Cigarette smoking, alcohol consumption and primary liver cancer: a case-control study in the USA.


:Cigarette smoking and alcohol consumption were examined as potential risk factors in a case-control study of primary liver cancer (PLC). A total of 165 PLC cases and 465 matched controls from several US hospitals were studied. A weak but statistically significant (p less than 0.05) dose-response relationship was observed between alcohol consumption and PLC in elderly females independent of other major risk factors (adjusted OR = 1.87 and 3.48 for 1-2 and greater than 3 drinks per day, respectively) and a similar trend was evident in elderly males. The risk for PLC was also elevated in elderly females who were current cigarette smokers (adjusted OR = 3.30). Our results suggest that alcohol consumption and cigarette smoking may have minor age- and sex-specific effects on the development of PLC, and underscore the need for further investigations to elucidate major PLC risk factors in US populations.


Int J Cancer


Yu H,Harris RE,Kabat GC,Wynder EL




Has Abstract


1988-09-15 00:00:00












  • Equivalent chemotherapy efficacy against leukemia in mice treated with topical vasoconstrictors to prevent cancer therapy side effects.

    abstract::Topically applied vasoconstrictor is a new strategy to prevent oral mucositis and alopecia, two complications of chemotherapy and stem-cell transplant. We sought to determine whether mice treated with topical vasoconstrictor minutes before chemotherapy to suppress L1210 leukemia would develop a vasoconstrictor-induced...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Graul-Conroy A,Hicks EJ,Fahl WE

    更新日期:2016-06-15 00:00:00

  • Risk of lung cancer among cigarette and pipe smokers in southern China.

    abstract::Studies in Shanghai and in north-east China indicate that cigarette smoking is a major contributor to the high rates of lung cancer in those areas, but doubts persist regarding the influence of cigarette use on lung cancer rates in other areas of China. In addition, the risk of lung cancer associated with other method...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lubin JH,Li JY,Xuan XZ,Cai SK,Luo QS,Yang LF,Wang JZ,Yang L,Blot WJ

    更新日期:1992-05-28 00:00:00

  • Expression of the ALK protein by anaplastic large-cell lymphomas correlates with high proliferative activity.

    abstract::A variable fraction of anaplastic large-cell lymphomas (ALCLs) exhibits a t(2;5)(p23;q35) translocation that results in expression of the chimeric hyperphosphorylated protein NPM-ALK (p80). Tumor cells expressing NPM-ALK exhibit markedly enhanced proliferative activity, but comparative cellular kinetic studies on ALK(...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Leoncini L,Lazzi S,Scano D,Mura A,Onida A,Massarelli G,Tosi P,Barbini P,Cevenini G,Massai MR,Pileri S,Falini B,Giordano A,Kraft R,Laissue JA,Cottier H

    更新日期:2000-06-15 00:00:00

  • Selective induction of endothelial cell tissue factor in the presence of a tumour-derived mediator: a potential mechanism of flavone acetic acid action in tumour vasculature.

    abstract::Flavone acetic acid (FAA) is a potentially useful anti-tumour agent which has been reported to induce changes in tumour vasculature, in particular loss of bloodflow. This led us to examine whether endothelium could be a cellular target of FAA action, with resultant modulation of cell-surface coagulant properties leadi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Murray JC,Clauss M,Denekamp J,Stern D

    更新日期:1991-09-09 00:00:00

  • Cloning and expression of the recombinant FAb fragment of monoclonal antibody K1 that reacts with mesothelin present on mesotheliomas and ovarian cancers.

    abstract::The monoclonal antibody (MAb) K1 recognizes an approximate 40 kDa glycoprotein, mesothelin, that is present on the surface of human mesothelial cells, mesotheliomas and ovarian cancers. We have cloned the cDNAs encoding the variable regions of MAb K1 and constructed plasmids for expression of recombinant K1(FAb). Reco...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Brinkmann U,Webber K,Di Carlo A,Beers R,Chowdhury P,Chang K,Chaudhary V,Gallo M,Pastan I

    更新日期:1997-05-16 00:00:00

  • Circulating tumor DNA and circulating tumor cells in metastatic triple negative breast cancer patients.

    abstract::Circulating tumor DNA (ctDNA) is a new circulating tumor biomarker which might be used as a prognostic biomarker in a way similar to circulating tumor cells (CTCs). Here, we used the high prevalence of TP53 mutations in triple negative breast cancer (TNBC) to compare ctDNA and CTC detection rates and prognostic value ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Madic J,Kiialainen A,Bidard FC,Birzele F,Ramey G,Leroy Q,Rio Frio T,Vaucher I,Raynal V,Bernard V,Lermine A,Clausen I,Giroud N,Schmucki R,Milder M,Horn C,Spleiss O,Lantz O,Stern MH,Pierga JY,Weisser M,Lebofsky R

