当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF CANCER期刊下所有文献 > Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer.

Activating NK cell receptor ligands are differentially expressed during progression to cervical cancer.

Abstract：

:Human papillomavirus-induced cervical carcinomas often show impaired expression of MHC class I molecules resulting in the inability of tumor cells to directly present viral peptides to cytotoxic T lymphocytes. Loss of MHC class I expression combined with the expression of activating NK cell receptor ligands renders tumor cells potentially susceptible to NK cell attack. Thus, in this study, we analyzed the expression of activating NK cell receptor ligands, NK cell accumulation and activation status in situ in normal ectocervical tissue (NCT), cervical intraepithelial neoplasia (CIN) and squamous cervical carcinoma (CxCa). We observed that expression of the DNAM-1 ligand CD155 was frequently upregulated in CxCa, but not in CIN. The NKG2D ligand MICA was upregulated in fewer CxCa biopsies. In contrast, another NKG2D ligand ULBP2 was preferentially expressed in differentiated epithelial cells of NCT. Increased numbers of NK cells were detected in CIN as compared to NCT and CxCa. Expression of activating NK cell receptor ligands combined with loss of MHC class I was not correlated with enhanced NK cell accumulation or activation status. Furthermore, we demonstrate that cervical cancer cell lines are killed by the NK cell line, NKL, in a NKG2D- and DNAM-1-dependent manner in vitro. Since a significant number of CxCa biopsies showed low MHC class I expression combined with high expression of one or more of the tested activating NK cell receptor ligands, we conclude that CxCa might be a promising target for NK cell-based adoptive immunotherapy.

journal_name

Int J Cancer

journal_title

International journal of cancer

authors

Textor S,Dürst M,Jansen L,Accardi R,Tommasino M,Trunk MJ,Porgador A,Watzl C,Gissmann L,Cerwenka A

doi

10.1002/ijc.23733

subject

Has Abstract

pub_date

2008-11-15 00:00:00

pages

2343-53

issue

10

eissn

0020-7136

issn

1097-0215

journal_volume

123

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF CANCER文献大全
  • International osteosarcoma incidence patterns in children and adolescents, middle ages and elderly persons.

    abstract：:Osteosarcoma incidence rates in the United States peak in adolescence and in the elderly. The international patterns of osteosarcoma incidence in children have been described, whereas those for young, middle age or elderly adults have not. Using the Cancer Incidence in Five Continents, International Agency for Cancer ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.24320

    authors： Mirabello L,Troisi RJ,Savage SA

    更新日期：2009-07-01 00:00:00

  • Leukaemias in BN/a and BN/b mice after prolonged treatment with antilymphocyte globulin.

    abstract：:The influence of prolonged treatment with antilymphocyte globulin on tumour incidence in BN/a and BN/b mice was studied. One ALG sample appeared to be highly leukaemogenic in two independent experiments. All treated mice developed, after a short latency period, non-thymic lymphomas with involvement of abdominal lymph ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910180615

    authors： Szkudlarek J,Radzikowski C,Czarnomska A,Dux K,Bartoszewicz W

    更新日期：1976-12-15 00:00:00

  • Breast cancer-associated mitochondrial DNA haplogroup promotes neoplastic growth via ROS-mediated AKT activation.

    abstract：:In the last decade, mitochondrial DNA (mtDNA) haplogroups have been associated with the occurrence of breast cancer. However, the underlying mechanism is not known. Combining a case-control study with a large cohort of women from Southern China with breast cancer and functional analyses with trans-mitochondrial techno...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.31207

    authors： Ma L,Fu Q,Xu B,Zhou H,Gao J,Shao X,Xiong J,Gu Q,Wen S,Li F,Shen L,Chen G,Fang H,Lyu J

    更新日期：2018-05-01 00:00:00

  • Germline variation in TP53 regulatory network genes associates with breast cancer survival and treatment outcome.

