Rab11-FIP2 promotes the metastasis of gastric cancer cells.


:Rab11-FIP2 can interact with MYO5B and plays an important role in regulating plasma membrane recycling. Our previous study has shown that MYO5B is epigenetically silenced and associated with c-Met signaling in human gastric cancer. However, little is known of the function of Rab11-FIP2 in gastric cancer. In this study, we investigated Rab11-FIP2 expression by immunohistochemistry in 86 patients with gastric cancer. We found that the expression level of Rab11-FIP2 was significantly increased in gastric cancer tissues and high expression of Rab11-FIP2 was closely correlated with nodal metastasis in gastric cancer patients. Rab11-FIP2 overexpression promoted epithelial-mesenchymal transition (EMT) in a manner associated with gastric cancer metastasis in vitro and in vivo. We also found that hypoxia could enhance the expression of Rab11-FIP2 through HIF-1α. Inactivation of Rab11-FIP2 dramatically decreased hypoxia-induced migration of gastric cancer cells. Suppression of the internalization of EGFR, at least in part, plays an important role in EMT induced by overexpression of Rab11-FIP2 in gastric cancer cells. Finally, we demonstrated that Rab11-FIP2 could regulate actin cytoskeleton dynamics. In conclusion, our findings reveal a novel mechanism underlying the role of Rab11-FIP2 in gastric cancer dissemination, suggesting that Rab11-FIP2 may be a promising candidate target for gastric cancer treatment.


Int J Cancer


Dong W,Qin G,Shen R




Has Abstract


2016-04-01 00:00:00












  • Characteristic patterns of HOX gene expression in different types of human leukemia.

    abstract::Homeobox-containing genes are a network of genes encoding DNA-binding proteins highly conserved throughout evolution. They are involved in the control of normal development as well as in the regulation of gene expression in adult differentiating systems, including hematopoiesis. Aberrant expression of homeobox-contain...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Celetti A,Barba P,Cillo C,Rotoli B,Boncinelli E,Magli MC

    更新日期:1993-01-21 00:00:00

  • Quantitative proteomics to study a small molecule targeting the loss of von Hippel-Lindau in renal cell carcinomas.

    abstract::Inactivation of the tumor suppressor gene, von Hippel-Lindau (VHL), is known to play an important role in the development of sporadic clear cell renal cell carcinomas (ccRCCs). Even if available targeted therapies for metastatic RCCs (mRCCs) have helped to improve progression-free survival rates, they have no durable ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bouhamdani N,Joy A,Barnett D,Cormier K,Léger D,Chute IC,Lamarre S,Ouellette R,Turcotte S

    更新日期:2017-08-15 00:00:00

  • Anxiety and distress following receipt of results from routine HPV primary testing in cervical screening: The psychological impact of primary screening (PIPS) study.

    abstract::We used a cross-sectional survey to examine short-term anxiety and distress in women receiving different results following routine human papillomavirus (HPV) primary testing at cervical screening. Participants were women aged 24-65 (n = 1,127) who had attended screening at one of five sites piloting HPV primary screen...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McBride E,Marlow LAV,Forster AS,Ridout D,Kitchener H,Patnick J,Waller J

    更新日期:2020-04-15 00:00:00

  • The prevalence and concordance of human papillomavirus infection in different anogenital sites among men and women in Liuzhou, China: A population-based study.

    abstract::Human papillomavirus (HPV) infection is the pathogenesis of anogenital cancers and genital warts in both men and women, whereas there is a scarcity of large studies focused on HPV prevalence in different anogenital sites of both sexes in the same population. From May to July 2014, 2,309 men and 2,378 women aged 18-55 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wei F,Li M,Wu X,Yin K,Lan J,Sheng W,Guo M,Huang S,Wang Y,Li Y,Li R,Su Y,Wu T,Zhang J,Xia N

    更新日期:2018-03-15 00:00:00

  • Prospective study of alcohol consumption and breast cancer risk in Japanese women.

    abstract::Epidemiologic evidence is lacking for the association between alcohol consumption and the risk of breast cancer in Japanese women. We addressed this association in a prospective cohort study with an average follow-up of 7.6 years. At baseline (1988-1990), cohort participants completed a self-administered questionnaire...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lin Y,Kikuchi S,Tamakoshi K,Wakai K,Kondo T,Niwa Y,Yatsuya H,Nishio K,Suzuki S,Tokudome S,Yamamoto A,Toyoshima H,Tamakoshi A

    更新日期:2005-09-20 00:00:00

  • Oesophageal cancer studies in the Caspian littoral of Iran: some residual results, including opium use as a risk factor.

