Abstract:
:Fine-needle aspiration cytology (FNAC) is currently used in evaluating the nature of breast nodules. In the present study we have examined whether monoclonal antibodies (MAbs) to breast-tumor-associated antigens (BTAA) can be employed in FNAC for the diagnosis of breast cancer. For this purpose we have used 2 murine MAbs recognizing 2 distinct BTAA expressed by breast tumors, irrespective of their histotype, in an indirect avidin-biotin immunohistochemical technique on aspirate smears. The results of this study show that, while benign lesions are consistently negative, tumor cells containing aspirates are reactive with at least one MAb in 95% of the cases. Thus, selected MAbs to BTAA may be a powerful diagnostic tool in conjunction with conventional cytology, and because of the objective interpretation of the immunohistochemical findings, FNAC of the breast can eventually be extended outside specialized institutions.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Nuti M,Mottolese M,Viora M,Donnorso RP,Schlom J,Natali PGdoi
10.1002/ijc.2910370404subject
Has Abstractpub_date
1986-04-15 00:00:00pages
493-8issue
4eissn
0020-7136issn
1097-0215journal_volume
37pub_type
杂志文章abstract::The expression of a gastrointestinal carcinoma-associated antigen (GICA), a monosialoganglioside, was investigated in tissues from human fetuses of various gestational ages (10-40 weeks). Mouse monoclonal antibody NS-19-9, generated in mice immunized with SW1116 human colon carcinoma cells, was used along with a secon...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340208
更新日期:1984-08-15 00:00:00
abstract::Small-cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often correlated with poor pro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971114)73:4<544::aid-ijc
更新日期:1997-11-14 00:00:00
abstract::The purpose of this analysis was to correlate isotope selection with the urinary symptoms of patients who received a combination of external beam radiotherapy (EBRT) and a transperineal interstitial permanent prostate brachytherapy (TIPPB) boost with either a (103)palladium ((103)Pd) or a (125)iodine ((125)I) radioiso...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10350
更新日期:2001-01-01 00:00:00
abstract::Primary cultures of rat microvascular endothelial cells were transformed, in vitro, by exposure to Rous sarcoma virus. Transformed cells were followed and evaluated cytogenetically through numerous passages. Highly specific karyotypic changes in karyotype (both structural and numerical) were documented. These changes ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910320416
更新日期:1983-10-15 00:00:00
abstract::The prognostic significance of circulating tumor cells (CTCs) and disseminated tumor cells (DTCs) in patients with gastric cancer (GC) is controversial. The aims of our meta-analysis are to assess its correlation with clinicopathological characteristics and prognostic significance in GC. PubMed, Embase, the Cochrane d...
journal_title:International journal of cancer
pub_type: 杂志文章,meta分析
doi:10.1002/ijc.28954
更新日期:2015-01-01 00:00:00
abstract::The effects of prolonged administration of genistein, a tyrosine-kinase inhibitor, on sodium-chloride-enhanced induction of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990129)80:3<396::aid-ijc
更新日期:1999-01-29 00:00:00
abstract::Lysine-specific demethylase-1 (LSD1) removes the methyl groups from mono- and di-methylated lysine 4 of histone H3. Previous studies have linked LSD1 to malignancy in several human tumors, and LSD1 is considered to epigenetically regulate the energy metabolism genes in adipocytes and hepatocellular carcinoma. This stu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29714
更新日期:2016-01-15 00:00:00
abstract::Responses to the genotoxic effect of bleomycin in lymphocytes of blood cultures, expressed as the average number of chromatid breaks per cell (b/c), varied from less than 0.20 to more than 2.00 in 335 normal individuals. More than 11% of the subjects tested showed a b/c rate above 1.00 and more than 22% showed a b/c r...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430310
更新日期:1989-03-15 00:00:00
abstract::Occupational X-ray examination programs have been conducted in many countries to screen for occupational and nonoccupational respiratory diseases, resulting in widespread exposure to X-radiation. We conducted a multicentre case-control study of lung cancer in the Czech Republic, Hungary, Poland, Romania, Russia and Sl...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.20854
更新日期:2005-06-10 00:00:00
abstract::A wide variety of primary and metastatic human neoplasms express somatostatin receptors (SS-Rs). We evaluated the SS-R status of malignant lymphomas that had been surgically removed from 31 patients by use of in vitro SS-R autoradiography with the SS analog 125I-[Tyr3]-octreotide as radioligand. Of 11 low-grade-malign...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500613
更新日期:1992-04-01 00:00:00
abstract::The growth of 7/9 Burkitt's lymphoma (BL) cell lines and 5/6 human melanoma cell lines was inhibited by certain human fibroblast-like cell lines, especially human myofibroblast cell lines. In contrast to BL lines, 3/5 lymphoblastoid cell lines were less susceptible and 3/4 human leukaemic lines were resistant. The eff...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350410
更新日期:1985-04-15 00:00:00
abstract::3H-HSV-2 DNA has been hybridized in situ to frozen sectioned tissue from human cervical biopsies. RNA complementary to the virus-specific probe was detected in cells undergoing pre-malignant changes, but not in the cells of the fully developed squamous-cell cancer. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250102
更新日期:1980-01-15 00:00:00
abstract::The majority of intermediate-risk rhabdomyosarcoma (RMS) patients have gross residual disease (Group III) after their first operative procedure. It is currently not known if local control rates can be maintained when, following induction chemotherapy, the radiation therapy (RT) dose is decreased after a delayed primar...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29351
更新日期:2015-07-01 00:00:00
abstract::Our study was designed to examine the effects of IL-2 gene therapy in a surgical minimal residual tumour disease (SMRTD). Mice were inoculated s.c. with methylcholanthrene (MC)-induced MC12 sarcoma cells. When the tumours reached 8 to 12 mm in diameter, they were excised, either completely ("microscopic SMRTD") or inc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980330)76:1<115::aid-ijc
