Endogenous sex hormones and the risk of prostate cancer: a prospective study.

abstract：:As Phase 0 studies have proven to be reasonably predictive of therapeutic dose pharmacokinetics, the application of microdosing has expanded into metabolism, drug-drug interactions and now diagnostics. One potentially serious issue with this application of microdosing that has not been previously discussed is the poss...

journal_title：International journal of cancer

authors： Wurz GT,DeGregorio MW

更新日期：2015-04-01 00:00:00

abstract：:Protein inhibitor of activated signal transducer and activator of transcription 3 (STAT3) (PIAS3) is an endogenous inhibitor of STAT3 that negatively regulates STAT3 transcriptional activity and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. In this study...

journal_title：International journal of cancer

authors： Dabir S,Kluge A,McColl K,Liu Y,Lam M,Halmos B,Wildey G,Dowlati A

更新日期：2014-03-01 00:00:00

abstract：:Several reports have suggested that one or both of the trinucleotide repeat polymorphisms in the human androgen receptor (hAR) gene, (CAG)n coding for polyglutamine and (GGC)n coding for polyglycine, may be associated with prostate cancer risk; but no study has investigated their association with disease progression. ...

journal_title：International journal of cancer

authors： Edwards SM,Badzioch MD,Minter R,Hamoudi R,Collins N,Ardern-Jones A,Dowe A,Osborne S,Kelly J,Shearer R,Easton DF,Saunders GF,Dearnaley DP,Eeles RA

更新日期：1999-10-22 00:00:00

abstract：:To examine the immunological mechanisms involved in cancer gene therapy using the herpes simplex virus thymidine kinase (HSV-tk) gene and ganciclovir (GCV), murine hepatocellular carcinoma (HCC) cells, BNL1ME A.7R.1, were transduced retrovirally with the HSV-tk gene. HSV-tk-transduced cells exhibited a more than 2,000...

journal_title：International journal of cancer

authors： Kuriyama S,Kikukawa M,Masui K,Okuda H,Nakatani T,Akahane T,Mitoro A,Tominaga K,Tsujinoue H,Yoshiji H,Okamoto S,Fukui H,Ikenaka K

更新日期：1999-10-29 00:00:00

abstract：:Biparatopic CEA, carcinoembryonic antigen (MAb) was newly designed and tested as to whether it enhanced the accuracy of tumor detection by reducing non-specific binding in experimental radioimmunoguided surgery. Biparatopic MAb was prepared by using cross-linking of reduced Fab' fragments from PR1A3 and T84.66. Fifty-...

journal_title：International journal of cancer

authors： Kim JC,Roh SA,Koo KH,Ryu JH,Hong HK,Oh SJ,Ryu JS,Kim HJ,Bodmer WF

更新日期：2002-02-01 00:00:00

abstract：:Telomerase, the enzyme responsible for maintenance of the telomeres, is absent from the vast majority of somatic cells but is present in most tumours. Little is known about how telomerase is activated in cancer, although it is thought vital for immortalisation to occur. The aim of our study was to identify genetic cha...

journal_title：International journal of cancer

authors： Loveday RL,Greenman J,Drew PJ,Monson JR,Kerin MJ

更新日期：1999-10-22 00:00:00

abstract：:The aim of this study was to investigate the ability of the new liver organotropic complex of cisplatin with glycocholate (GC), Bamet-R2, to interact with DNA, inhibit its replication and hence reduce tumor-cell proliferation. Changes in the electrophoretic mobility of the open and covalently closed circular forms of ...

journal_title：International journal of cancer

authors： Marin JJ,Macias RI,Criado JJ,Bueno A,Monte MJ,Serrano MA

更新日期：1998-10-29 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by ou...

journal_title：International journal of cancer

authors： Tsang YS,Lo KW,Leung SF,Choi PH,Fong Y,Lee JC,Huang DP

更新日期：1999-10-29 00:00:00

abstract：:A pilot case-control study on bladder cancer, with population-based controls matched for each of 74 cases, has been conducted in two industrial areas of Southern Belgium in order to analyze the influence of tobacco use and occupation. Observed bladder cancer risk for smokers is more than 5 times higher than that for n...

journal_title：International journal of cancer

authors： Schifflers E,Jamart J,Renard V

更新日期：1987-03-15 00:00:00

abstract：:Oncogenic mutations of the ras gene leading to constitutive activation of downstream effectors have been detected in a large spectrum of human cancers (pancreas, thyroid, colon and NSCLC). Membrane anchorage of Ras required for functional activity in signal transduction is facilitated by post-translational modificatio...

journal_title：International journal of cancer

authors： Prevost GP,Pradines A,Viossat I,Brezak MC,Miquel K,Lonchampt MO,Kasprzyk P,Favre G,Pignol B,Le Breton C,Dong J,Morgan B

