Accuracy of concurrent visual and cytology screening in detecting cervical cancer precursors in rural India.

abstract：:Conventionally bred rats possess in their sera an NA which has a cytotoxic effect on a tumor cell line (KMT-17) derived from a fibrosarcoma induced by 3-methylcholanthrene and which can be absorbed by normal rat tissues. We have succeeded in purifying a glycosphingolipid as an antigen reactive to NA. GSLs isolated fro...

journal_title：International journal of cancer

authors： Takimoto M,Suzuki E,Naiki M,Itaya T,Takeichi N,Hosokawa M,Kobayashi H

更新日期：1985-12-15 00:00:00

abstract：:A PCR assay using capillary electrophoresis was designed for the detection of c-erbB-2 gene amplification in alcohol-formalin-acetic acid (AFA)-fixed, paraffin-embedded biopsies from 81 consecutive breast tumors. c-erbB-2 expression was analyzed in the same samples using immuno-histochemistry (IHC). In the competitive...

journal_title：International journal of cancer

authors： de Cremoux P,Martin EC,Vincent-Salomon A,Dieras V,Barbaroux C,Liva S,Pouillart P,Sastre-Garau X,Magdelenat H

更新日期：1999-10-08 00:00:00

abstract：:Beta-lapachone and camptothecin are structurally unrelated agents thought to inhibit topoisomerase-I activity through distinct mechanisms. We find that beta-lapachone is much more potent than camptothecin in inducing acute cytotoxic effects on human malignant glioma cells. Acute cytotoxicity induced by both drugs is a...

journal_title：International journal of cancer

authors： Weller M,Winter S,Schmidt C,Esser P,Fontana A,Dichgans J,Groscurth P

更新日期：1997-11-27 00:00:00

abstract：:Cell kinetic studies are of interest for clarifying the concepts of chemotherapeutic strategy in the multimodality therapy of advanced squamous-cell carcinoma of the head and neck. A poorly-differentiated squamous-cell carcinoma of the head and neck heterotransplanted to nude mice was used for analyses of chemotherape...

journal_title：International journal of cancer

authors： Wennerberg J,Alm P,Biörklund A,Killander D,Långström E,Tropé C

更新日期：1984-02-15 00:00:00

abstract：:MART-1/MelanA and Pmel17/gp100 are melanoma-associated antigens (MAAs) that can be recognized by tumor-infiltrating lymphocytes (TILs) capable of mediating successful adoptive therapy in vivo. Analysis of melanoma cell lines in vitro has demonstrated that heterogeneous antigen expression in the context of class I MHC ...

journal_title：International journal of cancer

authors： Cormier JN,Hijazi YM,Abati A,Fetsch P,Bettinotti M,Steinberg SM,Rosenberg SA,Marincola FM

更新日期：1998-02-09 00:00:00

abstract：:Prostate-specific antigen (PSA) is a serine protease secreted by prostatic epithelial cells and is widely used as a marker for prostate cancer. The tissue specificity of PSA makes it a potential target for active specific immunotherapy, especially in prostate cancer patients who have undergone prostatectomy and in who...

journal_title：International journal of cancer

authors： Hodge JW,Schlom J,Donohue SJ,Tomaszewski JE,Wheeler CW,Levine BS,Gritz L,Panicali D,Kantor JA

更新日期：1995-10-09 00:00:00

abstract：:Gliomas are the most common tumors of the central nervous system and have a grave prognosis. Deletion of chromosome 10p15 is one of the most common chromosomal alterations in gliomas. Recently, a candidate tumor suppressor gene, KLF6, which is mapped to chromosome 10p, was found to be frequently mutated in prostate ca...

journal_title：International journal of cancer

authors： Jeng YM,Hsu HC

更新日期：2003-07-10 00:00:00

abstract：:Altered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression. We hypothesized that heritable methylation potential might be a risk factor for breast cancer and evaluated possible association with breast cancer for single nucleotide polymorphisms (S...

journal_title：International journal of cancer

authors： Harlid S,Ivarsson MI,Butt S,Hussain S,Grzybowska E,Eyfjörd JE,Lenner P,Försti A,Hemminki K,Manjer J,Dillner J,Carlson J

更新日期：2011-10-01 00:00:00

abstract：:Rabbits were immunized with extracts of primary or grafted intestinal adeno-carcinomas induced by carcinogenic drugs in inbred rats. After absorption with normal tissue extracts, the antisera were able to recognize three tumor-associated antigens. Two of them were glycoproteins, present in cancer cells but also, in tr...

journal_title：International journal of cancer

authors： Martin F,Martin MS,Bordes M,Knobel S

更新日期：1975-01-15 00:00:00

abstract：:Lung cancer is the leading cause of cancer mortality in the world. Although exposure to carcinogens is considered to be the main cause, genetic variation may contribute to lung cancer risk. Murine double minute 2, MDM2, is a key regulator of p53 activity and recently a polymorphism in the promoter region of the MDM2 g...

