Tissue and serum metabolomic phenotyping for diagnosis and prognosis of hepatocellular carcinoma.


:More than two-thirds of patients with hepatocellular carcinoma (HCC) cannot receive curative therapy and have poor survival due to late diagnosis and few prognostic directions. In our study, nontargeted and targeted metabolomics analyses were conducted by liquid chromatography-mass spectrometry to characterize metabolic features of HCC and identify diagnostic and prognostic biomarker candidate incorporating liver tissue and serum metabolites. A total of 552 subjects, including 432 with liver tissue and 120 with serum specimens, were recruited in China. In the discovery cohort, a series of 138 metabolites were identified to discriminate HCC tissues from matched nontumor tissues. Retinol presented with the highest area under the curve (AUC) of 0.991 and associated with Edmondson grade. In the validation cohort, all metabolites in retinol metabolism pathway were examined and the levels of retinol and retinal in tumor tissue and serum decreased in the order of normal to cirrhosis to HCC of Edmondson Grades I to IV. Retinol and retinal levels could also differentiate between HCC and cirrhosis, with AUCs of 0.996 and 0.994, respectively, in tissue and 0.812 and 0.744, respectively, in serum. The AUC of the combined retinol and retinal panel in serum was 0.852. Univariate and multivariate Cox regression identified this panel as an independent predictor for HCC and showed that low expression of retinol and retinal correlated with decreased survival time. In conclusion, the retinol metabolic signature had considerable diagnostic and prognostic value for identifying HCC patients who would benefit from prompt therapy and optimal prognostic direction.


Int J Cancer


Han J,Han ML,Xing H,Li ZL,Yuan DY,Wu H,Zhang H,Wang MD,Li C,Liang L,Song YY,Xu AJ,Wu MC,Shen F,Xie Y,Yang T




Has Abstract


2020-03-15 00:00:00












  • Molecular characteristics and physical state of human papillomavirus DNA change with progressing malignancy: studies in a patient with epidermodysplasia verruciformis.

    abstract::In order to establish the role of human papillomavirus (HPV) in carcinogenesis of epidermodysplasia verruciformis (EV), the presence, the molecular characteristics and the physical state of HPV DNA in a benign lesion, a primary carcinoma and a metastatic carcinoma developing in the same EV patient were studied and com...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yabe Y,Tanimura Y,Sakai A,Hitsumoto T,Nohara N

    更新日期:1989-06-15 00:00:00

  • Treatment of metastatic melanoma with autologous, hapten-modified melanoma vaccine: regression of pulmonary metastases.

    abstract::A human cancer vaccine composed of autologous tumor cells modified with the hapten dinitrofluorobenzene (DNP) induces cell-mediated immunity to the tumor cells and the development of inflammatory responses within metastatic sites. In this study we determined whether DNP vaccine could induce regression of established m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Berd D,Sato T,Cohn H,Maguire HC Jr,Mastrangelo MJ

    更新日期:2001-11-01 00:00:00

  • Dietary factors and risk of pancreatic cancer: results of a Canadian population-based case-control study.

    abstract::Dietary information from a case-control study of pancreatic cancer conducted in Metropolitan Toronto between 1983 and 1986 is reported. A total of 249 cases and 505 population-based controls completed quantitative diet histories from which total caloric intake and the intake of a number of nutrients were estimated. A ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Howe GR,Jain M,Miller AB

    更新日期:1990-04-15 00:00:00

  • Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden.

    abstract::The study of the relationship between dietary intake of fatty acids and the risk of breast cancer has not yielded definite conclusions with respect to causality, possibly because of methodological issues inherent to nutritional epidemiology. To evaluate the hypothesis of possible protection of n-3 polyunsaturated fatt...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chajès V,Hultén K,Van Kappel AL,Winkvist A,Kaaks R,Hallmans G,Lenner P,Riboli E

    更新日期:1999-11-26 00:00:00

  • Colposcopy is not necessary to assess the risk to the cervix in HIV-positive women: an international cohort study of cervical pathology in HIV-1 positive women.

    abstract::The objectives of this prospective multicentre international cohort study are to describe the characteristics of a cohort of HIV-1 positive women and determine the best management system by comparing cervical pathology according to results of cytology, colposcopy and human papillomavirus (HPV) testing at baseline and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Kitchener H,Nelson L,Adams J,Mesher D,Sasieni P,Cubie H,Moore C,Heard I,Agarossi A,Casolati E,Denny L,Bradbeer C,Lyons F,Beattie G,Niemiec T