    更新日期:2015-05-01 00:00:00

  • Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling.

    abstract::The aim of our study was to further explore the use of anti-angiogenic therapy targeting the vascular endothelial growth factor receptor (VEGFR) on endothelial cells while simultaneously targeting platelet-derived growth factor receptors (PDGFRs) on adjacent pericytes. B16 mouse melanoma tumors exogenously expressing ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hasumi Y,Kłosowska-Wardega A,Furuhashi M,Ostman A,Heldin CH,Hellberg C

    更新日期:2007-12-15 00:00:00

  • X-ray-induced chromatid damage in relation to DNA repair and cancer incidence in family members.

    abstract::The cytogenetic response to G2-phase X-irradiation was examined in phytohemagglutinin-stimulated peripheral-blood lymphocytes from 69 individuals, a few of whom were cancer patients. The cancer patients had not received radiation or chemotherapy. The responses of cells arrested by Colcemid 30 to 90 min after X-irradia...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Knight RD,Parshad R,Price FM,Tarone RE,Sanford KK

    更新日期:1993-06-19 00:00:00

  • Mutation analysis of the N-ras proto-oncogene in active and remission phase of human acute leukemias.

    abstract::DNA isolated from blood or bone-marrow samples from 18 patients with acute non-lymphocytic leukemia (ANLL) and 14 patients with acute lymphocytic leukemia (ALL) was analyzed for the presence of mutations in the N-ras gene. Using synthetic oligonucleotide probes we detected mutations in 5 cases of ANLL; 4 GGT----GAT tr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Senn HP,Trân-Thang C,Wodnar-Filipowicz A,Jiricny J,Fopp M,Gratwohl A,Signer E,Weber W,Moroni C

    更新日期:1988-01-15 00:00:00

  • High-resolution imaging for the detection and characterisation of circulating tumour cells from patients with oesophageal, hepatocellular, thyroid and ovarian cancers.

    abstract::Interest has increased in the potential role of circulating tumour cells in cancer management. Most cell-based studies have been designed to determine the number of circulating tumour cells in a given volume of blood. Ability to understand the biology of the cancer cells would increase the clinical potential. The purp...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dent BM,Ogle LF,O'Donnell RL,Hayes N,Malik U,Curtin NJ,Boddy AV,Plummer ER,Edmondson RJ,Reeves HL,May FE,Jamieson D

    更新日期:2016-01-01 00:00:00

  • Maternal and perinatal factors associated with non-Hodgkin's lymphoma among children.

    abstract::This nested case-control study based on 1.7 million live births in Sweden explores the associations between maternal and perinatal factors and the occurrence of childhood non-Hodgkin's lymphoma (NHL). The National Swedish Cancer Registry ascertained 168 cases in successive birth cohorts from 1973 through 1989 recorded...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Adami J,Glimelius B,Cnattingius S,Ekbom A,Zahm SH,Linet M,Zack M

    更新日期:1996-03-15 00:00:00

  • Parenteral is more efficient than mucosal immunization to induce regression of human papillomavirus-associated genital tumors.

    abstract::Cervical cancer is a public health concern as it represents the second cause of cancer death in women worldwide. High-risk human papillomaviruses (HPV) are the etiologic agents, and HPV E6 and/or E7 oncogene-specific therapeutic vaccines are under development to treat HPV-related lesions in women. Whether the use of m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Decrausaz L,Domingos-Pereira S,Duc M,Bobst M,Romero P,Schiller JT,Jichlinski P,Nardelli-Haefliger D

    更新日期:2011-08-01 00:00:00

  • Elevated expression of eIF4E in confined early breast cancer lesions: possible role of hypoxia.

    abstract::The translation-initiation factor eIF4E is rate-limiting for protein synthesis, and its over-expression results in oncogenic transformation of mammalian cells. eIF4E facilitates the synthesis of several powerful tumor angiogenic factors (FGF-2 and VEGF) by selectively enhancing their translation. In breast carcinomas,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: DeFatta RJ,Turbat-Herrera EA,Li BD,Anderson W,De Benedetti A

    更新日期:1999-02-09 00:00:00

  • Ganglioside GM2 expression on human melanoma cells correlates with sensitivity to lymphokine-activated killer cells.