    abstract：:Germline variation in the TP53 network genes PRKAG2, PPP2R2B, CCNG1, PIAS1 and YWHAQ was previously suggested to have an impact on drug response in vitro. Here, we investigated the effect on breast cancer survival of germline variation in these genes in 925 Finnish breast cancer patients and further analyzed five sing...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.27884

    authors： Jamshidi M,Schmidt MK,Dörk T,Garcia-Closas M,Heikkinen T,Cornelissen S,van den Broek AJ,Schürmann P,Meyer A,Park-Simon TW,Figueroa J,Sherman M,Lissowska J,Keong GT,Irwanto A,Laakso M,Hautaniemi S,Aittomäki K,Blomqvist

    更新日期：2013-05-01 00:00:00

  • Autocrine growth stimulation of human renal Wilms' tumour G401 cells by a gastrin-like peptide.

    abstract：:The role of gastrin in the control of growth of renal G401 cells isolated from a human nephroblastoma (Wilms' tumour) was investigated. G401 cell growth was enhanced in the presence of exogenous gastrin. Addition of anti-gastrin antibodies to serum-free medium significantly inhibited the growth of G401 cells. G401 cel...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910570316

    authors： Blackmore M,Doherty E,Manning JE,Hirst BH

    更新日期：1994-05-01 00:00:00

  • Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression.

    abstract：:Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding about the link between cell polarity and proliferation control comes from studies on the Drosophila tumor suppressors discs large (Dlg), scribble (Scrib) and lethal giant larvae (lgl). Mammalian homologues of these protein...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.21982

    authors： Gardiol D,Zacchi A,Petrera F,Stanta G,Banks L

    更新日期：2006-09-15 00:00:00

  • Anti-tumor effects of recombinant human macrophage colony-stimulating factor, alone or in combination with local irradiation, in mice inoculated with Lewis lung carcinoma cells.

    abstract：:Recombinant human (rhu) macrophage colony-stimulating factor (M-CSF) was evaluated for efficacy, either alone or in combination with local X-irradiation (LR), in mice inoculated subcutaneously (s.c.) with Lewis lung carcinoma (LLC) cells. The size of the primary tumor and numbers of lung metastases, 21 days after tumo...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910470125

    authors： Lu L,Shen RN,Lin ZH,Aukerman SL,Ralph P,Broxmeyer HE

    更新日期：1991-01-02 00:00:00

  • The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer.

    abstract：:Tumour cell anaerobic metabolism has been reported to be a prognostic factor in colorectal cancer. The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5, the tumour microenvironment, and outcome in patients with colorectal cancer. A c...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32045

    authors： Roseweir AK,Clark J,McSorley ST,vanWyk HC,Quinn JA,Horgan PG,McMillan DC,Park JH,Edwards J

    更新日期：2019-05-01 00:00:00

  • Partial characterization of viral DNA from human genital warts (Condylomata acuminata).

    abstract：:By centrifuging total cellular DNA derived from human genital warts (condylomata acuminata) in CsCl-ethidium bromide gradients, supercoiled DNA was isolated. The molecular weight of this DNA was determined by agarose gel electrophoresis and amounted to 5.1 X 10(4). This DNA isolated from an individual genital wart was...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910250509

    authors： Gissmann L,zur Hausen H

    更新日期：1980-05-15 00:00:00

  • Promoter methylation of p16 associated with Helicobacter pylori infection in precancerous gastric lesions: a population-based study.

    abstract：:To investigate the relationship between p16 methylation and Helicobacter pylori infection in precancerous gastric lesions, a population-based study was conducted in Linqu County, a high-risk area of gastric cancer in China. Methylation status of p16 was evaluated by methylation-specific polymerase chain reaction in 92...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.23891

    authors： Dong CX,Deng DJ,Pan KF,Zhang L,Zhang Y,Zhou J,You WC

    更新日期：2009-01-15 00:00:00

  • A 16 Yin Yang gene expression ratio signature for ER+/node- breast cancer.

