Constitutive activation of the androgen receptor by a point mutation in the hinge region: a new mechanism for androgen-independent growth in prostate cancer.

abstract：:Epigenetic inactivation by aberrant DNA methylation has been reported for many microRNA genes in various human malignancies. However, relatively little is known about microRNA gene methylation in hepatocellular carcinoma (HCC). Therefore, a systematic screen for identification of aberrantly hypermethylated microRNA ge...

journal_title：International journal of cancer

authors： Anwar SL,Albat C,Krech T,Hasemeier B,Schipper E,Schweitzer N,Vogel A,Kreipe H,Lehmann U

更新日期：2013-08-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. These tumors span a wide clinical spectrum from benign to malignant and have long been recognized for their nearly absolute resistance to chemotherapy and radiation treatment. We reviewed the worldwide experience on ...

journal_title：International journal of cancer

authors： Rossi CR,Mocellin S,Mencarelli R,Foletto M,Pilati P,Nitti D,Lise M

更新日期：2003-11-01 00:00:00

abstract：:We examined the biologic properties of a small-cell-lung-carcinoma (SCLC) cell line (designated MN-1112) established from a patient with SCLC who showed paraneoplastic retinopathy syndrome. Morphologic and immunocytochemical analyses showed that MN-1112 cells possess features of the classic type of SCLC. MN-1112 cells...

journal_title：International journal of cancer

authors： Yamaji Y,Matsubara S,Yamadori I,Sato M,Fujita T,Fujita J,Takahara J

更新日期：1996-03-01 00:00:00

abstract：:Non-small-cell lung cancers (NSCLC) are often infiltrated by T lymphocytes. It is postulated that the presence of tumor-infiltrating lymphocytes (TIL) reflects a local host immune response against autologous tumors. To identify the nature of NSCLC TIL, we have characterized the molecular structure of the TCRbeta chain...

journal_title：International journal of cancer

authors： Echchakir H,Asselin-Paturel C,Dorothee G,Vergnon I,Grunenwald D,Chouaib S,Mami-Chouaib F

更新日期：1999-04-12 00:00:00

abstract：:It is currently under debate whether the low serum cholesterol levels that are frequently observed in cancer patients represent a risk factor for/or, rather, are a consequence of the tumour. We postulate that malignant tumours are directly involved in an increased catabolism of cholesterol-rich low-density lipoprotein...

journal_title：International journal of cancer

authors： Niendorf A,Nägele H,Gerding D,Meyer-Pannwitt U,Gebhardt A

更新日期：1995-05-16 00:00:00

abstract：:The high burden of cervical cancer and inadequate/suboptimal cytology screening in developing countries led to the evaluation of visual screening tests, like visual inspection with acetic acid (VIA) and Lugol's iodine (VILI). We describe the performance of VIA, VILI and cytology, carried out in a multinational project...

journal_title：International journal of cancer

authors： Deodhar K,Sankaranarayanan R,Jayant K,Jeronimo J,Thorat R,Hingmire S,Muwonge R,Chiwate A,Deshpande R,Ajit D,Kelkar R,Rekhi B,Ruben I,Malvi SG,Chinoy R,Jambhekar N,Nene BM

更新日期：2012-09-15 00:00:00

abstract：:Transcription factor c-Jun serves for cellular proliferation, survival, differentiation and transformation and is recognized as an important factor in cancer development, including hepatocellular carcinoma (HCC). The purpose of present study is to determine the involvement of c-Jun in matrix metalloproteinase-1 (MMP-1...

journal_title：International journal of cancer

authors： Sugioka Y,Watanabe T,Inagaki Y,Kushida M,Niioka M,Endo H,Higashiyama R,Okazaki I

更新日期：2004-05-10 00:00:00

abstract：:Cancer Procoagulant (CP), a cysteine proteinase which triggers blood coagulation by directly activating Factor X (FX) in the absence of Factor VII (F VII), has recently been isolated from rabbit V2 carcinoma and biochemically characterized. We have studied the procoagulant activity of tissue extracts from 4 murine exp...