    abstract::A study was conducted in northern Iran in areas of very high, high and moderately low incidence of oesophageal cancer. Morphine metabolites in urine as an indicator of opium use, and a variety of nutritional and biochemical measures, including salivary antipyrine half-life, were determined in households with a case of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ghadirian P,Stein GF,Gorodetzky C,Roberfroid MB,Mahon GA,Bartsch H,Day NE

    更新日期:1985-05-15 00:00:00

  • Imaging of branched chain amino acid metabolism in tumors with hyperpolarized 13C ketoisocaproate.

    abstract::Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Karlsson M,Jensen PR,in 't Zandt R,Gisselsson A,Hansson G,Duus JØ,Meier S,Lerche MH

    更新日期:2010-08-01 00:00:00

  • Mutation analysis of the MYH gene in an Australian series of colorectal polyposis patients with or without germline APC mutations.

    abstract::The MYH gene has recently been shown to be associated with a recessive form of colorectal adenomatous polyposis. Two common mutations in the MYH gene have been identified that lend themselves to rapid screening. We have examined a series of 302 individuals comprising 120 control subjects, 120 patients diagnosed with a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kairupan CF,Meldrum CJ,Crooks R,Milward EA,Spigelman AD,Burgess B,Groombridge C,Kirk J,Tucker K,Ward R,Williams R,Scott RJ

    更新日期:2005-08-10 00:00:00

  • A candidate CpG SNP approach identifies a breast cancer associated ESR1-SNP.

    abstract::Altered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression. We hypothesized that heritable methylation potential might be a risk factor for breast cancer and evaluated possible association with breast cancer for single nucleotide polymorphisms (S...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Harlid S,Ivarsson MI,Butt S,Hussain S,Grzybowska E,Eyfjörd JE,Lenner P,Försti A,Hemminki K,Manjer J,Dillner J,Carlson J

    更新日期:2011-10-01 00:00:00

  • WAVE3, an actin remodeling protein, is regulated by the metastasis suppressor microRNA, miR-31, during the invasion-metastasis cascade.

    abstract::WAVE3, an actin cytoskeleton remodeling protein, is highly expressed in advanced stages of breast cancer and influences tumor cell invasion. Loss of miR-31 has been associated with cancer progression and metastasis. Here, we show that the activity of WAVE3 to promote cancer cell invasion is regulated by miR-31. An inv...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sossey-Alaoui K,Downs-Kelly E,Das M,Izem L,Tubbs R,Plow EF

    更新日期:2011-09-15 00:00:00

  • Prevention of benzo(a)pyrene-induced mutagenicity by homogeneous epoxide hydratase.

    abstract::Benzo(a)pyrene and benz(a) anthrancene which, in contrast to the K-region epoxides benzo(a)pyrene 4,5-oxide and benz(a)anthracene 5,6-oxide, are not mutagenic to Salmonella typhimurium TA 1537 in the absence of mammalian enzyme preparations, were activated by liver microsomes from C3H mice, which had not received any ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Oesch F,Bentley P,Glatt HR

    更新日期:1976-10-15 00:00:00

  • The association between change in body mass index and upper aerodigestive tract cancers in the ARCAGE project: multicenter case-control study.

    abstract::Previous studies reported an inverse relationship between body mass index (BMI) and upper aerodigestive tract (UADT) cancers. Examining change in BMI over time may clarify these previous observations. We used data from 2,048 cases and 2,173 hospital- and population-based controls from ten European countries (alcohol-r...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Park SL,Lee YC,Marron M,Agudo A,Ahrens W,Barzan L,Bencko V,Benhamou S,Bouchardy C,Canova C,Castellsague X,Conway DI,Healy CM,Holcátová I,Kjaerheim K,Lagiou P,Lowry RJ,Macfarlane TV,Macfarlane GJ,McCartan BE,McKinn

    更新日期:2011-03-15 00:00:00

  • Second primary neoplasms in 633,964 cancer patients in Sweden, 1958-1996.

    abstract::The Swedish Family-Cancer Database was used to analyze concordant (same site) and discordant (different site) second primary neoplasms in 633,964 cancer patients diagnosed from 1958 to 1996. Cases of second malignant neoplasms were extracted from the Database if the diagnosis date of the first and second cancer differ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dong C,Hemminki K

    更新日期:2001-07-15 00:00:00

  • Adenovirus-mediated wild-type-p53-gene expression sensitizes TNF-resistant tumor cells to TNF-induced cytotoxicity by altering the cellular redox state.

    abstract::We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombinant adenovirus encod...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shatrov VA,Ameyar M,Bouquet C,Cai Z,Stancou R,Haddada H,Chouaib S