    更新日期:2007-12-01 00:00:00

  • Targeted imaging of breast tumor progression and therapeutic response in a human uMUC-1 expressing transgenic mouse model.

    abstract::The ability to monitor breast cancer initiation and progression on the molecular level would provide an effective tool for early diagnosis and therapy. In the present study, we focused on the underglycosylated MUC-1 tumor antigen (uMUC-1), which is directly linked to tumor progression from pre-malignancy to advanced m...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ghosh SK,Uchida M,Yoo B,Ross AW,Gendler SJ,Gong J,Moore A,Medarova Z

    更新日期:2013-04-15 00:00:00

  • Benefits of catch-up in vaccination against human papillomavirus in medium- and low-income countries.

    abstract::Human papillomavirus (HPV) vaccination of a birth cohort of girls in the 9-13 age range is recommended as a priority, but decreases in HPV vaccine cost may make catch-up of a few additional cohorts more attractive not only in high-income countries. We assessed the reduction in HPV16 and 18 infections that could be ach...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Baussano I,Lazzarato F,Ronco G,Dillner J,Franceschi S

    更新日期:2013-10-15 00:00:00

  • Inhibition by galanin of experimental carcinogenesis induced by azaserine in rat pancreas.

    abstract::The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Iishi H,Tatsuta M,Baba M,Yano H,Iseki K,Uehara H,Nakaizumi A

    更新日期:1998-01-30 00:00:00

  • DNA interaction and cytostatic activity of the new liver organotropic complex of cisplatin with glycocholic acid: Bamet-R2.

    abstract::The aim of this study was to investigate the ability of the new liver organotropic complex of cisplatin with glycocholate (GC), Bamet-R2, to interact with DNA, inhibit its replication and hence reduce tumor-cell proliferation. Changes in the electrophoretic mobility of the open and covalently closed circular forms of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Marin JJ,Macias RI,Criado JJ,Bueno A,Monte MJ,Serrano MA

    更新日期:1998-10-29 00:00:00

  • Flow cytometric analysis of the expression of 9A3 antigen, E-cadherin and EGF receptor in TMK-1 stomach cancer cells.

    abstract::We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fukuyama R,Minoshima S,Ochiai A,Tahara E,Shimizu N

    更新日期:1991-04-22 00:00:00

  • Cervical cancer patterns with automation-assisted and conventional cytological screening: a randomized study.

    abstract::The purpose was to evaluate alternative cytological screening methods in population-based screening for cervical cancer up to cancer incidence and mortality outcome. Automation-assisted screening was compared to conventional cytological screening in a randomized design. The study was based on follow-up of 503,391 wome...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Anttila A,Pokhrel A,Kotaniemi-Talonen L,Hakama M,Malila N,Nieminen P

    更新日期:2011-03-01 00:00:00

  • Organochlorine insecticides DDT and chlordane in relation to survival following breast cancer.

    abstract::Organochlorine insecticides have been studied extensively in relation to breast cancer incidence, and results from two meta-analyses have been null for late-life residues, possibly due to measurement error. Whether these compounds influence survival remains to be fully explored. We examined associations between organo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Parada H Jr,Wolff MS,Engel LS,White AJ,Eng SM,Cleveland RJ,Khankari NK,Teitelbaum SL,Neugut AI,Gammon MD

    更新日期:2016-02-01 00:00:00

  • Low O-acetylation of sialyl-Le(x) contributes to its overexpression in colon carcinoma metastases.

    abstract::Two factors potentially determining the consistent overexpression of sialyl-Le(x) antigen in colon carcinoma and metastases were investigated: (i) the expression of the mucins MUC1 and MUC2, known to carry sialyl-Le(x), by Northern blotting; (ii) the extent of sialic acid O-acetylation, by Western blotting and HPLC. R...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mann B,Klussmann E,Vandamme-Feldhaus V,Iwersen M,Hanski ML,Riecken EO,Buhr HJ,Schauer R,Kim YS,Hanski C

    更新日期:1997-07-17 00:00:00

  • Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracil.

    abstract::The authors reported in a previous study that NK012, a 7-ethyl-10-hydroxy-camptothecin (SN-38)-releasing nano-system, exhibited high antitumor activity against human colorectal cancer xenografts. This study was conducted to investigate the advantages of NK012 over irinotecan hydrochloride (CPT-11) administered in comb...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nakajima TE,Yasunaga M,Kano Y,Koizumi F,Kato K,Hamaguchi T,Yamada Y,Shirao K,Shimada Y,Matsumura Y

    更新日期:2008-05-01 00:00:00

  • The intracellular association of B700 and B50 murine melanoma antigens and their role in tumor rejection.