journal_title：International journal of cancer

authors： Lind H,Zienolddiny S,Ekstrøm PO,Skaug V,Haugen A

更新日期：2006-08-01 00:00:00

abstract：:Transforming growth factor-beta (TGFbeta1) enhances human MDA-MB-231 breast tumour cell invasion of reconstituted basement membrane in vitro but does not inhibit proliferation of this cell line. In contrast to basal invasion, which is plasmin-, urokinase (uPA)-, tissue-type plasminogen activator (t-PA)-, matrix metall...

journal_title：International journal of cancer

authors： Farina AR,Coppa A,Tiberio A,Tacconelli A,Turco A,Colletta G,Gulino A,Mackay AR

更新日期：1998-03-02 00:00:00

abstract：:High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...

journal_title：International journal of cancer

authors： Smida Rezgui S,Honore S,Rognoni JB,Martin PM,Penel C

更新日期：2000-08-01 00:00:00

abstract：:To evaluate a possible association between infection with cag A-positive strains and gastric carcinoma increased risk we studied 119 Helicobacter pylori-positive patients with gastric carcinoma and 119 matched controls. The presence of cag A gene was investigated by PCR in H. pylori isolates and in gastric biopsy spec...

journal_title：International journal of cancer

authors： Queiroz DM,Mendes EN,Rocha GA,Oliveira AM,Oliveira CA,Magalhães PP,Moura SB,Cabral MM,Nogueira AM

更新日期：1998-10-05 00:00:00

abstract：:Histologic characteristics of bladder cancer in Boston, USA, Manchester, UK, and Nagoya, Japan, were evaluated. In each of these areas broadly-based series of cases were assembled during a collaborative case-control study. The present analysis was based on 589 cases in Boston, 484 cases in Manchester, and 241 cases in...

journal_title：International journal of cancer

authors： Morrison AS,Proppe KH,Verhoek WG,Aoki K,Leck I,Ohno Y,Obata K

更新日期：1982-12-15 00:00:00

abstract：:Cyclin D1 is a major positive regulator of the G1 restriction point promoting inactivation of the retinoblastoma protein (RB). The cyclin D1 gene is rearranged, amplified and/or over-expressed in several human neoplasms. In the present series of 64 human breast carcinomas, cyclin D1 amplification (4- to 8-fold) was se...

journal_title：International journal of cancer

authors： Barbareschi M,Pelosio P,Caffo O,Buttitta F,Pellegrini S,Barbazza R,Dalla Palma P,Bevilacqua G,Marchetti A

更新日期：1997-04-22 00:00:00

abstract：:Mucin-associated sialylated Lewis antigens are implicated in tumor cell metastasis and are used in several tests for pancreatic cancer. Despite their clinical importance, little is known about the structures of the oligosaccharides of pancreatic cancer mucins or about the regulation of their synthesis or of the synthe...

journal_title：International journal of cancer

authors： Yamashita Y,Ho JJ,Cheng S,Siddiki B,Chung YS,Sowa M,Kim YS

更新日期：1997-07-29 00:00:00

abstract：:In a hospital-based case-control study of esophageal cancer undertaken in Athens (1989-1991), 43 patients with incident esophageal squamous-cell carcinoma and 56 patients with incident esophageal adenocarcinoma were compared to 200 injury patients. Personal interviews were conducted in the hospital setting, and dietar...

journal_title：International journal of cancer

authors： Tzonou A,Lipworth L,Garidou A,Signorello LB,Lagiou P,Hsieh C,Trichopoulos D

更新日期：1996-11-04 00:00:00

abstract：:We tested the efficacy of gefitinib in the prevention of HER2/neu-mediated breast cancer development in BALB-NeuT transgenic mice. Oral administration of gefitinib to female transgenic mice from 5 to 14 weeks of age reduced tumor multiplicity from 9.6 +/- 0.82 to 0.58 +/- 1.1 (83%). We observed a decrease in the numbe...

journal_title：International journal of cancer

authors： Piechocki MP,Dibbley SK,Lonardo F,Yoo GH

更新日期：2008-04-15 00:00:00

abstract：:Accurate prognostic parameters in prostate biopsies are needed to better counsel individual patients with prostate cancer. We evaluated the prognostic impact of morphologic and immunohistochemical parameters in preoperative prostate cancer biopsies. A consecutive series of prostate biopsies of 279 men (72% with clinic...

journal_title：International journal of cancer

authors： Zellweger T,Günther S,Zlobec I,Savic S,Sauter G,Moch H,Mattarelli G,Eichenberger T,Curschellas E,Rüfenacht H,Bachmann A,Gasser TC,Mihatsch MJ,Bubendorf L

更新日期：2009-05-01 00:00:00

abstract：:To identify genes associated with radioresistant oral squamous cell carcinoma (OSCC), we compared gene expression signatures between OSCC cell lines exhibiting radioresistance and cells with radiosensitivity after X-ray irradiation in a dose-dependent manner using Affymetrix GeneChip analysis with Human Genome-U133 pl...