更新日期：1999-10-08 00:00:00

abstract：:Peripheral blood T cells from a patient with T-cell chronic lymphocytic leukemia (T-CLL) failed to respond to mitogenic lectins or alloantigens but could be induced to proliferate by the addition of exogenous interleukin-2 (IL-2). The T-CLL cells also proliferated in response to 12-O-tetradecanoyl phorbol-13-acetate (...

journal_title：International journal of cancer

authors： Vyth-Dreese FA,de Vries JE

更新日期：1983-07-15 00:00:00

abstract：:Activated T cells expressing endogenous or transduced TCRs are two cell types currently used in clinical adoptive T-cell therapy. The ability of these cells to recognize their antigen, expand and traffic to the tumor site are the initial steps necessary for successful therapy. In this study, we used in vivo biolumines...

journal_title：International journal of cancer

authors： Perez C,Jukica A,Listopad JJ,Anders K,Kühl AA,Loddenkemper C,Blankenstein T,Charo J

更新日期：2015-07-15 00:00:00

abstract：:A new cell line from a sporadic Wilms' tumor was established and extensively characterized. In nude mice, the tumor cells rapidly formed tumors which, in histological characteristics and extracellular-matrix (ECM) composition resembled sarcomatoid Wilms' tumor. The tumor cells produced B chains of laminin, but no A ch...

journal_title：International journal of cancer

authors： Talts JF,Aufderheide E,Sorokin L,Ocklind G,Mattsson R,Ekblom P

更新日期：1993-07-09 00:00:00

abstract：:Long-term survivors of childhood cancer suffer from a higher mortality than the general population. Here we evaluate late and very late mortality, and patterns of causes of death, in 5-year survivors after childhood and adolescent cancer in cases diagnosed during four decades in the five Nordic countries. The study is...

journal_title：International journal of cancer

authors： Garwicz S,Anderson H,Olsen JH,Winther JF,Sankila R,Langmark F,Tryggvadóttir L,Möller TR,Association of the Nordic Cancer Registries.,Nordic Society for Pediatric Hematology Oncology.

更新日期：2012-10-01 00:00:00

abstract：:A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...

journal_title：International journal of cancer

authors： Delia D,Greaves MF,Newman RA,Sutherland DR,Minowada J,Kung P,Goldstein G

更新日期：1982-01-15 00:00:00

abstract：:The major goal in cancer immunotherapy is the induction of tumor-specific T lymphocytes capable of killing tumor cells. As both dendritic cells (DCs) and interleukin-12 (IL-12) can play immunostimulatory roles in vivo, the use of a combination of these has become a promising approach. In the present study, we used a m...

journal_title：International journal of cancer

authors： Furumoto K,Arii S,Yamasaki S,Mizumoto M,Mori A,Inoue N,Isobe N,Imamura M

更新日期：2000-09-01 00:00:00

abstract：:Accurate survival estimates are essential for monitoring cancer survival trends, for health care planning and for resource allocation. To obtain precise estimates of survival, full dates (day, month and year) rather than partial dates (month and year) are required. In some jurisdictions, however, cancer registries are...

journal_title：International journal of cancer

authors： Woods LM,Rachet B,Ellis L,Coleman MP

更新日期：2012-10-01 00:00:00

abstract：:Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. To improve existing therapies and broaden the spectrum of cytotoxic agents that can be used in RMS treatment, we performed a phage-display-based screening for peptides that bind specifically to RMS cells. Two peptides binding to RMS and to othe...

journal_title：International journal of cancer

authors： Witt H,Hajdin K,Iljin K,Greiner O,Niggli FK,Schäfer BW,Bernasconi M

更新日期：2009-05-01 00:00:00

abstract：:A group of 83 Spanish BC/OC families were analysed for BRCA1 germ-line mutations. Analysis of the entire coding sequence was carried out by SSCP and PTT. We identified 5 frameshift mutations: 185delAG (2 times), 189insTGTC, 1241delAC, and 5537delA and 3 missense mutations in BRCA1: 330A > G, 1240C > T, and 5263G > A. ...

journal_title：International journal of cancer

authors： Díez O,Cortés J,Domènech M,Brunet J,Del Río E,Pericay C,Sanz J,Alonso C,Baiget M

更新日期：1999-11-12 00:00:00

abstract：:More than two-thirds of patients with hepatocellular carcinoma (HCC) cannot receive curative therapy and have poor survival due to late diagnosis and few prognostic directions. In our study, nontargeted and targeted metabolomics analyses were conducted by liquid chromatography-mass spectrometry to characterize metabol...

journal_title：International journal of cancer

authors： Han J,Han ML,Xing H,Li ZL,Yuan DY,Wu H,Zhang H,Wang MD,Li C,Liang L,Song YY,Xu AJ,Wu MC,Shen F,Xie Y,Yang T

