Dietary intake of fish, ω-3 and ω-6 fatty acids and risk of colorectal cancer: A prospective study in U.S. men and women.

abstract：:ErbB-2 and EGF receptors are often co-expressed in human tumors and have been shown to synergize in the transformation of cells in experimental model systems. Transactivation of ErbB-2 can occur via ligand-induced heterodimerization with EGF receptor or other members of the ErbB family of receptor tyrosine kinases. We...

journal_title：International journal of cancer

authors： Schmidt M,Hynes NE,Groner B,Wels W

更新日期：1996-02-08 00:00:00

abstract：:Triple-negative breast cancer [TNBC, which is negative for the estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2] is a high-risk form of the disease without a specific therapy. DNA microarray and immunohistochemical analyses have shown that most TNBCs fall within the basal-lik...

journal_title：International journal of cancer

authors： Arima Y,Hayashi N,Hayashi H,Sasaki M,Kai K,Sugihara E,Abe E,Yoshida A,Mikami S,Nakamura S,Saya H

更新日期：2012-06-01 00:00:00

abstract：:An important method for silencing tumor suppressor genes in cancers is by aberrant methylation (referred to as methylation) of CpG islands in gene promoter regions. In lung cancer, methylation of the genes retinoic acid receptor beta-2 (RARbeta-2), CDH13 (H-cadherin), p16(INK4a) (p16), RASSF1A (RAS association domain ...

journal_title：International journal of cancer

authors： Zöchbauer-Müller S,Lam S,Toyooka S,Virmani AK,Toyooka KO,Seidl S,Minna JD,Gazdar AF

更新日期：2003-11-20 00:00:00

abstract：:Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were ...

journal_title：International journal of cancer

authors： Daniel D,Kuchava V,Bondarenko I,Ivashchuk O,Reddy S,Jaal J,Kudaba I,Hart L,Matitashvili A,Pritchett Y,Morris SR,Sorrentino JA,Antal JM,Goldschmidt J

更新日期：2020-12-21 00:00:00

abstract：:A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3'UTR, and is associated with an increased risk for breast cancer in Asian women. Here, we explo...

journal_title：International journal of cancer

authors： Pan JW,Zabidi MMA,Chong BK,Meng MY,Ng PS,Hasan SN,Sandey B,Bahnu S,Rajadurai P,Yip CH,Rueda OM,Caldas C,Chin SF,Teo SH

更新日期：2021-01-07 00:00:00

abstract：:TP63 gene is a member of TP53 tumor suppressor gene family that encodes several protein isoforms involved in the process of epithelial stratification and in epithelial-mesenchyme interactions. TP63 is amplified in a significant proportion of squamous cell carcinoma of the esophagus (ESCC), resulting in the hyper-expre...

journal_title：International journal of cancer

authors： Thépot A,Hautefeuille A,Cros MP,Abedi-Ardekani B,Pétré A,Damour O,Krutovskikh V,Hainaut P

更新日期：2010-11-01 00:00:00

abstract：:Primary cultures derived from pre-cancerous and cancerous human colon tissue are essential for understanding normal and abnormal growth function in the large intestine. Here presented are (i) the methodology for routine establishment of primary cultures of normal, adenoma- and carcinoma-derived cells, and (ii) data fo...

journal_title：International journal of cancer

authors： Tong WM,Bises G,Sheinin Y,Ellinger A,Genser D,Pötzi R,Wrba F,Wenzl E,Roka R,Neuhold N,Peterlik M,Cross HS

更新日期：1998-01-30 00:00:00

abstract：:The coincubation of liposomes with mouse leukemia cells or fibroblasts can cause a wide of effects on their viability. These effects are not particular specific in terms of destroying the leukemic cells. However, it was observed that the combination of phosphorylcholine-cholesterol (PC-CHOL)1-liposomes, which are not ...

journal_title：International journal of cancer

authors： Luckenbach GA,Layton D

更新日期：1981-06-15 00:00:00

abstract：:Emerging reports now implicate alterations of arachidonic acid (AA) metabolism with prostate carcinogenesis. To test this hypothesis, androgen-primed benign hyperplastic (BHC) and malignant tumorigenic (MTC) cells derived from the Lobund-Wistar rat model of autochthonous prostate adenocarcinoma were incubated with (14...

journal_title：International journal of cancer

authors： Pham H,Banerjee T,Ziboh VA

更新日期：2004-08-20 00:00:00

abstract：:Human papillomavirus (HPV) infections and HPV-associated penile lesions are frequently found in male sexual partners of women with cervical intraepithelial neoplasia (CIN). To determine the significance of these findings, we studied the prevalence of HPV and HPV associated penile lesions in a male hospital population ...

journal_title：International journal of cancer

authors： Bleeker MC,Hogewoning CJ,Voorhorst FJ,van den Brule AJ,Berkhof J,Hesselink AT,Lettink M,Starink TM,Stoof TJ,Snijders PJ,Meijer CJ

