980209)75:4<517::aid-ijc
更新日期:1998-02-09 00:00:00
abstract::People living with HIV (PLHIV) are more likely than the general population to develop AIDS-defining malignancies (ADMs) and several non-ADMs (NADMs). Information is lacking on survival outcomes and cause-specific mortality after cancer diagnosis among PLHIV. We investigated causes of death within 5 years of cancer dia...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32895
更新日期:2020-06-01 00:00:00
abstract::Invasion of malignant cells requires altered cellular interaction with extracellular matrix. Integrin-type cell adhesion receptors play an important role in this process. Integrin-related cell biological phenomena explain cancer cell migration, and recent developments in the field have made it possible to propose that...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0215(19960315)65:6<717::AID-IJC
更新日期:1996-03-15 00:00:00
abstract::While dietary antioxidants are emerging as potentially modifiable risk factors for esophageal adenocarcinoma (EAC), studies on dietary antioxidants and its precursor Barrett's esophagus (BE) are limited. The present study extends previous work on BE by investigating risks of nondysplastic BE, dysplastic BE and EAC ass...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28016
更新日期:2013-07-01 00:00:00
abstract::We previously reported that exosomal nanoparticles secreted by human pancreatic tumoral cell lines decrease tumoral cell proliferation through the mitochondria-dependent apoptotic pathway, because of activation of pro-apoptotic phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and of glucose synthase kina...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24375
更新日期:2009-09-01 00:00:00
abstract::We previously found that the gene encoding the Myelin and Lymphocyte protein, MAL, was among the most highly expressed genes in serous ovarian cancers from short-term survivors (<3 years) relative to those of long-term survivors (>7 years). In the present study, we have found that this difference in expression is part...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24797
更新日期:2010-03-15 00:00:00
abstract::CD95/Fas is a cell surface protein that belongs to the tumor necrosis factor receptor family. Signals through CD95/Fas are able to induce apoptosis in sensitive cells. Therefore, modalities to regulate the CD95/Fas expression level in tumor cells are called for. In the present study, we show that sublethal doses of ar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20433
更新日期:2004-11-20 00:00:00
abstract::In order to examine whether or not the expression of the apoptosis-related receptor Fas (CD-95/APO-1) and its ligand (FasL) has relevance for patient survival, immunohistochemistry was used to analyze the proteins of both factors in 164 non-small cell lung carcinomas. Patients with Fas-positive tumors exhibited signif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990621)84:3<239::aid-ijc
更新日期:1999-06-21 00:00:00
abstract::Two metastatic cell lines, mouse B16-Fl melanoma and human Hs939 melanoma, were examined for their abilities to adhere to confluent vascular endothelial cell monolayers and to the underlying endothelial extracellular matrix. Tumor cells attacked slowly to the endothelial cell monolayers while they adhered rapidly to i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260516
更新日期:1980-11-15 00:00:00
abstract::Bone-marrow (BM) hematopoietic precursors are recruited into proliferative activity when colony-stimulating factors (CSF) are sequenced with chemotherapy (CT). Previous studies suggested that further CT can be safely administered only when the increased proliferative activity of these cells has subsided, because most ...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/ijc.2910630508
更新日期:1995-11-27 00:00:00
abstract::Natural killer (NK)6 cell activity of peripheral blood lymphocytes against human leukemia cell lines was measured in patients with chronic B-cell lymphocytic leukemia (CLL) and age- and sex-matched controls. In order to remove the leukemia cells that interfere with the in vitro assay we (1) isolated lymphocytes that f...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270310
更新日期:1981-03-15 00:00:00
abstract::We, and others, have recently shown that recombinant feline leukaemia viruses (FeLV) containing the myc gene (FeLV-myc) occur in up to 30% of naturally occurring cases of T-cell lymphosarcoma. Investigation of the disease spectrum of two FeLV-myc isolates showed that they induced clonal or oligoclonal T-cell tumours a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910400108
更新日期:1987-07-15 00:00:00
abstract::Flavone acetic acid (FAA) is a potentially useful anti-tumour agent which has been reported to induce changes in tumour vasculature, in particular loss of bloodflow. This led us to examine whether endothelium could be a cellular target of FAA action, with resultant modulation of cell-surface coagulant properties leadi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490219
更新日期:1991-09-09 00:00:00
abstract::The effects of prolonged administration of genistein, a tyrosine-kinase inhibitor, on sodium-chloride-enhanced induction of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990129)80:3<396::aid-ijc
更新日期:1999-01-29 00:00:00
abstract::It has been suggested that smoking is associated with estrogen-negative breast cancer but not with estrogen-positive breast cancer. A population-based case-control study was conducted in Geneva, Switzerland, to determine the relation of passive and active smoking to breast cancer when the referent unexposed category c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980130)75:3<339::aid-ijc
更新日期:1998-01-30 00:00:00