    abstract::B700 and B50 are melanoma-specific antigens originally isolated from B16 murine melanoma. B700, which elicits a strong tumor rejection response, is present on all murine melanomas tested to date. We now demonstrate the presence of B50 in the other murine melanomas and find that the 2 molecules are non-covalently compl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gersten DM,Williams LJ,Moody D,Montague PM,Law LW,Hearing VJ

    更新日期:1989-03-15 00:00:00

  • Modulation of viability and maturation of human monocyte-derived dendritic cells by oncolytic adenoviruses.

    abstract::Adenoviral oncolysis is a promising new modality for treatment of cancer based on selective viral replication in tumor cells. However, tumor cell killing by adenoviral oncolysis needs to be improved to achieve therapeutic benefit in the clinic. Towards this end, the activation of anti-tumor immunity by adenoviral onco...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schierer S,Hesse A,Müller I,Kämpgen E,Curiel DT,Schuler G,Steinkasserer A,Nettelbeck DM

    更新日期:2008-01-01 00:00:00

  • Combination therapy with 2-difluoromethylornithine and a polyamine transport inhibitor against murine squamous cell carcinoma.

    abstract::Using a recently developed autochthonous mouse model of squamous cell carcinoma (SCC), a combination therapy targeting polyamine metabolism was evaluated. The therapy combined 2-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase (ODC), and MQT 1426, a polyamine transport inhibitor. In 1 trial last...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen Y,Weeks RS,Burns MR,Boorman DW,Klein-Szanto A,O'Brien TG

    更新日期:2006-05-01 00:00:00

  • International patterns and trends in testis cancer incidence.

    abstract::Although the incidence of testis cancer has risen markedly in many Western populations over the past half-century, it is not clear whether rates in other populations also have increased. To clarify this issue, we examined testis cancer incidence rates over the 25-year time period of 1973-1997 for selected populations ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Purdue MP,Devesa SS,Sigurdson AJ,McGlynn KA

    更新日期:2005-07-10 00:00:00

  • Transient depletion of CD4(+) T cells augments IL-21-based immunotherapy of disseminated neuroblastoma in syngeneic mice.

    abstract::IL-21 is a member of the IL-2 cytokine family, produced by CD4+ T cells. We previously showed that immunotherapy (IT) with IL-21-transduced neuroblastoma cells (Neuro2a/IL-21) cured 33% of syngeneic mice bearing systemic NB. Here, we studied whether the removal of Treg cells could potentiate the therapeutic efficacy o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Croce M,Corrias MV,Orengo AM,Brizzolara A,Carlini B,Borghi M,Rigo V,Pistoia V,Ferrini S

    更新日期:2010-09-01 00:00:00

  • Nerve invasion distance is dependent on laminin gamma2 in tumors of pancreatic cancer.

    abstract::The distance of nerve invasion is an important prognostic factor in pancreatic cancer. The extracellular matrix (ECM) of nerve, mainly composed of laminin, collagen IV and anchoring fibrils, might affect nerve invasion. However, this relationship has not been demonstrated. Our study aimed at discovering the promoting ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mitsunaga S,Fujii S,Ishii G,Kinoshita T,Hasebe T,Aoyagi K,Sasaki H,Ochiai A

    更新日期:2010-08-15 00:00:00

  • Fruit and vegetable intake and the risk of stomach and oesophagus adenocarcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST).

    abstract::It is considered that fruit and vegetable (F&V) protect against oesophagus and gastric cancer (GC). However, 2 recent meta-analyses suggest that the strength of association on GC seems to be weaker for vegetables than for fruit and weaker in cohort than in case-control studies. No evidence exists from cohort studies a...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: González CA,Pera G,Agudo A,Bueno-de-Mesquita HB,Ceroti M,Boeing H,Schulz M,Del Giudice G,Plebani M,Carneiro F,Berrino F,Sacerdote C,Tumino R,Panico S,Berglund G,Simán H,Hallmans G,Stenling R,Martinez C,Dorronsoro M

    更新日期:2006-05-15 00:00:00

  • MicroRNA-125b suppresses the development of bladder cancer by targeting E2F3.

    abstract::Increasing evidence has suggested that dysregulation of certain microRNAs (miRNAs) may contribute to tumorigenesis. microRNA-125b (miR-125b) was implicated to have close relationship with cell proliferation and differentiation, and downregulation of miR-125b was observed in various types of cancers. However, the biolo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Huang L,Luo J,Cai Q,Pan Q,Zeng H,Guo Z,Dong W,Huang J,Lin T