更新日期：2005-01-01 00:00:00

abstract：:The correlation between tumorigenicity and cell-surface adhesiveness was investigated in eight mouse fibroblastoid cell lines. Four of the lines (Mc 11-Mc 15) were derived from mouse MC-induced fibrosarcomas, two were derivatives of L cells (A9, A9HT), and two (clone 3 and clone 7 H7F4) were obtained by fusion of A9HT...

journal_title：International journal of cancer

authors： Bubeník J,Perlmann P,Fenyö EM,Jandlová T,Suhajová E,Malkovský M

更新日期：1979-03-15 00:00:00

abstract：:The relationship between chemosensitivity and p53 is currently considered from two mutually exclusive points of view: (1) wt p53 increases chemosensitivity due to apoptosis and (2) wt p53 decreases chemosensitivity due to growth arrest and DNA repair. We used p53-expressing adenovirus (Ad-p53) to directly evaluate eff...

journal_title：International journal of cancer

authors： Blagosklonny MV,El-Deiry WS

更新日期：1998-03-16 00:00:00

abstract：:There are clear indications that inheritance plays an essential role in certain cases of human endometrial cancer, and there are at least 2 forms of early-onset heritable endometrial adenocarcinomas (EACs). Females of the BDII inbred rat strain are known to be genetically predisposed to endometrial carcinoma, and we h...

journal_title：International journal of cancer

authors： Roshani L,Wedekind D,Szpirer J,Taib Z,Szpirer C,Beckmann B,Rivière M,Hedrich HJ,Klinga-Levan K

更新日期：2001-12-15 00:00:00

abstract：:General cell-mediated immune (CMI) functions in NPC patients were investigated by the in vivo Mantoux and in vitro lymphocyte response to PHA assays. Thirty-eight (50%) of 76 untreated NPC patients were hyporesponsive in the Mantoux assay compared to 27 (25%) of 110 control patients. Forty-three (65.2%) of 66 untreate...

journal_title：International journal of cancer

authors： Chan SH,Chew TS,Goh EH,Simons MJ,Shanmugaratnam K

更新日期：1976-08-15 00:00:00

abstract：:Laboratory and epidemiological data have linked vitamin D to breast cancer prevention. Beside dietary intake, endogenous production of vitamin D substantially contributes to a subject's vitamin D status. Most studies, however, have assessed dietary intake only. Although differential effects of vitamin D on premenopaus...

journal_title：International journal of cancer

authors： Abbas S,Chang-Claude J,Linseisen J

更新日期：2009-01-01 00:00:00

abstract：:Randomized clinical trials have shown that use of 5α-reductase inhibitors (5-ARIs) lowers overall prostate cancer (PCa) risk compared to placebo, while the proportion of Gleason 8-10 tumors is elevated. It is unknown whether this affects PCa-specific survival. We studied disease-specific survival by 5-ARI usage in a c...

journal_title：International journal of cancer

authors： Murtola TJ,Karppa EK,Taari K,Talala K,Tammela TL,Auvinen A

更新日期：2016-06-15 00:00:00

abstract：:Renal cell cancer (RCC) has become a prototype example of the extensive intratumor heterogeneity and clonal evolution of human cancers. However, there is little direct evidence on how the genetic heterogeneity impacts on drug response profiles of the cancer cells. Our goal was to determine how genomic clonal evolution...

journal_title：International journal of cancer

authors： Saeed K,Ojamies P,Pellinen T,Eldfors S,Turkki R,Lundin J,Järvinen P,Nisen H,Taari K,Af Hällström TM,Rannikko A,Mirtti T,Kallioniemi O,Östling P

更新日期：2019-03-15 00:00:00

abstract：:Meibomian gland carcinoma (MGC) and basal cell carcinoma (BCC) are common eyelid carcinomas that exhibit highly dissimilar degrees of proliferation and prognoses. We address here the question of the differential mechanisms between these two eyelid cancers that explain their different outcome. A total of 102 confirmed ...

journal_title：International journal of cancer

authors： Zhang L,Huang X,Zhu X,Ge S,Gilson E,Jia R,Ye J,Fan X

更新日期：2016-03-15 00:00:00

abstract：:The cystine/glutamate antiporter, system xc- , is essential for the efficient uptake of cystine into cells. Interest in the mechanisms of system xc- function soared with the recognition that system xc- presents the most upstream node of ferroptosis, a recently described form of regulated necrosis relevant for degenera...

journal_title：International journal of cancer

authors： Sato M,Onuma K,Domon M,Hasegawa S,Suzuki A,Kusumi R,Hino R,Kakihara N,Kanda Y,Osaki M,Hamada J,Bannai S,Feederle R,Buday K,Angeli JPF,Proneth B,Conrad M,Okada F,Sato H

更新日期：2020-12-01 00:00:00

abstract：:We quantified the expression of survivin, both as mRNA in real-time PCR and protein in immunohistochemistry, in tumor samples of 112 patients with esophageal cancer (56 squamous cell carcinomas and 56 adenocarcinomas). Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantl...

journal_title：International journal of cancer

authors： Rosato A,Pivetta M,Parenti A,Iaderosa GA,Zoso A,Milan G,Mandruzzato S,Del Bianco P,Ruol A,Zaninotto G,Zanovello P

