Expression of gastrointestinal carcinoma-associated antigen (GICA) detected in human fetal tissues by monoclonal antibody NS-19-9.

abstract：:Human papilloma virus is a causative factor in the etiology of cervical cancer with HPV16 being the most prevalent genotype associated with it. Intratype variations in oncogenic E6/E7 and capsid L1 proteins of HPV 16 besides being of phylogenetic importance, are associated with risk of viral persistence and progressio...

journal_title：International journal of cancer

authors： Pillai MR,Hariharan R,Babu JM,Lakshmi S,Chiplunkar SV,Patkar M,Tongaonkar H,Dinshaw K,Jayshree RS,Reddy BK,Siddiqui M,Roychoudury S,Saha B,Abraham P,Gnanamony M,Peedicayil A,Subhashini J,Ram TS,Dey B,Sharma C,Jain

更新日期：2009-07-01 00:00:00

abstract：:During natural metastasis, cancer cells are released continuously into the bloodstream and arrested in target organs; the process is repetitive rather than a single event. In this communication, the effect of preceding on successive "pulses" of cancer cells is discussed in relation to the arrest, retention and tumor f...

journal_title：International journal of cancer

authors： Ward PM,Weiss L

更新日期：1985-10-15 00:00:00

abstract：:Prostate-specific antigen (PSA) has been characterized as a specific prostate marker, although recent studies have suggested the existence of PSA of nonprostatic sources. We have assessed the presence of PSA by an ultrasensitive assay in 276 serum and nonserum samples from women. Our data show the presence of PSA in 9...

journal_title：International journal of cancer

authors： Filella X,Molina R,Alcover J,Carretero P,Ballesta AM

更新日期：1996-11-15 00:00:00

abstract：:Chemotherapy-induced gastrointestinal toxicity (CIGT) occurs in up to 80% of all patients undergoing cancer treatment, and leads to symptoms such as diarrhoea, abdominal bleeding and pain. There is currently limited understanding of how to predict an individual patient's risk of CIGT. It is believed the gut microbiome...

journal_title：International journal of cancer

authors： Secombe KR,Coller JK,Gibson RJ,Wardill HR,Bowen JM

更新日期：2019-05-15 00:00:00

abstract：:The water-soluble scavengers ascorbic acid (Asc), cysteine (Cys), glutathione (GSH) and uric acid (UA) as well as DNA content were determined in 40 breast tissue samples (neoplastic and non-neoplastic tissues from 20 patients). To allow proper homogenization to take place, a fixed number of sections was cut from a tis...

journal_title：International journal of cancer

authors： Honegger CG,Torhorst J,Langemann H,Kabiersch A,Krenger W

更新日期：1988-05-15 00:00:00

abstract：:The metastatic dissemination of cancer cells to remote areas of the body is the most problematic aspect in cancer patients. Among cancers, melanomas are notoriously difficult to treat due to their significantly high metastatic potential even during early stages. Hence, the establishment of advanced therapeutic approac...

journal_title：International journal of cancer

authors： Kinoshita R,Sato H,Yamauchi A,Takahashi Y,Inoue Y,Sumardika IW,Chen Y,Tomonobu N,Araki K,Shien K,Tomida S,Torigoe H,Namba K,Kurihara E,Ogoshi Y,Murata H,Yamamoto KI,Futami J,Putranto EW,Ruma IMW,Yamamoto H,Soh J

更新日期：2019-07-15 00:00:00

abstract：:Polyclonal and monoclonal antibodies were used to characterize human milk fat globule (HMFG) membrane antigens, using gel filtration, ion exchange chromatography and western blotting. Although originally generated against HMFG, monoclonal antibodies also reacted with skim milk. In western blotting, several antigen mol...

journal_title：International journal of cancer

authors： Ashorn P,Krohn K

更新日期：1985-02-15 00:00:00

abstract：:Human conventional renal cell carcinoma (CCC) remains resistant to current therapies. Focal Adhesion Kinase (FAK) is upregulated in many epithelial tumors and clearly implicated in nearly all facets of cancer. However, only few reports have assessed whether FAK may be associated with renal tumorigenesis. In this study...

journal_title：International journal of cancer

authors： Béraud C,Dormoy V,Danilin S,Lindner V,Béthry A,Hochane M,Coquard C,Barthelmebs M,Jacqmin D,Lang H,Massfelder T

更新日期：2015-10-01 00:00:00

abstract：:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease characterized by early-onset colorectal tumors, primarily in the right colon, that are frequently associated with other cancers. In the absence of a reliable biomarker, clinical criteria for diagnosing HNPCC have been proposed by the I...

journal_title：International journal of cancer

authors： Percesepe A,Anti M,Marra G,Roncucci L,Pahor M,Coco C,Armelao F,Gasbarrini G,Ponz de Leon M