    更新日期:2011-04-15 00:00:00

  • Antitumour immunity invoked by hepatic arterial infusion of first-line oxaliplatin predicts durable colorectal cancer control after liver metastasis ablation: 8-12 years of follow-up.

    abstract::In colorectal cancer (CRC), hepatic arterial infusion (HAI) chemotherapy may convert primarily unresectable CRC liver metastases (CLM) into resectability, although the risk of metastatic recurrence remains high after CLM ablation. We investigated the role of antitumour immunity invoked by first-line oxaliplatin-HAI fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Abrahamsson H,Jensen BV,Berven LL,Nielsen DL,Šaltytė Benth J,Johansen JS,Larsen FO,Johansen JS,Ree AH

    更新日期:2020-04-01 00:00:00

  • DNA repair phenotype and cancer susceptibility--a mini review.

    abstract::DNA repair is a complicated biological process, consisting of several distinct pathways, that plays a fundamental role in the maintenance of genomic integrity. The very important field of DNA repair and cancer risk has developed rapidly in the past decades. In this review of selected published data from our laboratory...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Li C,Wang LE,Wei Q

    更新日期:2009-03-01 00:00:00

  • MLN64 exhibits homology with the steroidogenic acute regulatory protein (STAR) and is over-expressed in human breast carcinomas.

    abstract::The MLN64 gene, which is localized in q12-q21 of the human chromosome 17, encodes a novel protein containing 2 distinct domains. At the N-terminal, MLN64 exhibits a potential trans-membrane region, while at the C-terminal, it shares homology with the F26F4.4 protein of Coenorhabditis elegans and the steroidogenic acut...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Moog-Lutz C,Tomasetto C,Régnier CH,Wendling C,Lutz Y,Muller D,Chenard MP,Basset P,Rio MC

    更新日期:1997-04-10 00:00:00

  • Binding of some metastatic tumor cell lines to fibrous elastin and elastin peptides.

    abstract::Recent suggestions that tumor-cell targeting of elastin-rich tissues (e.g., lung) correlates with the presence of surface elastin receptors have been investigated. Receptors for insoluble (fibrous) elastin and for soluble elastin peptides have been implemented in these correlations. A rapid assay for binding of insolu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Svitkina TM,Parsons DF

    更新日期:1993-03-12 00:00:00

  • Loss of heterozygosity at locus F13B on chromosome 1q in human medulloblastoma.

    abstract::Medulloblastoma is a primitive neuroectodermal tumor of the cerebellum with poorly understood pathogenesis. Previous studies have reported loss of heterozygosity (LOH) on chromosome arms 17p, 11p and 9q and cytogenetic abnormalities of chromosome 1 in medulloblastoma. We have used the polymerase chain reaction to ampl...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kraus JA,Koch A,Albrecht S,Von Deimling A,Wiestler OD,Pietsch T

    更新日期:1996-07-03 00:00:00

  • Lactation and the risk of breast cancer in an Italian population.

    abstract::The relation between breast feeding and breast cancer was investigated in a multicentric case-control study conducted in Italy on 2,167 parous women with histologically confirmed breast cancer, diagnosed within 1 year, and 2,208 parous control women admitted to hospitals in the same catchment areas of cases for acute,...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Negri E,Braga C,La Vecchia C,Levi F,Talamini R,Franceschi S

    更新日期:1996-07-17 00:00:00

  • Positive correlation between p27Kip1 expression and progression of human esophageal squamous cell carcinoma.

    abstract::p27Kip1, one of the cyclin-dependent kinase (CDK) inhibitors (CDKIs), blocks progression from G1 to S phase by binding cyclin D1-CDK4 and/or cyclin E-CDK2 and inhibiting their activities. Reflecting the function of p27 as a CDKI in vitro, a reduced expression of protein p27 has recently been reported to be associated ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Anayama T,Furihata M,Ishikawa T,Ohtsuki Y,Ogoshi S

    更新日期:1998-08-21 00:00:00

  • Non-random allelic losses at 3p, 11p and 13q during HPV-mediated immortalization and concomitant loss of terminal differentiation of human keratinocytes.

    abstract::To obtain a comprehensive overview of chromosomal alterations that may underlie human papillomavirus (HPV)-mediated immortalization, 4 foreskin keratinocyte cell lines generated by transfection with either HPV 16 (cell lines FK16A and FK16B) or HPV 18 (FK18A and FK18B) were subjected to chromosomal analysis using comp...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Steenbergen RD,Hermsen MA,Walboomers JM,Meijer GA,Baak JP,Meijer CJ,Snijders PJ

    更新日期:1998-05-04 00:00:00