A case-control study of gastric cancer and diet in Italy. III. Risk patterns by histologic type.

abstract：:Folate receptor-alpha (FR-alpha) is generally over-expressed in non-mucinous human ovarian carcinomas. The meaning of FR-alpha over-expression and its role in the 5-methyltetrahydrofolic acid (N5-CH3-H4PteGlu) transport in such tumors is not clear, especially compared with the reduced folate carrier (RFC), the other k...

journal_title：International journal of cancer

authors： Corona G,Giannini F,Fabris M,Toffoli G,Boiocchi M

更新日期：1998-01-05 00:00:00

abstract：:Oral microbiome may play an important role in cancer pathogenesis. However, no study has prospectively investigated the association of the oral microbiome with subsequent risk of developing colorectal cancer (CRC). We conducted a nested case-control study including 231 incident CRC cases and 462 controls within the So...

journal_title：International journal of cancer

authors： Yang Y,Cai Q,Shu XO,Steinwandel MD,Blot WJ,Zheng W,Long J

更新日期：2019-05-15 00:00:00

abstract：:Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...

journal_title：International journal of cancer

authors： Tonn JC,Kerkau S,Hanke A,Bouterfa H,Mueller JG,Wagner S,Vince GH,Roosen K

更新日期：1999-03-01 00:00:00

abstract：:There is a familial aggregation of prostate cancer, and 5 to 10% of all prostate cancers are estimated to be inherited in an autosomal-dominant mode. A population-based cohort study was performed in order to study familial prostate cancer and associated malignancies. A nation-wide register cohort study was conducted u...

journal_title：International journal of cancer

authors： Damber L,Grönberg H,Damber JE

更新日期：1998-10-29 00:00:00

abstract：:Many tumors are impervious to anticancer agents. Resistance due to lack of cytotoxic penetration into the tumor is often overlooked but can play a significant role in undermining therapy. Insufficient and irregular vascularization of tumors is a possible barrier to drug delivery, but there are others, e.g., impaired v...

journal_title：International journal of cancer

authors： Wildiers H,Guetens G,de Boeck G,Landuyt W,Verbeken E,Highley M,de Bruijn EA,van Oosterom AT

更新日期：2002-06-01 00:00:00

abstract：:Bcl-2 protein inhibits apoptosis, reduces the requirement for growth factors, and thereby extends the survival of cells. Recent findings of Bcl-2 in several solid tumors suggest that it might contribute to the genesis of some types of cancer. Over-expression of Bcl-2 might play a role in carcinogenesis and malignant p...

journal_title：International journal of cancer

authors： Sakuragi N,Ohkouchi T,Hareyama H,Ikeda K,Watari H,Fujimoto T,Kuwabara M,Yamamoto R,Sagawa T,Fujino T,Fujimoto S

更新日期：1998-04-17 00:00:00

abstract：:There are approximately 100 genes which when mutated are known to predispose to one or more forms of cancer. Currently, genetic testing is offered for many of these, either as single genes or as multi-gene panels. Features of hereditary cancer include a positive family history of cancer, early age of onset and the app...

journal_title：International journal of cancer

authors： Cybulski C,Nazarali S,Narod SA

更新日期：2014-10-15 00:00:00

abstract：:Gene expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP) and orotate phosphoribosyl transferase (OPRT) have been shown to be associated with response to 5-fluorouracil-based therapies. Analyzing these gene expression levels in liver metastases is importan...

journal_title：International journal of cancer

authors： Kuramochi H,Hayashi K,Uchida K,Miyakura S,Shimizu D,Vallbohmer D,Park S,Danenberg KD,Takasaki K,Danenberg PV

更新日期：2006-08-01 00:00:00

abstract：:Examination of the effect of the farnesylprotein transferase (FPTase) inhibitor UCF1-C/manumycin on NIH3T3 cells transfected with a normal N-ras gene and expressing high levels of the corresponding p21-ras protein showed that 10 microm UCF1-C immediately and reversibly inhibited growth in these cells, without modifyin...

journal_title：International journal of cancer

authors： Servais P,Gulbis B,Fokan D,Galand P

更新日期：1998-05-18 00:00:00

abstract：:In a proportion of patients presenting mismatch repair (MMR)-deficient tumors, no germline MMR mutations are identified, the so-called Lynch-like syndrome (LLS). Recently, MMR-deficient tumors have been associated with germline mutations in POLE and MUTYH or double somatic MMR events. Our aim was to elucidate the mole...

journal_title：International journal of cancer

authors： Vargas-Parra GM,González-Acosta M,Thompson BA,Gómez C,Fernández A,Dámaso E,Pons T,Morak M,Del Valle J,Iglesias S,Velasco À,Solanes A,Sanjuan X,Padilla N,de la Cruz X,Valencia A,Holinski-Feder E,Brunet J,Feliubadaló L

更新日期：2017-10-01 00:00:00

abstract：:Oligodeoxynucleotides containing CpG motifs (CpG-ODN) display broad immunostimulating activity and are currently under clinical trial in various malignancies, including recurrent glioblastomas. Combining CpG-ODN with another therapy that could induce antigen release might enhance tumor-specific immune response. We inv...