journal_title：International journal of cancer

authors： Falanga A,Bolognese Dalessandro AP,Casali B,Roncaglioni MC,Donati MB

更新日期：1987-06-15 00:00:00

abstract：:Metastasis is a critical problem in the treatment of human lung cancer. Thus, a suitable animal model of metastasis of human lung cancer is required for in vivo biological and preclinical studies. In this study, we tried to establish a suitable model for this, using SCID mice. Neither human SCLC H69/VP cells (5 x 10(6...

journal_title：International journal of cancer

authors： Yano S,Nishioka Y,Izumi K,Tsuruo T,Tanaka T,Miyasaka M,Sone S

更新日期：1996-07-17 00:00:00

abstract：:The specific aim of three-dimensional conformal radiotherapy is to deliver adequate therapeutic radiation dose to the target volume while concomitantly keeping the dose to surrounding and intervening normal tissues to a minimum. The objective of this study is to examine dose distributions produced by various radiother...

journal_title：International journal of cancer

authors： Ahmad M,Nath R

更新日期：2001-02-20 00:00:00

abstract：:DT-diaphorase (DTD) is a flavoprotein which catalyzes obligate two-electron reduction of a diverse group of substrates. We have reported previously that non-tumorigenic mouse lung alveolar type-II pneumocytes have high DTD activity, while cell lines derived from lung tumors do not. In contrast, other investigators, us...

journal_title：International journal of cancer

authors： Thaete LG,Siegel D,Malkinson AM,Forrest GL,Ross D

更新日期：1991-08-19 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In this study, two sorafenib-resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms lead...

journal_title：International journal of cancer

authors： Li S,Dai W,Mo W,Li J,Feng J,Wu L,Liu T,Yu Q,Xu S,Wang W,Lu X,Zhang Q,Chen K,Xia Y,Lu J,Zhou Y,Fan X,Xu L,Guo C

更新日期：2017-12-15 00:00:00

abstract：:The Ontario Cancer Registry (OCR) and the Surveillance, Epidemiology and End Results (SEER) databases were used to describe temporal trends in the incidence and survival of squamous cancers of the upper aerodigestive tract (UADT) in Ontario and the US between 1984 and 2001. Between the 1984-86 and 1999-01 periods, the...

journal_title：International journal of cancer

authors： Gupta S,Kong W,Peng Y,Miao Q,Mackillop WJ

更新日期：2009-11-01 00:00:00

abstract：:Human mammary carcinoma cell lines (MCF-7) were analysed for their hormone sensitivity before and after transfection with a v-Ha-ras oncogene or with a neomycin-resistance gene followed by selection in vitro or in vivo. Our aim was to test how the expression of the ras oncogene would influence the estradiol sensitivit...

journal_title：International journal of cancer

authors： Van Roy F,Mareel M,Vleminckx K,Beyaert R,Fiers W,Devleeschouwer N,Muquardt C,Legros N,Bracke M,Leclercq G

更新日期：1990-09-15 00:00:00

abstract：:The aim of our study was to develop and validate a machine learning algorithm to predict response of individual HER2-amplified colorectal cancer liver metastases (lmCRC) undergoing dual HER2-targeted therapy. Twenty-four radiomics features were extracted after 3D manual segmentation of 141 lmCRC on pretreatment portal...

journal_title：International journal of cancer

authors： Giannini V,Rosati S,Defeudis A,Balestra G,Vassallo L,Cappello G,Mazzetti S,De Mattia C,Rizzetto F,Torresin A,Sartore-Bianchi A,Siena S,Vanzulli A,Leone F,Zagonel V,Marsoni S,Regge D

更新日期：2020-12-01 00:00:00

abstract：:Although tumor-specific T lymphocytes recognize tumor-associated antigens (TAA) present on their cell surface via major histocompatibility complex (MHC) molecules, T cells require other activating signals. These are provided by costimulatory molecules, including B7-1 (CD80), B7-2 (CD86) and intercellular adhesive mole...