更新日期：2006-10-01 00:00:00

abstract：:Spontaneous tumor development and primary oncogenesis were compared in a large number of NK4-deficient, homozygous C57Bl/6-bg/bg mice and their NK normal, heterozygous +/bg littermate controls. In a group of 167 retired breeders followed for spontaneous tumors, the probability of survival for mice eventually dying wit...

journal_title：International journal of cancer

authors： Haliotis T,Ball JK,Dexter D,Roder JC

更新日期：1985-04-15 00:00:00

abstract：:Two distinct cell lines (OPM-1 and OPM-2) were established from the peripheral blood of a 56-year-old female myeloma patient at the stage of terminal leukemic evolution associated with loss of cytoplasmic immunoglobulin heavy chain (G lambda----lambda). The lines grew in suspension with a doubling time of 36-42 hr and...

journal_title：International journal of cancer

authors： Katagiri S,Yonezawa T,Kuyama J,Kanayama Y,Nishida K,Abe T,Tamaki T,Ohnishi M,Tarui S

更新日期：1985-08-15 00:00:00

abstract：:Natural killer (NK) activity of human peripheral blood lymphocytes (HPBL) was studied in 32 alcoholics and 15 control subjects in a 4-h chromium release assay using K562 tumor target cells. The natural killer activity of human peripheral blood lymphocytes in alcoholics was significantly higher than the level found in ...

journal_title：International journal of cancer

authors： Saxena QB,Mezey E,Adler WH

更新日期：1980-10-15 00:00:00

abstract：:Burkitt's lymphoma cells that vary in their phenotypic characteristics show significantly different degrees of susceptibility to radiation-induced apoptosis. Propensity to undergo apoptosis is reflected in the degradation of substrates such as DNA-dependent protein kinase but the status of bcl-2, c-myc and p53 has bee...

journal_title：International journal of cancer

authors： Zhao EG,Song Q,Cross S,Misko I,Lees-Miller SP,Lavin MF

更新日期：1998-08-31 00:00:00

abstract：:The effects of prolonged administration of genistein, a tyrosine-kinase inhibitor, on sodium-chloride-enhanced induction of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine, and the labeling and apoptotic indices and vessel counts in the gastric mucosa and gastric cancers, were investigated in Wi...

journal_title：International journal of cancer

authors： Tatsuta M,Iishi H,Baba M,Yano H,Uehara H,Nakaizumi A

更新日期：1999-01-29 00:00:00

abstract：:A clone of Cloudman S91 murine melanoma was fused in vitro with non-malignant hamster cheek pouch cells by means of lysolecithin, and the putative hybrid progeny cells, HCP-MM, were found to be highly malignant in hamster, but not in appropriate mice. A malignant clone of HCP-MM cells was shown to have hamster species...

journal_title：International journal of cancer

authors： Goldenberg DM,Pavia RA

更新日期：1975-02-15 00:00:00

abstract：:Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose se...

journal_title：International journal of cancer

authors： Stepien M,Keski-Rahkonen P,Kiss A,Robinot N,Duarte-Salles T,Murphy N,Perlemuter G,Viallon V,Tjønneland A,Rostgaard-Hansen AL,Dahm CC,Overvad K,Boutron-Ruault MC,Mancini FR,Mahamat-Saleh Y,Aleksandrova K,Kaaks R,Kühn T,

更新日期：2021-02-01 00:00:00

abstract：:By radioimmunoassay (RIA) mammary tumour virus (MTV) antigens were detected in individual milk samples of C3Hf mice, (female BALB/c X male C3Hf)F1 mice and (female C3Hf X male BALB/c)F1 mice; milk samples of BALB/c mice were negative. In the segregating backcross I population, female BALB/c X male (female BALB/c X mal...

journal_title：International journal of cancer

authors： van Nie R,Verstraeten AA

更新日期：1975-12-15 00:00:00

abstract：:The majority of small-cell lung cancers (SCLCs) express p16 but not pRb. Given our previous study showing loss of pRb in Merkel cell carcinoma (MCC)/neuroendocrine carcinoma of the skin and the clinicopathological similarities between SCLC and MCC, we wished to determine if this was also the case in MCC. Twenty-nine M...

journal_title：International journal of cancer

authors： Cook AL,Pollock PM,Welch J,Walsh MD,Bowman RV,Baumann KC,Hayward NK,Leonard JH

更新日期：2001-08-01 00:00:00

abstract：:Human papillomavirus-induced cervical carcinomas often show impaired expression of MHC class I molecules resulting in the inability of tumor cells to directly present viral peptides to cytotoxic T lymphocytes. Loss of MHC class I expression combined with the expression of activating NK cell receptor ligands renders tu...

journal_title：International journal of cancer

authors： Textor S,Dürst M,Jansen L,Accardi R,Tommasino M,Trunk MJ,Porgador A,Watzl C,Gissmann L,Cerwenka A

更新日期：2008-11-15 00:00:00