更新日期：1994-09-15 00:00:00

abstract：:The association between fish, ω-3 and ω-6 polyunsaturated fatty acid (PUFA) intake and risk of colorectal cancer (CRC) remains inconclusive. Recent prospective studies suggest that the relationship may vary by gender, subsite and duration of follow-up. We followed 123,529 US adults (76,386 women and 47,143 men) withou...

journal_title：International journal of cancer

authors： Song M,Chan AT,Fuchs CS,Ogino S,Hu FB,Mozaffarian D,Ma J,Willett WC,Giovannucci EL,Wu K

更新日期：2014-11-15 00:00:00

abstract：:Biopsies obtained from 74 Tunisian women with breast cancer (33 cases), benign breast disease (17 cases), and cervical cancer (24 cases) were assayed for the presence of an antigen cross-reacting with gp52 of the mouse mammary tumor virus (MMTV) in order to determine the frequency and possible prognostic significance ...

journal_title：International journal of cancer

authors： Levine PH,Mesa-Tejada R,Keydar I,Tabbane F,Spiegelman S,Mourali N

更新日期：1984-03-15 00:00:00

abstract：:MEK1/2 inhibitors like U0126 can potentiate or antagonize the antitumor activity of cytotoxic agents such as cisplatin, paclitaxel or vinblastine, depending on the drug or the target cells. We now investigated whether U0126, differentially regulates melanoma signaling in response to UV radiation or betulinic acid, a d...

journal_title：International journal of cancer

authors： Rieber M,Rieber MS

更新日期：2006-03-01 00:00:00

abstract：:Epstein-Barr virus genome-positive Burkitt's lymphoma is endemic in Africa and Papua New Guinea and in both countries the tumour is restricted to regions with holoendemic malaria. The present work has compared groups of healthy indigenous individuals living in malarious and non-malarious regions of Papua New Guinea fo...

journal_title：International journal of cancer

authors： Moss DJ,Burrows SR,Castelino DJ,Kane RG,Pope JH,Rickinson AB,Alpers MP,Heywood PF

更新日期：1983-06-15 00:00:00

abstract：:The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of ...

journal_title：International journal of cancer

authors： Kang S,Kim JW,Kang GH,Lee S,Park NH,Song YS,Park SY,Kang SB,Lee HP

更新日期：2006-05-01 00:00:00

abstract：:Rat yolk-sac tumors were induced by intraperitoneal (i.p.) displacement of the visceral yolk sac in fetectomized W/Fu rats. Serum was obtained from each female rat prior to the pregnancy preceding the tumor-inducing procedure and then once a month during the induction period. The sera were analyzed for the presence of...

journal_title：International journal of cancer

authors： Lindvall ML,Alumets J,Sjögren HO

更新日期：1987-07-15 00:00:00

abstract：:In the perspective of in vivo therapeutic applications, the monoclonal antibody (MAb) MOv18 was selected for its restricted reactivity with human ovarian carcinoma. Using the pH 2.8 desorption assay, we found that the antigen recognized by MOv18 had a high stability on the cell membrane and poor internalization. There...

journal_title：International journal of cancer

authors： Mezzanzanica D,Canevari S,Ménard S,Pupa SM,Tagliabue E,Lanzavecchia A,Colnaghi MI

更新日期：1988-04-15 00:00:00

abstract：:In a cohort of 11,663 participants in a breast-cancer screening program, height, weight, waist circumference and hip circumference were measured, and information about menstrual and reproductive history was obtained by questionnaire. After exclusion of 83 women with unclear menopausal status, the subjects were divided...

journal_title：International journal of cancer

authors： Kaaks R,Van Noord PA,Den Tonkelaar I,Peeters PH,Riboli E,Grobbee DE

更新日期：1998-05-29 00:00:00

abstract：:Erythropoietin (Epo) regulates erythropoiesis by binding to its receptor (EpoR) and promoting cell proliferation, differentiation and inhibition of apoptosis. Epo is widely used to treat cervical cancer-related anaemia. However, there are data suggesting that administration of Epo is associated with an increment in re...

journal_title：International journal of cancer

authors： Lopez TV,Lappin TR,Maxwell P,Shi Z,Lopez-Marure R,Aguilar C,Rocha-Zavaleta L

更新日期：2011-12-01 00:00:00

abstract：:The stability of expression of a membrane antigen on human FME melanoma cells was investigated by means of flow cytometric cell sorting and analysis. The melanoma-associated 250 kd antigen was strongly expressed on all cells, as recognized by binding of the monoclonal antibody 9.2.27. By flow cytometric cell sorting, ...

journal_title：International journal of cancer

authors： Lindmo T,Davies C,Fodstad O,Morgan AC

更新日期：1984-10-15 00:00:00

abstract：:Angiogenesis, a critical driver of tumor development, is controlled by interconnected signaling pathways. Vascular endothelial growth factor receptor (VEGFR) 2 and tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 play crucial roles in the biology of normal and tumor vasculature. Regora...