journal_title：International journal of cancer

authors： Joki T,Kikuchi T,Akasaki Y,Saitoh S,Abe T,Ohno T

更新日期：1999-08-27 00:00:00

abstract：:Angiogenesis, a critical driver of tumor development, is controlled by interconnected signaling pathways. Vascular endothelial growth factor receptor (VEGFR) 2 and tyrosine kinase with immunoglobulin and epidermal growth factor homology domain 2 play crucial roles in the biology of normal and tumor vasculature. Regora...

journal_title：International journal of cancer

authors： Wilhelm SM,Dumas J,Adnane L,Lynch M,Carter CA,Schütz G,Thierauch KH,Zopf D

更新日期：2011-07-01 00:00:00

abstract：:We conducted a case-control study of adenocarcinoma of the lung and exposure to environmental tobacco smoke (ETS) in 7 countries. We interviewed 70 cases of adenocarcinoma of the lung and 178 population or hospital controls. All subjects had smoked fewer than 400 cigarettes in their lifetimes. Ever exposure to ETS fro...

journal_title：International journal of cancer

authors： Boffetta P,Ahrens W,Nyberg F,Mukeria A,Brüske-Hohlfeld I,Fortes C,Constantinescu V,Simonato L,Batura-Gabryel H,Lea S,Gaborieau V,Benhamou S

更新日期：1999-11-26 00:00:00

abstract：:Targeting of T lymphocytes against epidermal growth-factor-receptor (EGF-R)+ tumor cells was achieved by constructing a hybrid hybridoma which secretes an anti-EGF-R/anti-CD3 bispecific monoclonal antibody (biMAb) of hybrid isotype (IgG1/IgG2a). Purification of biMAb molecules from parental anti-EGF-R and anti-CD3 MAb...

journal_title：International journal of cancer

authors： Ferrini S,Cambiaggi A,Sforzini S,Marciano S,Canevari S,Mezzanzanica D,Colnaghi MI,Grossi CE,Moretta L

更新日期：1993-12-02 00:00:00

abstract：:The acyclic nucleoside phosphonate analogue cidofovir is a broad-spectrum anti-DNA virus agent, which also possesses potent inhibitory activity against various tumors associated with papillomaviruses in animal models and patients. Moreover, we recently described the potent inhibition of polyomavirus (PyV)-induced hema...

journal_title：International journal of cancer

authors： Liekens S,Verbeken E,De Clercq E,Neyts J

更新日期：2001-04-15 00:00:00

abstract：:An important feature of cytochrome P450 (CYP) 2B1 is its high ability to convert the prodrug cyclophosphamide (CPA) to therapeutically cytotoxic metabolites, resulting in interstrand DNA-cross-linking and cell death. We have examined whether and how the phosphorylation of CYP2B1 influences CPA metabolic activation in ...

journal_title：International journal of cancer

authors： Oesch-Bartlomowicz B,Richter B,Becker R,Vogel S,Padma PR,Hengstler JG,Oesch F

更新日期：2001-12-01 00:00:00

abstract：:Mismatch repair-deficient (dMMR) and/or microsatellite instability-high (MSI) colorectal cancers (CRC) represent about 5% of metastatic CRC (mCRC). Prognosis and chemosensitivity of dMMR/MSI mCRC remain unclear. This multicenter study included consecutive patients with dMMR/MSI mCRC from 2007 to 2017. The primary endp...

journal_title：International journal of cancer

authors： Tougeron D,Sueur B,Zaanan A,de la Fouchardiére C,Sefrioui D,Lecomte T,Aparicio T,Des Guetz G,Artru P,Hautefeuille V,Coriat R,Moulin V,Locher C,Touchefeu Y,Lecaille C,Goujon G,Ferru A,Evrard C,Chautard R,Gentilhomme