更新日期：2020-03-15 00:00:00

abstract：:Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclea...

journal_title：International journal of cancer

authors： Ward HA,Murphy N,Weiderpass E,Leitzmann MF,Aglago E,Gunter MJ,Freisling H,Jenab M,Boutron-Ruault MC,Severi G,Carbonnel F,Kühn T,Kaaks R,Boeing H,Tjønneland A,Olsen A,Overvad K,Merino S,Zamora-Ros R,Rodríguez-Barranc

更新日期：2019-09-15 00:00:00

abstract：:Melanoma is the most lethal human skin cancer. If metastatic, it becomes very aggressive and resistant to standard modalities of anticancer treatment. During the last 10 years, several therapeutic strategies have been tested including the use of single and combined small drugs. Experimental results indicate that RAS a...

journal_title：International journal of cancer

authors： López-Fauqued M,Gil R,Grueso J,Hernandez-Losa J,Pujol A,Moliné T,Recio JA

更新日期：2010-04-01 00:00:00

abstract：:The relationship of a basement membrane collagen degrading enzyme (BM collagenase) and plasminogen activator (PA) was studied in a number of non-malignant and malignant human and murine cell lines. Several non-malignant cell lines secreted significant amounts of PA but not detectable BM collagenase activity whereas th...

journal_title：International journal of cancer

authors： Salo T,Liotta LA,Keski-Oja J,Turpeenniemi-Hujanen T,Tryggvason K

更新日期：1982-11-15 00:00:00

abstract：:Carcinomatous meningitis is a devastating metastatic complication of systemic carcinoma, which may occur insidiously, accompanied by a confusing spectrum of clinical symptoms and signs. In the absence of reliable diagnostic tumour markers, the diagnosis is established by the demonstration of malignant cells within the...

journal_title：International journal of cancer

authors： Moseley RP,Oge K,Shafqat S,Moseley CM,Sullivan NM,Badley RA,Burchell J,Taylor-Papadimitriou J,Coakham HB

更新日期：1989-09-15 00:00:00

abstract：:Colorectal cancer is a heterogeneous disease at the histomorphological, clinical and molecular level. Approximately 20% of cases may progress through the "serrated" pathway characterized by BRAF mutation and high-level CpG Island Methylator Phenotype (CIMP). A large subgroup are additionally microsatellite instable (M...

journal_title：International journal of cancer

authors： Dawson H,Galván JA,Helbling M,Muller DE,Karamitopoulou E,Koelzer VH,Economou M,Hammer C,Lugli A,Zlobec I

更新日期：2014-05-15 00:00:00

abstract：:Little is known about age-dependent variation in outcomes of cervical cytology with modern technologies. This population-based study evaluated age-dependent changes after routine implementation of ThinPrep and SurePath technology in two independent laboratories, and controlled for time trends in a third laboratory usi...

journal_title：International journal of cancer

authors： Rask J,Lynge E,Franzmann M,Hansen B,Hjortebjerg A,Rygaard C,Schledermann D,Wåhlin A,Rebolj M

更新日期：2014-05-01 00:00:00

abstract：:A new cell line (K-LL-3) with exceptional characteristics was derived from a bone-marrow aspirate from a patient with poorly differentiated lymphoblastic lymphoma. The cell line was established and the cells maintained on agar feeders for over 1 year. The morphology and cytochemical staining of the primary tumor and t...

journal_title：International journal of cancer

authors： Smith SD,Rosen D

更新日期：1979-04-15 00:00:00

abstract：:Melanoma is a highly malignant and increasingly common neoplasm. Because metastatic melanoma remains incurable, new treatment approaches are needed. Immunoliposomes have been previously shown to enhance the selective localization of immunoliposome-entrapped drugs to solid tumors with improvements in the therapeutic in...

journal_title：International journal of cancer

authors： Pagnan G,Montaldo PG,Pastorino F,Raffaghello L,Kirchmeier M,Allen TM,Ponzoni M

更新日期：1999-04-12 00:00:00

abstract：:The tumor microenvironment consists of an immunosuppressive niche created by the complex interactions between cancer cells and surrounding stromal cells. A critical component of this environment are myeloid-derived suppressor cells (MDSCs), a heterogeneous group of immature myeloid cells arrested at different stages o...

journal_title：International journal of cancer

authors： Pyzer AR,Cole L,Rosenblatt J,Avigan DE

更新日期：2016-11-01 00:00:00

abstract：:The recently described PGM-2 leukemia displays a hierarchical structure with bipotential stem cells, B-lymphocyte and macrophage progenitor cells, and post-mitotic end cells. Because the different cell types can easily be identified in vitro by clonal culture assays and simple staining procedures, this leukemia is a u...

journal_title：International journal of cancer

authors： Dührsen U,Knieling G,Hossfeld DK

更新日期：1995-03-03 00:00:00