journal_title：International journal of cancer

authors： Ishigami T,Uzawa K,Higo M,Nomura H,Saito K,Kato Y,Nakashima D,Shiiba M,Bukawa H,Yokoe H,Kawata T,Ito H,Tanzawa H

更新日期：2007-05-15 00:00:00

abstract：:Multiple myeloma, a neoplasm of plasma cells, accounts for approximately approximately 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no esta...

journal_title：International journal of cancer

authors： Alexander DD,Mink PJ,Adami HO,Cole P,Mandel JS,Oken MM,Trichopoulos D

更新日期：2007-01-01 00:00:00

abstract：:Cytokines such as Interleukin (IL)-12p70 ("IL-12") and IL-23 can influence tumor progression. We tested the hypothesis that blood levels of IL-12p40, the common subunit of both cytokines, are associated with melanoma progression. Blood from 2,048 white melanoma patients were collected at a single institution between M...

journal_title：International journal of cancer

authors： Fang S,Wang Y,Chun YS,Liu H,Ross MI,Gershenwald JE,Cormier JN,Royal RE,Lucci A,Schacherer CW,Reveille JD,Sui D,Bassett RL Jr,Wang LE,Wei Q,Amos CI,Lee JE

更新日期：2015-04-15 00:00:00

abstract：:Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...

journal_title：International journal of cancer

authors： Dall'Olio F,Chiricolo M,Ceccarelli C,Minni F,Marrano D,Santini D

更新日期：2000-10-01 00:00:00

abstract：:Increased exposure to estrogen is a risk factor for postmenopausal breast cancer, and dietary factors can influence estrogen metabolism. However, studies of diet and breast cancer have been inconclusive. We developed a dietary pattern associated with levels of unconjugated estradiol and the ratio of 2- and 16-hydroxyl...

journal_title：International journal of cancer

authors： Guinter MA,McLain AC,Merchant AT,Sandler DP,Steck SE

更新日期：2018-08-01 00:00:00

abstract：:Data from a series of case-control studies, conducted in Italy and Switzerland between 1991 and 2001, have been analyzed to evaluate the role of n-3 polyunsaturated fatty acid (PUFA) intake in the etiology of cancer of oral cavity and pharynx (736 cases, 1772 controls), esophagus (395 cases, 1066 controls), large bowe...

journal_title：International journal of cancer

authors： Tavani A,Pelucchi C,Parpinel M,Negri E,Franceschi S,Levi F,La Vecchia C

更新日期：2003-05-20 00:00:00

abstract：:The relationship between breast cancer-associated fatty acid synthase (FAS; oncogenic antigen-519) and chemotherapy-induced cell damage has not been studied. We examined the ability of C75, a synthetic slow-binding inhibitor of FAS activity, to modulate the cytotoxic activity of the microtubule-interfering agent Taxol...

journal_title：International journal of cancer

authors： Menendez JA,Vellon L,Colomer R,Lupu R

更新日期：2005-05-20 00:00:00

abstract：:Dendritic cells (DCs) cross-present antigen (Ag) to initiate T-cell immunity against most infections and tumors. Natural killer (NK) cells are innate cytolytic lymphocytes that have emerged as key modulators of multiple DC functions. Here, we show that human NK cells promote cross-presentation of tumor cell-derived Ag...

journal_title：International journal of cancer

authors： Deauvieau F,Ollion V,Doffin AC,Achard C,Fonteneau JF,Verronese E,Durand I,Ghittoni R,Marvel J,Dezutter-Dambuyant C,Walzer T,Vie H,Perrot I,Goutagny N,Caux C,Valladeau-Guilemond J

更新日期：2015-03-01 00:00:00

abstract：:Loss of cell polarity is one of the hallmarks of malignant carcinomas. Most of the understanding about the link between cell polarity and proliferation control comes from studies on the Drosophila tumor suppressors discs large (Dlg), scribble (Scrib) and lethal giant larvae (lgl). Mammalian homologues of these protein...

journal_title：International journal of cancer

authors： Gardiol D,Zacchi A,Petrera F,Stanta G,Banks L

更新日期：2006-09-15 00:00:00

abstract：:The role of alcoholic beverages in the etiology of gastric cancer is unclear. Recent summaries showed a positive association between higher alcohol intake and gastric cancer risk, but the magnitude of association is small, there is moderate heterogeneity among studies, and most cases were from Asian populations. We pr...

journal_title：International journal of cancer

authors： Wang S,Freedman ND,Loftfield E,Hua X,Abnet CC

更新日期：2018-12-01 00:00:00

abstract：:Breast cancer cells frequently metastasize to the skeleton, where they induce OCL formation and activity, resulting in extensive bone destruction. However, the mechanisms by which breast cancer cells mediate increased osteolysis remain unclear. To elucidate this point, we investigated how 3 human breast cancer cell li...

journal_title：International journal of cancer

authors： Morgan H,Tumber A,Hill PA

更新日期：2004-05-01 00:00:00