journal_title：International journal of cancer

authors： Meng Y,Carpentier AF,Chen L,Boisserie G,Simon JM,Mazeron JJ,Delattre JY

更新日期：2005-10-10 00:00:00

abstract：:Crizotinib is an oral tyrosine kinase inhibitor approved for treating patients with non-small cell lung cancer (NSCLC) containing an anaplastic lymphoma kinase (ALK) rearrangement. We used knockout mice to study the roles of P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) in plasma pharmacokinetics...

journal_title：International journal of cancer

authors： Tang SC,Nguyen LN,Sparidans RW,Wagenaar E,Beijnen JH,Schinkel AH

更新日期：2014-03-15 00:00:00

abstract：:Murine SCC-VII squamous carcinoma cells have the capacity to penetrate reconstituted basement membranes (Matrigel) in vitro. The invasion of Matrigel layers by SCC-VII cells was significantly reduced by E-64, a specific inhibitor of lysosomal cysteine proteinases. The cathepsin-B-selective E-64 derivative, CA-074, inh...

journal_title：International journal of cancer

authors： Coulibaly S,Schwihla H,Abrahamson M,Albini A,Cerni C,Clark JL,Ng KM,Katunuma N,Schlappack O,Glössl J,Mach L

更新日期：1999-11-12 00:00:00

abstract：:To assess the relation between air pollution with airway irritants, including sulfuric acid and lung cancer, a case-control study was performed near an industry producing sulfuric acid and fertilizers in Kedainiai county, central Lithuania. The county had the highest lung cancer rates of the country among men. Between...

journal_title：International journal of cancer

authors： Petrauskaite R,Pershagen G,Gurevicius R

更新日期：2002-05-01 00:00:00

abstract：:Infection with a simian retrovirus (STLV-I) closely related to human T-lymphotropic virus type I (HTLV-I) was investigated in non-human primates living in their native countries in Africa and Asia. Serum antibodies cross-reacting with HTLV-I antigens were detected in 85 of 567 non-human primates of 30 species. Seropos...

journal_title：International journal of cancer

authors： Ishikawa K,Fukasawa M,Tsujimoto H,Else JG,Isahakia M,Ubhi NK,Ishida T,Takenaka O,Kawamoto Y,Shotake T

更新日期：1987-08-15 00:00:00

abstract：:Vaccination strategies based on repeated injections of NY-ESO-1 protein formulated in ISCOMATRIX particles (NY-ESO-1 ISCOMATRIX) have shown to elicit combined NY-ESO-1 specific antibody and T cell responses. However, it remains unclear whether heterologous prime-boost strategies based on the combination with NY-ESO-1 ...

journal_title：International journal of cancer

authors： Chen JL,Dawoodji A,Tarlton A,Gnjatic S,Tajar A,Karydis I,Browning J,Pratap S,Verfaille C,Venhaus RR,Pan L,Altman DG,Cebon JS,Old LL,Nathan P,Ottensmeier C,Middleton M,Cerundolo V

更新日期：2015-03-15 00:00:00

abstract：:Apoptosis protease-activating factor 1 (APAF-1), a transcriptional target of p53, is a cytosolic adaptor protein that links the mitochondrial apoptosis pathway to the caspase cascade. Here, we aimed to study the impact of APAF-1 expression levels on cell death induced by anticancer drugs or ionizing irradiation (IR) a...

journal_title：International journal of cancer

authors： Sturm I,Bosanquet AG,Radetzki S,Hummel M,Dörken B,Daniel PT

更新日期：2006-05-01 00:00:00

abstract：:The aim of this study was to determine whether the skin-sensitizing agent 2,4-dinitrofluorobenzene (DNFB) would elicit the same morphological and biochemical events that are characteristic of 12-O-tetradecanoylphorbol-13-acetate (TPA). While single applications of 0.1% or 0.2% DNFB produced only mild epidermal hyperpl...

journal_title：International journal of cancer

authors： Maldve RE,Fischer SM

更新日期：1995-02-08 00:00:00

abstract：:Three aspects of the rat model of HTLV-I/II infection were investigated. (i) The efficacy of HTLV-I-transformed rat cell lines in infecting different strains of rats: WKY and Lewis HTLV-I-transformed cell lines were injected into adult WKY, Lewis and Brown Norway rats, representing syngeneic and allogeneic combination...

journal_title：International journal of cancer

authors： Kazanji M,Ibrahim F,Fiette L,Bomford R,De Thé G

更新日期：1997-09-26 00:00:00

abstract：:Cyclin D1 is a major positive regulator of the G1 restriction point promoting inactivation of the retinoblastoma protein (RB). The cyclin D1 gene is rearranged, amplified and/or over-expressed in several human neoplasms. In the present series of 64 human breast carcinomas, cyclin D1 amplification (4- to 8-fold) was se...

journal_title：International journal of cancer

authors： Barbareschi M,Pelosio P,Caffo O,Buttitta F,Pellegrini S,Barbazza R,Dalla Palma P,Bevilacqua G,Marchetti A