    abstract：:Breast cancer is one of the leading causes of cancer death in women. It is a complex and heterogeneous disease with different clinical outcomes. Stratifying patients into subgroups with different outcomes could help guide clinical decision making. In this study, we used two opposing groups of genes, Yin and Yang, to d...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.30556

    authors： Xu W,Jia G,Cai N,Huang S,Davie JR,Pitz M,Banerji S,Murphy L

    更新日期：2017-03-15 00:00:00

  • Beta-galactoside alpha2,6 sialyltransferase in human colon cancer: contribution of multiple transcripts to regulation of enzyme activity and reactivity with Sambucus nigra agglutinin.

    abstract：:Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0215(20001001)88:1<58::aid-ijc9>3.0.c

    authors： Dall'Olio F,Chiricolo M,Ceccarelli C,Minni F,Marrano D,Santini D

    更新日期：2000-10-01 00:00:00

  • Identification of a 43-kDa nuclear antigen associated with proliferation by monoclonal antibody K 112.

    abstract：:Monoclonal antibody (MAb) K 112 was generated after a single intrasplenic immunization with a recurrent laryngeal squamous-cell carcinoma. The antibody detects a 43-kDa nuclear antigen, with a pI of 5.4, which is expressed only in cycling cells. Expression is typically seen in a granular pattern excluding the nucleoli...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910460111

    authors： Quak JJ,van Dongen G,Koken MA,Brakkee JG,Scheper RJ,Balm AJ,de Jong L,Snow GB,Meijer CJ

    更新日期：1990-07-15 00:00:00

  • Maternal and perinatal factors associated with non-Hodgkin's lymphoma among children.

    abstract：:This nested case-control study based on 1.7 million live births in Sweden explores the associations between maternal and perinatal factors and the occurrence of childhood non-Hodgkin's lymphoma (NHL). The National Swedish Cancer Registry ascertained 168 cases in successive birth cohorts from 1973 through 1989 recorded...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-0215(19960315)65:6<774::AID-IJC

    authors： Adami J,Glimelius B,Cnattingius S,Ekbom A,Zahm SH,Linet M,Zack M

    更新日期：1996-03-15 00:00:00

  • Effect of mistimed eating patterns on breast and prostate cancer risk (MCC-Spain Study).

    abstract：:Modern life involves mistimed sleeping and eating patterns that in experimental studies are associated with adverse health effects. We assessed whether timing of meals is associated with breast and prostate cancer risk taking into account lifestyle and chronotype, a characteristic correlating with preference for morni...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.31649

    authors： Kogevinas M,Espinosa A,Castelló A,Gómez-Acebo I,Guevara M,Martin V,Amiano P,Alguacil J,Peiro R,Moreno V,Costas L,Fernández-Tardón G,Jimenez JJ,Marcos-Gragera R,Perez-Gomez B,Llorca J,Moreno-Iribas C,Fernández-Villa T,

    更新日期：2018-11-15 00:00:00

  • Characterization of EBV-carrying B-cell populations in healthy seropositive individuals with regard to density, release of transforming virus and spontaneous outgrowth.

    abstract：:Peripheral or tonsil lymphocyte populations of EBV-seropositive donors give rise to EBV-carrying LCLs upon in vitro explantation. Such lines can arise either by a 2-step mechanism, namely release of virus from some of the explanted cells followed by infection of previously uninfected B cells, or by direct outgrowth of...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910390411

    authors： Lewin N,Aman P,Masucci MG,Klein E,Klein G,Oberg B,Strander H,Henle W,Henle G

    更新日期：1987-04-15 00:00:00

  • Constitutive expression of the Wilms tumor suppressor gene (WT1) in renal cell carcinoma.

    abstract：:The expression of the Wilms tumor suppressor gene WT1 is largely restricted to elements of the developing urogenital system. In the fetal kidney, WT1 transcripts are present at low levels in the condensing mesenchyme and at much higher levels in differentiating glomerular epithelium and are not detected in other mesen...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19981005)78:2<182::aid-ijc

    authors： Campbell CE,Kuriyan NP,Rackley RR,Caulfield MJ,Tubbs R,Finke J,Williams BR