    abstract::Ganglioside GM2 is expressed on cell surface membranes of a variety of human malignant cells and has been demonstrated to be immunogenic in humans. We have assessed the role of the antigen GM2 on melanoma cells as a recognition structure for lymphokine-activated killer (LAK) cells. LAK cells were generated by stimulat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hoon DS,Ando I,Sviland G,Tsuchida T,Okun E,Morton DL,Irie RF

    更新日期:1989-05-15 00:00:00

  • Applicability of an absolute quantitative procedure to monitor intra-individual bcr/abl transcript kinetics in clinical samples from chronic myelogenous leukemia patients.

    abstract::Chimeric bcr/abl fusion proteins are thought to be the molecular 'pathogen' of chronic myelogenous leukaemia (CML). Expression levels of the respective fusion RNAs reflect disease progression as well as remission upon therapeutic intervention in CML patients. However, there is no quick and reliable method that would a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kreuzer KA,Lass U,Nagel S,Ellerbrok H,Pauli G,Pawlaczyk-Peter B,Siegert W,Huhn D,Schmidt CA

    更新日期:2000-06-01 00:00:00

  • DNA repair phenotype and cancer susceptibility--a mini review.

    abstract::DNA repair is a complicated biological process, consisting of several distinct pathways, that plays a fundamental role in the maintenance of genomic integrity. The very important field of DNA repair and cancer risk has developed rapidly in the past decades. In this review of selected published data from our laboratory...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Li C,Wang LE,Wei Q

    更新日期:2009-03-01 00:00:00

  • Beta-galactoside alpha2,6 sialyltransferase in human colon cancer: contribution of multiple transcripts to regulation of enzyme activity and reactivity with Sambucus nigra agglutinin.

    abstract::Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dall'Olio F,Chiricolo M,Ceccarelli C,Minni F,Marrano D,Santini D

    更新日期:2000-10-01 00:00:00

  • Radiomics predicts response of individual HER2-amplified colorectal cancer liver metastases in patients treated with HER2-targeted therapy.

    abstract::The aim of our study was to develop and validate a machine learning algorithm to predict response of individual HER2-amplified colorectal cancer liver metastases (lmCRC) undergoing dual HER2-targeted therapy. Twenty-four radiomics features were extracted after 3D manual segmentation of 141 lmCRC on pretreatment portal...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Giannini V,Rosati S,Defeudis A,Balestra G,Vassallo L,Cappello G,Mazzetti S,De Mattia C,Rizzetto F,Torresin A,Sartore-Bianchi A,Siena S,Vanzulli A,Leone F,Zagonel V,Marsoni S,Regge D

    更新日期:2020-12-01 00:00:00

  • Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study.

    abstract::Dietary information from a case-control study of pancreatic cancer conducted in Metropolitan Toronto between 1983 and 1986 is reported. A total of 249 cases and 505 population-based controls completed quantitative diet histories from which total caloric intake and the intake of a number of nutrients were estimated. A ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Howe GR,Jain M,Miller AB

    更新日期:1990-04-15 00:00:00

  • MHC class I expression in HPV positive and negative tonsillar squamous cell carcinoma in correlation to clinical outcome.

    abstract::Human papillomavirus (HPV) is an important factor for the development of tonsillar squamous cell carcinoma (TSCC). In addition, patients with HPV-positive TSCC have a better clinical outcome than patients with HPV-negative TSCC. Although, HPV is an important prognostic marker, additional biomarkers are needed to bette...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Näsman A,Andersson E,Nordfors C,Grün N,Johansson H,Munck-Wikland E,Massucci G,Dalianis T,Ramqvist T

    更新日期:2013-01-01 00:00:00

  • Differential intracellular processing of the anthracycline drug ME2303 in doxorubicin-sensitive (A2780) and -resistant (A2780AD) human ovarian cancer cells as studied with confocal laser scanning microscopy and image analysis.

    abstract::Laser scanning confocal microscopy has been used to follow the uptake and efflux of the 2-fluoroglycoside of doxorubicin, ME2303, in live cultures of the human ovarian cancer cell line A2780 and its doxorubicin-resistant variant A2780AD. Our methods combine confocal laser scanning microscopy and image analysis to exam...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Huxham IM,Barlow AL,Lewis AD,Plumb J,Mairs RJ,Gaze MN,Workman P

    更新日期:1994-10-01 00:00:00

  • Treatment of AIDS-associated Kaposi's sarcoma in Zimbabwe: results of a randomized quality of life focused clinical trial.

    abstract::Kaposi's sarcoma is currently the most common tumor in Zimbabwe. The purpose of our study is to compare the effectiveness of supportive care vs. 3 intervention approaches, namely oral Etoposide, a 3-drug combination, and radiotherapy using quality of life (QOL) as the primary measure of success. In addition, our study...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Olweny CL,Borok M,Gudza I,Clinch J,Cheang M,Kiire CF,Levy L,Otim-Oyet D,Nyamasve J,Schipper H