更新日期：1997-04-22 00:00:00

abstract：:Previously, the induction of pancreatic carcinogenesis in the rat using azaserine has involved a multiple-dose treatment protocol. The objective of the present study was to determine the effect of multiple azaserine treatments on pancreatic DNA synthesis and to develop a protocol for a single-dose initiation of pancre...

journal_title：International journal of cancer

authors： Yager JD Jr,Roebuck BD,Zurlo J,Longnecker DS,Weselcouch EO,Wilpone SA

更新日期：1981-11-15 00:00:00

abstract：:High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...

journal_title：International journal of cancer

authors： Smida Rezgui S,Honore S,Rognoni JB,Martin PM,Penel C

更新日期：2000-08-01 00:00:00

abstract：:Bone-marrow (BM) hematopoietic precursors are recruited into proliferative activity when colony-stimulating factors (CSF) are sequenced with chemotherapy (CT). Previous studies suggested that further CT can be safely administered only when the increased proliferative activity of these cells has subsided, because most ...

journal_title：International journal of cancer

authors： Danova M,Rosti V,Mazzini G,De Renzis MR,Locatelli F,Cazzola M,Riccardi A,Ascari E

更新日期：1995-11-27 00:00:00

abstract：:The antigen recognized by the MOv18 MAb (Ca-MOv18) was recently shown to be a glycosylphosphatidylinositol (GPI)-linked protein. In this report we show that GPI-anchorage is not limited to IGROVI cells nor to other ovary carcinoma cell lines, but Ca-MOv18 was also found to be sensitive to phosphatidylinositol-specific...

journal_title：International journal of cancer

authors： Miotti S,Alberti S,Facheris P,Mantovani L,Fornaro M,Stella M,Ménard S,Canevari S,Colnaghi MI

更新日期：1992-05-28 00:00:00

abstract：:During the course of a mechanism-based screening program aimed at identifying new antimitotic agents, a novel microtubule depolymerizing piperazine derivative, 1-(5-chloro-2-methoxybenzoyl)-4-(3-chlorophenyl) piperazine, was identified. The compound, designated CB694, caused inhibition of proliferation of a wide range...

journal_title：International journal of cancer

authors： Weiderhold KN,Randall-Hlubek DA,Polin LA,Hamel E,Mooberry SL

更新日期：2006-02-15 00:00:00

abstract：:Sex steroid hormones influence prostate development and maintenance through their roles in prostate cellular proliferation, differentiation and apoptosis. Although suspected to be involved in prostate carcinogenesis, an association between circulating androgens and prostate cancer has not been clearly established in e...

journal_title：International journal of cancer

authors： Weiss JM,Huang WY,Rinaldi S,Fears TR,Chatterjee N,Hsing AW,Crawford ED,Andriole GL,Kaaks R,Hayes RB

更新日期：2008-05-15 00:00:00

abstract：:Phenotypic and functional characteristics of tumor-infiltrating lymphocytes (TIL) obtained from human primary and metastatic liver tumors were studied. Lymphocytes isolated from 18 tumors and autologous (A) peripheral blood (6 cases) were phenotyped by 2-color flow cytometry and cloned in a limiting dilution system, w...

journal_title：International journal of cancer

authors： Shimizu Y,Iwatsuki S,Herberman RB,Whiteside TL

更新日期：1990-11-15 00:00:00

abstract：:Using differential screening of a breast cancer cDNA library, we isolated a cDNA encoding the psoriasin (S100A7) protein, previously identified in psoriatic epidermis. In the present study, we demonstrate that the psoriasin gene is expressed in breast cancer cell lines and in cancer cells of some breast carcinomas but...

journal_title：International journal of cancer

authors： Moog-Lutz C,Bouillet P,Régnier CH,Tomasetto C,Mattei MG,Chenard MP,Anglard P,Rio MC,Basset P

更新日期：1995-10-09 00:00:00

abstract：:Pancreatic adenocarcinoma (PDAC) is known to have a poor prognosis partly because of lack of effective biomarkers. In the test set, we investigated dysbindin (DTNBP1) as a potential biomarker for PDAC by comparing preoperative and postoperative serum mass spectrometry (MS) proteomic profilings. Of the included 50 PDAC...

journal_title：International journal of cancer

authors： Guo X,Lv X,Fang C,Lv X,Wang F,Wang D,Zhao J,Ma Y,Xue Y,Bai Q,Yao X,Chen Y

更新日期：2016-10-15 00:00:00

abstract：:The active form of vitamin D(3), 1,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)), induces caspase-independent apoptosis in MCF-7 and T47D breast cancer cells. Before the appearance of apoptotic cells at Day 4 after the addition of 1,25(OH)(2)D(3), the MCF-7 cells are sensitized to the caspase-mediated apoptosis induced b...

journal_title：International journal of cancer

authors： Mathiasen IS,Hansen CM,Foghsgaard L,Jäättelä M

更新日期：2001-07-15 00:00:00