    更新日期：1998-10-05 00:00:00

  • Overexpression of RbAp46 facilitates stress-induced apoptosis and suppresses tumorigenicity of neoplastigenic breast epithelial cells.

    abstract：:We have found previously that the retinoblastoma (Rb) suppressor associated protein 46 (RbAp46) is a gene upregulated by the Wilms' tumor suppressor, WT1, and functions as a potent growth inhibitor. To investigate the effect of RbAp46 overexpression on early development of breast cancer, we established stable cell lin...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.11148

    authors： Li GC,Guan LS,Wang ZY

    更新日期：2003-07-20 00:00:00

  • cDNA and protein characterization of human MAGE-10.

    abstract：:MAGE genes are frequently expressed in several types of human malignancy and code for antigens recognized by cytotoxic T lymphocytes. We have previously described a monoclonal antibody (MAb), named 6C1, that recognizes the MAGE-1 protein and cross-reacts with a 72-kDa protein present in lysates of melanoma cells such ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19990909)82:6<901::aid-ijc

    authors： Rimoldi D,Salvi S,Reed D,Coulie P,Jongeneel VC,De Plaen E,Brasseur F,Rodriguez AM,Boon T,Cerottini JC

    更新日期：1999-09-09 00:00:00

  • Determination of HLA-A*02 antigen status in Hodgkin's disease and analysis of an HLA-A*02-restricted epitope of the Epstein-Barr virus LMP-2 protein.

    abstract：:There is good evidence for an association between Epstein-Barr virus (EBV) and Hodgkin's disease (HD). In approximately one-third of cases, the EBV genome is detectable in Reed-Sternberg (RS) cells and there is expression of the viral nuclear antigen EBNA-1 and the latent membrane protein LMP-1. Expression of LMP-2 ha...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-0215(19970807)72:4<614::aid-ijc

    authors： Bryden H,MacKenzie J,Andrew L,Alexander FE,Angus B,Krajewski AS,Armstrong AA,Gray D,Cartwright RA,Kane E,Wright DH,Taylor P,Jarrett RF

    更新日期：1997-08-07 00:00:00

  • Growth-inhibitory activity of interferon-beta against human colorectal carcinoma cell lines.

    abstract：:Recombinant human interferon beta (rIFN-beta) inhibited in a time- and dose-dependent manner the proliferation of 18/18 human colon carcinoma cell lines in monolayer culture and 8/9 lines in a soft agar assay but had no effect on 4 human fibroblast cell lines. Maximal inhibition of cell proliferation by rIFN-beta requ...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910430331

    authors： Wong VL,Rieman DJ,Aronson L,Dalton BJ,Greig R,Anzano MA

    更新日期：1989-03-15 00:00:00

  • A low DNA methylation epigenotype in lung squamous cell carcinoma and its association with idiopathic pulmonary fibrosis and poorer prognosis.

    abstract：:Patients with idiopathic pulmonary fibrosis (IPF) have higher risk of developing lung cancer, for example, squamous cell carcinoma (SCC), and show poor prognosis, while the molecular basis has not been fully investigated. Here we conducted DNA methylome analysis of lung SCC using 20 SCC samples with/without IPF, and n...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32532

    authors： Hata A,Nakajima T,Matsusaka K,Fukuyo M,Morimoto J,Yamamoto T,Sakairi Y,Rahmutulla B,Ota S,Wada H,Suzuki H,Matsubara H,Yoshino I,Kaneda A

    更新日期：2020-01-15 00:00:00

  • Rab11-FIP2 promotes the metastasis of gastric cancer cells.

    abstract：:Rab11-FIP2 can interact with MYO5B and plays an important role in regulating plasma membrane recycling. Our previous study has shown that MYO5B is epigenetically silenced and associated with c-Met signaling in human gastric cancer. However, little is known of the function of Rab11-FIP2 in gastric cancer. In this study...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.29899

    authors： Dong W,Qin G,Shen R

    更新日期：2016-04-01 00:00:00

  • A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects.