    更新日期:2000-01-01 00:00:00

  • Prevalence of Kaposi's sarcoma-associated herpesvirus infection in sex workers and women from the general population in Spain.

    abstract::Transmission routes of Kaposi's sarcoma-associated herpesvirus (KSHV) in the general population are poorly understood. Whereas sexual transmission appears to be common in homosexual men, the evidence for heterosexual transmission is less convincing. In our study, prevalence of KSHV infection was examined among women i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: de Sanjosé S,Marshall V,Solà J,Palacio V,Almirall R,Goedert JJ,Bosch FX,Whitby D

    更新日期:2002-03-01 00:00:00

  • Metabolic syndrome and risk of pancreatic cancer: A population-based prospective cohort study.

    abstract::Metabolic syndrome (MetS) and its components may link to pancreatic cancer risk; however, current epidemiological evidence is limited, and the potential mechanisms underlying the associations remain unclear. To investigate this, we carried out this prospective cohort study of 474 929 participants without a diagnosis o...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Xia B,He Q,Pan Y,Gao F,Liu A,Tang Y,Chong C,Teoh AYB,Li F,He Y,Zhang C,Yuan J

    更新日期:2020-12-15 00:00:00

  • Hypoxia upregulates ovarian cancer invasiveness via the binding of HIF-1α to a hypoxia-induced, methylation-free hypoxia response element of S100A4 gene.

    abstract::Hypoxia is known to play important roles in the development and progression of tumors. We previously demonstrated that S100A4, a critical molecule for metastasis, was upregulated in ovarian cancer cells. Therefore, we examined the mechanisms of the upregulation of S100A4 expression in ovarian carcinoma cells, with par...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Horiuchi A,Hayashi T,Kikuchi N,Hayashi A,Fuseya C,Shiozawa T,Konishi I

    更新日期:2012-10-15 00:00:00

  • Bromodomain and extraterminal domain inhibition synergizes with WEE1-inhibitor AZD1775 effect by impairing nonhomologous end joining and enhancing DNA damage in nonsmall cell lung cancer.

    abstract::Bromodomain and extraterminal domain (BET) inhibitors are broadly active against distinct types of cancer, including nonsmall cell lung cancer (NSCLC). Previous studies have addressed the effect of BET-inhibiting drugs on the expression of oncogenes such as c-Myc, but DNA damage repair pathways have also been reported...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Takashima Y,Kikuchi E,Kikuchi J,Suzuki M,Kikuchi H,Maeda M,Shoji T,Furuta M,Kinoshita I,Dosaka-Akita H,Sakakibara-Konishi J,Konno S

    更新日期:2020-02-15 00:00:00

  • Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene.

    abstract::Ganglioside functions in tumor metastasis were analyzed by carbohydrate remodeling of a mouse Lewis lung cancer (subline P29) by introducing beta1,4GalNAc-T cDNA. Although P29 was originally a low-metastatic subline in the s.c. injection system, it showed high potential in lung metastasis when i.v.-injected via the ta...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen HH,Fukumoto S,Furukawa K,Nakao A,Akiyama S,Urano T,Furukawa K

    更新日期:2003-01-10 00:00:00

  • In vitro and in vivo antitumor effect of 2-methoxyestradiol on human melanoma.

    abstract::2-methoxyestradiol (2ME(2)) is an endogenous metabolite of estradiol with estrogen-receptor-independent antitumor and antiangiogenic activity. We examined the effects of 2ME(2) on the cellular proliferation of 8 human melanoma cell lines. We show that 2ME(2) inhibited cell proliferation by inducing apoptosis and an ar...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dobos J,Tímár J,Bocsi J,Burián Z,Nagy K,Barna G,Peták I,Ladányi A

    更新日期:2004-12-10 00:00:00

  • Screening of human brain tumors for SV40-related T antigen.

    abstract::A series of 39 human brain tumors has been screened for the presence or absence of SV40-related T antigen by the direct and indirect immunoperoxidase methods. Two tumors of ependymal origin (malignant ependymoma, choroid plexus papilloma) revealed markedly positive nuclear staining for T antigen both in vivo and in vi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tabuchi K,Kirsch WM,Low M,Gaskin D,Van Buskirk J,Maa S

    更新日期:1978-01-15 00:00:00

  • p38 MAPK, but not ERK1/2, is critically involved in the cytotoxicity of the novel vascular disrupting agent combretastatin A4.

    abstract::Combretastatin A4 (CA4) is a novel vascular disrupting agent that has promising clinical efficacy because of its ability to inhibit microtubule assembly and subsequently disrupt tumor blood flow. In this study, we demonstrate that mitogen-activated protein kinases (MAPKs) are critically involved in the cytotoxicity of...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Quan H,Xu Y,Lou L