更新日期：2020-07-01 00:00:00

abstract：:Exercise has been shown to reduce risk and improve prognosis of several types of cancers. Irisin is a myokine linked to exercise and lean body mass, which is thought to favorably alter metabolism systemically, potentially providing benefit for metabolic disease (including cancer). We evaluated the effects of various c...

journal_title：International journal of cancer

authors： Gannon NP,Vaughan RA,Garcia-Smith R,Bisoffi M,Trujillo KA

更新日期：2015-02-15 00:00:00

abstract：:Luteolin is a polyphenolic flavone and has antitumor activity for many cancers. The prostate-derived Ets factor (PDEF), a novel epithelium-specific Ets transcription factor, acts as an androgen-independent transcriptional activator of the prostate-specific antigen (PSA) promoter. We determined the antitumor function o...

journal_title：International journal of cancer

authors： Tsui KH,Chung LC,Feng TH,Chang PL,Juang HH

更新日期：2012-06-15 00:00:00

abstract：:Hycanthone was administered to Schistosoma mansoni-infected and non-infected Syrian golden hamsters and Swiss mice by intraperitoneal and intramuscular injection of amounts up to the maximum tolerated dose. No tumors attributable to treatment were observed in hamsters. In infected mice, the overall incidence of hepato...

journal_title：International journal of cancer

authors： Bulay O,Urman H,Patil K,Clayson DB,Shubik P

更新日期：1979-01-15 00:00:00

abstract：:The flavonoids, a group of more than 4,000 polyphenolic antioxidants, are potential cancer preventive components of fruits and vegetables. Catechins, one of the 6 major groups of flavonoids, are present in high concentrations in tea as well. Our objective was to evaluate the association between intake of catechins and...

journal_title：International journal of cancer

authors： Arts IC,Hollman PC,Bueno De Mesquita HB,Feskens EJ,Kromhout D

更新日期：2001-04-15 00:00:00

abstract：:Twenty-seven human colorectal adenocarcinomas were implanted s.c. into nude mice. A comparative study of chromosomes and DNA between fresh tumor (FT) and xenografted tumor cells (XT) could be performed in 9 cases. Losses or deletions were consistently found in FTs as well as in XTs, particularly on chromosomes 17 and/...

journal_title：International journal of cancer

authors： Lefrançois D,Olschwang S,Delattre O,Muleris M,Dutrillaux AM,Thomas G,Dutrillaux B

更新日期：1989-11-15 00:00:00

abstract：:Annamycin (Ann) is a non-cross-resistant lipophilic anthracycline antiobiotic optimally suited for liposome delivery. We studied how vesicle size and presence of phospholipids with a high phase transition temperature and monosialoganglioside (GM I) in the liposome bilayers affect the pharmacokinetics, tumor selectivit...

journal_title：International journal of cancer

authors： Zou Y,Ling YH,Reddy S,Priebe W,Perez-Soler R

更新日期：1995-05-29 00:00:00

abstract：:In order to analyze the mutational events and to understand the biological significance of the p53 gene in chemical carcinogenesis, we applied a new yeast-based p53 functional assay to ovarian tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA), as well as to transitional cell carcinomas of the urinary bladder in...

journal_title：International journal of cancer

authors： Yamamoto K,Nakata D,Tada M,Tonoki H,Nishida T,Hirai A,Ba Y,Aoyama T,Hamada J,Furuuchi K,Harada H,Hirai K,Shibahara N,Katsuoka Y,Moriuchi T

更新日期：1999-11-26 00:00:00

abstract：:Cytogenetic analysis of short-term cultures from 26 primary bronchial large cell carcinomas and 1 metastasis from a primary large cell carcinoma revealed clonal chromosome abnormalities in 20 tumors and a normal karyotype in 6. No outgrowth was obtained in 1 case. Simple aberrations were present in 3 tumors; in 1, the...

journal_title：International journal of cancer

authors： Johansson M,Dietrich C,Mandahl N,Hambraeus G,Johansson L,Clausen PP,Mitelman F,Heim S

更新日期：1994-05-15 00:00:00