    abstract：:Effects of therapeutic and supratherapeutic concentrations of bosutinib, a dual Src/Abl tyrosine kinase inhibitor, on the corrected QT interval (QTc) in 60 healthy adults were assessed, according to ICH-E14 guidelines, in this 2-part, randomized, single-dose, double-blind, crossover, placebo- and open-label moxifloxac...

    journal_title：International journal of cancer

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1002/ijc.27348

    authors： Abbas R,Hug BA,Leister C,Sonnichsen D

    更新日期：2012-08-01 00:00:00

  • Antitumor effects of a recombinant fowlpox virus expressing Apoptin in vivo and in vitro.

    abstract：:Apoptin is a chicken anemia virus-derived, p53-independent, bcl-2-insensitive apoptotic protein with the ability to specifically induce apoptosis in tumor cells. To explore the use of the Apoptin gene in cancer gene therapy, we constructed a recombinant fowlpox virus expressing the Apoptin protein (vFV-Apoptin) and co...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.22215

    authors： Li X,Jin N,Mi Z,Lian H,Sun L,Li X,Zheng H

    更新日期：2006-12-15 00:00:00

  • Constitutive activation of the androgen receptor by a point mutation in the hinge region: a new mechanism for androgen-independent growth in prostate cancer.

    abstract：:Androgen receptor (AR) mutations that modify both the ligand binding and the transactivation capacities of the AR represent one of the mechanisms involved in the transition of prostate cancer (PCa) from androgen-dependent to androgen-independent growth. We use a yeast-based functional assay to detect and analyze mutan...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.11404

    authors： Céraline J,Cruchant MD,Erdmann E,Erbs P,Kurtz JE,Duclos B,Jacqmin D,Chopin D,Bergerat JP

    更新日期：2004-01-01 00:00:00

  • Tobacco smoking, chewing habits, alcohol drinking and the risk of head and neck cancer in Nepal.

    abstract：:Although tobacco smoking, pan chewing and alcohol drinking are important risk factors for head and neck cancer (HNC), the HNC risks conferred by products available in Nepal for these habits are unknown. We assessed the associations of tobacco smoking, chewing habits, and alcohol drinking with HNC risk in Nepal. A case...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32823

    authors： Chang CP,Siwakoti B,Sapkota A,Gautam DK,Lee YA,Monroe M,Hashibe M

    更新日期：2020-08-01 00:00:00

  • Flow cytometric analysis of the expression of 9A3 antigen, E-cadherin and EGF receptor in TMK-1 stomach cancer cells.

    abstract：:We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.2910480115

    authors： Fukuyama R,Minoshima S,Ochiai A,Tahara E,Shimizu N

    更新日期：1991-04-22 00:00:00

  • Reverse transcription-polymerase chain reaction assay for multiple mRNA markers in the detection of breast cancer metastases in sentinel lymph nodes.

    abstract：:The identification of specific tumor mRNA markers by reverse transcription-polymerase chain reaction might be a valuable diagnostic adjunct for the detection of breast cancer metastases in axillary sentinel lymph nodes (SLNs). In this study we have compared the diagnostic accuracy of an extensive histopathologic exami...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/1097-0215(20010920)95:5<307::aid-ijc0153>3

    authors： Manzotti M,Dell'Orto P,Maisonneuve P,Zurrida S,Mazzarol G,Viale G

    更新日期：2001-09-20 00:00:00

  • Overuse of antianaerobic drug is associated with poor postchemotherapy prognosis of patients with hepatocellular carcinoma.

    abstract：:Overuse of antibiotic drugs alters the composition of gut microbiota and has detrimental effects on the host. In our study, we investigated association of gut flora and antibiotics in the prognosis of patients with liver cancer who have undergone chemotherapy by analyzing two independent clinical studies. We retrospec...

    journal_title：International journal of cancer

    pub_type： 杂志文章

    doi：10.1002/ijc.32339

    authors： Iida N,Mizukoshi E,Yamashita T,Terashima T,Arai K,Seishima J,Kaneko S

    更新日期：2019-11-15 00:00:00