journal_title：International journal of cancer

authors： Wilhelm SM,Dumas J,Adnane L,Lynch M,Carter CA,Schütz G,Thierauch KH,Zopf D

更新日期：2011-07-01 00:00:00

abstract：:Ras expression induces increased expression and altered targeting of lysosomal proteases in multiple cell types, but the specific downstream cytoplasmic signaling pathways mediating these changes have not been identified. In this study, we compared the involvement of 3 major Ras effectors, Raf, phosphatidylinositol 3-...

journal_title：International journal of cancer

authors： Collette J,Ulku AS,Der CJ,Jones A,Erickson AH

更新日期：2004-11-01 00:00:00

abstract：:DNA-dependent protein kinase (DNA-PK) has been intensively investigated for its roles in the nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair and maintenance of genomic stability. Its catalytic subunit, DNA-PKcs, a serine/threonine protein kinase, has recently been reported to be overexpresse...

journal_title：International journal of cancer

authors： An J,Xu QZ,Sui JL,Bai B,Zhou PK

更新日期：2005-11-20 00:00:00

abstract：:In analogy to apoptosis of nucleated cells, erythrocytes may enter eryptosis characterized by cell shrinkage and cell membrane scrambling. Eryptotic erythrocytes are rapidly cleared from circulating blood and may adhere to the vascular wall. Stimulation of eryptosis thus impairs microcirculation and leads to anemia as...

journal_title：International journal of cancer

authors： Lang E,Bissinger R,Qadri SM,Lang F

更新日期：2017-10-15 00:00:00

abstract：:The potential role of p16(INK4a) methylation in breast cancer is controversial whereas there are no data on fibroadenoma. To assess if inactivation of p16(INK4a) by promoter hypermethylation occurs in this hyperproliferative benign breast lesion or, on the contrary, it is strictly related to the carcinogenic process, ...

journal_title：International journal of cancer

authors： Di Vinci A,Perdelli L,Banelli B,Salvi S,Casciano I,Gelvi I,Allemanni G,Margallo E,Gatteschi B,Romani M

更新日期：2005-04-10 00:00:00

abstract：:We have recently shown in the BDII rat model of human endometrial adenocarcinoma (EAC), rat chromosome 10 (RNO10) is frequently involved in chromosomal aberrations. In the present study, we investigated the association between RNO10 deletions, allelic imbalance (AI) at RNO10q24 and Tp53 mutation in 27 rat EAC tumors. ...

journal_title：International journal of cancer

authors： Nordlander C,Karlsson S,Karlsson A,Sjöling A,Winnes M,Klinga-Levan K,Behboudi A

更新日期：2007-04-01 00:00:00

abstract：:The Swedish Family-Cancer Database was used to analyze familial relationships in mothers and daughters in invasive and in situ cervical cancers from years 1958-1994, including a total of 125,000 in situ and 14,000 invasive cancers. In situ cancers were diagnosed on average 10 years earlier than invasive cancers. Famil...

journal_title：International journal of cancer

authors： Hemminki K,Dong C,Vaittinen P

更新日期：1999-09-09 00:00:00

abstract：:BALB/c and C3H- mice were given a single injection of methylcholanthrene (MCA) and were tested at various times thereafter for immunologic reactivity and resistance to syngeneic tumor challenge. MCA treatment did not affect the rejection of H-2-incompatible tumor allografts, the rejection of H-2-compatible skin allogr...

journal_title：International journal of cancer

authors： Lill PH,Jessup JM,Kripke ML

更新日期：1978-04-15 00:00:00

abstract：:Leukocyte adherence inhibition (LAI) reactivity of various lymphoid tissues of dogs with canine transmissible venereal sarcoma (CTVS) at different stages of growth was determined by the tube LAI test. Tumors were classified at the time of excision into progressor, steady state, and regressor stages of growth. The LAI ...

journal_title：International journal of cancer

authors： Harding MW,Yang TJ

更新日期：1981-03-15 00:00:00

abstract：:Risks of 2nd primary cancer were assessed in all patients with cutaneous melanoma (12,460) and all patients with ocular melanoma (2,018) incident in Denmark from 1943 to 1989 and followed for totals of 88,667 person-years and 16,045 person-years, respectively. After cutaneous melanoma, 972 2nd cancers occurred. The ri...

journal_title：International journal of cancer

authors： Swerdlow AJ,Storm HH,Sasieni PD

更新日期：1995-06-09 00:00:00

abstract：:Genomic instability plays a key role in hereditary nonpolyposis colorectal cancer and in a significant sub-set of non-hereditary colorectal tumors. Recent evidence suggests that microsatellite instability also occurs in various sub-sets of common, non-hereditary forms of extra-colorectal carcinoma. To investigate the ...

journal_title：International journal of cancer

authors： Contegiacomo A,Palmirotta R,De Marchis L,Pizzi C,Mastranzo P,Delrio P,Petrella G,Figliolini M,Bianco AR,Frati L

更新日期：1995-08-22 00:00:00