    更新日期:2005-02-10 00:00:00

  • Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome.

    abstract::CDKN2A (p16) disruption is reported as a frequent event in head and neck squamous cell carcinomas that confers poor prognosis. We investigated the frequency of different potential mechanisms of CDKN2A inactivation in oral tongue squamous cell carcinomas (OTSCC) and their impact on patient outcome. From a cohort of 153...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lim AM,Do H,Young RJ,Wong SQ,Angel C,Collins M,Takano EA,Corry J,Wiesenfeld D,Kleid S,Sigston E,Lyons B,Fox SB,Rischin D,Dobrovic A,Solomon B

    更新日期:2014-08-15 00:00:00

  • AFP-synthesis induction in mouse hepatomas.

    abstract::Highly differentiated, spontaneous hepatomas occurring in 13- to 15-month-old CBA mice were unable to produce embryo-specific serum protein alpha-fetoprotein (AFP). AFP synthesis, however, was induced in such tumors by minimal mechanical damage (small incisions of the tumors). On the 3rd day following surgery, AFP-pos...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shipova LY,Gleiberman AS

    更新日期:1985-01-15 00:00:00

  • H-Ras selectively up-regulates MMP-9 and COX-2 through activation of ERK1/2 and NF-kappaB: an implication for invasive phenotype in rat liver epithelial cells.

    abstract::One of the most frequent events in carcinogenesis is uncontrolled activation of Ras signaling pathway. A previous study demonstrated that the introduction of H-Ras into the normal WB-F344 rat liver epithelial (WB) cell line and adult male F344 rats resulted in tumorigenicity. The present study investigated whether H-R...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee KW,Kim MS,Kang NJ,Kim DH,Surh YJ,Lee HJ,Moon A

    更新日期:2006-10-15 00:00:00

  • Tumor targeting with radiolabeled antibodies in a human carcinoembryonic antigen transgenic mouse model.

    abstract::Mice transgenic for the carcinoembryonic (CEA) gene were used to study the biodistribution and tumor targeting of a radioiodinated monoclonal antibody (MAb), T84.66. The specificity of antibody uptake in tumors was assessed in mice bearing a CEA-transfected syngeneic tumor as well as the antigen-negative parental tumo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Szalai G,Williams LE,Primus FJ

    更新日期:2000-03-15 00:00:00

  • Statin use and head and neck squamous cell carcinoma outcomes.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is a morbid cancer with poor outcomes. Statins possess anticancer properties such as immunomodulatory and anti-inflammatory effects. The objective of our study is to identify the association between statin use among untreated HNSCC patients and overall death, disease-speci...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Getz KR,Bellile E,Zarins KR,Rullman C,Chinn SB,Taylor JMG,Rozek LS,Wolf GT,Mondul AM

    更新日期:2020-12-15 00:00:00

  • International trends in prostatic cancer.

    abstract::The most recent data available demonstrate a 120-fold difference between the lowest and highest incidence rates of prostatic cancer, the disease being very common in North America, particularly among Blacks, and in Scandinavia, while it is rare in Japan and other oriental countries. The highest mortality for prostatic...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zaridze DG,Boyle P,Smans M

    更新日期:1984-02-15 00:00:00

  • Proliferating cell nuclear antigen (PCNA) in relation to ras, c-erbB-2,p53, clinico-pathological variables and prognosis in colorectal adenocarcinoma.

    abstract::Proliferating cell nuclear antigen (PCNA) expression was studied by immunohistochemistry on paraffin-embedded sections of 293 primary colorectal adenocarcinomas and 56 corresponding lymph node metastases. PCNA-positive expression was detected in <25% of tumour cells in 172 (59%) cases and in > 25% in 121 (41%) cases. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sun XF,Carstensen JM,Stål O,Zhang H,Nordenskjöld B

    更新日期:1996-02-20 00:00:00

  • NAD(P)H:quinone oxidoreductase (DT-diaphorase) activity and mRNA content in normal and neoplastic mouse lung epithelia.

    abstract::DT-diaphorase (DTD) is a flavoprotein which catalyzes obligate two-electron reduction of a diverse group of substrates. We have reported previously that non-tumorigenic mouse lung alveolar type-II pneumocytes have high DTD activity, while cell lines derived from lung tumors do not. In contrast, other investigators, us...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Thaete LG,Siegel D,Malkinson AM,Forrest GL,Ross D

    更新日期:1991-08-19 00:00:00