    更新日期:2008-04-15 00:00:00

  • LIM kinase 1 increases tumor metastasis of human breast cancer cells via regulation of the urokinase-type plasminogen activator system.

    abstract::Mammalian LIM kinase 1 (LIMK1) phosphorylates and inactivates the actin-binding and -depolymerizing factor cofilin and induces actin cytoskeletal changes. LIMK1 is reported to play an important role in cell motility, but the mechanism of induction of cell motility and the role of LIMK1 in tumor growth, angiogenesis an...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bagheri-Yarmand R,Mazumdar A,Sahin AA,Kumar R

    更新日期:2006-06-01 00:00:00

  • Activation of ras oncogenes and expression of tumor-specific transplantation antigens in methylcholanthrene-induced murine fibrosarcomas.

    abstract::The DNA of 22 fibrosarcomas, newly induced in BALB/c mice by subcutaneous doses of 3-methylcholanthrene (3-MCA), was tested in NIH 3T3 transformation assay. Activation of K-ras and N-ras was found in 7 and 3 cases respectively. No H-ras activation was detected. Polymerase chain reaction and oligonucleotide hybridizati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Carbone G,Borrello MG,Molla A,Rizzetti MG,Pierotti MA,Della Porta G,Parmiani G

    更新日期:1991-02-20 00:00:00

  • Glycoconjugates of murine tumor lines with different metastatic capacities. II. Diversity of glycolipid composition.

    abstract::A syngeneic tumor system in DBA/2 mice consisting of a methyl-cholanthrene-induced, weakly metastatic lymphoma, L5178YE (= Eb), its spontaneous strongly metastatic variant, L5178YES (= ESb), and an unrelated, methylcholanthrene-induced, metastasizing tumor, MDAY-D2, were used to study the relationship between metastat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schwartz R,Kniep B,Müthing J,Mühlradt PF

    更新日期:1985-11-15 00:00:00

  • Lifecourse socioeconomic status and cancer-related risk factors: Analysis of the WHO study on global ageing and adult health (SAGE).

    abstract::Few studies have examined cancer-related risk factors in relation to SES across the lifecourse in low to middle income countries. This analysis focuses on adult women in India, China, Mexico, Russia and South Africa, and examines the association between individual, parental and lifecourse SES with smoking, alcohol, BM...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Akinyemiju T,Ogunsina K,Okwali M,Sakhuja S,Braithwaite D

    更新日期:2017-02-15 00:00:00

  • Sex-specificity in lung cancer risk.

    abstract::Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops this disease. Although previously tobacco-derived carcinogens and enzyme polymorphisms have been identified to increase the risk for smokers, recent epidemiological data suggest even sex-specificity as a new and additional fac...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Stapelfeld C,Dammann C,Maser E

    更新日期:2020-05-01 00:00:00

  • Randomized phase II trial of TEGAFIRI (tegafur/uracil, oral leucovorin, irinotecan) compared with FOLFIRI (folinic acid, 5-fluorouracil, irinotecan) in patients with unresectable/recurrent colorectal cancer.

    abstract::Irinotecan-based chemotherapy with bevacizumab is one of the first-line standard therapies for metastatic colorectal cancer (mCRC). TEGAFIRI (UFT/LV + irinotecan) is an irinotecan-based chemotherapy regimen. Currently, few clinical data regarding TEGAFIRI are available. This study evaluated the efficacy and safety of ...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Shigeta K,Hasegawa H,Okabayashi K,Tsuruta M,Ishii Y,Endo T,Ochiai H,Kondo T,Kitagawa Y

    更新日期:2016-08-15 00:00:00

  • Inhibition of tumor growth by biodegradable microspheres containing all-trans-retinoic acid in a human head-and-neck cancer xenograft.

    abstract::Retinoids play essential roles in the regulation of cell differentiation and in the proliferation of various epithelial tissues, and atRA is one such active metabolite of retinoids. However, despite the known functions of atRA, its clinical applications are limited due to the induced metabolism by the specific cytochr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Choi Y,Kim SY,Kim SH,Yang J,Park K,Byun Y

    更新日期:2003-10-20 00:00:00

  • Trilaciclib prior to chemotherapy and atezolizumab in patients with newly diagnosed extensive-stage small cell lung cancer: A multicentre, randomised, double-blind, placebo-controlled Phase II trial.

    abstract::Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Daniel D,Kuchava V,Bondarenko I,Ivashchuk O,Reddy S,Jaal J,Kudaba I,Hart L,Matitashvili A,Pritchett Y,Morris SR,Sorrentino JA,Antal JM,Goldschmidt J

    更新日期:2020-12-21 00:00:00