更新日期:1998-03-30 00:00:00
abstract::Rabbit V2 carcinoma cells and normal rabbit skin fibroblasts produced cysteine proteinases with properties similar to those of purified rabbit liver cathepsin B. Both cell types secreted into the culture medium enzymes with an apparent Mr of 43,000, which reacted with synthetic substrates commonly used for cathepsin B...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910380520
更新日期:1986-11-15 00:00:00
abstract::A displacement assay with tamoxifen, based on the relative binding affinity of tamoxifen and estradiol for the estrogen receptor (ER), was proposed in 1990 as prognostic indicator for breast-cancer patients. Validation of its predictive results in relation to the outcome of 73 patients with ER+ tumors is analyzed. ER,...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971114)73:4<486::aid-ijc
更新日期:1997-11-14 00:00:00
abstract::Cancer survival varies by place of residence, but it remains uncertain whether this reflects differences in tumour, patient and treatment characteristics (including tumour stage, indicators of socioeconomic status (SES), comorbidity and information on received surgery and radiotherapy) or possibly regional differences...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29967
更新日期:2016-05-01 00:00:00
abstract::Previous studies have revealed a robust association between exposure to asbestos and human lung cancer. Accumulating evidence has highlighted the role of epigenome deregulation in the mechanism of carcinogen-induced malignancies. We examined the impact of asbestos on DNA methylation. Our genome-wide studies (using Ill...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30897
更新日期:2017-11-15 00:00:00
abstract::Human alpha interferon (IFN-alpha) and beta interferon (IFN-beta) showed antiviral and anticellular effects on human lymphoblastoid Daudi and P3HR-1 cells, but up to 1,000 units/ ml of gamma interferon (IFN-gamma) showed no such effect. Though a fairly high level of dsRNA-dependent 2'-5'-oligoadenylate synthetase (2-5...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300206
更新日期:1982-08-15 00:00:00
abstract::Syrian-hamster-derived lymphotoxin inhibits benzo(a)pyrene and ultraviolet carcinogen-induced in vitro morphologic transformation of diploid secondary passage hamster embryo cells. When lymphotoxin is added up to 4 days post carcinogen, the reduction in the frequency of morphologic transformation 6 days after carcinog...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270108
更新日期:1981-01-15 00:00:00
abstract::Epstein-Barr virus (EBV) type 2 is considered to be a much less potent transformer of lymphocytes than type 1. However, type-2 EBV may be involved in the pathogenesis of non-Hodgkin's lymphomas (NHLs) arising in immunocompromised patients, i.e., subjects with malaria or HIV-1 infection. To determine whether type-2 EBV...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540603
更新日期:1993-07-30 00:00:00
abstract::BALB/cfC3H female mice which develop mammary tumor virus (MTV)-induced mammary tumors possess not only serun antibodies directed against virus-associated antigens which are expressed on mammary tumor cells but also antibodies directed against antigenic specificities which are unique to each tumor. The possible range o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910210413
更新日期:1978-04-15 00:00:00
abstract::While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33008
更新日期:2020-10-15 00:00:00
abstract::A critical requirement for cancer vaccines is that they stimulate CD8+ T cell responses. In this study, we tested the ability of a polyvalent melanoma vaccine to induce CD8+ T cell responses to the melanoma associated antigens MAGE-3 and Melan A/MART-1. Fifteen HLA-A2+ patients with resected malignant melanoma were im...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0215(19970917)72:6<972::aid-ijc
更新日期:1997-09-17 00:00:00
abstract::The effects of long-term treatment with mouse interferon on the phenotype of untransformed C3H/10T1/2 cells and cloned derivatives transformed by methylcholanthrene (MCA) and Simian virus 40 (SV40) were investigated. Continuous presence of interferon induced morphologic reversion, with the development of thick, submem...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340119
更新日期:1984-07-15 00:00:00
abstract::To identify molecular markers for the progression of head-and-neck squamous cell carcinoma (HNSCC), we used RNA arbitrarily primed (RAP) PCR to determine the qualitative and quantitative differences in gene expression between normal epithelial cells, those derived from dysplastic oral mucosa and invasive and metastati...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10403
更新日期:2002-06-01 00:00:00
abstract::Osteosarcoma incidence rates in the United States peak in adolescence and in the elderly. The international patterns of osteosarcoma incidence in children have been described, whereas those for young, middle age or elderly adults have not. Using the Cancer Incidence in Five Continents, International Agency for Cancer ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24320
更新日期:2009-07-01 00:00:00
abstract::Normal thyroid epithelial cells lack major histocompatibility complex (MHC) Class II antigen. Oncogenic kinases involved in papillary thyroid carcinoma (PTC) trigger the expression of Class II transactivator and MHC Class II complex. However, the relationship between MHC Class II antigen expression and clinical outcom...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23167
更新日期:2008-02-15 00:00:00
abstract::Subcellular distribution of hexokinase (HK) isoenzymes in 22 human breast cancers (21 primary cancers and 1 axillary metastatic growth) and 7 non-pathological human mammary gland tissue samples was studied with starch gel electrophoresis on isolated cell fractions obtained by differential centrifugation. Fractions use...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910340111
更新日期:1984-07-15 00:00:00
abstract::Conjugates (immunotoxins) comprising ricin A-chain and monoclonal antibody 96.5, which is specific for human melanoma-associated antigen p97, inhibited protein synthesis and colony formation of cultured human melanoma cells that expressed more than 80,000 molecules of p97 per cell. Cells expressing fewer than 5,000 mo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910300410
更新日期:1982-10-15 00:00:00